Fscn1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fscn1
Entrez Gene ID	14086
Full Name	fascin actin-bundling protein 1
Synonyms	AI663989,Fan1,fascin-1
General protein information	Preferred Names fascin actin-bundling protein 1 Names fascin fascin 1 singed-like protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5 G2\|5 81.84 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_007984.2	NP_032010.2	fascin

Pathways from BioSystems

Homologies

Homo sapiens (human)	FSCN1	NP_003079.1
Bos taurus (cattle)	FSCN1	NP_001030217.1
Rattus norvegicus (Norway rat)	Fscn1	NP_001094276.1
Xenopus tropicalis (tropical clawed frog)	fscn1	NP_989128.1
Mus musculus (house mouse)	Fscn1	NP_032010.2
Gallus gallus (chicken)	FSCN1	NP_001171603.1
Danio rerio (zebrafish)	fscn1a	NP_001070028.1
Pan troglodytes (chimpanzee)	FSCN1	XP_518954.4
Canis lupus familiaris (dog)	FSCN1	XP_546998.3

Gene Ontology
Bibliography

Related articles in PubMed

Studying the role of fascin-1 in mechanically stressed podocytes.
Kliewe F, Scharf C, Rogge H, Darm K, Lindenmeyer MT, Amann K, Cohen CD, Endlich K, Endlich N
Scientific reports7(1)9916(2017 Aug)

Daam1 regulates fascin for actin assembly in mouse oocyte meiosis.
Lu Y, Zhang Y, Pan MH, Kim NH, Sun SC, Cui XS
Cell cycle (Georgetown, Tex.)16(14)1350-1356(2017 Jul)

Identification of Novel MAGE-G1-Interacting Partners in Retinoic Acid-Induced P19 Neuronal Differentiation Using SILAC-Based Proteomics.
Liu Y, Chen Y, Lin S, Yang S, Liu S
Scientific reports744699(2017 Apr)

A mouse gene of the paired-related homeobox class expressed in the caudal somite compartment and in the developing vertebral column, kidney and nervous system.
Neidhardt LM, Kispert A, Herrmann BG
Development genes and evolution207(5)330-339(1997 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Fascin-1 expression, cadherin-17 expression, tumor size, and differentiation were independent risk factors for GC.
Title: Correlations of fascin-1 and cadherin-17 protein expression with clinicopathologic features and prognosis of patients with gastric cancer.

Filopodia formation by crosslinking of F-actin with fascin in two different binding manners
Title: Filopodia formation by crosslinking of F-actin with fascin in two different binding manners.

Fascin1 facilitates phagolysosomal fusion for killing of phagocytosed Listeria. It binds to LC3, an autophagosome marker, both in vivo & in vitro. It plays a critical role in dendritic cell survivalduring Listeria infection.
Title: Fascin confers resistance to Listeria infection in dendritic cells.

A tightly regulated phospho/dephospho-fascin cycle modulated by extracellular signals is required for the polarized morphology and migration in neuroblasts, thus contributing to efficient neurogenesis.
Title: Fascin regulates the migration of subventricular zone-derived neuroblasts in the postnatal brain.

fascin 1 promotes cell migration and has a role in growth and cell cycle progression
Title: Fascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation.

The following Fscn1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fscn1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15097	NM_007984.2 Latest version!	Mus musculus fascin actin-bundling protein 1 (Fscn1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fscn1 ( NM_007984.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032010.2 Mus musculus fascin actin-bundling protein 1 (Fscn1), mRNA.

Price & Availability↑

CloneID	OMu15097
Clone ID Related Accession (Same CDS sequence)	NM_007984.2
Accession Version	NM_007984.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1482bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	fascin
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY311024.1, BC052408.1 and CJ286472.1. On Aug 31, 2006 this sequence version replaced NM_007984.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK083935.1, AK167670.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCGCCA ACGGCACGGC AGAGGCTGTG CAGATTCAGT TCGGGCTCAT CAGCTGCGGC 
AACAAGTACC TGACAGCCGA GGCGTTCGGG TTCAAGGTGA ACGCATCCGC TAGTAGCTTG 
AAAAAGAAGC AGATCTGGAC GCTGGAGCAA CCTCCCGATG AGGCGGGCAG CGCGGCCGTG 
TGTCTGCGCA GCCACCTGGG TCGCTACCTG GCCGCCGACA AGGACGGCAA CGTGACCTGC 
GAGCGCGAGG TGCCCGACGG CGACTGCCGC TTTCTCGTCG TGGCGCACGA CGACGGCCGC 
TGGTCGCTGC AGTCCGAGGC TCACCGGCGC TACTTTGGCG GCACCGAGGA CCGCCTGTCC 
TGCTTCGCGC AGAGCGTGTC GCCGGCCGAG AAGTGGAGCG TGCACATCGC CATGCACCCG 
CAGGTTAACA TCTACAGCGT TACCCGCAAG CGCTACGCGC ATCTGAGCGC GCGGCCGGCC 
GACGAGATCG CGGTAGACCG CGACGTGCCT TGGGGCGTCG ACTCGCTCAT CACCTTGGCC 
TTCCAGGACC AACGCTACAG TGTGCAGACG TCCGACCACC GCTTCCTGCG CCACGACGGG 
CGCCTTGTGG CACGGCCGGA GCCCGCCACG GGCTTCACGC TGGAGTTCCG CTCCGGCAAG 
GTGGCCTTTC GCGACTGCGA AGGTCGCTAC CTGGCTCCGT CCGGGCCCAG CGGCACCCTC 
AAGGCTGGCA AGGCCACCAA GGTGGGCAAA GATGAGCTCT TCGCCCTGGA ACAGAGCTGC 
GCTCAGGTGG TGCTGCAGGC GGCCAACGAG AGGAACGTGT CCACGCGCCA GGGAATGGAC 
CTGTCAGCCA ATCAGGATGA AGAGACCGAT CAGGAGACCT TCCAGCTGGA GATCGACCGC 
GACACAAGAA AGTGTGCCTT TCGCACCCAC ACGGGCAAGT ACTGGACACT GACGGCGACC 
GGAGGTGTGC AATCCACTGC GTCCACCAAG AACGCCAGCT GCTACTTTGA CATCGAGTGG 
TGTGACCGCC GGATCACTCT GAGAGCCTCC AACGGCAAGT TTGTGACCGC CAAGAAAAAT 
GGCCAGCTGG CCGCCTCGGT GGAGACAGCA GGGGACTCGG AACTCTTCCT CATGAAGCTG 
ATTAACCGCC CCATCATCGT GTTCCGGGGG GAACACGGGT TCATTGGCTG CCGCAAGGTC 
ACGGGCACTC TGGATGCCAA CCGTTCCAGT TACGATGTCT TCCAGTTGGA ATTCAATGAC 
GGCGCCTACA ACATCAAAGA CTCCACGGGC AAGTACTGGA CGGTGGGTAG TGATTCCTCG 
GTCACCAGCA GCAGCGACAC CCCTGTGGAT TTCTTCCTTG AGTTCTGTGA CTACAATAAG 
GTGGCTCTCA AGGTGGGCGG CCGCTACCTG AAGGGGGACC ACGCTGGGGT CCTGAAGGCC 
TGCGCGGAGA CTATCGACCC CGCCTCACTC TGGGAGTACT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032010.2
CDS	95..1576
Translation	MTANGTAEAVQIQFGLISCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQPPDEAGSAAVCLRSHLGRYLAADKDGNVTCEREVPDGDCRFLVVAHDDGRWSLQSEAHRRYFGGTEDRLSCFAQSVSPAEKWSVHIAMHPQVNIYSVTRKRYAHLSARPADEIAVDRDVPWGVDSLITLAFQDQRYSVQTSDHRFLRHDGRLVARPEPATGFTLEFRSGKVAFRDCEGRYLAPSGPSGTLKAGKATKVGKDELFALEQSCAQVVLQAANERNVSTRQGMDLSANQDEETDQETFQLEIDRDTRKCAFRTHTGKYWTLTATGGVQSTASTKNASCYFDIEWCDRRITLRASNGKFVTAKKNGQLAASVETAGDSELFLMKLINRPIIVFRGEHGFIGCRKVTGTLDANRSSYDVFQLEFNDGAYNIKDSTGKYWTVGSDSSVTSSSDTPVDFFLEFCDYNKVALKVGGRYLKGDHAGVLKACAETIDPASLWEY

Target ORF information:

RefSeq Version	NM_007984.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus fascin actin-bundling protein 1 (Fscn1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007984.2

ORF Insert Sequence:

ATGACCGCCA ACGGCACGGC AGAGGCTGTG CAGATTCAGT TCGGGCTCAT CAGCTGCGGC 
AACAAGTACC TGACAGCCGA GGCGTTCGGG TTCAAGGTGA ACGCATCCGC TAGTAGCTTG 
AAAAAGAAGC AGATCTGGAC GCTGGAGCAA CCTCCCGATG AGGCGGGCAG CGCGGCCGTG 
TGTCTGCGCA GCCACCTGGG TCGCTACCTG GCCGCCGACA AGGACGGCAA CGTGACCTGC 
GAGCGCGAGG TGCCCGACGG CGACTGCCGC TTTCTCGTCG TGGCGCACGA CGACGGCCGC 
TGGTCGCTGC AGTCCGAGGC TCACCGGCGC TACTTTGGCG GCACCGAGGA CCGCCTGTCC 
TGCTTCGCGC AGAGCGTGTC GCCGGCCGAG AAGTGGAGCG TGCACATCGC CATGCACCCG 
CAGGTTAACA TCTACAGCGT TACCCGCAAG CGCTACGCGC ATCTGAGCGC GCGGCCGGCC 
GACGAGATCG CGGTAGACCG CGACGTGCCT TGGGGCGTCG ACTCGCTCAT CACCTTGGCC 
TTCCAGGACC AACGCTACAG TGTGCAGACG TCCGACCACC GCTTCCTGCG CCACGACGGG 
CGCCTTGTGG CACGGCCGGA GCCCGCCACG GGCTTCACGC TGGAGTTCCG CTCCGGCAAG 
GTGGCCTTTC GCGACTGCGA AGGTCGCTAC CTGGCTCCGT CCGGGCCCAG CGGCACCCTC 
AAGGCTGGCA AGGCCACCAA GGTGGGCAAA GATGAGCTCT TCGCCCTGGA ACAGAGCTGC 
GCTCAGGTGG TGCTGCAGGC GGCCAACGAG AGGAACGTGT CCACGCGCCA GGGAATGGAC 
CTGTCAGCCA ATCAGGATGA AGAGACCGAT CAGGAGACCT TCCAGCTGGA GATCGACCGC 
GACACAAGAA AGTGTGCCTT TCGCACCCAC ACGGGCAAGT ACTGGACACT GACGGCGACC 
GGAGGTGTGC AATCCACTGC GTCCACCAAG AACGCCAGCT GCTACTTTGA CATCGAGTGG 
TGTGACCGCC GGATCACTCT GAGAGCCTCC AACGGCAAGT TTGTGACCGC CAAGAAAAAT 
GGCCAGCTGG CCGCCTCGGT GGAGACAGCA GGGGACTCGG AACTCTTCCT CATGAAGCTG 
ATTAACCGCC CCATCATCGT GTTCCGGGGG GAACACGGGT TCATTGGCTG CCGCAAGGTC 
ACGGGCACTC TGGATGCCAA CCGTTCCAGT TACGATGTCT TCCAGTTGGA ATTCAATGAC 
GGCGCCTACA ACATCAAAGA CTCCACGGGC AAGTACTGGA CGGTGGGTAG TGATTCCTCG 
GTCACCAGCA GCAGCGACAC CCCTGTGGAT TTCTTCCTTG AGTTCTGTGA CTACAATAAG 
GTGGCTCTCA AGGTGGGCGG CCGCTACCTG AAGGGGGACC ACGCTGGGGT CCTGAAGGCC 
TGCGCGGAGA CTATCGACCC CGCCTCACTC TGGGAGTACT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Studying the role of fascin-1 in mechanically stressed podocytes.
Scientific reports7(1)9916(2017 Aug)
Kliewe F,Scharf C,Rogge H,Darm K,Lindenmeyer MT,Amann K,Cohen CD,Endlich K,Endlich N

Daam1 regulates fascin for actin assembly in mouse oocyte meiosis.
Cell cycle (Georgetown, Tex.)16(14)1350-1356(2017 Jul)
Lu Y,Zhang Y,Pan MH,Kim NH,Sun SC,Cui XS

Identification of Novel MAGE-G1-Interacting Partners in Retinoic Acid-Induced P19 Neuronal Differentiation Using SILAC-Based Proteomics.
Scientific reports744699(2017 Apr)
Liu Y,Chen Y,Lin S,Yang S,Liu S

A mouse gene of the paired-related homeobox class expressed in the caudal somite compartment and in the developing vertebral column, kidney and nervous system.
Development genes and evolution207(5)330-339(1997 Nov)
Neidhardt LM,Kispert A,Herrmann BG