Il13ra1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Il13ra1
Entrez Gene ID	16164
Full Name	interleukin 13 receptor, alpha 1
Synonyms	AI882074,CD213a1,IL-13R-alpha-1,IL-13r[a],Il13ra,NR4
General protein information	Preferred Names interleukin 13 receptor, alpha 1 Names interleukin-13 receptor subunit alpha-1 IL-13 receptor subunit alpha-1 IL-13R subunit alpha-1 interleukin-13-binding protein novel cytokine receptor 4
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X A3.3\|X 20.49 cM
Summary	This gene encodes a transmembrane protein that complexes with interleukin 4 receptor alpha (IL4RA) to form a functional receptor for interleukin-13. Signalling through this pathway mediates allergy response and occurs during bronchial asthma. [provided by RefSeq, May 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_133990.5	NP_598751.3	interleukin-13 receptor subunit alpha-1 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Il13ra1	NP_598751.3
Rattus norvegicus (Norway rat)	Il13ra1	NP_665732.2
Homo sapiens (human)	IL13RA1	NP_001551.1
Bos taurus (cattle)	IL13RA1	NP_001193606.1
Xenopus tropicalis (tropical clawed frog)	il13ra1	XP_004916986.1
Gallus gallus (chicken)	IL13RA1	XP_420218.3
Pan troglodytes (chimpanzee)	IL13RA1	XP_001134844.3
Canis lupus familiaris (dog)	IL13RA1	XP_538150.3
Rattus norvegicus (Norway rat)	LOC100360218	XP_003751125.1

Gene Ontology
Bibliography

Related articles in PubMed

Soluble interleukin-13r?1: a circulating regulator of glucose.
Rachmin I, O'Meara CC, Ricci-Blair EM, Feng Y, Christensen EM, Duffy JF, Zitting KM, Czeisler CA, Pancoast JR, Cannon CP, O'Donoghue ML, Morrow DA, Lee RT
American journal of physiology. Endocrinology and metabolism313(6)E663-E671(2017 Dec)

IL-4/IL-13 Heteroreceptor Influences Th17 Cell Conversion and Sensitivity to Regulatory T Cell Suppression To Restrain Experimental Allergic Encephalomyelitis.
Barik S, Ellis JS, Cascio JA, Miller MM, Ukah TK, Cattin-Roy AN, Zaghouani H
Journal of immunology (Baltimore, Md. : 1950)199(7)2236-2248(2017 Oct)

IL-4/IL-13 Signaling Inhibits the Potential of Early Thymic Progenitors To Commit to the T Cell Lineage.
Barik S, Miller MM, Cattin-Roy AN, Ukah TK, Chen W, Zaghouani H
Journal of immunology (Baltimore, Md. : 1950)199(8)2767-2776(2017 Oct)

Characterization of the mouse interleukin-13 receptor alpha1 gene.
Osawa M, Miyoshi S, Copeland NG, Gilbert DJ, Jenkins NA, Hiroyama T, Motohashi T, Nakamura Y, Iwama A, Nakauchi H
Immunogenetics51(11)974-81(2000 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Delivery of sIL13ralpha1 to mice by either gene transfer or recombinant protein decreases blood glucose levels. Surprisingly, the glucose-lowering effect of sIL13ralpha1 was preserved in mice lacking IL-13, demonstrating that IL-13 was not required for the effect. In contrast, deletion of IL-4 in mice eliminated the hypoglycemic effect of sIL13ralpha1.
Title: Soluble interleukin-13r?1: a circulating regulator of glucose.

findings indicate that NOD mice lacking the IL-4Ralpha/IL-13Ralpha1 heteroreceptor (HR) display resistance to Type 1 Diabetes as the rise in blood glucose level and islet inflammation were significantly delayed in these HR-deficient relative to HR-sufficient mice
Title: On the Role IL-4/IL-13 Heteroreceptor Plays in Regulation of Type 1 Diabetes.

Chronic stress significantly reduced the number of substantia nigra dopaminergic neurons in Il13a1 knock-out mice.
Title: Lack of interleukin-13 receptor ?1 delays the loss of dopaminergic neurons during chronic stress.

These results show that activation of IL-13Ralpha1 is critical for key aspects of the immune and functional responses to Hb2 infection that facilitate expulsion.
Title: Interleukin-13 Receptor ?1-Dependent Responses in the Intestine Are Critical to Parasite Clearance.

These data establish for the first time a molecular mechanism by which Mac-1 regulates the signaling activity of IL-13 in macrophages.
Title: Mac-1 Regulates IL-13 Activity in Macrophages by Directly Interacting with IL-13R?1.

The following Il13ra1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Il13ra1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu20435	NM_133990.5 Latest version!	Mus musculus interleukin 13 receptor, alpha 1 (Il13ra1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Il13ra1 ( NM_133990.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_598751.3 Mus musculus interleukin 13 receptor, alpha 1 (Il13ra1), mRNA.

Price & Availability↑

CloneID	OMu20435
Clone ID Related Accession (Same CDS sequence)	NM_133990.5
Accession Version	NM_133990.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1275bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-17
Organism	Mus musculus(house mouse)
Product	interleukin-13 receptor subunit alpha-1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL672038.7, BC052425.1, AK082889.1 and CK334115.1. On May 8, 2015 this sequence version replaced NM_133990.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC052425.1, AK154675.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGCGGC CAGCGCTGCT GGGCGAGCTG TTGGTGCTGC TACTGTGGAC CGCCACCGTG 
GGCCAAGTTG CCGCGGCCAC AGAAGTTCAG CCACCTGTGA CGAATTTGAG CGTCTCTGTC 
GAAAATCTCT GCACGATAAT ATGGACGTGG AGTCCTCCTG AAGGAGCCAG TCCAAATTGC 
ACTCTCAGAT ATTTTAGTCA CTTTGATGAC CAACAGGATA AGAAAATTGC TCCAGAAACT 
CATCGTAAAG AGGAATTACC CCTGGATGAG AAAATCTGTC TGCAGGTGGG CTCTCAGTGT 
AGTGCCAATG AAAGTGAGAA GCCTAGCCCT TTGGTGAAAA AGTGCATCTC ACCCCCTGAA 
GGTGATCCTG AGTCCGCTGT GACTGAGCTC AAGTGCATTT GGCATAACCT GAGCTATATG 
AAGTGTTCCT GGCTCCCTGG AAGGAATACA AGCCCTGACA CACACTATAC TCTGTACTAT 
TGGTACAGCA GCCTGGAGAA AAGTCGTCAA TGTGAAAACA TCTATAGAGA AGGTCAACAC 
ATTGCTTGTT CCTTTAAATT GACTAAAGTG GAACCTAGTT TTGAACATCA GAACGTTCAA 
ATAATGGTCA AGGATAATGC TGGGAAAATT AGGCCATCCT GCAAAATAGT GTCTTTAACT 
TCCTATGTGA AACCTGATCC TCCACATATT AAACATCTTC TCCTCAAAAA TGGTGCCTTA 
TTAGTGCAGT GGAAGAATCC ACAAAATTTT AGAAGCAGAT GCTTAACTTA TGAAGTGGAG 
GTCAATAATA CTCAAACCGA CCGACATAAT ATTTTAGAGG TTGAAGAGGA CAAATGCCAG 
AATTCCGAAT CTGATAGAAA CATGGAGGGT ACAAGTTGTT TCCAACTCCC TGGTGTTCTT 
GCCGACGCTG TCTACACAGT CAGAGTAAGA GTCAAAACAA ACAAGTTATG CTTTGATGAC 
AACAAACTGT GGAGTGATTG GAGTGAAGCA CAGAGTATAG GTAAGGAGCA AAACTCCACC 
TTCTACACCA CCATGTTACT CACCATTCCA GTCTTTGTCG CAGTGGCAGT CATAATCCTC 
CTTTTTTACC TGAAAAGGCT TAAGATCATT ATATTTCCTC CAATTCCTGA TCCTGGCAAG 
ATTTTTAAAG AAATGTTTGG AGACCAGAAT GATGATACCC TGCACTGGAA GAAGTATGAC 
ATCTATGAGA AACAATCCAA AGAAGAAACG GATTCTGTAG TGCTGATAGA AAACCTGAAG 
AAAGCAGCTC CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598751.3
CDS	87..1361
Translation	MARPALLGELLVLLLWTATVGQVAAATEVQPPVTNLSVSVENLCTIIWTWSPPEGASPNCTLRYFSHFDDQQDKKIAPETHRKEELPLDEKICLQVGSQCSANESEKPSPLVKKCISPPEGDPESAVTELKCIWHNLSYMKCSWLPGRNTSPDTHYTLYYWYSSLEKSRQCENIYREGQHIACSFKLTKVEPSFEHQNVQIMVKDNAGKIRPSCKIVSLTSYVKPDPPHIKHLLLKNGALLVQWKNPQNFRSRCLTYEVEVNNTQTDRHNILEVEEDKCQNSESDRNMEGTSCFQLPGVLADAVYTVRVRVKTNKLCFDDNKLWSDWSEAQSIGKEQNSTFYTTMLLTIPVFVAVAVIILLFYLKRLKIIIFPPIPDPGKIFKEMFGDQNDDTLHWKKYDIYEKQSKEETDSVVLIENLKKAAP

Target ORF information:

RefSeq Version	NM_133990.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus interleukin 13 receptor, alpha 1 (Il13ra1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133990.5

ORF Insert Sequence:

ATGGCGCGGC CAGCGCTGCT GGGCGAGCTG TTGGTGCTGC TACTGTGGAC CGCCACCGTG 
GGCCAAGTTG CCGCGGCCAC AGAAGTTCAG CCACCTGTGA CGAATTTGAG CGTCTCTGTC 
GAAAATCTCT GCACGATAAT ATGGACGTGG AGTCCTCCTG AAGGAGCCAG TCCAAATTGC 
ACTCTCAGAT ATTTTAGTCA CTTTGATGAC CAACAGGATA AGAAAATTGC TCCAGAAACT 
CATCGTAAAG AGGAATTACC CCTGGATGAG AAAATCTGTC TGCAGGTGGG CTCTCAGTGT 
AGTGCCAATG AAAGTGAGAA GCCTAGCCCT TTGGTGAAAA AGTGCATCTC ACCCCCTGAA 
GGTGATCCTG AGTCCGCTGT GACTGAGCTC AAGTGCATTT GGCATAACCT GAGCTATATG 
AAGTGTTCCT GGCTCCCTGG AAGGAATACA AGCCCTGACA CACACTATAC TCTGTACTAT 
TGGTACAGCA GCCTGGAGAA AAGTCGTCAA TGTGAAAACA TCTATAGAGA AGGTCAACAC 
ATTGCTTGTT CCTTTAAATT GACTAAAGTG GAACCTAGTT TTGAACATCA GAACGTTCAA 
ATAATGGTCA AGGATAATGC TGGGAAAATT AGGCCATCCT GCAAAATAGT GTCTTTAACT 
TCCTATGTGA AACCTGATCC TCCACATATT AAACATCTTC TCCTCAAAAA TGGTGCCTTA 
TTAGTGCAGT GGAAGAATCC ACAAAATTTT AGAAGCAGAT GCTTAACTTA TGAAGTGGAG 
GTCAATAATA CTCAAACCGA CCGACATAAT ATTTTAGAGG TTGAAGAGGA CAAATGCCAG 
AATTCCGAAT CTGATAGAAA CATGGAGGGT ACAAGTTGTT TCCAACTCCC TGGTGTTCTT 
GCCGACGCTG TCTACACAGT CAGAGTAAGA GTCAAAACAA ACAAGTTATG CTTTGATGAC 
AACAAACTGT GGAGTGATTG GAGTGAAGCA CAGAGTATAG GTAAGGAGCA AAACTCCACC 
TTCTACACCA CCATGTTACT CACCATTCCA GTCTTTGTCG CAGTGGCAGT CATAATCCTC 
CTTTTTTACC TGAAAAGGCT TAAGATCATT ATATTTCCTC CAATTCCTGA TCCTGGCAAG 
ATTTTTAAAG AAATGTTTGG AGACCAGAAT GATGATACCC TGCACTGGAA GAAGTATGAC 
ATCTATGAGA AACAATCCAA AGAAGAAACG GATTCTGTAG TGCTGATAGA AAACCTGAAG 
AAAGCAGCTC CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Soluble interleukin-13r?1: a circulating regulator of glucose.
American journal of physiology. Endocrinology and metabolism313(6)E663-E671(2017 Dec)
Rachmin I,O'Meara CC,Ricci-Blair EM,Feng Y,Christensen EM,Duffy JF,Zitting KM,Czeisler CA,Pancoast JR,Cannon CP,O'Donoghue ML,Morrow DA,Lee RT

IL-4/IL-13 Heteroreceptor Influences Th17 Cell Conversion and Sensitivity to Regulatory T Cell Suppression To Restrain Experimental Allergic Encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)199(7)2236-2248(2017 Oct)
Barik S,Ellis JS,Cascio JA,Miller MM,Ukah TK,Cattin-Roy AN,Zaghouani H

IL-4/IL-13 Signaling Inhibits the Potential of Early Thymic Progenitors To Commit to the T Cell Lineage.
Journal of immunology (Baltimore, Md. : 1950)199(8)2767-2776(2017 Oct)
Barik S,Miller MM,Cattin-Roy AN,Ukah TK,Chen W,Zaghouani H

Characterization of the mouse interleukin-13 receptor alpha1 gene.
Immunogenetics51(11)974-81(2000 Sep)
Osawa M,Miyoshi S,Copeland NG,Gilbert DJ,Jenkins NA,Hiroyama T,Motohashi T,Nakamura Y,Iwama A,Nakauchi H

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Il13ra1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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