Gdf2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gdf2
Entrez Gene ID	12165
Full Name	growth differentiation factor 2
Synonyms	Bmp9
General protein information	Preferred Names growth differentiation factor 2 Names growth/differentiation factor 2 bone morphogenetic protein 9
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14\|14 B
Summary	This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates cartilage and bone development, angiogenesis and differentiation of cholinergic central nervous system neurons. Homozygous null mice exhibit malformations of the vasculature and skeleton. [provided by RefSeq, Jul 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_019506.4	NP_062379.3	growth/differentiation factor 2 preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	GDF2	NP_057288.1
Canis lupus familiaris (dog)	GDF2	XP_853886.2
Mus musculus (house mouse)	Gdf2	NP_062379.3
Rattus norvegicus (Norway rat)	Gdf2	NP_001099566.1
Xenopus tropicalis (tropical clawed frog)	gdf2	XP_002940692.2
	GDF2	XP_001109523.1
Gallus gallus (chicken)	GDF2	NP_990763.1
Pan troglodytes (chimpanzee)	GDF2	XP_507775.2
Bos taurus (cattle)	GDF2	NP_001179349.1
Danio rerio (zebrafish)	gdf2	NP_001165057.1

Gene Ontology

The following Gdf2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gdf2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu11142	NM_019506.4 Latest version!	Mus musculus growth differentiation factor 2 (Gdf2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gdf2 ( NM_019506.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062379.3 Mus musculus growth differentiation factor 2 (Gdf2), mRNA.

Price & Availability↑

CloneID	OMu11142
Clone ID Related Accession (Same CDS sequence)	NM_019506.4
Accession Version	NM_019506.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1287bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Mus musculus(house mouse)
Product	growth/differentiation factor 2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC166828.3. On Nov 17, 2006 this sequence version replaced NM_019506.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF156890.1, AK147029.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849383 [ECO:0000348] ##Evidence-Data-END##

ATGTCCCCTG GGGCCTTCCG GGTGGCCCTG CTCCCGCTGT TCCTGCTGGT CTGTGTCACA 
CAGCAGAAGC CGCTGCAGAA CTGGGAACAA GCATCCCCTG GGGAAAATGC CCACAGCTCC 
CTGGGATTGT CTGGAGCTGG AGAGGAGGGT GTCTTTGACC TGCAGATGTT CCTGGAGAAC 
ATGAAGGTGG ATTTCCTACG CAGCCTTAAC CTCAGCGGCA TTCCCTCCCA GGACAAAACC 
AGAGCGGAGC CACCCCAGTA CATGATCGAC TTGTACAACA GATACACAAC GGACAAATCG 
TCTACGCCTG CCTCCAACAT CGTGCGGAGC TTCAGCGTGG AAGATGCTAT ATCGACAGCT 
GCCACGGAGG ACTTCCCCTT TCAGAAGCAC ATCCTGATCT TCAACATCTC CATCCCGAGG 
CACGAGCAGA TCACCAGGGC TGAGCTCCGA CTCTATGTCT CCTGCCAAAA TGATGTGGAC 
TCCACTCATG GGCTGGAAGG AAGCATGGTC GTTTATGATG TTCTGGAGGA CAGTGAGACT 
TGGGACCAGG CCACGGGGAC CAAGACCTTC TTGGTATCCC AGGACATTCG GGACGAAGGA 
TGGGAGACTT TAGAAGTATC GAGTGCCGTG AAGCGGTGGG TCAGGGCAGA CTCCACAACA 
AACAAAAATA AGCTCGAGGT GACAGTGCAG AGCCACAGGG AGAGCTGTGA CACACTGGAC 
ATCAGTGTCC CTCCAGGTTC CAAAAACCTG CCCTTCTTTG TTGTCTTCTC CAATGACCGC 
AGCAATGGGA CCAAGGAGAC CAGACTGGAG CTGAAGGAGA TGATCGGCCA TGAGCAGGAG 
ACCATGCTTG TGAAGACAGC CAAAAATGCT TACCAGGTGG CAGGTGAGAG CCAAGAGGAG 
GAGGGTCTAG ATGGATACAC AGCTGTGGGA CCACTTTTAG CTAGAAGGAA GAGGAGCACC 
GGAGCCAGCA GCCACTGCCA GAAGACTTCT CTCAGGGTGA ACTTTGAGGA CATCGGCTGG 
GACAGCTGGA TCATTGCACC CAAGGAATAT GACGCCTATG AGTGTAAAGG GGGTTGCTTC 
TTCCCATTGG CTGATGACGT GACACCCACC AAACATGCCA TCGTGCAGAC CCTGGTGCAT 
CTCAAGTTCC CCACAAAGGT GGGCAAAGCC TGCTGCGTTC CCACCAAACT GAGTCCCATC 
TCCATCCTCT ACAAGGATGA CATGGGGGTG CCAACCCTCA AGTACCACTA TGAGGGGATG 
AGTGTGGCTG AGTGTGGGTG TAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062379.3
CDS	113..1399
Translation	MSPGAFRVALLPLFLLVCVTQQKPLQNWEQASPGENAHSSLGLSGAGEEGVFDLQMFLENMKVDFLRSLNLSGIPSQDKTRAEPPQYMIDLYNRYTTDKSSTPASNIVRSFSVEDAISTAATEDFPFQKHILIFNISIPRHEQITRAELRLYVSCQNDVDSTHGLEGSMVVYDVLEDSETWDQATGTKTFLVSQDIRDEGWETLEVSSAVKRWVRADSTTNKNKLEVTVQSHRESCDTLDISVPPGSKNLPFFVVFSNDRSNGTKETRLELKEMIGHEQETMLVKTAKNAYQVAGESQEEEGLDGYTAVGPLLARRKRSTGASSHCQKTSLRVNFEDIGWDSWIIAPKEYDAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISILYKDDMGVPTLKYHYEGMSVAECGCR

Target ORF information:

RefSeq Version	NM_019506.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus growth differentiation factor 2 (Gdf2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019506.4

ORF Insert Sequence:

ATGTCCCCTG GGGCCTTCCG GGTGGCCCTG CTCCCGCTGT TCCTGCTGGT CTGTGTCACA 
CAGCAGAAGC CGCTGCAGAA CTGGGAACAA GCATCCCCTG GGGAAAATGC CCACAGCTCC 
CTGGGATTGT CTGGAGCTGG AGAGGAGGGT GTCTTTGACC TGCAGATGTT CCTGGAGAAC 
ATGAAGGTGG ATTTCCTACG CAGCCTTAAC CTCAGCGGCA TTCCCTCCCA GGACAAAACC 
AGAGCGGAGC CACCCCAGTA CATGATCGAC TTGTACAACA GATACACAAC GGACAAATCG 
TCTACGCCTG CCTCCAACAT CGTGCGGAGC TTCAGCGTGG AAGATGCTAT ATCGACAGCT 
GCCACGGAGG ACTTCCCCTT TCAGAAGCAC ATCCTGATCT TCAACATCTC CATCCCGAGG 
CACGAGCAGA TCACCAGGGC TGAGCTCCGA CTCTATGTCT CCTGCCAAAA TGATGTGGAC 
TCCACTCATG GGCTGGAAGG AAGCATGGTC GTTTATGATG TTCTGGAGGA CAGTGAGACT 
TGGGACCAGG CCACGGGGAC CAAGACCTTC TTGGTATCCC AGGACATTCG GGACGAAGGA 
TGGGAGACTT TAGAAGTATC GAGTGCCGTG AAGCGGTGGG TCAGGGCAGA CTCCACAACA 
AACAAAAATA AGCTCGAGGT GACAGTGCAG AGCCACAGGG AGAGCTGTGA CACACTGGAC 
ATCAGTGTCC CTCCAGGTTC CAAAAACCTG CCCTTCTTTG TTGTCTTCTC CAATGACCGC 
AGCAATGGGA CCAAGGAGAC CAGACTGGAG CTGAAGGAGA TGATCGGCCA TGAGCAGGAG 
ACCATGCTTG TGAAGACAGC CAAAAATGCT TACCAGGTGG CAGGTGAGAG CCAAGAGGAG 
GAGGGTCTAG ATGGATACAC AGCTGTGGGA CCACTTTTAG CTAGAAGGAA GAGGAGCACC 
GGAGCCAGCA GCCACTGCCA GAAGACTTCT CTCAGGGTGA ACTTTGAGGA CATCGGCTGG 
GACAGCTGGA TCATTGCACC CAAGGAATAT GACGCCTATG AGTGTAAAGG GGGTTGCTTC 
TTCCCATTGG CTGATGACGT GACACCCACC AAACATGCCA TCGTGCAGAC CCTGGTGCAT 
CTCAAGTTCC CCACAAAGGT GGGCAAAGCC TGCTGCGTTC CCACCAAACT GAGTCCCATC 
TCCATCCTCT ACAAGGATGA CATGGGGGTG CCAACCCTCA AGTACCACTA TGAGGGGATG 
AGTGTGGCTG AGTGTGGGTG TAGGTAG