Qdpr cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Qdpr
Entrez Gene ID	110391
Full Name	quinoid dihydropteridine reductase
Synonyms	2610008L04Rik,D5Ertd371e,Dhpr,PKU2
General protein information	Preferred Names quinoid dihydropteridine reductase Names dihydropteridine reductase HDHPR
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5 B3\|5 24.9 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_024236.2	NP_077198.1	dihydropteridine reductase

Pathways from BioSystems

Homologies

Caenorhabditis elegans (roundworm)	qdpr-1	NP_499760.1
Homo sapiens (human)	QDPR	NP_000311.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002534	XP_312404.2
Pan troglodytes (chimpanzee)	QDPR	XP_001161997.1
Canis lupus familiaris (dog)	QDPR	XP_536229.2
Bos taurus (cattle)	QDPR	NP_001069960.1
Mus musculus (house mouse)	Qdpr	NP_077198.1
Rattus norvegicus (Norway rat)	Qdpr	NP_071785.1
Drosophila melanogaster (fruit fly)	Dhpr	NP_001014579.1
	LOC714966	XP_001102244.1
Gallus gallus (chicken)	QDPR	NP_001006566.1
Danio rerio (zebrafish)	qdprb1	NP_001018534.1
Xenopus tropicalis (tropical clawed frog)	qdpr	NP_001011492.1

Gene Ontology
Bibliography

Related articles in PubMed

Disturbed biopterin and folate metabolism in the Qdpr-deficient mouse.
Xu F, Sudo Y, Sanechika S, Yamashita J, Shimaguchi S, Honda S, Sumi-Ichinose C, Mori-Kojima M, Nakata R, Furuta T, Sakurai M, Sugimoto M, Soga T, Kondo K, Ichinose H
FEBS letters588(21)3924-31(2014 Nov)

Endoplasmic reticulum resident protein 44 (ERp44) deficiency in mice and zebrafish leads to cardiac developmental and functional defects.
Wang DY, Abbasi C, El-Rass S, Li JY, Dawood F, Naito K, Sharma P, Bousette N, Singh S, Backx PH, Cox B, Wen XY, Liu PP, Gramolini AO
Journal of the American Heart Association3(5)e001018(2014 Oct)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

Junctophilin 1 and 2 proteins interact with the L-type Ca2+ channel dihydropyridine receptors (DHPRs) in skeletal muscle.
Golini L, Chouabe C, Berthier C, Cusimano V, Fornaro M, Bonvallet R, Formoso L, Giacomello E, Jacquemond V, Sorrentino V
The Journal of biological chemistry286(51)43717-25(2011 Dec)

A retrograde signal from RyR1 alters DHP receptor inactivation and limits window Ca2+ release in muscle fibers of Y522S RyR1 knock-in mice.
Andronache Z, Hamilton SL, Dirksen RT, Melzer W
Proceedings of the National Academy of Sciences of the United States of America106(11)4531-6(2009 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

wide alterations in folate-associated metabolism in the Qdpr(-/-) mice
Title: Disturbed biopterin and folate metabolism in the Qdpr-deficient mouse.

JP1 and JP2 can facilitate the assembly of DHPR with other proteins of the excitation-contraction coupling machinery
Title: Junctophilin 1 and 2 proteins interact with the L-type Ca2+ channel dihydropyridine receptors (DHPRs) in skeletal muscle.

voltage dependence of DHPR-triggered Ca(2+) release flux was left-shifted by approximately 8 mV by mutation in RyR1 (Y522S)
Title: A retrograde signal from RyR1 alters DHP receptor inactivation and limits window Ca2+ release in muscle fibers of Y522S RyR1 knock-in mice.

The following Qdpr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Qdpr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15824	NM_024236.2 Latest version!	Mus musculus quinoid dihydropteridine reductase (Qdpr), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Qdpr ( NM_024236.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_077198.1 Mus musculus quinoid dihydropteridine reductase (Qdpr), mRNA.

Price & Availability↑

CloneID	OMu15824
Clone ID Related Accession (Same CDS sequence)	NM_024236.2
Accession Version	NM_024236.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 726bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	dihydropteridine reductase
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC092711.14 and AK166694.1. On Aug 26, 2009 this sequence version replaced NM_024236.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK078123.1, AK166694.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849386 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGCTT CAGGCGAGGC GCGCCGGGTG CTGGTGTACG GCGGCAGGGG CGCTCTGGGC 
TCGCGCTGCG TACAGGCCTT CCGGGCCCGC AACTGGTGGG TTGCCAGCAT CGATGTGGTG 
GAGAACGAAG AGGCCAGTGC CAGCGTGGTT GTTAAGATGA CAGATTCATT CACAGAGCAG 
GCTGACCAGG TCACTGCTGA TGTTGGAAAG CTCCTAGGTG ACCAGAAGGT GGATGCAATT 
CTCTGTGTGG CTGGAGGATG GGCCGGGGGC AATGCCAAAT CCAAGTCGCT TTTTAAAAAC 
TGTGACATGA TGTGGAAGCA GAGTATGTGG ACATCCACTA TCTCCAGCCA CTTGGCCACA 
AAGCACCTGA AGGAAGGAGG CCTCTTGACC CTGGCTGGGG CCAAAGCTGC CTTGGATGGG 
ACTCCTGGGA TGATCGGCTA TGGCATGGCC AAGGGAGCCG TCCATCAGCT CTGCCAGAGC 
CTGGCAGGGA AGAACAGTGG CATGCCCCCT GGGGCTGCTG CCATTGCTGT GCTCCCCGTT 
ACCCTGGATA CCCCGATGAA CAGGAAATCA ATGCCTGAGG CAGACTTCAG CTCCTGGACA 
CCCTTAGAGT TCCTGGTGGA AACCTTCCAT GACTGGATCA CTGGGAACAA ACGGCCAAAC 
TCAGGAAGCC TAATCCAGGT GGTAACCACA GATGGGAAGA CAGAGCTTAC TCCAGCATAT 
TTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077198.1
CDS	128..853
Translation	MAASGEARRVLVYGGRGALGSRCVQAFRARNWWVASIDVVENEEASASVVVKMTDSFTEQADQVTADVGKLLGDQKVDAILCVAGGWAGGNAKSKSLFKNCDMMWKQSMWTSTISSHLATKHLKEGGLLTLAGAKAALDGTPGMIGYGMAKGAVHQLCQSLAGKNSGMPPGAAAIAVLPVTLDTPMNRKSMPEADFSSWTPLEFLVETFHDWITGNKRPNSGSLIQVVTTDGKTELTPAYF

Target ORF information:

RefSeq Version	NM_024236.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus quinoid dihydropteridine reductase (Qdpr), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024236.2

ORF Insert Sequence:

ATGGCGGCTT CAGGCGAGGC GCGCCGGGTG CTGGTGTACG GCGGCAGGGG CGCTCTGGGC 
TCGCGCTGCG TACAGGCCTT CCGGGCCCGC AACTGGTGGG TTGCCAGCAT CGATGTGGTG 
GAGAACGAAG AGGCCAGTGC CAGCGTGGTT GTTAAGATGA CAGATTCATT CACAGAGCAG 
GCTGACCAGG TCACTGCTGA TGTTGGAAAG CTCCTAGGTG ACCAGAAGGT GGATGCAATT 
CTCTGTGTGG CTGGAGGATG GGCCGGGGGC AATGCCAAAT CCAAGTCGCT TTTTAAAAAC 
TGTGACATGA TGTGGAAGCA GAGTATGTGG ACATCCACTA TCTCCAGCCA CTTGGCCACA 
AAGCACCTGA AGGAAGGAGG CCTCTTGACC CTGGCTGGGG CCAAAGCTGC CTTGGATGGG 
ACTCCTGGGA TGATCGGCTA TGGCATGGCC AAGGGAGCCG TCCATCAGCT CTGCCAGAGC 
CTGGCAGGGA AGAACAGTGG CATGCCCCCT GGGGCTGCTG CCATTGCTGT GCTCCCCGTT 
ACCCTGGATA CCCCGATGAA CAGGAAATCA ATGCCTGAGG CAGACTTCAG CTCCTGGACA 
CCCTTAGAGT TCCTGGTGGA AACCTTCCAT GACTGGATCA CTGGGAACAA ACGGCCAAAC 
TCAGGAAGCC TAATCCAGGT GGTAACCACA GATGGGAAGA CAGAGCTTAC TCCAGCATAT 
TTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Disturbed biopterin and folate metabolism in the Qdpr-deficient mouse.
FEBS letters588(21)3924-31(2014 Nov)
Xu F,Sudo Y,Sanechika S,Yamashita J,Shimaguchi S,Honda S,Sumi-Ichinose C,Mori-Kojima M,Nakata R,Furuta T,Sakurai M,Sugimoto M,Soga T,Kondo K,Ichinose H

Endoplasmic reticulum resident protein 44 (ERp44) deficiency in mice and zebrafish leads to cardiac developmental and functional defects.
Journal of the American Heart Association3(5)e001018(2014 Oct)
Wang DY,Abbasi C,El-Rass S,Li JY,Dawood F,Naito K,Sharma P,Bousette N,Singh S,Backx PH,Cox B,Wen XY,Liu PP,Gramolini AO

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

Junctophilin 1 and 2 proteins interact with the L-type Ca2+ channel dihydropyridine receptors (DHPRs) in skeletal muscle.
The Journal of biological chemistry286(51)43717-25(2011 Dec)
Golini L,Chouabe C,Berthier C,Cusimano V,Fornaro M,Bonvallet R,Formoso L,Giacomello E,Jacquemond V,Sorrentino V

A retrograde signal from RyR1 alters DHP receptor inactivation and limits window Ca2+ release in muscle fibers of Y522S RyR1 knock-in mice.
Proceedings of the National Academy of Sciences of the United States of America106(11)4531-6(2009 Mar)
Andronache Z,Hamilton SL,Dirksen RT,Melzer W

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Qdpr cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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