Apoc2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Apoc2
Entrez Gene ID	11813
Full Name	apolipoprotein C-II
Synonyms	apo-CII,apoC-II
General protein information	Preferred Names apolipoprotein C-II Names apolipoprotein C-II apolipoprotein C2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 A3\|7 9.94 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001309795.1	NP_001296724.1	apolipoprotein C-II precursor
NM_001277944.1	NP_001264873.1	apolipoprotein C-II precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	APOC2	NP_000474.2
	APOC2	XP_002801531.1
Rattus norvegicus (Norway rat)	Apoc2	NP_001078821.1
Canis lupus familiaris (dog)	APOC2	NP_001003368.1
Bos taurus (cattle)	APOC2	NP_001095850.1
Mus musculus (house mouse)	Apoc2	NP_001264873.1
Pan troglodytes (chimpanzee)	APOC2	NP_001230828.1

Gene Ontology
Bibliography

Related articles in PubMed

Creation of Apolipoprotein C-II (ApoC-II) Mutant Mice and Correction of Their Hypertriglyceridemia with an ApoC-II Mimetic Peptide.
Sakurai T, Sakurai A, Vaisman BL, Amar MJ, Liu C, Gordon SM, Drake SK, Pryor M, Sampson ML, Yang L, Freeman LA, Remaley AT
The Journal of pharmacology and experimental therapeutics356(2)341-53(2016 Feb)

GATA4 and GATA6 regulate intestinal epithelial cytodifferentiation during development.
Walker EM, Thompson CA, Battle MA
Developmental biology392(2)283-94(2014 Aug)

Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment.
Seth A, Ye J, Yu N, Guez F, Bedford DC, Neale GA, Cordi S, Brindle PK, Lemaigre FP, Kaestner KH, Sosa-Pineda B
Development (Cambridge, England)141(3)538-47(2014 Feb)

Role of the gut endoderm in relaying left-right patterning in mice.
Viotti M, Niu L, Shi SH, Hadjantonakis AK
PLoS biology10(3)e1001276(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A novel mouse model of apoC-II deficiency was created with an apoC-II peptide that reverses the hypertriglyceridemia.
Title: Creation of Apolipoprotein C-II (ApoC-II) Mutant Mice and Correction of Their Hypertriglyceridemia with an ApoC-II Mimetic Peptide.

Data show that apoC-II and LPL mRNAs correlate temporally and geographically with surfactant lipid synthesis in preparation for birth and suggest that fatty acid recruitment from the circulation by apoC-II-activated LPL is modulated by apoC-II secretion.
Title: Apolipoprotein C-II and lipoprotein lipase show a temporal and geographic correlation with surfactant lipid synthesis in preparation for birth.

These results are compatible with a role for apolipoproteins in lipid metabolism and transport in the developing lung in association with the sex difference in surfactant lipid synthesis.
Title: Apolipoprotein A-I, A-II, C-II, and H expression in the developing lung and sex difference in surfactant lipids.

TR4 can also regulate apolipoprotein E, C-I, and C-II gene expression via the TR4 response element within the hepatic control region
Title: Disruption of TR4 orphan nuclear receptor reduces the expression of liver apolipoprotein E/C-I/C-II gene cluster.

regulated expression of gene cluster in macrophages
Title: Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta.

The following Apoc2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Apoc2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu08095	NM_001277944.1 Latest version!	Mus musculus apolipoprotein C-II (Apoc2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu08095	NM_001309795.1 Latest version!	Mus musculus apolipoprotein C-II (Apoc2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Apoc2 ( NM_001309795.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001296724.1 Mus musculus apolipoprotein C-II (Apoc2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu08095
Clone ID Related Accession (Same CDS sequence)	NM_001309795.1 , NM_001277944.1
Accession Version	NM_001309795.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 294bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-17
Organism	Mus musculus(house mouse)
Product	apolipoprotein C-II precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC149282.2, AK146468.1 and AA059961.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AA617232.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGTCTC GGTTCTTCCT GGCTCTATTC CTGGTCATCC TGATGTTGGG AAATGAGGTC 
CAGGGGAACC AGGAAGATGA CTCGGGCAGC CTGGCTCTGC TGGGCACGGT GCAGGGCTCC 
CTCTTAAGTT ACTGGACCTC TGCCAAGGAG GTTGCCAAAG ACCTGTACCA GAAGACATAC 
CCGATCAGCA TGGATGAGAA ACTCAGGGAC ATGTACAGCA AAAGCTCGGC GGCCATGAGC 
ACTTACGCAG GCATTTTTAC AGACCAGCTC CTTACTCTCC TGAGGGGAGA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001296724.1
CDS	99..392
Translation	MGSRFFLALFLVILMLGNEVQGNQEDDSGSLALLGTVQGSLLSYWTSAKEVAKDLYQKTYPISMDEKLRDMYSKSSAAMSTYAGIFTDQLLTLLRGE

Target ORF information:

RefSeq Version	NM_001309795.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus apolipoprotein C-II (Apoc2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001309795.1

ORF Insert Sequence:

ATGGGGTCTC GGTTCTTCCT GGCTCTATTC CTGGTCATCC TGATGTTGGG AAATGAGGTC 
CAGGGGAACC AGGAAGATGA CTCGGGCAGC CTGGCTCTGC TGGGCACGGT GCAGGGCTCC 
CTCTTAAGTT ACTGGACCTC TGCCAAGGAG GTTGCCAAAG ACCTGTACCA GAAGACATAC 
CCGATCAGCA TGGATGAGAA ACTCAGGGAC ATGTACAGCA AAAGCTCGGC GGCCATGAGC 
ACTTACGCAG GCATTTTTAC AGACCAGCTC CTTACTCTCC TGAGGGGAGA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Apoc2 ( NM_001277944.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001264873.1 Mus musculus apolipoprotein C-II (Apoc2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu08095
Clone ID Related Accession (Same CDS sequence)	NM_001309795.1 , NM_001277944.1
Accession Version	NM_001277944.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 294bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Mus musculus(house mouse)
Product	apolipoprotein C-II precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC149282.2 and BG085960.2. On May 1, 2013 this sequence version replaced NM_009695.3. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC024697.1, BF385571.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849386 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGTCTC GGTTCTTCCT GGCTCTATTC CTGGTCATCC TGATGTTGGG AAATGAGGTC 
CAGGGGAACC AGGAAGATGA CTCGGGCAGC CTGGCTCTGC TGGGCACGGT GCAGGGCTCC 
CTCTTAAGTT ACTGGACCTC TGCCAAGGAG GTTGCCAAAG ACCTGTACCA GAAGACATAC 
CCGATCAGCA TGGATGAGAA ACTCAGGGAC ATGTACAGCA AAAGCTCGGC GGCCATGAGC 
ACTTACGCAG GCATTTTTAC AGACCAGCTC CTTACTCTCC TGAGGGGAGA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001264873.1
CDS	252..545
Translation	MGSRFFLALFLVILMLGNEVQGNQEDDSGSLALLGTVQGSLLSYWTSAKEVAKDLYQKTYPISMDEKLRDMYSKSSAAMSTYAGIFTDQLLTLLRGE

Target ORF information:

RefSeq Version	NM_001277944.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus apolipoprotein C-II (Apoc2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001277944.1

ORF Insert Sequence:

ATGGGGTCTC GGTTCTTCCT GGCTCTATTC CTGGTCATCC TGATGTTGGG AAATGAGGTC 
CAGGGGAACC AGGAAGATGA CTCGGGCAGC CTGGCTCTGC TGGGCACGGT GCAGGGCTCC 
CTCTTAAGTT ACTGGACCTC TGCCAAGGAG GTTGCCAAAG ACCTGTACCA GAAGACATAC 
CCGATCAGCA TGGATGAGAA ACTCAGGGAC ATGTACAGCA AAAGCTCGGC GGCCATGAGC 
ACTTACGCAG GCATTTTTAC AGACCAGCTC CTTACTCTCC TGAGGGGAGA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Creation of Apolipoprotein C-II (ApoC-II) Mutant Mice and Correction of Their Hypertriglyceridemia with an ApoC-II Mimetic Peptide.
The Journal of pharmacology and experimental therapeutics356(2)341-53(2016 Feb)
Sakurai T,Sakurai A,Vaisman BL,Amar MJ,Liu C,Gordon SM,Drake SK,Pryor M,Sampson ML,Yang L,Freeman LA,Remaley AT

GATA4 and GATA6 regulate intestinal epithelial cytodifferentiation during development.
Developmental biology392(2)283-94(2014 Aug)
Walker EM,Thompson CA,Battle MA

Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment.
Development (Cambridge, England)141(3)538-47(2014 Feb)
Seth A,Ye J,Yu N,Guez F,Bedford DC,Neale GA,Cordi S,Brindle PK,Lemaigre FP,Kaestner KH,Sosa-Pineda B

Role of the gut endoderm in relaying left-right patterning in mice.
PLoS biology10(3)e1001276(2012)
Viotti M,Niu L,Shi SH,Hadjantonakis AK

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Apoc2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

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電話

FAX

オンラインフォーム