Zfp36l1 cDNA ORF clone, Mus musculus(house mouse)

RNA-binding protein ZFP36L1 maintains posttranscriptional regulation of bile acid metabolism.
Tarling EJ, Clifford BL, Cheng J, Morand P, Cheng A, Lester E, Sallam T, Turner M, de Aguiar Vallim TQ
The Journal of clinical investigation127(10)3741-3754(2017 Oct)

Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1.
Newman R, Ahlfors H, Saveliev A, Galloway A, Hodson DJ, Williams R, Besra GS, Cook CN, Cunningham AF, Bell SE, Turner M
Nature immunology18(6)683-693(2017 Jun)

the ZFP36L1-dependent regulation of bile acid metabolism is an important metabolic contributor to obesity and hepatosteatosis.
Title: RNA-binding protein ZFP36L1 maintains posttranscriptional regulation of bile acid metabolism.

ZFP36L1 is the regulator of a post-transcriptional hub that determined the identity of marginal-zone B cells by promoting their proper localization and survival. ZFP36L1 controlled a gene-expression program related to signaling, cell adhesion and locomotion; it achieved this in part by limiting expression of the transcription factors KLF2 and IRF8, which are known to enforce e follicular B cell phenotype.
Title: Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1.

Our data indicated that ZFP36L1 could act as an enhancer of osteoblastic differentiation but a repressor of adipogenic differentiation, supporting the notion that decreased ZFP36L1 expression in bone marrow stem cells might contribute to aging-related bone loss.
Title: Zinc finger protein ZFP36L1 promotes osteoblastic differentiation but represses adipogenic differentiation of mouse multipotent cells.

The Zfp36l1 therefore act as posttranscriptional safeguards against chromosomal instability and replication stress by integrating pre-TCR and IL-7 signaling with DNA damage and cell cycle control.
Title: The RNA-Binding Proteins Zfp36l1 and Zfp36l2 Enforce the Thymic ?-Selection Checkpoint by Limiting DNA Damage Response Signaling and Cell Cycle Progression.

ZFP36L1 and ZFP36L2 suppress an evolutionarily conserved posttranscriptional regulon consisting of messenger RNAs whose protein products cooperatively promote transition into the S phase of the cell cycle.
Title: RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence.