Cyba cDNA ORF clone, Mus musculus(house mouse)

Increased Expression of p22phox Mediates Airway Hyperresponsiveness in an Experimental Model of Asthma.
Nagaraj C, Haitchi HM, Heinemann A, Howarth PH, Olschewski A, Marsh LM
Antioxidants & redox signaling27(18)1460-1472(2017 Dec)

Hypoxic vascular response and ventilation/perfusion matching in end-stage COPD may depend on p22phox.
Nagaraj C, Tabeling C, Nagy BM, Jain PP, Marsh LM, Papp R, Pienn M, Witzenrath M, Ghanim B, Klepetko W, Weir EK, Heschl S, Kwapiszewska G, Olschewski A, Olschewski H
The European respiratory journal50(1)(2017 Jul)

Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.
Thomas DC, Clare S, Sowerby JM, Pardo M, Juss JK, Goulding DA, van der Weyden L, Storisteanu D, Prakash A, Esp?li M, Flint S, Lee JC, Hoenderdos K, Kane L, Harcourt K, Mukhopadhyay S, Umrania Y, Antrobus R, Nathan JA, Adams DJ, Bateman A, Choudhary JS, Lyons PA, Condliffe AM, Chilvers ER, Dougan G, Smith KG
The Journal of experimental medicine214(4)1111-1128(2017 Apr)

Knockout of the cytochrome P450 reductase by CRISPR/Cas9 technology (POR(-/-)) in HEK293 cells overexpressing Nox4 or Nox5 did not interfere with ROS production in intact cells. However, POR(-/-) abolished the signal in NADPH-stimulated assays using membrane fractions from the very same cells. Moreover, membranes of rat smooth muscle cells treated with angiotensin II showed an increased NADPH-dependent signal with lucigen
Title: Cytochrome P450 enzymes but not NADPH oxidases are the source of the NADPH-dependent lucigenin chemiluminescence in membrane assays.

Identification of a PPAR-gamma --> NF-kappaB --> p22phox neuroprotective signaling cascade opens a new avenue for protecting the brain against ischemic insult.
Title: PPAR-? Ameliorates Neuronal Apoptosis and Ischemic Brain Injury via Suppressing NF-?B-Driven p22phox Transcription.

p22phox mRNA expression was increased in diet-induced obese (DIO) mice.
Title: Impaired compensation to femoral artery ligation in diet-induced obese mice is primarily mediated via suppression of collateral growth by Nox2 and p47phox.

The present study provides evidence that augmented EGFRtk impairs vascular function by NADPH oxidase-dependent mechanism. Therefore, EGFRtk and oxidative stress should be potential targets to treat vascular dysfunction in TD2.
Title: Augmented EGF receptor tyrosine kinase activity impairs vascular function by NADPH oxidase-dependent mechanism in type 2 diabetic mouse.

Enhanced p22(phox) expression causes vascular dysfunction through ERK1/2 and p38-mitogen-activated protein kinase-dependent mechanisms in male type 2 diabetic mice.
Title: Enhanced p22phox expression impairs vascular function through p38 and ERK1/2 MAP kinase-dependent mechanisms in type 2 diabetic mice.