Acp1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Acp1
Entrez Gene ID	11431
Full Name	acid phosphatase 1, soluble
Synonyms	4632432E04Rik,AI427468,Acp-1,LMW-PTP,Lmptp
General protein information	Preferred Names acid phosphatase 1, soluble Names low molecular weight phosphotyrosine protein phosphatase LMW-PTPase low molecular weight cytosolic acid phosphatase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12\|12 A2

mRNA and Protein(s)

mRNA	Protein	Name
NM_021330.4	NP_067305.2	low molecular weight phosphotyrosine protein phosphatase isoform 2
NM_001110239.1	NP_001103709.1	low molecular weight phosphotyrosine protein phosphatase isoform 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	ACP1	NP_004291.1
Drosophila melanogaster (fruit fly)	primo-1	NP_001027186.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004079	XP_309631.5
Caenorhabditis elegans (roundworm)	Y94H6A.7	NP_500246.5
Pan troglodytes (chimpanzee)	ACP1	XP_515271.3
Gallus gallus (chicken)	ACP1	NP_001034380.1
Mus musculus (house mouse)	Acp1	NP_067305.2
Danio rerio (zebrafish)	acp1	NP_001231711.1
Rattus norvegicus (Norway rat)	RGD1565965	XP_237746.2

Gene Ontology
Bibliography

Related articles in PubMed

Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.
Stanford SM, Aleshin AE, Zhang V, Ardecky RJ, Hedrick MP, Zou J, Ganji SR, Bliss MR, Yamamoto F, Bobkov AA, Kiselar J, Liu Y, Cadwell GW, Khare S, Yu J, Barquilla A, Chung TDY, Mustelin T, Schenk S, Bankston LA, Liddington RC, Pinkerton AB, Bottini N
Nature chemical biology13(6)624-632(2017 Jun)

Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy.
Wade F, Quijada P, Al-Haffar KM, Awad SM, Kunhi M, Toko H, Marashly Q, Belhaj K, Zahid I, Al-Mohanna F, Stanford SM, Alvarez R, Liu Y, Colak D, Jordan MC, Roos KP, Assiri A, Al-Habeeb W, Sussman M, Bottini N, Poizat C
The Journal of pathology237(4)482-94(2015 Dec)

Osteoblast adhesion dynamics: a possible role for ROS and LMW-PTP.
Fernandes GV, Cavagis AD, Ferreira CV, Olej B, Le?o Mde S, Yano CL, Peppelenbosch M, Granjeiro JM, Zambuzzi WF
Journal of cellular biochemistry115(6)1063-9(2014 Jun)

A mouse knockout library for secreted and transmembrane proteins.
Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M, Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice DS, Hansen GM, Abuin A, Eberhart DE, Godowski P, Holt KH, Peterson A, Zambrowicz BP, de Sauvage FJ
Nature biotechnology28(7)749-55(2010 Jul)

Modulation of Src activity by low molecular weight protein tyrosine phosphatase during osteoblast differentiation.
Zambuzzi WF, Granjeiro JM, Parikh K, Yuvaraj S, Peppelenbosch MP, Ferreira CV
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology22(5-6)497-506(2008)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our data show that ablation of Lmptp inhibits pathological cardiac remodelling
Title: Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy.

Data indicate there was no significant change in low molecular weight protein tyrosine phosphatase (LMW-PTP) expression at 30 min or 2 h.
Title: Osteoblast adhesion dynamics: a possible role for ROS and LMW-PTP.

The expression and activity of Src and low molecular weight protein tyrosine phosphatase (LMWPTP) during osteoblast differentiation was examined and the modulation of Src kinase by LMWPTP was assessed.
Title: Modulation of Src activity by low molecular weight protein tyrosine phosphatase during osteoblast differentiation.

The formation of LMW-PTP/caveolin-1 complexes is accompanied by modulation of the enzyme activities, and the inhibitory effect elicited against IF1 is stronger than that against IF2
Title: Low molecular weight protein tyrosine phosphatase and caveolin-1: interaction and isoenzyme-dependent regulation.

The redox-dependent enhancement of Grb2 recruitment to LMW-PTP ultimately leads to an improvement of ERK activation, likely triggering a prosurvival signal against the oxidant environment.
Title: A novel redox-based switch: LMW-PTP oxidation enhances Grb2 binding and leads to ERK activation.

The following Acp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Acp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu12187	NM_021330.4 Latest version!	Mus musculus acid phosphatase 1, soluble (Acp1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu04564	NM_001110239.1 Latest version!	Mus musculus acid phosphatase 1, soluble (Acp1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Acp1 ( NM_021330.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_067305.2 Mus musculus acid phosphatase 1, soluble (Acp1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu12187
Clone ID Related Accession (Same CDS sequence)	NM_021330.4
Accession Version	NM_021330.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 477bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	low molecular weight phosphotyrosine protein phosphatase isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC160932.3 and AK082955.1. On Nov 2, 2007 this sequence version replaced NM_021330.3. Transcript Variant: This variant (2) includes an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 2, also known as IF1) is the same length as isoform 1 but differs at an internal region, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK082955.1, BC111893.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END##

ATGGCAGAGG TTGGGTCCAA GTCAGTGCTG TTCGTGTGTC TCGGTAACAT TTGCCGGTCA 
CCCATTGCAG AAGCAGTATT CAGGAAACTG GTAACTGATG AAAAGGTTTC AGATAATTGG 
AGGATAGACA GTGCGGCTAC ATCCACCTAT GAAGTGGGGA ACCCTCCTGA CTATCGAGGG 
CAGAACTGCA TGAGAAAACA TGGCATCCAC ATGCAGCACA TTGCACGGCA GATTACAAAA 
GAAGACTTTG CCACATTCGA TTATATACTA TGTATGGATG AAAGCAATCT GAGAGATCTC 
AATAGAAAAA GTAATCAAGT TAAAAACTGC AAAGCTAAAA TTGAGCTACT TGGGAGCTAT 
GATCCACAGA AACAGCTCAT CATTGAAGAT CCCTATTATG GCAATGACTC TGACTTCGAG 
GTGGTGTACC AGCAATGCCT TAGGTGCTGC AAGGCCTTCC TGGAGAAGAC TTACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067305.2
CDS	81..557
Translation	MAEVGSKSVLFVCLGNICRSPIAEAVFRKLVTDEKVSDNWRIDSAATSTYEVGNPPDYRGQNCMRKHGIHMQHIARQITKEDFATFDYILCMDESNLRDLNRKSNQVKNCKAKIELLGSYDPQKQLIIEDPYYGNDSDFEVVYQQCLRCCKAFLEKTY

Target ORF information:

RefSeq Version	NM_021330.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus acid phosphatase 1, soluble (Acp1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021330.4

ORF Insert Sequence:

ATGGCAGAGG TTGGGTCCAA GTCAGTGCTG TTCGTGTGTC TCGGTAACAT TTGCCGGTCA 
CCCATTGCAG AAGCAGTATT CAGGAAACTG GTAACTGATG AAAAGGTTTC AGATAATTGG 
AGGATAGACA GTGCGGCTAC ATCCACCTAT GAAGTGGGGA ACCCTCCTGA CTATCGAGGG 
CAGAACTGCA TGAGAAAACA TGGCATCCAC ATGCAGCACA TTGCACGGCA GATTACAAAA 
GAAGACTTTG CCACATTCGA TTATATACTA TGTATGGATG AAAGCAATCT GAGAGATCTC 
AATAGAAAAA GTAATCAAGT TAAAAACTGC AAAGCTAAAA TTGAGCTACT TGGGAGCTAT 
GATCCACAGA AACAGCTCAT CATTGAAGAT CCCTATTATG GCAATGACTC TGACTTCGAG 
GTGGTGTACC AGCAATGCCT TAGGTGCTGC AAGGCCTTCC TGGAGAAGAC TTACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Acp1 ( NM_001110239.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001103709.1 Mus musculus acid phosphatase 1, soluble (Acp1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu04564
Clone ID Related Accession (Same CDS sequence)	NM_001110239.1
Accession Version	NM_001110239.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 477bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	low molecular weight phosphotyrosine protein phosphatase isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC160932.3, AK152429.1 and AK014603.1. Transcript Variant: This variant (1) encodes the predominant isoform (1, also known as IF2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC112413.1, AK014603.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END##

ATGGCAGAGG TTGGGTCCAA GTCAGTGCTG TTCGTGTGTC TCGGTAACAT TTGCCGGTCA 
CCCATTGCAG AAGCAGTATT CAGGAAACTG GTAACTGATG AAAAGGTTTC AGATAATTGG 
GCCATTGACA GCAGCGCCGT TTCCGACTGG AACGTGGGCC GGCCCCCAGA CCCAAGAGCT 
GTCAGCTGCC TAAGAAATCA TGGCATTAGC ACAGCCCATA AGGCAAGACA GATTACAAAA 
GAAGACTTTG CCACATTCGA TTATATACTA TGTATGGATG AAAGCAATCT GAGAGATCTC 
AATAGAAAAA GTAATCAAGT TAAAAACTGC AAAGCTAAAA TTGAGCTACT TGGGAGCTAT 
GATCCACAGA AACAGCTCAT CATTGAAGAT CCCTATTATG GCAATGACTC TGACTTCGAG 
GTGGTGTACC AGCAATGCCT TAGGTGCTGC AAGGCCTTCC TGGAGAAGAC TTACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001103709.1
CDS	81..557
Translation	MAEVGSKSVLFVCLGNICRSPIAEAVFRKLVTDEKVSDNWAIDSSAVSDWNVGRPPDPRAVSCLRNHGISTAHKARQITKEDFATFDYILCMDESNLRDLNRKSNQVKNCKAKIELLGSYDPQKQLIIEDPYYGNDSDFEVVYQQCLRCCKAFLEKTY

Target ORF information:

RefSeq Version	NM_001110239.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus acid phosphatase 1, soluble (Acp1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001110239.1

ORF Insert Sequence:

ATGGCAGAGG TTGGGTCCAA GTCAGTGCTG TTCGTGTGTC TCGGTAACAT TTGCCGGTCA 
CCCATTGCAG AAGCAGTATT CAGGAAACTG GTAACTGATG AAAAGGTTTC AGATAATTGG 
GCCATTGACA GCAGCGCCGT TTCCGACTGG AACGTGGGCC GGCCCCCAGA CCCAAGAGCT 
GTCAGCTGCC TAAGAAATCA TGGCATTAGC ACAGCCCATA AGGCAAGACA GATTACAAAA 
GAAGACTTTG CCACATTCGA TTATATACTA TGTATGGATG AAAGCAATCT GAGAGATCTC 
AATAGAAAAA GTAATCAAGT TAAAAACTGC AAAGCTAAAA TTGAGCTACT TGGGAGCTAT 
GATCCACAGA AACAGCTCAT CATTGAAGAT CCCTATTATG GCAATGACTC TGACTTCGAG 
GTGGTGTACC AGCAATGCCT TAGGTGCTGC AAGGCCTTCC TGGAGAAGAC TTACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.
Nature chemical biology13(6)624-632(2017 Jun)
Stanford SM,Aleshin AE,Zhang V,Ardecky RJ,Hedrick MP,Zou J,Ganji SR,Bliss MR,Yamamoto F,Bobkov AA,Kiselar J,Liu Y,Cadwell GW,Khare S,Yu J,Barquilla A,Chung TDY,Mustelin T,Schenk S,Bankston LA,Liddington RC,Pinkerton AB,Bottini N

Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy.
The Journal of pathology237(4)482-94(2015 Dec)
Wade F,Quijada P,Al-Haffar KM,Awad SM,Kunhi M,Toko H,Marashly Q,Belhaj K,Zahid I,Al-Mohanna F,Stanford SM,Alvarez R,Liu Y,Colak D,Jordan MC,Roos KP,Assiri A,Al-Habeeb W,Sussman M,Bottini N,Poizat C

Osteoblast adhesion dynamics: a possible role for ROS and LMW-PTP.
Journal of cellular biochemistry115(6)1063-9(2014 Jun)
Fernandes GV,Cavagis AD,Ferreira CV,Olej B,Le?o Mde S,Yano CL,Peppelenbosch M,Granjeiro JM,Zambuzzi WF

A mouse knockout library for secreted and transmembrane proteins.
Nature biotechnology28(7)749-55(2010 Jul)
Tang T,Li L,Tang J,Li Y,Lin WY,Martin F,Grant D,Solloway M,Parker L,Ye W,Forrest W,Ghilardi N,Oravecz T,Platt KA,Rice DS,Hansen GM,Abuin A,Eberhart DE,Godowski P,Holt KH,Peterson A,Zambrowicz BP,de Sauvage FJ

Modulation of Src activity by low molecular weight protein tyrosine phosphatase during osteoblast differentiation.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology22(5-6)497-506(2008)
Zambuzzi WF,Granjeiro JM,Parikh K,Yuvaraj S,Peppelenbosch MP,Ferreira CV

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Acp1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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見積依頼

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FAX

オンラインフォーム