Cyp2f2 cDNA ORF clone, Mus musculus(house mouse)

Editor's Highlight: Complete Attenuation of Mouse Lung Cell Proliferation and Tumorigenicity in CYP2F2 Knockout and CYP2F1 Humanized Mice Exposed to Inhaled Styrene for up to 2?Years Supports a Lack of Human Relevance.
Cruzan G, Bus JS, Banton MI, Sarang SS, Waites R, Layko DB, Raymond J, Dodd D, Andersen ME
Toxicological sciences : an official journal of the Society of Toxicology159(2)413-421(2017 Oct)

Relationship of Metabolism and Cell Proliferation to the Mode of Action of Fluensulfone-Induced Mouse Lung Tumors. II: Additional Mechanistic Studies.
Strupp C, Bomann W, Cohen SM, Weber K
Toxicological sciences : an official journal of the Society of Toxicology154(2)296-308(2016 Dec)

Involvement of Igf1r in Bronchiolar Epithelial Regeneration: Role during Repair Kinetics after Selective Club Cell Ablation.
L?pez IP, Pi?eiro-Hermida S, Pais RS, Torrens R, Hoeflich A, Pichel JG
PloS one11(11)e0166388(2016)

The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver Zonation.
Rocha AS, Vidal V, Mertz M, Kendall TJ, Charlet A, Okamoto H, Schedl A
Cell reports13(9)1757-64(2015 Dec)

Identification of cytochrome P450 enzymes critical for lung tumorigenesis by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): insights from a novel Cyp2abfgs-null mouse.
Li L, Megaraj V, Wei Y, Ding X
Carcinogenesis35(11)2584-91(2014 Nov)

The P450 2F2 is responsible for the metabolic activation of styrene and plays an important role in styrene-induced pulmonary toxicity.
Title: Metabolism of styrene to styrene oxide and vinylphenols in cytochrome P450 2F2- and P450 2E1-knockout mouse liver and lung microsomes.

These results provide the basis for understanding the respective roles of CYP2A5 and CYP2F2 in 3MI's toxicity in the respiratory tract.
Title: Respective roles of CYP2A5 and CYP2F2 in the bioactivation of 3-methylindole in mouse olfactory mucosa and lung: studies using Cyp2a5-null and Cyp2f2-null mouse models.

After secondary exposure to naphtalene (NA)female mice had decreased gene/protein expression of CYP2F2 and glutamate-cysteine ligase than NA-tolerant males at all airway levels examined.
Title: Sex differences in the development of airway epithelial tolerance to naphthalene.

It is unlikely several chemicals that cause mouse lung tumors via CYP2F2 metabolism will cause lung tumors in humans
Title: Mouse specific lung tumors from CYP2F2-mediated cytotoxic metabolism: an endpoint/toxic response where data from multiple chemicals converge to support a mode of action.