Gng5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gng5
Entrez Gene ID	14707
Full Name	guanine nucleotide binding protein (G protein), gamma 5
Synonyms	G(y)5
General protein information	Preferred Names guanine nucleotide binding protein (G protein), gamma 5 Names guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 guanine nucleotide binding protein (G protein), gamma 5 subunit
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 H2

mRNA and Protein(s)

mRNA	Protein	Name
NM_010318.2	NP_034448.2	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	GNG5	NP_005265.1
Pan troglodytes (chimpanzee)	GNG5	NP_001238951.1
	GNG5	XP_001107243.1
Canis lupus familiaris (dog)	GNG5	XP_003434843.1
Mus musculus (house mouse)	Gm15776	XP_003945606.1
Gallus gallus (chicken)	GNG5	XP_422375.4
Xenopus tropicalis (tropical clawed frog)	gng5	NP_001165076.1
Mus musculus (house mouse)	Gng5	NP_034448.2
Rattus norvegicus (Norway rat)	Gng5	NP_077353.1
Danio rerio (zebrafish)	gng5	NP_999886.1
Bos taurus (cattle)	GNG5	NP_777236.1

Gene Ontology
Bibliography

Related articles in PubMed

Disruption of G-protein ?5 subtype causes embryonic lethality in mice.
Moon AM, Stauffer AM, Schwindinger WF, Sheridan K, Firment A, Robishaw JD
PloS one9(3)e90970(2014)

KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression.
Ahmed SM, Th?riault BL, Uppalapati M, Chiu CW, Gallie BL, Sidhu SS, Angers S
The Journal of cell biology199(6)951-67(2012 Dec)

The heterotrimeric G protein subunits G?(q) and G?(1) have lysophospholipase D activity.
Aoyama C, Sugimoto H, Ando H, Yamashita S, Horibata Y, Sugimoto S, Satou M
The Biochemical journal440(2)241-50(2011 Dec)

Genomic analysis of mouse retinal development.
Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL
PLoS biology2(9)E247(2004 Sep)

Developmental expression of heterotrimeric G-proteins in the murine cerebellar cortex.
Sch?ller U, Lamp EC, Schilling K
Histochemistry and cell biology116(2)149-59(2001 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Targeted disruption of the mouse Gng5 gene encoding the gamma5 subtype produces embryonic lethality associated with severe head and heart defects.
Title: Disruption of G-protein ?5 subtype causes embryonic lethality in mice.

The following Gng5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gng5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu05952	NM_010318.2 Latest version!	Mus musculus guanine nucleotide binding protein (G protein), gamma 5 (Gng5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gng5 ( NM_010318.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034448.2 Mus musculus guanine nucleotide binding protein (G protein), gamma 5 (Gng5), mRNA.

Price & Availability↑

CloneID	OMu05952
Clone ID Related Accession (Same CDS sequence)	NM_010318.2
Accession Version	NM_010318.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 207bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Mus musculus(house mouse)
Product	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY132164.1 and AK146065.1. On or before May 4, 2006 this sequence version replaced XM_001000288.1, NM_010318.1. ##Evidence-Data-START## Transcript exon combination :: CK791703.1, CJ044800.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGTCGGGTT CTTCTAGCGT CGCCGCCATG AAGAAGGTGG TCCAGCAGCT CCGGCTGGAG 
GCCGGGCTCA ACCGCGTGAA GGTTTCCCAG GCAGCTGCAG ACTTGAAACA GTTCTGTCTG 
CAGAATGCTC AACATGACCC TCTGCTGACT GGAGTGTCTT CAAGTACGAA TCCCTTCAGA 
CCCCAGAAAG TCTGCTCCTT TTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034448.2
CDS	105..311
Translation	MSGSSSVAAMKKVVQQLRLEAGLNRVKVSQAAADLKQFCLQNAQHDPLLTGVSSSTNPFRPQKVCSFL

Target ORF information:

RefSeq Version	NM_010318.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus guanine nucleotide binding protein (G protein), gamma 5 (Gng5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010318.2

ORF Insert Sequence:

ATGTCGGGTT CTTCTAGCGT CGCCGCCATG AAGAAGGTGG TCCAGCAGCT CCGGCTGGAG 
GCCGGGCTCA ACCGCGTGAA GGTTTCCCAG GCAGCTGCAG ACTTGAAACA GTTCTGTCTG 
CAGAATGCTC AACATGACCC TCTGCTGACT GGAGTGTCTT CAAGTACGAA TCCCTTCAGA 
CCCCAGAAAG TCTGCTCCTT TTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Disruption of G-protein ?5 subtype causes embryonic lethality in mice.
PloS one9(3)e90970(2014)
Moon AM,Stauffer AM,Schwindinger WF,Sheridan K,Firment A,Robishaw JD

KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression.
The Journal of cell biology199(6)951-67(2012 Dec)
Ahmed SM,Th?riault BL,Uppalapati M,Chiu CW,Gallie BL,Sidhu SS,Angers S

The heterotrimeric G protein subunits G?(q) and G?(1) have lysophospholipase D activity.
The Biochemical journal440(2)241-50(2011 Dec)
Aoyama C,Sugimoto H,Ando H,Yamashita S,Horibata Y,Sugimoto S,Satou M

Genomic analysis of mouse retinal development.
PLoS biology2(9)E247(2004 Sep)
Blackshaw S,Harpavat S,Trimarchi J,Cai L,Huang H,Kuo WP,Weber G,Lee K,Fraioli RE,Cho SH,Yung R,Asch E,Ohno-Machado L,Wong WH,Cepko CL

Developmental expression of heterotrimeric G-proteins in the murine cerebellar cortex.
Histochemistry and cell biology116(2)149-59(2001 Aug)
Sch?ller U,Lamp EC,Schilling K