Crcp cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Crcp
Entrez Gene ID	12909
Full Name	calcitonin gene-related peptide-receptor component protein
Synonyms	AL022669
General protein information	Preferred Names calcitonin gene-related peptide-receptor component protein Names DNA-directed RNA polymerase III subunit RPC9 CGRP-RCP CGRP-receptor component protein CGRPRCP RNA polymerase III subunit C9
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 G1.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_007761.2	NP_031787.1	DNA-directed RNA polymerase III subunit RPC9

Pathways from BioSystems

Homologies

Homo sapiens (human)	CRCP	NP_055293.1
Rattus norvegicus (Norway rat)	Crcp	NP_446122.1
Canis lupus familiaris (dog)	CRCP	XP_536833.2
Danio rerio (zebrafish)	crcp	NP_001038838.1
Pan troglodytes (chimpanzee)	CRCP	NP_001229358.1
Mus musculus (house mouse)	Crcp	NP_031787.1
Gallus gallus (chicken)	CRCP	XP_415793.1
Drosophila melanogaster (fruit fly)	Rcp	NP_996493.1
Xenopus tropicalis (tropical clawed frog)	crcp	NP_001016478.1
Bos taurus (cattle)	CRCP	NP_001071338.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007220	XP_308566.3

Gene Ontology
Bibliography

Related articles in PubMed

Involvement of calcitonin gene-related peptide and receptor component protein in experimental autoimmune encephalomyelitis.
Sardi C, Zambusi L, Finardi A, Ruffini F, Tolun AA, Dickerson IM, Righi M, Zacchetti D, Grohovaz F, Provini L, Furlan R, Morara S
Journal of neuroimmunology271(1-2)18-29(2014 Jun)

Direct interactions between calcitonin-like receptor (CLR) and CGRP-receptor component protein (RCP) regulate CGRP receptor signaling.
Egea SC, Dickerson IM
Endocrinology153(4)1850-60(2012 Apr)

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic acids research31(1)278-81(2003 Jan)

Molecular cloning and characterization of mouse calcitonin gene-related peptide receptor.
Miyauchi K, Tadotsu N, Hayashi T, Ono Y, Tokoyoda K, Tsujikawa K, Yamamoto H
Neuropeptides36(1)22-33(2002 Feb)

Characterization and localization of the rabbit ocular calcitonin gene-related peptide (CGRP)-receptor component protein (RCP).
Rosenblatt MI, Dahl GP, Dickerson IM
Investigative ophthalmology & visual science41(5)1159-67(2000 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CGRP can inhibit microglia activation in vivo in EAE. CGRP and its receptor may represent novel protective factors in EAE.
Title: Involvement of calcitonin gene-related peptide and receptor component protein in experimental autoimmune encephalomyelitis.

CGRP-receptor component protein has been found to interact only with calcitonin-like receptor and represents a novel neuroendocrine regulatory step in calcitonin gene-related peptide signaling.
Title: Direct interactions between calcitonin-like receptor (CLR) and CGRP-receptor component protein (RCP) regulate CGRP receptor signaling.

The mouse cDNA for calcitonin receptor-like receptor (CRLR) was cloned. The signal transduction mechanism through the CGRP receptor was studied. mCRLR is a 462-amino acid G-protein-coupled heptahelical receptor.
Title: Molecular cloning and characterization of mouse calcitonin gene-related peptide receptor.

The following Crcp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Crcp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00749	NM_007761.2 Latest version!	Mus musculus calcitonin gene-related peptide-receptor component protein (Crcp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Crcp ( NM_007761.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031787.1 Mus musculus calcitonin gene-related peptide-receptor component protein (Crcp), mRNA.

Price & Availability↑

CloneID	OMu00749
Clone ID Related Accession (Same CDS sequence)	NM_007761.2
Accession Version	NM_007761.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 447bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	DNA-directed RNA polymerase III subunit RPC9
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC161345.4 and AC122339.3. On Nov 17, 2006 this sequence version replaced NM_007761.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AF118271.1, AK075587.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGAAGTGA AGGATGCGAA CGCAGCACTG CTCAGCAACT ATGAGGTGTT CCAGTTACTA 
ACGGATCTCA AAGAGCAGCG GAAGGAGAGT GGGAAGAACA AGCATAGCGC TGGGCAGCAG 
AACTTGAACG CCATCACCTA TGAGACACTA AAGTACATAT CAAAAACACC ATGTAGGAAC 
CAGAGTCCAG CGATTGTCCA AGAATTCCTC ACAGCAATGA AAAGCCACAA GCTGACCAAA 
GCGGAGAAGC TGCAGCTGCT GAATCACAGG CCGATGACTG CGGTGGAGAT CCAGCTGATG 
GTAGAAGAGA GTGAAGAACG GCTCACAGAG GAGCAGATCG AAGCCCTCCT GCACACTGTC 
ACTAGCATTC TGCCTGCAGG TCCAGAGGAT GAACAGAGCA AAAGCACTAG CAATGACGTG 
GCTATGGAAG AGGAGGAGCC AGCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031787.1
CDS	95..541
Translation	MEVKDANAALLSNYEVFQLLTDLKEQRKESGKNKHSAGQQNLNAITYETLKYISKTPCRNQSPAIVQEFLTAMKSHKLTKAEKLQLLNHRPMTAVEIQLMVEESEERLTEEQIEALLHTVTSILPAGPEDEQSKSTSNDVAMEEEEPA

Target ORF information:

RefSeq Version	NM_007761.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus calcitonin gene-related peptide-receptor component protein (Crcp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007761.2

ORF Insert Sequence:

ATGGAAGTGA AGGATGCGAA CGCAGCACTG CTCAGCAACT ATGAGGTGTT CCAGTTACTA 
ACGGATCTCA AAGAGCAGCG GAAGGAGAGT GGGAAGAACA AGCATAGCGC TGGGCAGCAG 
AACTTGAACG CCATCACCTA TGAGACACTA AAGTACATAT CAAAAACACC ATGTAGGAAC 
CAGAGTCCAG CGATTGTCCA AGAATTCCTC ACAGCAATGA AAAGCCACAA GCTGACCAAA 
GCGGAGAAGC TGCAGCTGCT GAATCACAGG CCGATGACTG CGGTGGAGAT CCAGCTGATG 
GTAGAAGAGA GTGAAGAACG GCTCACAGAG GAGCAGATCG AAGCCCTCCT GCACACTGTC 
ACTAGCATTC TGCCTGCAGG TCCAGAGGAT GAACAGAGCA AAAGCACTAG CAATGACGTG 
GCTATGGAAG AGGAGGAGCC AGCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Involvement of calcitonin gene-related peptide and receptor component protein in experimental autoimmune encephalomyelitis.
Journal of neuroimmunology271(1-2)18-29(2014 Jun)
Sardi C,Zambusi L,Finardi A,Ruffini F,Tolun AA,Dickerson IM,Righi M,Zacchetti D,Grohovaz F,Provini L,Furlan R,Morara S

Direct interactions between calcitonin-like receptor (CLR) and CGRP-receptor component protein (RCP) regulate CGRP receptor signaling.
Endocrinology153(4)1850-60(2012 Apr)
Egea SC,Dickerson IM

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Nucleic acids research31(1)278-81(2003 Jan)
Stryke D,Kawamoto M,Huang CC,Johns SJ,King LA,Harper CA,Meng EC,Lee RE,Yee A,L'Italien L,Chuang PT,Young SG,Skarnes WC,Babbitt PC,Ferrin TE

Molecular cloning and characterization of mouse calcitonin gene-related peptide receptor.
Neuropeptides36(1)22-33(2002 Feb)
Miyauchi K,Tadotsu N,Hayashi T,Ono Y,Tokoyoda K,Tsujikawa K,Yamamoto H

Characterization and localization of the rabbit ocular calcitonin gene-related peptide (CGRP)-receptor component protein (RCP).
Investigative ophthalmology & visual science41(5)1159-67(2000 Apr)
Rosenblatt MI,Dahl GP,Dickerson IM