Cdc37 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cdc37
Entrez Gene ID	12539
Full Name	cell division cycle 37
Synonyms	p50,p50Cdc37
General protein information	Preferred Names cell division cycle 37 Names hsp90 co-chaperone Cdc37 cell division cycle 37 homolog hsp90 chaperone protein kinase-targeting subunit
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 A3

mRNA and Protein(s)

mRNA	Protein	Name
XM_006509967.2	XP_006510030.1	hsp90 co-chaperone Cdc37 isoform X1
XM_006509967.1	XP_006510030.1	hsp90 co-chaperone Cdc37 isoform X1
NM_016742.4	NP_058022.1	hsp90 co-chaperone Cdc37

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Cdc37	NP_058022.1
Drosophila melanogaster (fruit fly)	Cdc37	NP_477006.1
Xenopus tropicalis (tropical clawed frog)	cdc37	NP_001015912.1
Homo sapiens (human)	CDC37	NP_008996.1
Pan troglodytes (chimpanzee)	CDC37	XP_003953416.1
Rattus norvegicus (Norway rat)	Cdc37	NP_446195.1
Danio rerio (zebrafish)	cdc37	NP_957332.1
	CDC37	XP_001105596.2
Canis lupus familiaris (dog)	CDC37	XP_854103.1
Bos taurus (cattle)	CDC37	NP_001030415.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001914	XP_321151.4
Caenorhabditis elegans (roundworm)	cdc-37	NP_001040821.1

Gene Ontology
Bibliography

Related articles in PubMed

Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In?Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling.
Chen B, Wei W, Ma L, Yang B, Gill RM, Chua MS, Butte AJ, So S
Gastroenterology152(8)2022-2036(2017 Jun)

The co-chaperone Cdc37 regulates the rabies virus phosphoprotein stability by targeting to Hsp90AA1 machinery.
Xu Y, Liu F, Liu J, Wang D, Yan Y, Ji S, Zan J, Zhou J
Scientific reports627123(2016 Jun)

Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex.
Erazo T, Moreno A, Ruiz-Babot G, Rodr?guez-Asiain A, Morrice NA, Espadamala J, Bayascas JR, G?mez N, Lizcano JM
Molecular and cellular biology33(8)1671-86(2013 Apr)

Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine.
Xu W, Mollapour M, Prodromou C, Wang S, Scroggins BT, Palchick Z, Beebe K, Siderius M, Lee MJ, Couvillon A, Trepel JB, Miyata Y, Matts R, Neckers L
Molecular cell47(3)434-43(2012 Aug)

Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy.
Joo JH, Dorsey FC, Joshi A, Hennessy-Walters KM, Rose KL, McCastlain K, Zhang J, Iyengar R, Jung CH, Suen DF, Steeves MA, Yang CY, Prater SM, Kim DH, Thompson CB, Youle RJ, Ney PA, Cleveland JL, Kundu M
Molecular cell43(4)572-85(2011 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Niclosamide ethanolamine disrupted the interaction between cell division cycle 37 and heat shock protein 90 in hepatocellular carcinoma, reducing tumor growth.
Title: Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In?Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling.

A series of tyrosine phosphorylation events, involving both p50(Cdc37) and Hsp90, are minimally sufficient to provide directionality to the chaperone cycle.
Title: Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine.

Hsp90-Cdc37 complex acta as an endogenous regulator of noncanonical p38alpha activity.
Title: Specific regulation of noncanonical p38alpha activation by Hsp90-Cdc37 chaperone complex in cardiomyocyte.

This growth inhibition is partially rescued by expression of ectopic Gli1, suggesting that Fu may contribute to enhance Hh signaling activity in cancer cells.
Title: Fused kinase is stabilized by Cdc37/Hsp90 and enhances Gli protein levels.

JAK1/2 are client proteins of Hsp90 alpha and beta; Hsp90 and CDC37 play a critical role in types I and II interferon pathways
Title: The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons.

The following Cdc37 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cdc37 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu10527	NM_016742.4 Latest version!	Mus musculus cell division cycle 37 (Cdc37), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
OMu41971	XM_006509967.2 Latest version!	Mus musculus cell division cycle 37 (Cdc37), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OMu41971	XM_006509967.1	Mus musculus cell division cycle 37 (Cdc37), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cdc37 ( XM_006509967.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006510030.1 Mus musculus cell division cycle 37 (Cdc37), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu41971
Clone ID Related Accession (Same CDS sequence)	XM_006509967.2 , XM_006509967.1
Accession Version	XM_006509967.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1287bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	hsp90 co-chaperone Cdc37 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGGACT ACAGCGTTTG GGATCACATC GAGGTGTCGG ACGATGAGGA CGAGACGCAC 
CCCAACATAG ACACTGCCAG CCTCTTCCGC TGGCGGCACC AGGCCCGGGT GGAACGCATG 
GAGCAGTTTC AGAAGGAGAA AGAGGAACTG GACCGGGGCT GCCGGGAGTG CAAGCGCAAG 
GTAGCCGAGT GCCAGCGCAA GCTGAAGGAG CTGGAAGTGG CTGAGAGCGA TGGCCAGGTG 
GAGCTTGAGC GGCTGAGAGC TGAGGCACAG CAACTGCGCA AGGAGGAGCG GAGCTGGGAG 
CAGAAGCTGG AAGACATGCG CAAAAAGGAG AAGAACATGC CCTGGAATGT GGACACGCTC 
AGCAAAGATG GCTTTAGCAA GGCCCGCGGC CATGCCTCCG CCACCTTGAT GCACTTAGCG 
ACGCCACCGC CTCCGATGTG GACAGGATGG GCGCGGCGGC CACGGCCCCC AAACCCCAGG 
CGCACCCCTG CCTTGCCCCA GCCCACTTGC CCTCTCACCC TGTCACAGAG CATGGTCAAT 
ACCAAGCCTG AGAAGGCAGA GGAGGACTCA GAGGAGGCAA GGGAGCAGAA ACACAAGACC 
TTCGTTGAAA AATATGAGAA ACAGATCAAG CATTTCGGCA TGCTCCACCG CTGGGATGAC 
AGCCAGAAAT ACCTGTCGGA CAACGTCCAC CTGGTGTGTG AGGAAACGGC CAACTACCTG 
GTTATCTGGT GCATTGACCT GGAGGTAGAG GAGAAATGTG CACTGATGGA GCAGGTAGCT 
CACCAGACCA TGGTGATGCA GTTTATTCTG GAGCTGGCCA AGAGTCTGAA GGTCGACCCC 
CGAGCCTGCT TCCGGCAGTT TTTCACCAAG ATCAAGACCG CTGACCACCA GTACATGGAG 
GGCTTCAAGT ATGAACTGGA AGCCTTTAAG GAGCGAGTGC GGGGCCGCGC CAAGCTGCGA 
ATAGAGAAGG CCATGAAGGA ATATGAAGAG GAGGAGCGCA AGAAGAGGCT AGGCCCTGGT 
GGCCTGGACC CCGTGGAGGT CTACGAATCC CTGCCTGAGG AGCTGCAGAA GTGCTTTGAT 
GTGAAGGATG TACAGATGCT GCAAGACGCC ATCAGCAAAA TGGATCCCAC TGATGCCAAG 
TATCACATGC AGCGTTGCAT CGATTCTGGC CTCTGGGTCC CCAACTCCAA GTCTGGTGAG 
GCCAAGGAGG GGGAGGAGGC GGGCCCCGGG GACCCATTGC TGGAAGCCGT CCCCAAAGCG 
GGCAACGAGA AAGACGTCAG TGCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006510030.1
CDS	121..1407
Translation	MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAESDGQVELERLRAEAQQLRKEERSWEQKLEDMRKKEKNMPWNVDTLSKDGFSKARGHASATLMHLATPPPPMWTGWARRPRPPNPRRTPALPQPTCPLTLSQSMVNTKPEKAEEDSEEAREQKHKTFVEKYEKQIKHFGMLHRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTMVMQFILELAKSLKVDPRACFRQFFTKIKTADHQYMEGFKYELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKSGEAKEGEEAGPGDPLLEAVPKAGNEKDVSA

Target ORF information:

RefSeq Version	XM_006509967.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus cell division cycle 37 (Cdc37), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006509967.1

ORF Insert Sequence:

ATGGTGGACT ACAGCGTTTG GGATCACATC GAGGTGTCGG ACGATGAGGA CGAGACGCAC 
CCCAACATAG ACACTGCCAG CCTCTTCCGC TGGCGGCACC AGGCCCGGGT GGAACGCATG 
GAGCAGTTTC AGAAGGAGAA AGAGGAACTG GACCGGGGCT GCCGGGAGTG CAAGCGCAAG 
GTAGCCGAGT GCCAGCGCAA GCTGAAGGAG CTGGAAGTGG CTGAGAGCGA TGGCCAGGTG 
GAGCTTGAGC GGCTGAGAGC TGAGGCACAG CAACTGCGCA AGGAGGAGCG GAGCTGGGAG 
CAGAAGCTGG AAGACATGCG CAAAAAGGAG AAGAACATGC CCTGGAATGT GGACACGCTC 
AGCAAAGATG GCTTTAGCAA GGCCCGCGGC CATGCCTCCG CCACCTTGAT GCACTTAGCG 
ACGCCACCGC CTCCGATGTG GACAGGATGG GCGCGGCGGC CACGGCCCCC AAACCCCAGG 
CGCACCCCTG CCTTGCCCCA GCCCACTTGC CCTCTCACCC TGTCACAGAG CATGGTCAAT 
ACCAAGCCTG AGAAGGCAGA GGAGGACTCA GAGGAGGCAA GGGAGCAGAA ACACAAGACC 
TTCGTTGAAA AATATGAGAA ACAGATCAAG CATTTCGGCA TGCTCCACCG CTGGGATGAC 
AGCCAGAAAT ACCTGTCGGA CAACGTCCAC CTGGTGTGTG AGGAAACGGC CAACTACCTG 
GTTATCTGGT GCATTGACCT GGAGGTAGAG GAGAAATGTG CACTGATGGA GCAGGTAGCT 
CACCAGACCA TGGTGATGCA GTTTATTCTG GAGCTGGCCA AGAGTCTGAA GGTCGACCCC 
CGAGCCTGCT TCCGGCAGTT TTTCACCAAG ATCAAGACCG CTGACCACCA GTACATGGAG 
GGCTTCAAGT ATGAACTGGA AGCCTTTAAG GAGCGAGTGC GGGGCCGCGC CAAGCTGCGA 
ATAGAGAAGG CCATGAAGGA ATATGAAGAG GAGGAGCGCA AGAAGAGGCT AGGCCCTGGT 
GGCCTGGACC CCGTGGAGGT CTACGAATCC CTGCCTGAGG AGCTGCAGAA GTGCTTTGAT 
GTGAAGGATG TACAGATGCT GCAAGACGCC ATCAGCAAAA TGGATCCCAC TGATGCCAAG 
TATCACATGC AGCGTTGCAT CGATTCTGGC CTCTGGGTCC CCAACTCCAA GTCTGGTGAG 
GCCAAGGAGG GGGAGGAGGC GGGCCCCGGG GACCCATTGC TGGAAGCCGT CCCCAAAGCG 
GGCAACGAGA AAGACGTCAG TGCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cdc37 ( NM_016742.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_058022.1 Mus musculus cell division cycle 37 (Cdc37), mRNA.

Price & Availability↑

CloneID	OMu10527
Clone ID Related Accession (Same CDS sequence)	NM_016742.4
Accession Version	NM_016742.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1140bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	hsp90 co-chaperone Cdc37
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC163637.4. On Apr 28, 2007 this sequence version replaced NM_016742.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK013255.1, AK145671.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END##

ATGGTGGACT ACAGCGTTTG GGATCACATC GAGGTGTCGG ACGATGAGGA CGAGACGCAC 
CCCAACATAG ACACTGCCAG CCTCTTCCGC TGGCGGCACC AGGCCCGGGT GGAACGCATG 
GAGCAGTTTC AGAAGGAGAA AGAGGAACTG GACCGGGGCT GCCGGGAGTG CAAGCGCAAG 
GTAGCCGAGT GCCAGCGCAA GCTGAAGGAG CTGGAAGTGG CTGAGAGCGA TGGCCAGGTG 
GAGCTTGAGC GGCTGAGAGC TGAGGCACAG CAACTGCGCA AGGAGGAGCG GAGCTGGGAG 
CAGAAGCTGG AAGACATGCG CAAAAAGGAG AAGAACATGC CCTGGAATGT GGACACGCTC 
AGCAAAGATG GCTTTAGCAA GAGCATGGTC AATACCAAGC CTGAGAAGGC AGAGGAGGAC 
TCAGAGGAGG CAAGGGAGCA GAAACACAAG ACCTTCGTTG AAAAATATGA GAAACAGATC 
AAGCATTTCG GCATGCTCCA CCGCTGGGAT GACAGCCAGA AATACCTGTC GGACAACGTC 
CACCTGGTGT GTGAGGAAAC GGCCAACTAC CTGGTTATCT GGTGCATTGA CCTGGAGGTA 
GAGGAGAAAT GTGCACTGAT GGAGCAGGTA GCTCACCAGA CCATGGTGAT GCAGTTTATT 
CTGGAGCTGG CCAAGAGTCT GAAGGTCGAC CCCCGAGCCT GCTTCCGGCA GTTTTTCACC 
AAGATCAAGA CCGCTGACCA CCAGTACATG GAGGGCTTCA AGTATGAACT GGAAGCCTTT 
AAGGAGCGAG TGCGGGGCCG CGCCAAGCTG CGAATAGAGA AGGCCATGAA GGAATATGAA 
GAGGAGGAGC GCAAGAAGAG GCTAGGCCCT GGTGGCCTGG ACCCCGTGGA GGTCTACGAA 
TCCCTGCCTG AGGAGCTGCA GAAGTGCTTT GATGTGAAGG ATGTACAGAT GCTGCAAGAC 
GCCATCAGCA AAATGGATCC CACTGATGCC AAGTATCACA TGCAGCGTTG CATCGATTCT 
GGCCTCTGGG TCCCCAACTC CAAGTCTGGT GAGGCCAAGG AGGGGGAGGA GGCGGGCCCC 
GGGGACCCAT TGCTGGAAGC CGTCCCCAAA GCGGGCAACG AGAAAGACGT CAGTGCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058022.1
CDS	50..1189
Translation	MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAESDGQVELERLRAEAQQLRKEERSWEQKLEDMRKKEKNMPWNVDTLSKDGFSKSMVNTKPEKAEEDSEEAREQKHKTFVEKYEKQIKHFGMLHRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTMVMQFILELAKSLKVDPRACFRQFFTKIKTADHQYMEGFKYELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKSGEAKEGEEAGPGDPLLEAVPKAGNEKDVSA

Target ORF information:

RefSeq Version	NM_016742.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus cell division cycle 37 (Cdc37), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016742.4

ORF Insert Sequence:

ATGGTGGACT ACAGCGTTTG GGATCACATC GAGGTGTCGG ACGATGAGGA CGAGACGCAC 
CCCAACATAG ACACTGCCAG CCTCTTCCGC TGGCGGCACC AGGCCCGGGT GGAACGCATG 
GAGCAGTTTC AGAAGGAGAA AGAGGAACTG GACCGGGGCT GCCGGGAGTG CAAGCGCAAG 
GTAGCCGAGT GCCAGCGCAA GCTGAAGGAG CTGGAAGTGG CTGAGAGCGA TGGCCAGGTG 
GAGCTTGAGC GGCTGAGAGC TGAGGCACAG CAACTGCGCA AGGAGGAGCG GAGCTGGGAG 
CAGAAGCTGG AAGACATGCG CAAAAAGGAG AAGAACATGC CCTGGAATGT GGACACGCTC 
AGCAAAGATG GCTTTAGCAA GAGCATGGTC AATACCAAGC CTGAGAAGGC AGAGGAGGAC 
TCAGAGGAGG CAAGGGAGCA GAAACACAAG ACCTTCGTTG AAAAATATGA GAAACAGATC 
AAGCATTTCG GCATGCTCCA CCGCTGGGAT GACAGCCAGA AATACCTGTC GGACAACGTC 
CACCTGGTGT GTGAGGAAAC GGCCAACTAC CTGGTTATCT GGTGCATTGA CCTGGAGGTA 
GAGGAGAAAT GTGCACTGAT GGAGCAGGTA GCTCACCAGA CCATGGTGAT GCAGTTTATT 
CTGGAGCTGG CCAAGAGTCT GAAGGTCGAC CCCCGAGCCT GCTTCCGGCA GTTTTTCACC 
AAGATCAAGA CCGCTGACCA CCAGTACATG GAGGGCTTCA AGTATGAACT GGAAGCCTTT 
AAGGAGCGAG TGCGGGGCCG CGCCAAGCTG CGAATAGAGA AGGCCATGAA GGAATATGAA 
GAGGAGGAGC GCAAGAAGAG GCTAGGCCCT GGTGGCCTGG ACCCCGTGGA GGTCTACGAA 
TCCCTGCCTG AGGAGCTGCA GAAGTGCTTT GATGTGAAGG ATGTACAGAT GCTGCAAGAC 
GCCATCAGCA AAATGGATCC CACTGATGCC AAGTATCACA TGCAGCGTTG CATCGATTCT 
GGCCTCTGGG TCCCCAACTC CAAGTCTGGT GAGGCCAAGG AGGGGGAGGA GGCGGGCCCC 
GGGGACCCAT TGCTGGAAGC CGTCCCCAAA GCGGGCAACG AGAAAGACGT CAGTGCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cdc37 ( XM_006509967.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006510030.1 Mus musculus cell division cycle 37 (Cdc37), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu41971
Clone ID Related Accession (Same CDS sequence)	XM_006509967.2 , XM_006509967.1
Accession Version	XM_006509967.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1287bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	hsp90 co-chaperone Cdc37 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006509967.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGGACT ACAGCGTTTG GGATCACATC GAGGTGTCGG ACGATGAGGA CGAGACGCAC 
CCCAACATAG ACACTGCCAG CCTCTTCCGC TGGCGGCACC AGGCCCGGGT GGAACGCATG 
GAGCAGTTTC AGAAGGAGAA AGAGGAACTG GACCGGGGCT GCCGGGAGTG CAAGCGCAAG 
GTAGCCGAGT GCCAGCGCAA GCTGAAGGAG CTGGAAGTGG CTGAGAGCGA TGGCCAGGTG 
GAGCTTGAGC GGCTGAGAGC TGAGGCACAG CAACTGCGCA AGGAGGAGCG GAGCTGGGAG 
CAGAAGCTGG AAGACATGCG CAAAAAGGAG AAGAACATGC CCTGGAATGT GGACACGCTC 
AGCAAAGATG GCTTTAGCAA GGCCCGCGGC CATGCCTCCG CCACCTTGAT GCACTTAGCG 
ACGCCACCGC CTCCGATGTG GACAGGATGG GCGCGGCGGC CACGGCCCCC AAACCCCAGG 
CGCACCCCTG CCTTGCCCCA GCCCACTTGC CCTCTCACCC TGTCACAGAG CATGGTCAAT 
ACCAAGCCTG AGAAGGCAGA GGAGGACTCA GAGGAGGCAA GGGAGCAGAA ACACAAGACC 
TTCGTTGAAA AATATGAGAA ACAGATCAAG CATTTCGGCA TGCTCCACCG CTGGGATGAC 
AGCCAGAAAT ACCTGTCGGA CAACGTCCAC CTGGTGTGTG AGGAAACGGC CAACTACCTG 
GTTATCTGGT GCATTGACCT GGAGGTAGAG GAGAAATGTG CACTGATGGA GCAGGTAGCT 
CACCAGACCA TGGTGATGCA GTTTATTCTG GAGCTGGCCA AGAGTCTGAA GGTCGACCCC 
CGAGCCTGCT TCCGGCAGTT TTTCACCAAG ATCAAGACCG CTGACCACCA GTACATGGAG 
GGCTTCAAGT ATGAACTGGA AGCCTTTAAG GAGCGAGTGC GGGGCCGCGC CAAGCTGCGA 
ATAGAGAAGG CCATGAAGGA ATATGAAGAG GAGGAGCGCA AGAAGAGGCT AGGCCCTGGT 
GGCCTGGACC CCGTGGAGGT CTACGAATCC CTGCCTGAGG AGCTGCAGAA GTGCTTTGAT 
GTGAAGGATG TACAGATGCT GCAAGACGCC ATCAGCAAAA TGGATCCCAC TGATGCCAAG 
TATCACATGC AGCGTTGCAT CGATTCTGGC CTCTGGGTCC CCAACTCCAA GTCTGGTGAG 
GCCAAGGAGG GGGAGGAGGC GGGCCCCGGG GACCCATTGC TGGAAGCCGT CCCCAAAGCG 
GGCAACGAGA AAGACGTCAG TGCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006510030.1
CDS	125..1411
Translation	MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAESDGQVELERLRAEAQQLRKEERSWEQKLEDMRKKEKNMPWNVDTLSKDGFSKARGHASATLMHLATPPPPMWTGWARRPRPPNPRRTPALPQPTCPLTLSQSMVNTKPEKAEEDSEEAREQKHKTFVEKYEKQIKHFGMLHRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTMVMQFILELAKSLKVDPRACFRQFFTKIKTADHQYMEGFKYELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKSGEAKEGEEAGPGDPLLEAVPKAGNEKDVSA

Target ORF information:

RefSeq Version	XM_006509967.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus cell division cycle 37 (Cdc37), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006509967.2

ORF Insert Sequence:

ATGGTGGACT ACAGCGTTTG GGATCACATC GAGGTGTCGG ACGATGAGGA CGAGACGCAC 
CCCAACATAG ACACTGCCAG CCTCTTCCGC TGGCGGCACC AGGCCCGGGT GGAACGCATG 
GAGCAGTTTC AGAAGGAGAA AGAGGAACTG GACCGGGGCT GCCGGGAGTG CAAGCGCAAG 
GTAGCCGAGT GCCAGCGCAA GCTGAAGGAG CTGGAAGTGG CTGAGAGCGA TGGCCAGGTG 
GAGCTTGAGC GGCTGAGAGC TGAGGCACAG CAACTGCGCA AGGAGGAGCG GAGCTGGGAG 
CAGAAGCTGG AAGACATGCG CAAAAAGGAG AAGAACATGC CCTGGAATGT GGACACGCTC 
AGCAAAGATG GCTTTAGCAA GGCCCGCGGC CATGCCTCCG CCACCTTGAT GCACTTAGCG 
ACGCCACCGC CTCCGATGTG GACAGGATGG GCGCGGCGGC CACGGCCCCC AAACCCCAGG 
CGCACCCCTG CCTTGCCCCA GCCCACTTGC CCTCTCACCC TGTCACAGAG CATGGTCAAT 
ACCAAGCCTG AGAAGGCAGA GGAGGACTCA GAGGAGGCAA GGGAGCAGAA ACACAAGACC 
TTCGTTGAAA AATATGAGAA ACAGATCAAG CATTTCGGCA TGCTCCACCG CTGGGATGAC 
AGCCAGAAAT ACCTGTCGGA CAACGTCCAC CTGGTGTGTG AGGAAACGGC CAACTACCTG 
GTTATCTGGT GCATTGACCT GGAGGTAGAG GAGAAATGTG CACTGATGGA GCAGGTAGCT 
CACCAGACCA TGGTGATGCA GTTTATTCTG GAGCTGGCCA AGAGTCTGAA GGTCGACCCC 
CGAGCCTGCT TCCGGCAGTT TTTCACCAAG ATCAAGACCG CTGACCACCA GTACATGGAG 
GGCTTCAAGT ATGAACTGGA AGCCTTTAAG GAGCGAGTGC GGGGCCGCGC CAAGCTGCGA 
ATAGAGAAGG CCATGAAGGA ATATGAAGAG GAGGAGCGCA AGAAGAGGCT AGGCCCTGGT 
GGCCTGGACC CCGTGGAGGT CTACGAATCC CTGCCTGAGG AGCTGCAGAA GTGCTTTGAT 
GTGAAGGATG TACAGATGCT GCAAGACGCC ATCAGCAAAA TGGATCCCAC TGATGCCAAG 
TATCACATGC AGCGTTGCAT CGATTCTGGC CTCTGGGTCC CCAACTCCAA GTCTGGTGAG 
GCCAAGGAGG GGGAGGAGGC GGGCCCCGGG GACCCATTGC TGGAAGCCGT CCCCAAAGCG 
GGCAACGAGA AAGACGTCAG TGCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In?Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling.
Gastroenterology152(8)2022-2036(2017 Jun)
Chen B,Wei W,Ma L,Yang B,Gill RM,Chua MS,Butte AJ,So S

The co-chaperone Cdc37 regulates the rabies virus phosphoprotein stability by targeting to Hsp90AA1 machinery.
Scientific reports627123(2016 Jun)
Xu Y,Liu F,Liu J,Wang D,Yan Y,Ji S,Zan J,Zhou J

Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex.
Molecular and cellular biology33(8)1671-86(2013 Apr)
Erazo T,Moreno A,Ruiz-Babot G,Rodr?guez-Asiain A,Morrice NA,Espadamala J,Bayascas JR,G?mez N,Lizcano JM

Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine.
Molecular cell47(3)434-43(2012 Aug)
Xu W,Mollapour M,Prodromou C,Wang S,Scroggins BT,Palchick Z,Beebe K,Siderius M,Lee MJ,Couvillon A,Trepel JB,Miyata Y,Matts R,Neckers L

Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy.
Molecular cell43(4)572-85(2011 Aug)
Joo JH,Dorsey FC,Joshi A,Hennessy-Walters KM,Rose KL,McCastlain K,Zhang J,Iyengar R,Jung CH,Suen DF,Steeves MA,Yang CY,Prater SM,Kim DH,Thompson CB,Youle RJ,Ney PA,Cleveland JL,Kundu M

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Cdc37 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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