Itln1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Itln1
Entrez Gene ID	16429
Full Name	intelectin 1 (galactofuranose binding)
Synonyms	IntL,Itln,Itln2,Itln3,Itln5,Itlna,Lfr
General protein information	Preferred Names intelectin 1 (galactofuranose binding) Names intelectin-1a calcium-dependent galactosyl-specific lectin galactofuranose-binding lectin intelectin 2 intelectin 5 intelectin a intestinal lactoferrin receptor truncated intelectin 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 H3

mRNA and Protein(s)

mRNA	Protein	Name
NM_010584.3	NP_034714.1	intelectin-1a precursor
XM_006496676.1	XP_006496739.1	intelectin-1a isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Itln1	NP_034714.1
Danio rerio (zebrafish)	LOC555755	XP_683463.3
Xenopus tropicalis (tropical clawed frog)	LOC100127857	NP_001106624.1
Pan troglodytes (chimpanzee)	ITLN1	XP_513928.2
Danio rerio (zebrafish)	zgc:153219	NP_001070049.1
Danio rerio (zebrafish)	LOC564958	XP_693369.2
Danio rerio (zebrafish)	im:7150573	XP_693581.3
Danio rerio (zebrafish)	itln3	NP_001153056.1
Xenopus tropicalis (tropical clawed frog)	itln2	NP_001164984.2
Homo sapiens (human)	ITLN1	NP_060095.2
Xenopus tropicalis (tropical clawed frog)	LOC100127565	NP_001106404.1
Xenopus tropicalis (tropical clawed frog)	LOC100497215	XP_002934660.2
	ITLN1	XP_002801914.1
Rattus norvegicus (Norway rat)	Itln1	NP_001030118.1
Danio rerio (zebrafish)	LOC565124	XP_005169007.1
Danio rerio (zebrafish)	intl2	NP_001153013.1
Danio rerio (zebrafish)	LOC799640	XP_001335910.3
Xenopus tropicalis (tropical clawed frog)	itln1	NP_988929.2
Xenopus tropicalis (tropical clawed frog)	LOC100485391	XP_004917383.1

Gene Ontology
Bibliography

Related articles in PubMed

Intelectin contributes to allergen-induced IL-25, IL-33, and TSLP expression and type 2 response in asthma and atopic dermatitis.
Yi L, Cheng D, Zhang K, Huo X, Mo Y, Shi H, Di H, Zou Y, Zhang H, Zhao J, Xu Y, Erle DJ, Zhen G
Mucosal immunology10(6)1491-1503(2017 Nov)

Omentin protects against LPS-induced ARDS through suppressing pulmonary inflammation and promoting endothelial barrier via an Akt/eNOS-dependent mechanism.
Qi D, Tang X, He J, Wang D, Zhao Y, Deng W, Deng X, Zhou G, Xia J, Zhong X, Pu S
Cell death & disease7(9)e2360(2016 Sep)

Omentin attenuates atherosclerotic lesion formation in apolipoprotein E-deficient mice.
Hiramatsu-Ito M, Shibata R, Ohashi K, Uemura Y, Kanemura N, Kambara T, Enomoto T, Yuasa D, Matsuo K, Ito M, Hayakawa S, Ogawa H, Otaka N, Kihara S, Murohara T, Ouchi N
Cardiovascular research110(1)107-17(2016 May)

Recognition of microbial glycans by human intelectin-1.
Wesener DA, Wangkanont K, McBride R, Song X, Kraft MB, Hodges HL, Zarling LC, Splain RA, Smith DF, Cummings RD, Paulson JC, Forest KT, Kiessling LL
Nature structural & molecular biology22(8)603-10(2015 Aug)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Omentin protects against lipopysaccharides-induced acute respiratory distress syndrome through suppressing pulmonary inflammation and promoting endothelial barrier via an Akt/NOS3-dependent mechanism.
Title: Omentin protects against LPS-induced ARDS through suppressing pulmonary inflammation and promoting endothelial barrier via an Akt/eNOS-dependent mechanism.

omentin reduces the development of atherosclerosis by reducing inflammatory response of macrophages through the Akt-dependent mechanisms
Title: Omentin attenuates atherosclerotic lesion formation in apolipoprotein E-deficient mice.

miR-584 contributes to the post-transcriptional expression of lactoferrin receptor during the perinatal period.
Title: miR-584 mediates post-transcriptional expression of lactoferrin receptor in Caco-2 cells and in mouse small intestine during the perinatal period.

Intelectin, a molecule expressed by airway epithelial cells and upregulated in asthma, is required for IL-13-induced MCP-1 and -3 production in mouse lung epithelial cells and contributes to allergic airway inflammation.
Title: Intelectin is required for IL-13-induced monocyte chemotactic protein-1 and -3 expression in lung epithelial cells and promotes allergic airway inflammation.

intelectin is a host defense lectin that assists phagocytic clearance of microorganisms.
Title: Capture of heat-killed Mycobacterium bovis bacillus Calmette-Gu?rin by intelectin-1 deposited on cell surfaces.

The following Itln1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Itln1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu06391	NM_010584.3 Latest version!	Mus musculus intelectin 1 (galactofuranose binding) (Itln1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu28636	XM_006496676.1 Latest version!	Mus musculus intelectin 1 (galactofuranose binding) (Itln1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Itln1 ( NM_010584.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034714.1 Mus musculus intelectin 1 (galactofuranose binding) (Itln1), mRNA.

Price & Availability↑

CloneID	OMu06391
Clone ID Related Accession (Same CDS sequence)	NM_010584.3
Accession Version	NM_010584.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 942bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	intelectin-1a precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK007447.1 and AY157364.1. On Feb 26, 2011 this sequence version replaced NM_010584.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB016496.1, BC150795.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCCAAC TGGGATTCCT GCTGTTTATC ATGGTTGCTA CCAGAGGTTG CAGTGCAGCT 
GAAGAGAACC TGGACACCAA CAGGTGGGGC AATTCTTTCT TTTCCTCTCT GCCCAGAAGC 
TGCAAGGAAA TCAAGCAGGA GCACACAAAG GCACAAGATG GTCTCTATTT CCTGCGCACG 
AAGAATGGTG TCATCTACCA GACCTTCTGT GACATGACCA CTGCAGGTGG TGGCTGGACC 
CTGGTGGCTA GTGTGCATGA GAACAACATG CGTGGGAAGT GCACTGTGGG TGATCGCTGG 
TCCAGTCAGC AAGGCAACAG AGCTGACTAC CCAGAGGGGG ATGGCAACTG GGCCAACTAC 
AACACCTTTG GGTCTGCAGA GGCTGCCACA AGTGATGACT ACAAGAACCC TGGCTACTTT 
GACATCCAGG CTGAGAACCT GGGCATCTGG CACGTGCCCA ACAAAAGCCC CCTGCACAAC 
TGGAGGAAGA GCTCCCTGCT GAGGTACCGC ACCTTCACTG GCTTCCTGCA GCACTTGGGA 
CATAATCTGT TTGGCCTCTA CAAGAAGTAC CCAGTGAAAT ACGGAGAAGG AAAGTGTTGG 
ACTGACAATG GCCCAGCATT ACCTGTGGTC TATGACTTTG GTGATGCTCG GAAGACAGCC 
TCTTATTACT CCCCCTCTGG CCAGAGGGAA TTTACTGCAG GATATGTTCA GTTCAGAGTG 
TTTAATAATG AGAGAGCGGC CAGTGCCTTG TGTGCTGGCG TGAGGGTCAC TGGATGTAAT 
ACTGAACATC ACTGCATCGG TGGAGGAGGA TTCTTCCCAG AAGGTAACCC CGTGCAGTGT 
GGAGACTTTG CGTCATTTGA TTGGGATGGA TATGGAACTC ACAATGGGTA CAGCAGTAGC 
CGGAAGATAA CTGAAGCAGC TGTGCTTCTG TTTTATCGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034714.1
CDS	81..1022
Translation	MTQLGFLLFIMVATRGCSAAEENLDTNRWGNSFFSSLPRSCKEIKQEHTKAQDGLYFLRTKNGVIYQTFCDMTTAGGGWTLVASVHENNMRGKCTVGDRWSSQQGNRADYPEGDGNWANYNTFGSAEAATSDDYKNPGYFDIQAENLGIWHVPNKSPLHNWRKSSLLRYRTFTGFLQHLGHNLFGLYKKYPVKYGEGKCWTDNGPALPVVYDFGDARKTASYYSPSGQREFTAGYVQFRVFNNERAASALCAGVRVTGCNTEHHCIGGGGFFPEGNPVQCGDFASFDWDGYGTHNGYSSSRKITEAAVLLFYR

Target ORF information:

RefSeq Version	NM_010584.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus intelectin 1 (galactofuranose binding) (Itln1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010584.3

ORF Insert Sequence:

ATGACCCAAC TGGGATTCCT GCTGTTTATC ATGGTTGCTA CCAGAGGTTG CAGTGCAGCT 
GAAGAGAACC TGGACACCAA CAGGTGGGGC AATTCTTTCT TTTCCTCTCT GCCCAGAAGC 
TGCAAGGAAA TCAAGCAGGA GCACACAAAG GCACAAGATG GTCTCTATTT CCTGCGCACG 
AAGAATGGTG TCATCTACCA GACCTTCTGT GACATGACCA CTGCAGGTGG TGGCTGGACC 
CTGGTGGCTA GTGTGCATGA GAACAACATG CGTGGGAAGT GCACTGTGGG TGATCGCTGG 
TCCAGTCAGC AAGGCAACAG AGCTGACTAC CCAGAGGGGG ATGGCAACTG GGCCAACTAC 
AACACCTTTG GGTCTGCAGA GGCTGCCACA AGTGATGACT ACAAGAACCC TGGCTACTTT 
GACATCCAGG CTGAGAACCT GGGCATCTGG CACGTGCCCA ACAAAAGCCC CCTGCACAAC 
TGGAGGAAGA GCTCCCTGCT GAGGTACCGC ACCTTCACTG GCTTCCTGCA GCACTTGGGA 
CATAATCTGT TTGGCCTCTA CAAGAAGTAC CCAGTGAAAT ACGGAGAAGG AAAGTGTTGG 
ACTGACAATG GCCCAGCATT ACCTGTGGTC TATGACTTTG GTGATGCTCG GAAGACAGCC 
TCTTATTACT CCCCCTCTGG CCAGAGGGAA TTTACTGCAG GATATGTTCA GTTCAGAGTG 
TTTAATAATG AGAGAGCGGC CAGTGCCTTG TGTGCTGGCG TGAGGGTCAC TGGATGTAAT 
ACTGAACATC ACTGCATCGG TGGAGGAGGA TTCTTCCCAG AAGGTAACCC CGTGCAGTGT 
GGAGACTTTG CGTCATTTGA TTGGGATGGA TATGGAACTC ACAATGGGTA CAGCAGTAGC 
CGGAAGATAA CTGAAGCAGC TGTGCTTCTG TTTTATCGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Itln1 ( XM_006496676.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006496739.1 Mus musculus intelectin 1 (galactofuranose binding) (Itln1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu28636
Clone ID Related Accession (Same CDS sequence)	XM_006496676.1
Accession Version	XM_006496676.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 939bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	intelectin-1a isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCCAAC TGGGATTCCT GCTGTTTATC ATGGTTGCTA CCAGAGGTTG CAGTGCAGCT 
GAAGAGAACC TGGACACCAA CAGGTGGGGC AATTCTTTCT TTTCCTCTCT GCCCAGAAGC 
TGCAAGGAAA TCAAGCAGGA GCACACAAAG GCACAAGATG GTCTCTATTT CCTGCGCACG 
AAGAATGGTG TCATCTACCA GACCTTCTGT GACATGACCA CTGCAGGTGG TGGCTGGACC 
CTGGTGGCTA GTGTGCATGA GAACAACATG CGTGGGAAGT GCACTGTGGG TGATCGCTGG 
TCCAGTCAGC AAGGCAACAG AGCTGACTAC CCAGAGGGGG ATGGCAACTG GGCCAACTAC 
AACACCTTTG GGTCTGCAGA GGCTGCCACA AGTGATGACT ACAAGAACCC TGGCTACTTT 
GACATCCAGG CTGAGAACCT GGGCATCTGG CACGTGCCCA ACAAAAGCCC CCTGCACAAC 
TGGAGGAAGA GCTCCCTGCT GAGGTACCGC ACCTTCACTG GCTTCCTGCA GCACTTGGGA 
CATAATCTGT TTGGCCTCTA CAAGAAGTAC CCAGTGAAAT ACGGAGAAGG AAAGTGTTGG 
ACTGACAATG GCCCAGCATT ACCTGTGGTC TATGACTTTG GTGATGCTCG GAAGACAGCC 
TCTTATTACT CCCCCTCTGG CCAGAGGGAA TTTACTGCAG GATATGTTCA GTTCAGAGTG 
TTTAATAATG AGAGAGCGGC CAGTGCCTTG TGTGCTGGCG TGAGGGTCAC TGGATGTAAT 
ACTGAACATG TGCTTCTCTG CCATTCGGTA TTCCTCAGCA CTGCATCGGT GGAGGAGGAT 
TCTTCCCAGA AGGTAACCCC GTGCAGTGTG GAGACTTTGC GTCATTTGAT TGGGATGGAT 
ATGGAACTCA CAATGGGTAC AGCAGTAGCC GGAAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006496739.1
CDS	112..1050
Translation	MTQLGFLLFIMVATRGCSAAEENLDTNRWGNSFFSSLPRSCKEIKQEHTKAQDGLYFLRTKNGVIYQTFCDMTTAGGGWTLVASVHENNMRGKCTVGDRWSSQQGNRADYPEGDGNWANYNTFGSAEAATSDDYKNPGYFDIQAENLGIWHVPNKSPLHNWRKSSLLRYRTFTGFLQHLGHNLFGLYKKYPVKYGEGKCWTDNGPALPVVYDFGDARKTASYYSPSGQREFTAGYVQFRVFNNERAASALCAGVRVTGCNTEHVLLCHSVFLSTASVEEDSSQKVTPCSVETLRHLIGMDMELTMGTAVAGR

Target ORF information:

RefSeq Version	XM_006496676.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus intelectin 1 (galactofuranose binding) (Itln1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006496676.1

ORF Insert Sequence:

ATGACCCAAC TGGGATTCCT GCTGTTTATC ATGGTTGCTA CCAGAGGTTG CAGTGCAGCT 
GAAGAGAACC TGGACACCAA CAGGTGGGGC AATTCTTTCT TTTCCTCTCT GCCCAGAAGC 
TGCAAGGAAA TCAAGCAGGA GCACACAAAG GCACAAGATG GTCTCTATTT CCTGCGCACG 
AAGAATGGTG TCATCTACCA GACCTTCTGT GACATGACCA CTGCAGGTGG TGGCTGGACC 
CTGGTGGCTA GTGTGCATGA GAACAACATG CGTGGGAAGT GCACTGTGGG TGATCGCTGG 
TCCAGTCAGC AAGGCAACAG AGCTGACTAC CCAGAGGGGG ATGGCAACTG GGCCAACTAC 
AACACCTTTG GGTCTGCAGA GGCTGCCACA AGTGATGACT ACAAGAACCC TGGCTACTTT 
GACATCCAGG CTGAGAACCT GGGCATCTGG CACGTGCCCA ACAAAAGCCC CCTGCACAAC 
TGGAGGAAGA GCTCCCTGCT GAGGTACCGC ACCTTCACTG GCTTCCTGCA GCACTTGGGA 
CATAATCTGT TTGGCCTCTA CAAGAAGTAC CCAGTGAAAT ACGGAGAAGG AAAGTGTTGG 
ACTGACAATG GCCCAGCATT ACCTGTGGTC TATGACTTTG GTGATGCTCG GAAGACAGCC 
TCTTATTACT CCCCCTCTGG CCAGAGGGAA TTTACTGCAG GATATGTTCA GTTCAGAGTG 
TTTAATAATG AGAGAGCGGC CAGTGCCTTG TGTGCTGGCG TGAGGGTCAC TGGATGTAAT 
ACTGAACATG TGCTTCTCTG CCATTCGGTA TTCCTCAGCA CTGCATCGGT GGAGGAGGAT 
TCTTCCCAGA AGGTAACCCC GTGCAGTGTG GAGACTTTGC GTCATTTGAT TGGGATGGAT 
ATGGAACTCA CAATGGGTAC AGCAGTAGCC GGAAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Intelectin contributes to allergen-induced IL-25, IL-33, and TSLP expression and type 2 response in asthma and atopic dermatitis.
Mucosal immunology10(6)1491-1503(2017 Nov)
Yi L,Cheng D,Zhang K,Huo X,Mo Y,Shi H,Di H,Zou Y,Zhang H,Zhao J,Xu Y,Erle DJ,Zhen G

Omentin protects against LPS-induced ARDS through suppressing pulmonary inflammation and promoting endothelial barrier via an Akt/eNOS-dependent mechanism.
Cell death & disease7(9)e2360(2016 Sep)
Qi D,Tang X,He J,Wang D,Zhao Y,Deng W,Deng X,Zhou G,Xia J,Zhong X,Pu S

Omentin attenuates atherosclerotic lesion formation in apolipoprotein E-deficient mice.
Cardiovascular research110(1)107-17(2016 May)
Hiramatsu-Ito M,Shibata R,Ohashi K,Uemura Y,Kanemura N,Kambara T,Enomoto T,Yuasa D,Matsuo K,Ito M,Hayakawa S,Ogawa H,Otaka N,Kihara S,Murohara T,Ouchi N

Recognition of microbial glycans by human intelectin-1.
Nature structural & molecular biology22(8)603-10(2015 Aug)
Wesener DA,Wangkanont K,McBride R,Song X,Kraft MB,Hodges HL,Zarling LC,Splain RA,Smith DF,Cummings RD,Paulson JC,Forest KT,Kiessling LL

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

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Itln1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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