Dusp2 cDNA ORF clone, Mus musculus(house mouse)

The phosphatase DUSP2 controls the activity of the transcription activator STAT3 and regulates TH17 differentiation.
Lu D, Liu L, Ji X, Gao Y, Chen X, Liu Y, Liu Y, Zhao X, Li Y, Li Y, Jin Y, Zhang Y, McNutt MA, Yin Y
Nature immunology16(12)1263-73(2015 Dec)

The dual-specificity phosphatase 2 (DUSP2) does not regulate obesity-associated inflammation or insulin resistance in mice.
Lancaster GI, Kraakman MJ, Kammoun HL, Langley KG, Estevez E, Banerjee A, Grumont RJ, Febbraio MA, Gerondakis S
PloS one9(11)e111524(2014)

Differential phosphorylation of Smad1 integrates BMP and neurotrophin pathways through Erk/Dusp in axon development.
Finelli MJ, Murphy KJ, Chen L, Zou H
Cell reports3(5)1592-606(2013 May)

Data indicate that dual specificity phosphatase 2 protein (DUSP2) is a true STAT3 transcription factor phosphatase that modulates the development of TH17 cells in the autoimmune response and inflammation.
Title: The phosphatase DUSP2 controls the activity of the transcription activator STAT3 and regulates TH17 differentiation.

DUSP2 plays no role in regulating obesity-associated inflammation and only a minor role in controlling insulin sensitivity following high-fat diet in female, but not male, mice.
Title: The dual-specificity phosphatase 2 (DUSP2) does not regulate obesity-associated inflammation or insulin resistance in mice.

the expression of PAC1 in the thymus changes in reverse ratio with thymus index and in direct ratio with cell apoptosis and only low dose of PACAP had positive effects against the CPS-induced thymus atrophy.
Title: The expression of PAC1 increases in the degenerative thymus and low dose PACAP protects female mice from cyclophosphamide induced thymus atrophy.

Arg294 and Arg295 play an important role in PAC-1 catalytic activation induced by ERK2 binding
Title: New insights into the catalytic activation of the MAPK phosphatase PAC-1 induced by its substrate MAPK ERK2 binding.