Uhmk1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Uhmk1
Entrez Gene ID	16589
Full Name	U2AF homology motif (UHM) kinase 1
Synonyms	4732477C12Rik,4930500M09Rik,AA673513,AI449218,AU021979,C820018A03Rik,KIS,Kist,P-CIP2
General protein information	Preferred Names U2AF homology motif (UHM) kinase 1 Names serine/threonine-protein kinase Kist PAM COOH-terminal interactor protein 2 U2AF homology motif kinase 1 kinase interacting with leukemia-associated gene (stathmin) kinase interacting with stathmin
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 H3

mRNA and Protein(s)

mRNA	Protein	Name
NM_010633.3	NP_034763.3	serine/threonine-protein kinase Kist
XM_006496682.4	XP_006496745.1	serine/threonine-protein kinase Kist isoform X1
XM_006496682.3	XP_006496745.1	serine/threonine-protein kinase Kist isoform X1
NM_001360809.1	NP_001347738.1	serine/threonine-protein kinase Kist isoform 2
NM_010633.4	NP_034763.3	serine/threonine-protein kinase Kist isoform 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	UHMK1	XP_001174268.1
Mus musculus (house mouse)	Uhmk1	NP_034763.3
Homo sapiens (human)	UHMK1	NP_787062.1
	UHMK1	XP_001118183.1
Canis lupus familiaris (dog)	UHMK1	XP_536143.3
Danio rerio (zebrafish)	uhmk1	NP_001070127.1
Bos taurus (cattle)	UHMK1	NP_001192514.1
Rattus norvegicus (Norway rat)	RGD1561897	XP_574033.2
Gallus gallus (chicken)	UHMK1	XP_422213.4
Rattus norvegicus (Norway rat)	Uhmk1	NP_058989.1

Gene Ontology
Bibliography

Related articles in PubMed

Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss.
Scekic-Zahirovic J, Sendscheid O, El Oussini H, Jambeau M, Sun Y, Mersmann S, Wagner M, Dieterl? S, Sinniger J, Dirrig-Grosch S, Drenner K, Birling MC, Qiu J, Zhou Y, Li H, Fu XD, Rouaux C, Shelkovnikova T, Witting A, Ludolph AC, Kiefer F, Storkebaum E, Lagier-Tourenne C, Dupuis L
The EMBO journal35(10)1077-97(2016 05)

KIS, a kinase associated with microtubule regulators, enhances translation of AMPA receptors and stimulates dendritic spine remodeling.
Pedraza N, Ortiz R, Cornad? A, Llobet A, Aldea M, Gallego C
The Journal of neuroscience : the official journal of the Society for Neuroscience34(42)13988-97(2014 Oct)

The protein kinase KIS impacts gene expression during development and fear conditioning in adult mice.
Manceau V, Kremmer E, Nabel EG, Maucuer A
PloS one7(8)e43946(2012)

Signaling from the secretory granule to the nucleus: Uhmk1 and PAM.
Francone VP, Ifrim MF, Rajagopal C, Leddy CJ, Wang Y, Carson JH, Mains RE, Eipper BA
Molecular endocrinology (Baltimore, Md.)24(8)1543-58(2010 Aug)

KIS protects against adverse vascular remodeling by opposing stathmin-mediated VSMC migration in mice.
Langenickel TH, Olive M, Boehm M, San H, Crook MF, Nabel EG
The Journal of clinical investigation118(12)3848-59(2008 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The absence of KIS results in a significant decrease in AMPA receptors in dendritic spines.
Title: KIS, a kinase associated with microtubule regulators, enhances translation of AMPA receptors and stimulates dendritic spine remodeling.

disregulation of gene expression due to KIS inactivation affects specific brain functions.
Title: The protein kinase KIS impacts gene expression during development and fear conditioning in adult mice.

Uhmk1 was concentrated in the nucleus, but cycled rapidly between nucleus and cytosol.
Title: Signaling from the secretory granule to the nucleus: Uhmk1 and PAM.

KIS is a component of the molecular device that modulates translation in RNA-transporting granules as a result of local signals.
Title: Protein kinase KIS localizes to RNA granules and enhances local translation.

Phosphorylation of p27Kip1 by KIS leads to cell-cycle progression, whereas the target sequence and the physiological relevance of KIS-mediated stathmin phosphorylation in VSMCs
Title: KIS protects against adverse vascular remodeling by opposing stathmin-mediated VSMC migration in mice.

The following Uhmk1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Uhmk1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu06489	NM_010633.4 Latest version!	Mus musculus U2AF homology motif (UHM) kinase 1 (Uhmk1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
OMu84008	NM_001360809.1 Latest version!	Mus musculus U2AF homology motif (UHM) kinase 1 (Uhmk1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OMu28641	XM_006496682.4 Latest version!	Mus musculus U2AF homology motif (UHM) kinase 1 (Uhmk1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OMu28641	XM_006496682.3	Mus musculus U2AF homology motif (UHM) kinase 1 (Uhmk1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu06489	NM_010633.3	Mus musculus U2AF homology motif (UHM) kinase 1 (Uhmk1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Uhmk1 ( XM_006496682.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006496745.1 Mus musculus U2AF homology motif (UHM) kinase 1 (Uhmk1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu28641
Clone ID Related Accession (Same CDS sequence)	XM_006496682.4 , XM_006496682.3
Accession Version	XM_006496682.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1035bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	serine/threonine-protein kinase Kist isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006496682.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGGGT CCGGCTGCGC GTGGGGCGCC GAGCCGCCGC GCTTCCTGGA GGCCTTCGGG 
CGGCTGTGGC AGGTCCAGAG CCGCCTGGGC AGCGGCTCGT CGGCCTCGGT GTACCGGGTG 
CGGTGCTGCG GTACCCCGGG CTCGCCCCCC GGCGCCCTCA AGCAGTTCCT GCCTCCGGGA 
ACCACCGGGG CTGCGGCCTC GGCCGCGGAG TATGGTTTCC GCAAAGAGAG GGCGGCGCTG 
GAGCAGTTGC AGGGTCACAG GAACATCGTG ACTTTATATG GAGTCTTTAC CATACACTTC 
TCTCCCAATG TGCCATCACG CTGTCTGCTG CTTGAACTCC TGGATGTCAG TGTTTCGGAA 
TTGCTTTTAT ATTCCAGTCA TCAGGGCTGC TCCATGTGGA TGATACAGCA CTGTGCCCGA 
GATGTTCTGG AGGCCCTCGC TTTTCTTCAC CATGAGGGCT ACGTCCATGC AGACCTCAAA 
CCACGAAACA TCCTGTGGAG TGCGGAGAAT GAGTGTTTTA AGCTTATTGA CTTTGGACTC 
AGCTTCAAAG AAGGCAATCA GGACGTAAAG TATATTCAGA CAGACGGGTA TCGCGCTCCT 
GAAGCAGAGC TGCAGAACTG CTTGGCCCAG GCCGGCCTGC AGAGTGATAC AGAATGTACC 
TCAGCTGTTG ATCTGTGGAG CCTCGGAATC ATTTTACTGG AAATGTTCTC AGGAATGAAG 
CTGAAACATA CAGTCAGATC TCAGGAATGG AAGGCAAACA GTTCTGCTAT TATTGATCAT 
ATATTTGCCA GTAAAGCAGT GGTGAATGCC GCAATTCCAG CCTATCACCT CAGAGACCTT 
ATCAAAAGCA TGCTTCATGA TGACCCGGGC AGAAGAATCC CTGCTGAGAT GGCATTGTGC 
AGCCCATTCT TTAGCATTCC TTTTGCCCCT CATATTGAAG ATCTGGTGAT GCTTCCGACT 
CCAGTGCTCA GGCTCCTCAA TGTGCTGGAT GATGATTACC TTGAAAATGA AGATGAATAT 
GAAGGTCTTC GTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006496745.1
CDS	196..1230
Translation	MAGSGCAWGAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCGTPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPGRRIPAEMALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEDEYEGLR

Target ORF information:

RefSeq Version	XM_006496682.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus U2AF homology motif (UHM) kinase 1 (Uhmk1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006496682.3

ORF Insert Sequence:

ATGGCGGGGT CCGGCTGCGC GTGGGGCGCC GAGCCGCCGC GCTTCCTGGA GGCCTTCGGG 
CGGCTGTGGC AGGTCCAGAG CCGCCTGGGC AGCGGCTCGT CGGCCTCGGT GTACCGGGTG 
CGGTGCTGCG GTACCCCGGG CTCGCCCCCC GGCGCCCTCA AGCAGTTCCT GCCTCCGGGA 
ACCACCGGGG CTGCGGCCTC GGCCGCGGAG TATGGTTTCC GCAAAGAGAG GGCGGCGCTG 
GAGCAGTTGC AGGGTCACAG GAACATCGTG ACTTTATATG GAGTCTTTAC CATACACTTC 
TCTCCCAATG TGCCATCACG CTGTCTGCTG CTTGAACTCC TGGATGTCAG TGTTTCGGAA 
TTGCTTTTAT ATTCCAGTCA TCAGGGCTGC TCCATGTGGA TGATACAGCA CTGTGCCCGA 
GATGTTCTGG AGGCCCTCGC TTTTCTTCAC CATGAGGGCT ACGTCCATGC AGACCTCAAA 
CCACGAAACA TCCTGTGGAG TGCGGAGAAT GAGTGTTTTA AGCTTATTGA CTTTGGACTC 
AGCTTCAAAG AAGGCAATCA GGACGTAAAG TATATTCAGA CAGACGGGTA TCGCGCTCCT 
GAAGCAGAGC TGCAGAACTG CTTGGCCCAG GCCGGCCTGC AGAGTGATAC AGAATGTACC 
TCAGCTGTTG ATCTGTGGAG CCTCGGAATC ATTTTACTGG AAATGTTCTC AGGAATGAAG 
CTGAAACATA CAGTCAGATC TCAGGAATGG AAGGCAAACA GTTCTGCTAT TATTGATCAT 
ATATTTGCCA GTAAAGCAGT GGTGAATGCC GCAATTCCAG CCTATCACCT CAGAGACCTT 
ATCAAAAGCA TGCTTCATGA TGACCCGGGC AGAAGAATCC CTGCTGAGAT GGCATTGTGC 
AGCCCATTCT TTAGCATTCC TTTTGCCCCT CATATTGAAG ATCTGGTGAT GCTTCCGACT 
CCAGTGCTCA GGCTCCTCAA TGTGCTGGAT GATGATTACC TTGAAAATGA AGATGAATAT 
GAAGGTCTTC GTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Uhmk1 ( NM_010633.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034763.3 Mus musculus U2AF homology motif (UHM) kinase 1 (Uhmk1), mRNA.

Price & Availability↑

CloneID	OMu06489
Clone ID Related Accession (Same CDS sequence)	NM_010633.3 , NM_010633.4
Accession Version	NM_010633.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1260bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-28
Organism	Mus musculus(house mouse)
Product	serine/threonine-protein kinase Kist
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC058732.1. On or before Mar 2, 2012 this sequence version replaced XM_003689331.1, NM_010633.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC058732.1, AK013347.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGGCGGGGT CCGGCTGCGC GTGGGGCGCC GAGCCGCCGC GCTTCCTGGA GGCCTTCGGG 
CGGCTGTGGC AGGTCCAGAG CCGCCTGGGC AGCGGCTCGT CGGCCTCGGT GTACCGGGTG 
CGGTGCTGCG GTACCCCGGG CTCGCCCCCC GGCGCCCTCA AGCAGTTCCT GCCTCCGGGA 
ACCACCGGGG CTGCGGCCTC GGCCGCGGAG TATGGTTTCC GCAAAGAGAG GGCGGCGCTG 
GAGCAGTTGC AGGGTCACAG GAACATCGTG ACTTTATATG GAGTCTTTAC CATACACTTC 
TCTCCCAATG TGCCATCACG CTGTCTGCTG CTTGAACTCC TGGATGTCAG TGTTTCGGAA 
TTGCTTTTAT ATTCCAGTCA TCAGGGCTGC TCCATGTGGA TGATACAGCA CTGTGCCCGA 
GATGTTCTGG AGGCCCTCGC TTTTCTTCAC CATGAGGGCT ACGTCCATGC AGACCTCAAA 
CCACGAAACA TCCTGTGGAG TGCGGAGAAT GAGTGTTTTA AGCTTATTGA CTTTGGACTC 
AGCTTCAAAG AAGGCAATCA GGACGTAAAG TATATTCAGA CAGACGGGTA TCGCGCTCCT 
GAAGCAGAGC TGCAGAACTG CTTGGCCCAG GCCGGCCTGC AGAGTGATAC AGAATGTACC 
TCAGCTGTTG ATCTGTGGAG CCTCGGAATC ATTTTACTGG AAATGTTCTC AGGAATGAAG 
CTGAAACATA CAGTCAGATC TCAGGAATGG AAGGCAAACA GTTCTGCTAT TATTGATCAT 
ATATTTGCCA GTAAAGCAGT GGTGAATGCC GCAATTCCAG CCTATCACCT CAGAGACCTT 
ATCAAAAGCA TGCTTCATGA TGACCCGGGC AGAAGAATCC CTGCTGAGAT GGCATTGTGC 
AGCCCATTCT TTAGCATTCC TTTTGCCCCT CATATTGAAG ATCTGGTGAT GCTTCCGACT 
CCAGTGCTCA GGCTCCTCAA TGTGCTGGAT GATGATTACC TTGAAAATGA AGATGAATAT 
GAAGATGTTG TAGAAGATGT GAAAGAGGAG TGTCAGAAAT ATGGACCAGT GGTTTCTCTG 
CTTGTTCCAA AGGAAAATCC TGGCAGAGGA CAAGTCTTCG TTGAGTACGC GAACGCTGGT 
GATTCCAAAG CTGCTCAGAA GTTGCTGACT GGGAGGATGT TTGACGGGAA GTTTGTTGTG 
GCTACATTCT ACCCGCTGAG TGCCTACAAG AGGGGATATC TTTATCAAAC CTTGCTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034763.3
CDS	154..1413
Translation	MAGSGCAWGAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCGTPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPGRRIPAEMALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEDEYEDVVEDVKEECQKYGPVVSLLVPKENPGRGQVFVEYANAGDSKAAQKLLTGRMFDGKFVVATFYPLSAYKRGYLYQTLL

Target ORF information:

RefSeq Version	NM_010633.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus U2AF homology motif (UHM) kinase 1 (Uhmk1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010633.3

ORF Insert Sequence:

ATGGCGGGGT CCGGCTGCGC GTGGGGCGCC GAGCCGCCGC GCTTCCTGGA GGCCTTCGGG 
CGGCTGTGGC AGGTCCAGAG CCGCCTGGGC AGCGGCTCGT CGGCCTCGGT GTACCGGGTG 
CGGTGCTGCG GTACCCCGGG CTCGCCCCCC GGCGCCCTCA AGCAGTTCCT GCCTCCGGGA 
ACCACCGGGG CTGCGGCCTC GGCCGCGGAG TATGGTTTCC GCAAAGAGAG GGCGGCGCTG 
GAGCAGTTGC AGGGTCACAG GAACATCGTG ACTTTATATG GAGTCTTTAC CATACACTTC 
TCTCCCAATG TGCCATCACG CTGTCTGCTG CTTGAACTCC TGGATGTCAG TGTTTCGGAA 
TTGCTTTTAT ATTCCAGTCA TCAGGGCTGC TCCATGTGGA TGATACAGCA CTGTGCCCGA 
GATGTTCTGG AGGCCCTCGC TTTTCTTCAC CATGAGGGCT ACGTCCATGC AGACCTCAAA 
CCACGAAACA TCCTGTGGAG TGCGGAGAAT GAGTGTTTTA AGCTTATTGA CTTTGGACTC 
AGCTTCAAAG AAGGCAATCA GGACGTAAAG TATATTCAGA CAGACGGGTA TCGCGCTCCT 
GAAGCAGAGC TGCAGAACTG CTTGGCCCAG GCCGGCCTGC AGAGTGATAC AGAATGTACC 
TCAGCTGTTG ATCTGTGGAG CCTCGGAATC ATTTTACTGG AAATGTTCTC AGGAATGAAG 
CTGAAACATA CAGTCAGATC TCAGGAATGG AAGGCAAACA GTTCTGCTAT TATTGATCAT 
ATATTTGCCA GTAAAGCAGT GGTGAATGCC GCAATTCCAG CCTATCACCT CAGAGACCTT 
ATCAAAAGCA TGCTTCATGA TGACCCGGGC AGAAGAATCC CTGCTGAGAT GGCATTGTGC 
AGCCCATTCT TTAGCATTCC TTTTGCCCCT CATATTGAAG ATCTGGTGAT GCTTCCGACT 
CCAGTGCTCA GGCTCCTCAA TGTGCTGGAT GATGATTACC TTGAAAATGA AGATGAATAT 
GAAGATGTTG TAGAAGATGT GAAAGAGGAG TGTCAGAAAT ATGGACCAGT GGTTTCTCTG 
CTTGTTCCAA AGGAAAATCC TGGCAGAGGA CAAGTCTTCG TTGAGTACGC GAACGCTGGT 
GATTCCAAAG CTGCTCAGAA GTTGCTGACT GGGAGGATGT TTGACGGGAA GTTTGTTGTG 
GCTACATTCT ACCCGCTGAG TGCCTACAAG AGGGGATATC TTTATCAAAC CTTGCTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Uhmk1 ( NM_010633.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034763.3 Mus musculus U2AF homology motif (UHM) kinase 1 (Uhmk1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu06489
Clone ID Related Accession (Same CDS sequence)	NM_010633.3 , NM_010633.4
Accession Version	NM_010633.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1260bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Mus musculus(house mouse)
Product	serine/threonine-protein kinase Kist isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC123650.7 and BC058732.1. On Feb 14, 2018 this sequence version replaced NM_010633.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC058732.1, SRR7345562.4701609.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCGGGGT CCGGCTGCGC GTGGGGCGCC GAGCCGCCGC GCTTCCTGGA GGCCTTCGGG 
CGGCTGTGGC AGGTCCAGAG CCGCCTGGGC AGCGGCTCGT CGGCCTCGGT GTACCGGGTG 
CGGTGCTGCG GTACCCCGGG CTCGCCCCCC GGCGCCCTCA AGCAGTTCCT GCCTCCGGGA 
ACCACCGGGG CTGCGGCCTC GGCCGCGGAG TATGGTTTCC GCAAAGAGAG GGCGGCGCTG 
GAGCAGTTGC AGGGTCACAG GAACATCGTG ACTTTATATG GAGTCTTTAC CATACACTTC 
TCTCCCAATG TGCCATCACG CTGTCTGCTG CTTGAACTCC TGGATGTCAG TGTTTCGGAA 
TTGCTTTTAT ATTCCAGTCA TCAGGGCTGC TCCATGTGGA TGATACAGCA CTGTGCCCGA 
GATGTTCTGG AGGCCCTCGC TTTTCTTCAC CATGAGGGCT ACGTCCATGC AGACCTCAAA 
CCACGAAACA TCCTGTGGAG TGCGGAGAAT GAGTGTTTTA AGCTTATTGA CTTTGGACTC 
AGCTTCAAAG AAGGCAATCA GGACGTAAAG TATATTCAGA CAGACGGGTA TCGCGCTCCT 
GAAGCAGAGC TGCAGAACTG CTTGGCCCAG GCCGGCCTGC AGAGTGATAC AGAATGTACC 
TCAGCTGTTG ATCTGTGGAG CCTCGGAATC ATTTTACTGG AAATGTTCTC AGGAATGAAG 
CTGAAACATA CAGTCAGATC TCAGGAATGG AAGGCAAACA GTTCTGCTAT TATTGATCAT 
ATATTTGCCA GTAAAGCAGT GGTGAATGCC GCAATTCCAG CCTATCACCT CAGAGACCTT 
ATCAAAAGCA TGCTTCATGA TGACCCGGGC AGAAGAATCC CTGCTGAGAT GGCATTGTGC 
AGCCCATTCT TTAGCATTCC TTTTGCCCCT CATATTGAAG ATCTGGTGAT GCTTCCGACT 
CCAGTGCTCA GGCTCCTCAA TGTGCTGGAT GATGATTACC TTGAAAATGA AGATGAATAT 
GAAGATGTTG TAGAAGATGT GAAAGAGGAG TGTCAGAAAT ATGGACCAGT GGTTTCTCTG 
CTTGTTCCAA AGGAAAATCC TGGCAGAGGA CAAGTCTTCG TTGAGTACGC GAACGCTGGT 
GATTCCAAAG CTGCTCAGAA GTTGCTGACT GGGAGGATGT TTGACGGGAA GTTTGTTGTG 
GCTACATTCT ACCCGCTGAG TGCCTACAAG AGGGGATATC TTTATCAAAC CTTGCTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034763.3
CDS	168..1427
Translation	MAGSGCAWGAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCGTPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPGRRIPAEMALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEDEYEDVVEDVKEECQKYGPVVSLLVPKENPGRGQVFVEYANAGDSKAAQKLLTGRMFDGKFVVATFYPLSAYKRGYLYQTLL

Target ORF information:

RefSeq Version	NM_010633.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus U2AF homology motif (UHM) kinase 1 (Uhmk1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010633.4

ORF Insert Sequence:

ATGGCGGGGT CCGGCTGCGC GTGGGGCGCC GAGCCGCCGC GCTTCCTGGA GGCCTTCGGG 
CGGCTGTGGC AGGTCCAGAG CCGCCTGGGC AGCGGCTCGT CGGCCTCGGT GTACCGGGTG 
CGGTGCTGCG GTACCCCGGG CTCGCCCCCC GGCGCCCTCA AGCAGTTCCT GCCTCCGGGA 
ACCACCGGGG CTGCGGCCTC GGCCGCGGAG TATGGTTTCC GCAAAGAGAG GGCGGCGCTG 
GAGCAGTTGC AGGGTCACAG GAACATCGTG ACTTTATATG GAGTCTTTAC CATACACTTC 
TCTCCCAATG TGCCATCACG CTGTCTGCTG CTTGAACTCC TGGATGTCAG TGTTTCGGAA 
TTGCTTTTAT ATTCCAGTCA TCAGGGCTGC TCCATGTGGA TGATACAGCA CTGTGCCCGA 
GATGTTCTGG AGGCCCTCGC TTTTCTTCAC CATGAGGGCT ACGTCCATGC AGACCTCAAA 
CCACGAAACA TCCTGTGGAG TGCGGAGAAT GAGTGTTTTA AGCTTATTGA CTTTGGACTC 
AGCTTCAAAG AAGGCAATCA GGACGTAAAG TATATTCAGA CAGACGGGTA TCGCGCTCCT 
GAAGCAGAGC TGCAGAACTG CTTGGCCCAG GCCGGCCTGC AGAGTGATAC AGAATGTACC 
TCAGCTGTTG ATCTGTGGAG CCTCGGAATC ATTTTACTGG AAATGTTCTC AGGAATGAAG 
CTGAAACATA CAGTCAGATC TCAGGAATGG AAGGCAAACA GTTCTGCTAT TATTGATCAT 
ATATTTGCCA GTAAAGCAGT GGTGAATGCC GCAATTCCAG CCTATCACCT CAGAGACCTT 
ATCAAAAGCA TGCTTCATGA TGACCCGGGC AGAAGAATCC CTGCTGAGAT GGCATTGTGC 
AGCCCATTCT TTAGCATTCC TTTTGCCCCT CATATTGAAG ATCTGGTGAT GCTTCCGACT 
CCAGTGCTCA GGCTCCTCAA TGTGCTGGAT GATGATTACC TTGAAAATGA AGATGAATAT 
GAAGATGTTG TAGAAGATGT GAAAGAGGAG TGTCAGAAAT ATGGACCAGT GGTTTCTCTG 
CTTGTTCCAA AGGAAAATCC TGGCAGAGGA CAAGTCTTCG TTGAGTACGC GAACGCTGGT 
GATTCCAAAG CTGCTCAGAA GTTGCTGACT GGGAGGATGT TTGACGGGAA GTTTGTTGTG 
GCTACATTCT ACCCGCTGAG TGCCTACAAG AGGGGATATC TTTATCAAAC CTTGCTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Uhmk1 ( NM_001360809.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001347738.1 Mus musculus U2AF homology motif (UHM) kinase 1 (Uhmk1), transcript variant 2, mRNA.

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CloneID	OMu84008
Clone ID Related Accession (Same CDS sequence)	NM_001360809.1
Accession Version	NM_001360809.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Mus musculus(house mouse)
Product	serine/threonine-protein kinase Kist isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK030152.1 and AC123650.7. Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK030152.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGACTTTAT ATGGAGTCTT TACCATACAC TTCTCTCCCA ATGTGCCATC ACGCTGTCTG 
CTGCTTGAAC TCCTGGATGT CAGTGTTTCG GAATTGCTTT TATATTCCAG TCATCAGGGC 
TGCTCCATGT GGATGATACA GCACTGTGCC CGAGATGTTC TGGAGGCCCT CGCTTTTCTT 
CACCATGAGG GCTACGTCCA TGCAGACCTC AAACCACGAA ACATCCTGTG GAGTGCGGAG 
AATGAGTGTT TTAAGCTTAT TGACTTTGGA CTCAGCTTCA AAGAAGGCAA TCAGGACGTA 
AAGTATATTC AGACAGACGG GTATCGCGCT CCTGAAGCAG AGCTGCAGAA CTGCTTGGCC 
CAGGCCGGCC TGCAGAGTGA TACAGAATGT ACCTCAGCTG TTGATCTGTG GAGCCTCGGA 
ATCATTTTAC TGGAAATGTT CTCAGGAATG AAGCTGAAAC ATACAGTCAG ATCTCAGGAA 
TGGAAGGCAA ACAGTTCTGC TATTATTGAT CATATATTTG CCAGTAAAGC AGTGGTGAAT 
GCCGCAATTC CAGCCTATCA CCTCAGAGAC CTTATCAAAA GCATGCTTCA TGATGACCCG 
GGCAGAAGAA TCCCTGCTGA GATGGCATTG TGCAGCCCAT TCTTTAGCAT TCCTTTTGCC 
CCTCATATTG AAGATCTGGT GATGCTTCCG ACTCCAGTGC TCAGGCTCCT CAATGTGCTG 
GATGATGATT ACCTTGAAAA TGAAGATGAA TATGAAGATG TTGTAGAAGA TGTGAAAGAG 
GAGTGTCAGA AATATGGACC AGTGGTTTCT CTGCTTGTTC CAAAGGAAAA TCCTGGCAGA 
GGACAAGTCT TCGTTGAGTA CGCGAACGCT GGTGATTCCA AAGCTGCTCA GAAGTTGCTG 
ACTGGGAGGA TGTTTGACGG GAAGTTTGTT GTGGCTACAT TCTACCCGCT GAGTGCCTAC 
AAGAGGGGAT ATCTTTATCA AACCTTGCTT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001347738.1
CDS	237..1229
Translation	MTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPGRRIPAEMALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEDEYEDVVEDVKEECQKYGPVVSLLVPKENPGRGQVFVEYANAGDSKAAQKLLTGRMFDGKFVVATFYPLSAYKRGYLYQTLL

Target ORF information:

RefSeq Version	NM_001360809.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus U2AF homology motif (UHM) kinase 1 (Uhmk1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001360809.1

ORF Insert Sequence:

ATGACTTTAT ATGGAGTCTT TACCATACAC TTCTCTCCCA ATGTGCCATC ACGCTGTCTG 
CTGCTTGAAC TCCTGGATGT CAGTGTTTCG GAATTGCTTT TATATTCCAG TCATCAGGGC 
TGCTCCATGT GGATGATACA GCACTGTGCC CGAGATGTTC TGGAGGCCCT CGCTTTTCTT 
CACCATGAGG GCTACGTCCA TGCAGACCTC AAACCACGAA ACATCCTGTG GAGTGCGGAG 
AATGAGTGTT TTAAGCTTAT TGACTTTGGA CTCAGCTTCA AAGAAGGCAA TCAGGACGTA 
AAGTATATTC AGACAGACGG GTATCGCGCT CCTGAAGCAG AGCTGCAGAA CTGCTTGGCC 
CAGGCCGGCC TGCAGAGTGA TACAGAATGT ACCTCAGCTG TTGATCTGTG GAGCCTCGGA 
ATCATTTTAC TGGAAATGTT CTCAGGAATG AAGCTGAAAC ATACAGTCAG ATCTCAGGAA 
TGGAAGGCAA ACAGTTCTGC TATTATTGAT CATATATTTG CCAGTAAAGC AGTGGTGAAT 
GCCGCAATTC CAGCCTATCA CCTCAGAGAC CTTATCAAAA GCATGCTTCA TGATGACCCG 
GGCAGAAGAA TCCCTGCTGA GATGGCATTG TGCAGCCCAT TCTTTAGCAT TCCTTTTGCC 
CCTCATATTG AAGATCTGGT GATGCTTCCG ACTCCAGTGC TCAGGCTCCT CAATGTGCTG 
GATGATGATT ACCTTGAAAA TGAAGATGAA TATGAAGATG TTGTAGAAGA TGTGAAAGAG 
GAGTGTCAGA AATATGGACC AGTGGTTTCT CTGCTTGTTC CAAAGGAAAA TCCTGGCAGA 
GGACAAGTCT TCGTTGAGTA CGCGAACGCT GGTGATTCCA AAGCTGCTCA GAAGTTGCTG 
ACTGGGAGGA TGTTTGACGG GAAGTTTGTT GTGGCTACAT TCTACCCGCT GAGTGCCTAC 
AAGAGGGGAT ATCTTTATCA AACCTTGCTT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Uhmk1 ( XM_006496682.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006496745.1 Mus musculus U2AF homology motif (UHM) kinase 1 (Uhmk1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu28641
Clone ID Related Accession (Same CDS sequence)	XM_006496682.4 , XM_006496682.3
Accession Version	XM_006496682.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1035bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	serine/threonine-protein kinase Kist isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006496682.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGGGT CCGGCTGCGC GTGGGGCGCC GAGCCGCCGC GCTTCCTGGA GGCCTTCGGG 
CGGCTGTGGC AGGTCCAGAG CCGCCTGGGC AGCGGCTCGT CGGCCTCGGT GTACCGGGTG 
CGGTGCTGCG GTACCCCGGG CTCGCCCCCC GGCGCCCTCA AGCAGTTCCT GCCTCCGGGA 
ACCACCGGGG CTGCGGCCTC GGCCGCGGAG TATGGTTTCC GCAAAGAGAG GGCGGCGCTG 
GAGCAGTTGC AGGGTCACAG GAACATCGTG ACTTTATATG GAGTCTTTAC CATACACTTC 
TCTCCCAATG TGCCATCACG CTGTCTGCTG CTTGAACTCC TGGATGTCAG TGTTTCGGAA 
TTGCTTTTAT ATTCCAGTCA TCAGGGCTGC TCCATGTGGA TGATACAGCA CTGTGCCCGA 
GATGTTCTGG AGGCCCTCGC TTTTCTTCAC CATGAGGGCT ACGTCCATGC AGACCTCAAA 
CCACGAAACA TCCTGTGGAG TGCGGAGAAT GAGTGTTTTA AGCTTATTGA CTTTGGACTC 
AGCTTCAAAG AAGGCAATCA GGACGTAAAG TATATTCAGA CAGACGGGTA TCGCGCTCCT 
GAAGCAGAGC TGCAGAACTG CTTGGCCCAG GCCGGCCTGC AGAGTGATAC AGAATGTACC 
TCAGCTGTTG ATCTGTGGAG CCTCGGAATC ATTTTACTGG AAATGTTCTC AGGAATGAAG 
CTGAAACATA CAGTCAGATC TCAGGAATGG AAGGCAAACA GTTCTGCTAT TATTGATCAT 
ATATTTGCCA GTAAAGCAGT GGTGAATGCC GCAATTCCAG CCTATCACCT CAGAGACCTT 
ATCAAAAGCA TGCTTCATGA TGACCCGGGC AGAAGAATCC CTGCTGAGAT GGCATTGTGC 
AGCCCATTCT TTAGCATTCC TTTTGCCCCT CATATTGAAG ATCTGGTGAT GCTTCCGACT 
CCAGTGCTCA GGCTCCTCAA TGTGCTGGAT GATGATTACC TTGAAAATGA AGATGAATAT 
GAAGGTCTTC GTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006496745.1
CDS	658..1692
Translation	MAGSGCAWGAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCGTPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPGRRIPAEMALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEDEYEGLR

Target ORF information:

RefSeq Version	XM_006496682.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus U2AF homology motif (UHM) kinase 1 (Uhmk1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006496682.4

ORF Insert Sequence:

ATGGCGGGGT CCGGCTGCGC GTGGGGCGCC GAGCCGCCGC GCTTCCTGGA GGCCTTCGGG 
CGGCTGTGGC AGGTCCAGAG CCGCCTGGGC AGCGGCTCGT CGGCCTCGGT GTACCGGGTG 
CGGTGCTGCG GTACCCCGGG CTCGCCCCCC GGCGCCCTCA AGCAGTTCCT GCCTCCGGGA 
ACCACCGGGG CTGCGGCCTC GGCCGCGGAG TATGGTTTCC GCAAAGAGAG GGCGGCGCTG 
GAGCAGTTGC AGGGTCACAG GAACATCGTG ACTTTATATG GAGTCTTTAC CATACACTTC 
TCTCCCAATG TGCCATCACG CTGTCTGCTG CTTGAACTCC TGGATGTCAG TGTTTCGGAA 
TTGCTTTTAT ATTCCAGTCA TCAGGGCTGC TCCATGTGGA TGATACAGCA CTGTGCCCGA 
GATGTTCTGG AGGCCCTCGC TTTTCTTCAC CATGAGGGCT ACGTCCATGC AGACCTCAAA 
CCACGAAACA TCCTGTGGAG TGCGGAGAAT GAGTGTTTTA AGCTTATTGA CTTTGGACTC 
AGCTTCAAAG AAGGCAATCA GGACGTAAAG TATATTCAGA CAGACGGGTA TCGCGCTCCT 
GAAGCAGAGC TGCAGAACTG CTTGGCCCAG GCCGGCCTGC AGAGTGATAC AGAATGTACC 
TCAGCTGTTG ATCTGTGGAG CCTCGGAATC ATTTTACTGG AAATGTTCTC AGGAATGAAG 
CTGAAACATA CAGTCAGATC TCAGGAATGG AAGGCAAACA GTTCTGCTAT TATTGATCAT 
ATATTTGCCA GTAAAGCAGT GGTGAATGCC GCAATTCCAG CCTATCACCT CAGAGACCTT 
ATCAAAAGCA TGCTTCATGA TGACCCGGGC AGAAGAATCC CTGCTGAGAT GGCATTGTGC 
AGCCCATTCT TTAGCATTCC TTTTGCCCCT CATATTGAAG ATCTGGTGAT GCTTCCGACT 
CCAGTGCTCA GGCTCCTCAA TGTGCTGGAT GATGATTACC TTGAAAATGA AGATGAATAT 
GAAGGTCTTC GTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss.
The EMBO journal35(10)1077-97(2016 05)
Scekic-Zahirovic J,Sendscheid O,El Oussini H,Jambeau M,Sun Y,Mersmann S,Wagner M,Dieterl? S,Sinniger J,Dirrig-Grosch S,Drenner K,Birling MC,Qiu J,Zhou Y,Li H,Fu XD,Rouaux C,Shelkovnikova T,Witting A,Ludolph AC,Kiefer F,Storkebaum E,Lagier-Tourenne C,Dupuis L

KIS, a kinase associated with microtubule regulators, enhances translation of AMPA receptors and stimulates dendritic spine remodeling.
The Journal of neuroscience : the official journal of the Society for Neuroscience34(42)13988-97(2014 Oct)
Pedraza N,Ortiz R,Cornad? A,Llobet A,Aldea M,Gallego C

The protein kinase KIS impacts gene expression during development and fear conditioning in adult mice.
PloS one7(8)e43946(2012)
Manceau V,Kremmer E,Nabel EG,Maucuer A

Signaling from the secretory granule to the nucleus: Uhmk1 and PAM.
Molecular endocrinology (Baltimore, Md.)24(8)1543-58(2010 Aug)
Francone VP,Ifrim MF,Rajagopal C,Leddy CJ,Wang Y,Carson JH,Mains RE,Eipper BA

KIS protects against adverse vascular remodeling by opposing stathmin-mediated VSMC migration in mice.
The Journal of clinical investigation118(12)3848-59(2008 Dec)
Langenickel TH,Olive M,Boehm M,San H,Crook MF,Nabel EG

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Uhmk1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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