Il18bp cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Il18bp
Entrez Gene ID	16068
Full Name	interleukin 18 binding protein
Synonyms	IL-18BP,Igifbp,MC54L
General protein information	Preferred Names interleukin 18 binding protein Names interleukin-18-binding protein interferon gamma-inducing factor-binding protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 E2

mRNA and Protein(s)

mRNA	Protein	Name
XM_017321987.1	XP_017177476.1	interleukin-18-binding protein isoform X1
NM_010531.1	NP_034661.1	interleukin-18-binding protein precursor
XM_030242160.1	XP_030098020.1	interleukin-18-binding protein isoform X2
NM_010531.2	NP_034661.1	interleukin-18-binding protein precursor
NM_001363982.1	NP_001350911.1	interleukin-18-binding protein precursor
XM_017321987.2	XP_017177476.1	interleukin-18-binding protein isoform X1
XM_030242161.1	XP_030098021.1	interleukin-18-binding protein isoform X2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Il18bp	NP_034661.1
Pan troglodytes (chimpanzee)	IL18BP	XP_001174598.1
Rattus norvegicus (Norway rat)	Il18bp	NP_445826.2
Canis lupus familiaris (dog)	IL18BP	NP_001041483.1
Homo sapiens (human)	IL18BP	NP_766630.2
	IL18BP	NP_001116825.1
Bos taurus (cattle)	IL18BP	XP_002693478.2

Gene Ontology
Bibliography

Related articles in PubMed

Unopposed IL-18 signaling leads to severe TLR9-induced macrophage activation syndrome in mice.
Girard-Guyonvarc'h C, Palomo J, Martin P, Rodriguez E, Troccaz S, Palmer G, Gabay C
Blood(2018 Jan)

Role of IL-18 in atopic asthma is determined by balance of IL-18/IL-18BP/IL-18R.
Zhang H, Wang J, Wang L, Xie H, Chen L, He S
Journal of cellular and molecular medicine22(1)354-373(2018 Jan)

Interleukin (IL)-18 Binding Protein Deficiency Disrupts Natural Killer Cell Maturation and Diminishes Circulating IL-18.
Harms RZ, Creer AJ, Lorenzo-Arteaga KM, Ostlund KR, Sarvetnick NE
Frontiers in immunology81020(2017)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

IL-18BP ameliorates cardiac ischemia/reperfusion injury in part through suppression of Th17 differentiation.
Title: The protective role of interleukin-18 binding protein in a murine model of cardiac ischemia/reperfusion injury.

Data show that IL-18bp acts as a sensor for IFN-gamma and can regulate both Th1 and Th17 responses in the CNS.
Title: Inflammation in the central nervous system and Th17 responses are inhibited by IFN-gamma-Induced IL-18 binding protein.

A single intravenous dose of recombinant mouse IL18BP decreased neointimal hyperplasia and improved arterial L/A ratios in an atherosclerotic balloon-injury animal model.
Title: Interleukin 18 binding protein (IL18-BP) inhibits neointimal hyperplasia after balloon injury in an atherosclerotic rabbit model.

IL-18 and IL-18BP may have roles in testicular development, and also in the regulation of testicular functions under physiological conditions
Title: Constitutive expression of IL-18 binding protein in murine testicular tissues and cells.

functional polarization of Ag-specific CD4(+) Th2 cells entering the CNS during the accelerating phase of experimental autoimmune encephalomyelitis is flexible and dependent on IL-18, which is overturned by IL-18 binding protein
Title: Targeted overexpression of IL-18 binding protein at the central nervous system overrides flexibility in functional polarization of antigen-specific Th2 cells.

The following Il18bp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Il18bp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu06332	NM_010531.2 Latest version!	Mus musculus interleukin 18 binding protein (Il18bp), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu06332	NM_001363982.1 Latest version!	Mus musculus interleukin 18 binding protein (Il18bp), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu06332	XM_030242161.1 Latest version!	Mus musculus interleukin 18 binding protein (Il18bp), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OMu06332	XM_030242160.1 Latest version!	Mus musculus interleukin 18 binding protein (Il18bp), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OMu39322	XM_017321987.2 Latest version!	Mus musculus interleukin 18 binding protein (Il18bp), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu06332	NM_010531.1	Mus musculus interleukin 18 binding protein (Il18bp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu39322	XM_017321987.1	Mus musculus interleukin 18 binding protein (Il18bp), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Il18bp ( NM_010531.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034661.1 Mus musculus interleukin 18 binding protein (Il18bp), mRNA.

Price & Availability↑

CloneID	OMu06332
Clone ID Related Accession (Same CDS sequence)	NM_010531.1 , XM_030242160.1 , NM_010531.2 , NM_001363982.1 , XM_030242161.1
Accession Version	NM_010531.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-25
Organism	Mus musculus(house mouse)
Product	interleukin-18-binding protein precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF122907.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF122907.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164143 [ECO:0000348] ##Evidence-Data-END##

ATGACCATGA GACACTGCTG GACAGCAGGC CCCAGTTCTT GGTGGGTCCT GCTTTTGTAT 
GTCCATGTCA TTTTGGCCAG AGCCACATCT GCACCTCAGA CAACTGCCAC TGTCTTAACT 
GGAAGCTCAA AAGACCCATG CTCTTCCTGG TCTCCAGCAG TCCCAACTAA GCAGTACCCA 
GCACTGGATG TGATTTGGCC AGAAAAAGAA GTGCCACTGA ATGGAACTCT GACCTTGTCC 
TGTACTGCCT GCAGCCGCTT CCCCTACTTC AGCATCCTCT ACTGGCTGGG CAATGGTTCC 
TTCATTGAGC ACCTCCCAGG CCGGCTGAAG GAGGGCCACA CAAGTCGCGA GCACAGGAAC 
ACAAGCACCT GGCTGCACAG GGCCTTGGTG CTGGAAGAAC TGAGCCCCAC CCTACGAAGT 
ACCAACTTCT CCTGTTTGTT TGTGGATCCT GGACAAGTGG CCCAGTATCA CATCATTCTG 
GCCCAGCTCT GGGATGGGTT GAAGACAGCT CCGTCCCCTT CTCAAGAAAC CCTCTCTAGC 
CACAGCCCAG TATCCAGATC AGCAGGCCCA GGGGTTGCAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034661.1
CDS	152..733
Translation	MTMRHCWTAGPSSWWVLLLYVHVILARATSAPQTTATVLTGSSKDPCSSWSPAVPTKQYPALDVIWPEKEVPLNGTLTLSCTACSRFPYFSILYWLGNGSFIEHLPGRLKEGHTSREHRNTSTWLHRALVLEELSPTLRSTNFSCLFVDPGQVAQYHIILAQLWDGLKTAPSPSQETLSSHSPVSRSAGPGVA

Target ORF information:

RefSeq Version	NM_010531.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus interleukin 18 binding protein (Il18bp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010531.1

ORF Insert Sequence:

ATGACCATGA GACACTGCTG GACAGCAGGC CCCAGTTCTT GGTGGGTCCT GCTTTTGTAT 
GTCCATGTCA TTTTGGCCAG AGCCACATCT GCACCTCAGA CAACTGCCAC TGTCTTAACT 
GGAAGCTCAA AAGACCCATG CTCTTCCTGG TCTCCAGCAG TCCCAACTAA GCAGTACCCA 
GCACTGGATG TGATTTGGCC AGAAAAAGAA GTGCCACTGA ATGGAACTCT GACCTTGTCC 
TGTACTGCCT GCAGCCGCTT CCCCTACTTC AGCATCCTCT ACTGGCTGGG CAATGGTTCC 
TTCATTGAGC ACCTCCCAGG CCGGCTGAAG GAGGGCCACA CAAGTCGCGA GCACAGGAAC 
ACAAGCACCT GGCTGCACAG GGCCTTGGTG CTGGAAGAAC TGAGCCCCAC CCTACGAAGT 
ACCAACTTCT CCTGTTTGTT TGTGGATCCT GGACAAGTGG CCCAGTATCA CATCATTCTG 
GCCCAGCTCT GGGATGGGTT GAAGACAGCT CCGTCCCCTT CTCAAGAAAC CCTCTCTAGC 
CACAGCCCAG TATCCAGATC AGCAGGCCCA GGGGTTGCAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Il18bp ( NM_010531.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034661.1 Mus musculus interleukin 18 binding protein (Il18bp), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu06332
Clone ID Related Accession (Same CDS sequence)	NM_010531.1 , XM_030242160.1 , NM_010531.2 , NM_001363982.1 , XM_030242161.1
Accession Version	NM_010531.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-20
Organism	Mus musculus(house mouse)
Product	interleukin-18-binding protein precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC167240.5 and AF122907.1. On Jun 3, 2018 this sequence version replaced NM_010531.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF122907.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164143 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCATGA GACACTGCTG GACAGCAGGC CCCAGTTCTT GGTGGGTCCT GCTTTTGTAT 
GTCCATGTCA TTTTGGCCAG AGCCACATCT GCACCTCAGA CAACTGCCAC TGTCTTAACT 
GGAAGCTCAA AAGACCCATG CTCTTCCTGG TCTCCAGCAG TCCCAACTAA GCAGTACCCA 
GCACTGGATG TGATTTGGCC AGAAAAAGAA GTGCCACTGA ATGGAACTCT GACCTTGTCC 
TGTACTGCCT GCAGCCGCTT CCCCTACTTC AGCATCCTCT ACTGGCTGGG CAATGGTTCC 
TTCATTGAGC ACCTCCCAGG CCGGCTGAAG GAGGGCCACA CAAGTCGCGA GCACAGGAAC 
ACAAGCACCT GGCTGCACAG GGCCTTGGTG CTGGAAGAAC TGAGCCCCAC CCTACGAAGT 
ACCAACTTCT CCTGTTTGTT TGTGGATCCT GGACAAGTGG CCCAGTATCA CATCATTCTG 
GCCCAGCTCT GGGATGGGTT GAAGACAGCT CCGTCCCCTT CTCAAGAAAC CCTCTCTAGC 
CACAGCCCAG TATCCAGATC AGCAGGCCCA GGGGTTGCAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034661.1
CDS	229..810
Translation	MTMRHCWTAGPSSWWVLLLYVHVILARATSAPQTTATVLTGSSKDPCSSWSPAVPTKQYPALDVIWPEKEVPLNGTLTLSCTACSRFPYFSILYWLGNGSFIEHLPGRLKEGHTSREHRNTSTWLHRALVLEELSPTLRSTNFSCLFVDPGQVAQYHIILAQLWDGLKTAPSPSQETLSSHSPVSRSAGPGVA

Target ORF information:

RefSeq Version	NM_010531.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus interleukin 18 binding protein (Il18bp), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010531.2

ORF Insert Sequence:

ATGACCATGA GACACTGCTG GACAGCAGGC CCCAGTTCTT GGTGGGTCCT GCTTTTGTAT 
GTCCATGTCA TTTTGGCCAG AGCCACATCT GCACCTCAGA CAACTGCCAC TGTCTTAACT 
GGAAGCTCAA AAGACCCATG CTCTTCCTGG TCTCCAGCAG TCCCAACTAA GCAGTACCCA 
GCACTGGATG TGATTTGGCC AGAAAAAGAA GTGCCACTGA ATGGAACTCT GACCTTGTCC 
TGTACTGCCT GCAGCCGCTT CCCCTACTTC AGCATCCTCT ACTGGCTGGG CAATGGTTCC 
TTCATTGAGC ACCTCCCAGG CCGGCTGAAG GAGGGCCACA CAAGTCGCGA GCACAGGAAC 
ACAAGCACCT GGCTGCACAG GGCCTTGGTG CTGGAAGAAC TGAGCCCCAC CCTACGAAGT 
ACCAACTTCT CCTGTTTGTT TGTGGATCCT GGACAAGTGG CCCAGTATCA CATCATTCTG 
GCCCAGCTCT GGGATGGGTT GAAGACAGCT CCGTCCCCTT CTCAAGAAAC CCTCTCTAGC 
CACAGCCCAG TATCCAGATC AGCAGGCCCA GGGGTTGCAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Il18bp ( NM_001363982.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001350911.1 Mus musculus interleukin 18 binding protein (Il18bp), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu06332
Clone ID Related Accession (Same CDS sequence)	NM_010531.1 , XM_030242160.1 , NM_010531.2 , NM_001363982.1 , XM_030242161.1
Accession Version	NM_001363982.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Mus musculus(house mouse)
Product	interleukin-18-binding protein precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC167240.5 and AK003370.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK003370.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164143 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCATGA GACACTGCTG GACAGCAGGC CCCAGTTCTT GGTGGGTCCT GCTTTTGTAT 
GTCCATGTCA TTTTGGCCAG AGCCACATCT GCACCTCAGA CAACTGCCAC TGTCTTAACT 
GGAAGCTCAA AAGACCCATG CTCTTCCTGG TCTCCAGCAG TCCCAACTAA GCAGTACCCA 
GCACTGGATG TGATTTGGCC AGAAAAAGAA GTGCCACTGA ATGGAACTCT GACCTTGTCC 
TGTACTGCCT GCAGCCGCTT CCCCTACTTC AGCATCCTCT ACTGGCTGGG CAATGGTTCC 
TTCATTGAGC ACCTCCCAGG CCGGCTGAAG GAGGGCCACA CAAGTCGCGA GCACAGGAAC 
ACAAGCACCT GGCTGCACAG GGCCTTGGTG CTGGAAGAAC TGAGCCCCAC CCTACGAAGT 
ACCAACTTCT CCTGTTTGTT TGTGGATCCT GGACAAGTGG CCCAGTATCA CATCATTCTG 
GCCCAGCTCT GGGATGGGTT GAAGACAGCT CCGTCCCCTT CTCAAGAAAC CCTCTCTAGC 
CACAGCCCAG TATCCAGATC AGCAGGCCCA GGGGTTGCAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001350911.1
CDS	202..783
Translation	MTMRHCWTAGPSSWWVLLLYVHVILARATSAPQTTATVLTGSSKDPCSSWSPAVPTKQYPALDVIWPEKEVPLNGTLTLSCTACSRFPYFSILYWLGNGSFIEHLPGRLKEGHTSREHRNTSTWLHRALVLEELSPTLRSTNFSCLFVDPGQVAQYHIILAQLWDGLKTAPSPSQETLSSHSPVSRSAGPGVA

Target ORF information:

RefSeq Version	NM_001363982.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus interleukin 18 binding protein (Il18bp), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001363982.1

ORF Insert Sequence:

ATGACCATGA GACACTGCTG GACAGCAGGC CCCAGTTCTT GGTGGGTCCT GCTTTTGTAT 
GTCCATGTCA TTTTGGCCAG AGCCACATCT GCACCTCAGA CAACTGCCAC TGTCTTAACT 
GGAAGCTCAA AAGACCCATG CTCTTCCTGG TCTCCAGCAG TCCCAACTAA GCAGTACCCA 
GCACTGGATG TGATTTGGCC AGAAAAAGAA GTGCCACTGA ATGGAACTCT GACCTTGTCC 
TGTACTGCCT GCAGCCGCTT CCCCTACTTC AGCATCCTCT ACTGGCTGGG CAATGGTTCC 
TTCATTGAGC ACCTCCCAGG CCGGCTGAAG GAGGGCCACA CAAGTCGCGA GCACAGGAAC 
ACAAGCACCT GGCTGCACAG GGCCTTGGTG CTGGAAGAAC TGAGCCCCAC CCTACGAAGT 
ACCAACTTCT CCTGTTTGTT TGTGGATCCT GGACAAGTGG CCCAGTATCA CATCATTCTG 
GCCCAGCTCT GGGATGGGTT GAAGACAGCT CCGTCCCCTT CTCAAGAAAC CCTCTCTAGC 
CACAGCCCAG TATCCAGATC AGCAGGCCCA GGGGTTGCAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Il18bp ( XM_017321987.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017177476.1 Mus musculus interleukin 18 binding protein (Il18bp), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu39322
Clone ID Related Accession (Same CDS sequence)	XM_017321987.1 , XM_017321987.2
Accession Version	XM_017321987.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 585bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	interleukin-18-binding protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCATGA GACACTGCTG GACAGCAGGC CCCAGTTCTT GGTGGGTCCT GCTTTTGTAT 
GTCCATGTCA TTTTGGCCAG AGCCACATCT GCACCTCAGA CAACTGCCAC TGTCTTAACT 
GGAAGCTCAA AAGACCCATG CTCTTCCTGG TCTCCAGCAG TCCCAACTAA GCAGTACCCA 
GCACTGGATG TGATTTGGCC AGAAAAAGAA GTGCCACTGA ATGGAACTCT GACCTTGTCC 
TGTACTGCCT GCAGCCGCTT CCCCTACTTC AGCATCCTCT ACTGGCTGGG CAATGGTTCC 
TTCATTGAGC ACCTCCCAGG CCGGCTGAAG GAGGGCCACA CAAGTCGCGA GCACAGGAAC 
ACAAGCACCT GGCTGCACAG GGCCTTGGTG CTGGAAGAAC TGAGCCCCAC CCTACGAAGT 
ACCAACTTCT CCTGTTTGTT TGTGGATCCT GGACAAGTGG CCCAGTATCA CATCATTCTG 
GCCCAGCTCT GGGTAAGGAA CCTGAAAGAA GGCATCCAGG GATGGGAGGA ACGCTACTAC 
CTGGGGAAGG AAGGATTGGC TTTTCCAGTA CAACCTGTAA GCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017177476.1
CDS	309..893
Translation	MTMRHCWTAGPSSWWVLLLYVHVILARATSAPQTTATVLTGSSKDPCSSWSPAVPTKQYPALDVIWPEKEVPLNGTLTLSCTACSRFPYFSILYWLGNGSFIEHLPGRLKEGHTSREHRNTSTWLHRALVLEELSPTLRSTNFSCLFVDPGQVAQYHIILAQLWVRNLKEGIQGWEERYYLGKEGLAFPVQPVS

Target ORF information:

RefSeq Version	XM_017321987.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus interleukin 18 binding protein (Il18bp), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017321987.1

ORF Insert Sequence:

ATGACCATGA GACACTGCTG GACAGCAGGC CCCAGTTCTT GGTGGGTCCT GCTTTTGTAT 
GTCCATGTCA TTTTGGCCAG AGCCACATCT GCACCTCAGA CAACTGCCAC TGTCTTAACT 
GGAAGCTCAA AAGACCCATG CTCTTCCTGG TCTCCAGCAG TCCCAACTAA GCAGTACCCA 
GCACTGGATG TGATTTGGCC AGAAAAAGAA GTGCCACTGA ATGGAACTCT GACCTTGTCC 
TGTACTGCCT GCAGCCGCTT CCCCTACTTC AGCATCCTCT ACTGGCTGGG CAATGGTTCC 
TTCATTGAGC ACCTCCCAGG CCGGCTGAAG GAGGGCCACA CAAGTCGCGA GCACAGGAAC 
ACAAGCACCT GGCTGCACAG GGCCTTGGTG CTGGAAGAAC TGAGCCCCAC CCTACGAAGT 
ACCAACTTCT CCTGTTTGTT TGTGGATCCT GGACAAGTGG CCCAGTATCA CATCATTCTG 
GCCCAGCTCT GGGTAAGGAA CCTGAAAGAA GGCATCCAGG GATGGGAGGA ACGCTACTAC 
CTGGGGAAGG AAGGATTGGC TTTTCCAGTA CAACCTGTAA GCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Il18bp ( XM_030242160.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030098020.1 Mus musculus interleukin 18 binding protein (Il18bp), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu06332
Clone ID Related Accession (Same CDS sequence)	NM_010531.1 , XM_030242160.1 , NM_010531.2 , NM_001363982.1 , XM_030242161.1
Accession Version	XM_030242160.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	interleukin-18-binding protein isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCATGA GACACTGCTG GACAGCAGGC CCCAGTTCTT GGTGGGTCCT GCTTTTGTAT 
GTCCATGTCA TTTTGGCCAG AGCCACATCT GCACCTCAGA CAACTGCCAC TGTCTTAACT 
GGAAGCTCAA AAGACCCATG CTCTTCCTGG TCTCCAGCAG TCCCAACTAA GCAGTACCCA 
GCACTGGATG TGATTTGGCC AGAAAAAGAA GTGCCACTGA ATGGAACTCT GACCTTGTCC 
TGTACTGCCT GCAGCCGCTT CCCCTACTTC AGCATCCTCT ACTGGCTGGG CAATGGTTCC 
TTCATTGAGC ACCTCCCAGG CCGGCTGAAG GAGGGCCACA CAAGTCGCGA GCACAGGAAC 
ACAAGCACCT GGCTGCACAG GGCCTTGGTG CTGGAAGAAC TGAGCCCCAC CCTACGAAGT 
ACCAACTTCT CCTGTTTGTT TGTGGATCCT GGACAAGTGG CCCAGTATCA CATCATTCTG 
GCCCAGCTCT GGGATGGGTT GAAGACAGCT CCGTCCCCTT CTCAAGAAAC CCTCTCTAGC 
CACAGCCCAG TATCCAGATC AGCAGGCCCA GGGGTTGCAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030098020.1
CDS	641..1222
Translation	MTMRHCWTAGPSSWWVLLLYVHVILARATSAPQTTATVLTGSSKDPCSSWSPAVPTKQYPALDVIWPEKEVPLNGTLTLSCTACSRFPYFSILYWLGNGSFIEHLPGRLKEGHTSREHRNTSTWLHRALVLEELSPTLRSTNFSCLFVDPGQVAQYHIILAQLWDGLKTAPSPSQETLSSHSPVSRSAGPGVA

Target ORF information:

RefSeq Version	XM_030242160.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus interleukin 18 binding protein (Il18bp), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030242160.1

ORF Insert Sequence:

ATGACCATGA GACACTGCTG GACAGCAGGC CCCAGTTCTT GGTGGGTCCT GCTTTTGTAT 
GTCCATGTCA TTTTGGCCAG AGCCACATCT GCACCTCAGA CAACTGCCAC TGTCTTAACT 
GGAAGCTCAA AAGACCCATG CTCTTCCTGG TCTCCAGCAG TCCCAACTAA GCAGTACCCA 
GCACTGGATG TGATTTGGCC AGAAAAAGAA GTGCCACTGA ATGGAACTCT GACCTTGTCC 
TGTACTGCCT GCAGCCGCTT CCCCTACTTC AGCATCCTCT ACTGGCTGGG CAATGGTTCC 
TTCATTGAGC ACCTCCCAGG CCGGCTGAAG GAGGGCCACA CAAGTCGCGA GCACAGGAAC 
ACAAGCACCT GGCTGCACAG GGCCTTGGTG CTGGAAGAAC TGAGCCCCAC CCTACGAAGT 
ACCAACTTCT CCTGTTTGTT TGTGGATCCT GGACAAGTGG CCCAGTATCA CATCATTCTG 
GCCCAGCTCT GGGATGGGTT GAAGACAGCT CCGTCCCCTT CTCAAGAAAC CCTCTCTAGC 
CACAGCCCAG TATCCAGATC AGCAGGCCCA GGGGTTGCAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Il18bp ( XM_030242161.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030098021.1 Mus musculus interleukin 18 binding protein (Il18bp), transcript variant X3, mRNA.

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CloneID	OMu06332
Clone ID Related Accession (Same CDS sequence)	NM_010531.1 , XM_030242160.1 , NM_010531.2 , NM_001363982.1 , XM_030242161.1
Accession Version	XM_030242161.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	interleukin-18-binding protein isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCATGA GACACTGCTG GACAGCAGGC CCCAGTTCTT GGTGGGTCCT GCTTTTGTAT 
GTCCATGTCA TTTTGGCCAG AGCCACATCT GCACCTCAGA CAACTGCCAC TGTCTTAACT 
GGAAGCTCAA AAGACCCATG CTCTTCCTGG TCTCCAGCAG TCCCAACTAA GCAGTACCCA 
GCACTGGATG TGATTTGGCC AGAAAAAGAA GTGCCACTGA ATGGAACTCT GACCTTGTCC 
TGTACTGCCT GCAGCCGCTT CCCCTACTTC AGCATCCTCT ACTGGCTGGG CAATGGTTCC 
TTCATTGAGC ACCTCCCAGG CCGGCTGAAG GAGGGCCACA CAAGTCGCGA GCACAGGAAC 
ACAAGCACCT GGCTGCACAG GGCCTTGGTG CTGGAAGAAC TGAGCCCCAC CCTACGAAGT 
ACCAACTTCT CCTGTTTGTT TGTGGATCCT GGACAAGTGG CCCAGTATCA CATCATTCTG 
GCCCAGCTCT GGGATGGGTT GAAGACAGCT CCGTCCCCTT CTCAAGAAAC CCTCTCTAGC 
CACAGCCCAG TATCCAGATC AGCAGGCCCA GGGGTTGCAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030098021.1
CDS	130..711
Translation	MTMRHCWTAGPSSWWVLLLYVHVILARATSAPQTTATVLTGSSKDPCSSWSPAVPTKQYPALDVIWPEKEVPLNGTLTLSCTACSRFPYFSILYWLGNGSFIEHLPGRLKEGHTSREHRNTSTWLHRALVLEELSPTLRSTNFSCLFVDPGQVAQYHIILAQLWDGLKTAPSPSQETLSSHSPVSRSAGPGVA

Target ORF information:

RefSeq Version	XM_030242161.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus interleukin 18 binding protein (Il18bp), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030242161.1

ORF Insert Sequence:

ATGACCATGA GACACTGCTG GACAGCAGGC CCCAGTTCTT GGTGGGTCCT GCTTTTGTAT 
GTCCATGTCA TTTTGGCCAG AGCCACATCT GCACCTCAGA CAACTGCCAC TGTCTTAACT 
GGAAGCTCAA AAGACCCATG CTCTTCCTGG TCTCCAGCAG TCCCAACTAA GCAGTACCCA 
GCACTGGATG TGATTTGGCC AGAAAAAGAA GTGCCACTGA ATGGAACTCT GACCTTGTCC 
TGTACTGCCT GCAGCCGCTT CCCCTACTTC AGCATCCTCT ACTGGCTGGG CAATGGTTCC 
TTCATTGAGC ACCTCCCAGG CCGGCTGAAG GAGGGCCACA CAAGTCGCGA GCACAGGAAC 
ACAAGCACCT GGCTGCACAG GGCCTTGGTG CTGGAAGAAC TGAGCCCCAC CCTACGAAGT 
ACCAACTTCT CCTGTTTGTT TGTGGATCCT GGACAAGTGG CCCAGTATCA CATCATTCTG 
GCCCAGCTCT GGGATGGGTT GAAGACAGCT CCGTCCCCTT CTCAAGAAAC CCTCTCTAGC 
CACAGCCCAG TATCCAGATC AGCAGGCCCA GGGGTTGCAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Il18bp ( XM_017321987.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017177476.1 Mus musculus interleukin 18 binding protein (Il18bp), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu39322
Clone ID Related Accession (Same CDS sequence)	XM_017321987.1 , XM_017321987.2
Accession Version	XM_017321987.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 585bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	interleukin-18-binding protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_017321987.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCATGA GACACTGCTG GACAGCAGGC CCCAGTTCTT GGTGGGTCCT GCTTTTGTAT 
GTCCATGTCA TTTTGGCCAG AGCCACATCT GCACCTCAGA CAACTGCCAC TGTCTTAACT 
GGAAGCTCAA AAGACCCATG CTCTTCCTGG TCTCCAGCAG TCCCAACTAA GCAGTACCCA 
GCACTGGATG TGATTTGGCC AGAAAAAGAA GTGCCACTGA ATGGAACTCT GACCTTGTCC 
TGTACTGCCT GCAGCCGCTT CCCCTACTTC AGCATCCTCT ACTGGCTGGG CAATGGTTCC 
TTCATTGAGC ACCTCCCAGG CCGGCTGAAG GAGGGCCACA CAAGTCGCGA GCACAGGAAC 
ACAAGCACCT GGCTGCACAG GGCCTTGGTG CTGGAAGAAC TGAGCCCCAC CCTACGAAGT 
ACCAACTTCT CCTGTTTGTT TGTGGATCCT GGACAAGTGG CCCAGTATCA CATCATTCTG 
GCCCAGCTCT GGGTAAGGAA CCTGAAAGAA GGCATCCAGG GATGGGAGGA ACGCTACTAC 
CTGGGGAAGG AAGGATTGGC TTTTCCAGTA CAACCTGTAA GCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017177476.1
CDS	100..684
Translation	MTMRHCWTAGPSSWWVLLLYVHVILARATSAPQTTATVLTGSSKDPCSSWSPAVPTKQYPALDVIWPEKEVPLNGTLTLSCTACSRFPYFSILYWLGNGSFIEHLPGRLKEGHTSREHRNTSTWLHRALVLEELSPTLRSTNFSCLFVDPGQVAQYHIILAQLWVRNLKEGIQGWEERYYLGKEGLAFPVQPVS

Target ORF information:

RefSeq Version	XM_017321987.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus interleukin 18 binding protein (Il18bp), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017321987.2

ORF Insert Sequence:

ATGACCATGA GACACTGCTG GACAGCAGGC CCCAGTTCTT GGTGGGTCCT GCTTTTGTAT 
GTCCATGTCA TTTTGGCCAG AGCCACATCT GCACCTCAGA CAACTGCCAC TGTCTTAACT 
GGAAGCTCAA AAGACCCATG CTCTTCCTGG TCTCCAGCAG TCCCAACTAA GCAGTACCCA 
GCACTGGATG TGATTTGGCC AGAAAAAGAA GTGCCACTGA ATGGAACTCT GACCTTGTCC 
TGTACTGCCT GCAGCCGCTT CCCCTACTTC AGCATCCTCT ACTGGCTGGG CAATGGTTCC 
TTCATTGAGC ACCTCCCAGG CCGGCTGAAG GAGGGCCACA CAAGTCGCGA GCACAGGAAC 
ACAAGCACCT GGCTGCACAG GGCCTTGGTG CTGGAAGAAC TGAGCCCCAC CCTACGAAGT 
ACCAACTTCT CCTGTTTGTT TGTGGATCCT GGACAAGTGG CCCAGTATCA CATCATTCTG 
GCCCAGCTCT GGGTAAGGAA CCTGAAAGAA GGCATCCAGG GATGGGAGGA ACGCTACTAC 
CTGGGGAAGG AAGGATTGGC TTTTCCAGTA CAACCTGTAA GCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Unopposed IL-18 signaling leads to severe TLR9-induced macrophage activation syndrome in mice.
Blood(2018 Jan)
Girard-Guyonvarc'h C,Palomo J,Martin P,Rodriguez E,Troccaz S,Palmer G,Gabay C

Role of IL-18 in atopic asthma is determined by balance of IL-18/IL-18BP/IL-18R.
Journal of cellular and molecular medicine22(1)354-373(2018 Jan)
Zhang H,Wang J,Wang L,Xie H,Chen L,He S

Interleukin (IL)-18 Binding Protein Deficiency Disrupts Natural Killer Cell Maturation and Diminishes Circulating IL-18.
Frontiers in immunology81020(2017)
Harms RZ,Creer AJ,Lorenzo-Arteaga KM,Ostlund KR,Sarvetnick NE

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

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Il18bp cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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