Fdps cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fdps
Entrez Gene ID	110196
Full Name	farnesyl diphosphate synthetase
Synonyms	6030492I17Rik,AI256750,Fdpsl1,mKIAA1293
General protein information	Preferred Names farnesyl diphosphate synthetase Names farnesyl pyrophosphate synthase (2E,6E)-farnesyl diphosphate synthase CR 39 FPP synthase FPP synthetase FPS cholesterol-regulated 39 kDa protein dimethylallyltranstransferase farnesyl diphosphate synthase farnesyl pyrophosphate synthetase geranyltranstransferase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3 F1\|3 39.01 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_134469.4	NP_608219.1	farnesyl pyrophosphate synthase isoform 2
NM_001253751.1	NP_001240680.1	farnesyl pyrophosphate synthase isoform 1 precursor

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	Fpps	NP_477380.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007104	XP_308653.4
Magnaporthe oryzae (rice blast fungus)	MGG_08649	XP_003711082.1
Kluyveromyces lactis	KLLA0A06732g	XP_451300.1
Eremothecium gossypii	AGOS_AEL122W	NP_984739.1
Schizosaccharomyces pombe (fission yeast)	fps1	NP_593299.1
Canis lupus familiaris (dog)	FDPS	XP_005622781.1
Bos taurus (cattle)	FDPS	NP_803463.1
Mus musculus (house mouse)	Fdps	NP_001240680.1
Rattus norvegicus (Norway rat)	Fdps	NP_114028.1
Danio rerio (zebrafish)	fdps	NP_001020642.1
Xenopus tropicalis (tropical clawed frog)	fdps	NP_001015867.1
Homo sapiens (human)	FDPS	NP_001995.1
Pan troglodytes (chimpanzee)	FDPS	XP_001160391.1
Gallus gallus (chicken)	FDPS	XP_422855.3
Saccharomyces cerevisiae (baker's yeast)	ERG20	NP_012368.1
Neurospora crassa	NCU01175	XP_961541.1
Arabidopsis thaliana (thale cress)	FPS1	NP_199588.1
Arabidopsis thaliana (thale cress)	FPS2	NP_193452.1
Oryza sativa (rice)	Os05g0543400	NP_001056204.1
Oryza sativa (rice)	Os01g0703400	NP_001044000.1

Gene Ontology
Bibliography

Related articles in PubMed

Embryonic poly(A)-binding protein is required at the preantral stage of mouse folliculogenesis for oocyte-somatic communication.
Lowther KM, Favero F, Yang CR, Taylor HS, Seli E
Biology of reproduction96(2)341-351(2017 02)

A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo.
?i?ecio?lu M, Budak H, Geffers L, ?ankaya M, ?iftci M, Thaller C, Eichele G, K?frevio?lu ??, ?zdemir H
Journal of lipid research56(8)1551-9(2015 Aug)

Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis.
Patra D, DeLassus E, Liang G, Sandell LJ
PloS one9(8)e105674(2014)

Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in mice.
Yang J, Mou Y, Wu T, Ye Y, Jiang JC, Zhao CZ, Zhu HH, Du CQ, Zhou L, Hu SJ
Cardiovascular research97(3)490-9(2013 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Farnesyl pyrophosphate synthase (FPPS) may function as a potent regulator in myocardial remodelling. The FPPS-regulated signalling pathway is relevant to the pathological changes in cardiac hypertrophy and heart failure.
Title: Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in mice.

identified a single putative direct repeat 4 (DR4) LXR response element in the FPS promoter isolated from immortalized murine astrocyte P11-5 cells
Title: Transcriptional regulation of farnesyl pyrophosphate synthase by liver X receptors.

novel role in fibroblast growth factor-mediated signal transduction
Title: A novel role for farnesyl pyrophosphate synthase in fibroblast growth factor-mediated signal transduction.

The following Fdps gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fdps cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu05586	NM_001253751.1 Latest version!	Mus musculus farnesyl diphosphate synthetase (Fdps), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu15781	NM_134469.4 Latest version!	Mus musculus farnesyl diphosphate synthetase (Fdps), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fdps ( NM_001253751.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001240680.1 Mus musculus farnesyl diphosphate synthetase (Fdps), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu05586
Clone ID Related Accession (Same CDS sequence)	NM_001253751.1
Accession Version	NM_001253751.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1263bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	farnesyl pyrophosphate synthase isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ082322.1, BY144580.1, AC140468.2, BC048497.1 and BE994006.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCCTGT CCTGCTGGCT GAGATCTCTG GGGGTCTTCC TGCTGCCAGC CCCCTGCTGG 
GCACCCCGGG AGAGGTGGCT TGGTTTCCTA CAACGACCCT CCCTGGCATA TGGGTGTCCA 
GTCCTGGGGG CCTGGCACAG TGCCCGCTGG TGGTGCCAAG TGTGGACAGA GGAGCCTCGA 
GCATTTAGCT CCTCTGTCAG AATGAATGGG AACCAGAAAT TGGATGCTTA TAACCAAGAA 
AAGCAGAATT TCATCCAGCA CTTCTCCCAG ATCGTCAAGG TGCTGACTGA GAAGGAGCTG 
GGACACCCAG AGATAGGGGA TGCTATTGCC CGGCTCAAGG AGGTCCTAGA GTACAATGCC 
TTAGGAGGCA AGTACAACCG GGGTTTGACC GTGGTACAAG CCTTCCAGGA GCTGGTGGAG 
CCGAAGAAAC AGGATGCTGA GAGTCTTCAG CGGGCCCTGA CAGTGGGCTG GTGTGTAGAA 
CTGCTCCAGG CTTTCTTCCT TGTGTCAGAT GACATCATGG ACTCTTCCCT CACTCGCCGG 
GGACAGATCT GCTGGTATCA GAAGCCAGGC ATAGGCTTGG ATGCCATCAA CGACGCTCTG 
CTTCTGGAAG CCTCCATCTA TCGTTTGCTG AAGTTCTACT GCAGGGAGCA GCCCTACTAC 
CTGAACCTGC TGGAGCTCTT TCTGCAGAGT TCCTATCAGA CAGAGATCGG GCAGACTCTA 
GACCTCATGA CAGCACCCCA GGGCCATGTG GATCTTGGTA GATACACTGA AAAGAGGTAC 
AAATCGATTG TCAAGTACAA GACGGCTTTC TACTCTTTCT ACCTGCCTAT TGCGGCCGCC 
ATGTACATGG CAGGCATTGA TGGGGAGAAG GAACACGCCA ATGCCCTGAA GATCCTGATG 
GAGATGGGCG AGTTCTTCCA GGTCCAGGAC GACTACCTTG ATCTCTTTGG AGACCCCAGT 
GTGACGGGAA AGGTCGGCAC TGACATCCAG GACAACAAAT GCAGCTGGCT GGTGGTTCAG 
TGTCTGCTAC GAGCCTCTCC TCAACAGCGC CAGATCTTAG AGGAGAATTA TGGGCAGAAG 
GACCCAGAAA AAGTGGCTCG GGTGAAAGCA CTGTATGAGG CGCTGGATCT GCAGTCTGCT 
TTCTTCAAGT ATGAGGAAGA CAGTTACAAC CGCCTCAAGA GTCTCATAGA GCAGTGCTCT 
GCGCCCCTGC CCCCATCCAT CTTCATGGAA CTTGCAAACA AGATCTACAA ACGGAGAAAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001240680.1
CDS	144..1406
Translation	MPLSCWLRSLGVFLLPAPCWAPRERWLGFLQRPSLAYGCPVLGAWHSARWWCQVWTEEPRAFSSSVRMNGNQKLDAYNQEKQNFIQHFSQIVKVLTEKELGHPEIGDAIARLKEVLEYNALGGKYNRGLTVVQAFQELVEPKKQDAESLQRALTVGWCVELLQAFFLVSDDIMDSSLTRRGQICWYQKPGIGLDAINDALLLEASIYRLLKFYCREQPYYLNLLELFLQSSYQTEIGQTLDLMTAPQGHVDLGRYTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANALKILMEMGEFFQVQDDYLDLFGDPSVTGKVGTDIQDNKCSWLVVQCLLRASPQQRQILEENYGQKDPEKVARVKALYEALDLQSAFFKYEEDSYNRLKSLIEQCSAPLPPSIFMELANKIYKRRK

Target ORF information:

RefSeq Version	NM_001253751.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus farnesyl diphosphate synthetase (Fdps), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001253751.1

ORF Insert Sequence:

ATGCCCCTGT CCTGCTGGCT GAGATCTCTG GGGGTCTTCC TGCTGCCAGC CCCCTGCTGG 
GCACCCCGGG AGAGGTGGCT TGGTTTCCTA CAACGACCCT CCCTGGCATA TGGGTGTCCA 
GTCCTGGGGG CCTGGCACAG TGCCCGCTGG TGGTGCCAAG TGTGGACAGA GGAGCCTCGA 
GCATTTAGCT CCTCTGTCAG AATGAATGGG AACCAGAAAT TGGATGCTTA TAACCAAGAA 
AAGCAGAATT TCATCCAGCA CTTCTCCCAG ATCGTCAAGG TGCTGACTGA GAAGGAGCTG 
GGACACCCAG AGATAGGGGA TGCTATTGCC CGGCTCAAGG AGGTCCTAGA GTACAATGCC 
TTAGGAGGCA AGTACAACCG GGGTTTGACC GTGGTACAAG CCTTCCAGGA GCTGGTGGAG 
CCGAAGAAAC AGGATGCTGA GAGTCTTCAG CGGGCCCTGA CAGTGGGCTG GTGTGTAGAA 
CTGCTCCAGG CTTTCTTCCT TGTGTCAGAT GACATCATGG ACTCTTCCCT CACTCGCCGG 
GGACAGATCT GCTGGTATCA GAAGCCAGGC ATAGGCTTGG ATGCCATCAA CGACGCTCTG 
CTTCTGGAAG CCTCCATCTA TCGTTTGCTG AAGTTCTACT GCAGGGAGCA GCCCTACTAC 
CTGAACCTGC TGGAGCTCTT TCTGCAGAGT TCCTATCAGA CAGAGATCGG GCAGACTCTA 
GACCTCATGA CAGCACCCCA GGGCCATGTG GATCTTGGTA GATACACTGA AAAGAGGTAC 
AAATCGATTG TCAAGTACAA GACGGCTTTC TACTCTTTCT ACCTGCCTAT TGCGGCCGCC 
ATGTACATGG CAGGCATTGA TGGGGAGAAG GAACACGCCA ATGCCCTGAA GATCCTGATG 
GAGATGGGCG AGTTCTTCCA GGTCCAGGAC GACTACCTTG ATCTCTTTGG AGACCCCAGT 
GTGACGGGAA AGGTCGGCAC TGACATCCAG GACAACAAAT GCAGCTGGCT GGTGGTTCAG 
TGTCTGCTAC GAGCCTCTCC TCAACAGCGC CAGATCTTAG AGGAGAATTA TGGGCAGAAG 
GACCCAGAAA AAGTGGCTCG GGTGAAAGCA CTGTATGAGG CGCTGGATCT GCAGTCTGCT 
TTCTTCAAGT ATGAGGAAGA CAGTTACAAC CGCCTCAAGA GTCTCATAGA GCAGTGCTCT 
GCGCCCCTGC CCCCATCCAT CTTCATGGAA CTTGCAAACA AGATCTACAA ACGGAGAAAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fdps ( NM_134469.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_608219.1 Mus musculus farnesyl diphosphate synthetase (Fdps), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu15781
Clone ID Related Accession (Same CDS sequence)	NM_134469.4
Accession Version	NM_134469.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1062bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	farnesyl pyrophosphate synthase isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ082244.1, BC048497.1 and BE994006.1. On Dec 2, 2011 this sequence version replaced NM_134469.3. Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC087886.1, BC048497.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAATGGGA ACCAGAAATT GGATGCTTAT AACCAAGAAA AGCAGAATTT CATCCAGCAC 
TTCTCCCAGA TCGTCAAGGT GCTGACTGAG AAGGAGCTGG GACACCCAGA GATAGGGGAT 
GCTATTGCCC GGCTCAAGGA GGTCCTAGAG TACAATGCCT TAGGAGGCAA GTACAACCGG 
GGTTTGACCG TGGTACAAGC CTTCCAGGAG CTGGTGGAGC CGAAGAAACA GGATGCTGAG 
AGTCTTCAGC GGGCCCTGAC AGTGGGCTGG TGTGTAGAAC TGCTCCAGGC TTTCTTCCTT 
GTGTCAGATG ACATCATGGA CTCTTCCCTC ACTCGCCGGG GACAGATCTG CTGGTATCAG 
AAGCCAGGCA TAGGCTTGGA TGCCATCAAC GACGCTCTGC TTCTGGAAGC CTCCATCTAT 
CGTTTGCTGA AGTTCTACTG CAGGGAGCAG CCCTACTACC TGAACCTGCT GGAGCTCTTT 
CTGCAGAGTT CCTATCAGAC AGAGATCGGG CAGACTCTAG ACCTCATGAC AGCACCCCAG 
GGCCATGTGG ATCTTGGTAG ATACACTGAA AAGAGGTACA AATCGATTGT CAAGTACAAG 
ACGGCTTTCT ACTCTTTCTA CCTGCCTATT GCGGCCGCCA TGTACATGGC AGGCATTGAT 
GGGGAGAAGG AACACGCCAA TGCCCTGAAG ATCCTGATGG AGATGGGCGA GTTCTTCCAG 
GTCCAGGACG ACTACCTTGA TCTCTTTGGA GACCCCAGTG TGACGGGAAA GGTCGGCACT 
GACATCCAGG ACAACAAATG CAGCTGGCTG GTGGTTCAGT GTCTGCTACG AGCCTCTCCT 
CAACAGCGCC AGATCTTAGA GGAGAATTAT GGGCAGAAGG ACCCAGAAAA AGTGGCTCGG 
GTGAAAGCAC TGTATGAGGC GCTGGATCTG CAGTCTGCTT TCTTCAAGTA TGAGGAAGAC 
AGTTACAACC GCCTCAAGAG TCTCATAGAG CAGTGCTCTG CGCCCCTGCC CCCATCCATC 
TTCATGGAAC TTGCAAACAA GATCTACAAA CGGAGAAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_608219.1
CDS	129..1190
Translation	MNGNQKLDAYNQEKQNFIQHFSQIVKVLTEKELGHPEIGDAIARLKEVLEYNALGGKYNRGLTVVQAFQELVEPKKQDAESLQRALTVGWCVELLQAFFLVSDDIMDSSLTRRGQICWYQKPGIGLDAINDALLLEASIYRLLKFYCREQPYYLNLLELFLQSSYQTEIGQTLDLMTAPQGHVDLGRYTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANALKILMEMGEFFQVQDDYLDLFGDPSVTGKVGTDIQDNKCSWLVVQCLLRASPQQRQILEENYGQKDPEKVARVKALYEALDLQSAFFKYEEDSYNRLKSLIEQCSAPLPPSIFMELANKIYKRRK

Target ORF information:

RefSeq Version	NM_134469.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus farnesyl diphosphate synthetase (Fdps), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_134469.4

ORF Insert Sequence:

ATGAATGGGA ACCAGAAATT GGATGCTTAT AACCAAGAAA AGCAGAATTT CATCCAGCAC 
TTCTCCCAGA TCGTCAAGGT GCTGACTGAG AAGGAGCTGG GACACCCAGA GATAGGGGAT 
GCTATTGCCC GGCTCAAGGA GGTCCTAGAG TACAATGCCT TAGGAGGCAA GTACAACCGG 
GGTTTGACCG TGGTACAAGC CTTCCAGGAG CTGGTGGAGC CGAAGAAACA GGATGCTGAG 
AGTCTTCAGC GGGCCCTGAC AGTGGGCTGG TGTGTAGAAC TGCTCCAGGC TTTCTTCCTT 
GTGTCAGATG ACATCATGGA CTCTTCCCTC ACTCGCCGGG GACAGATCTG CTGGTATCAG 
AAGCCAGGCA TAGGCTTGGA TGCCATCAAC GACGCTCTGC TTCTGGAAGC CTCCATCTAT 
CGTTTGCTGA AGTTCTACTG CAGGGAGCAG CCCTACTACC TGAACCTGCT GGAGCTCTTT 
CTGCAGAGTT CCTATCAGAC AGAGATCGGG CAGACTCTAG ACCTCATGAC AGCACCCCAG 
GGCCATGTGG ATCTTGGTAG ATACACTGAA AAGAGGTACA AATCGATTGT CAAGTACAAG 
ACGGCTTTCT ACTCTTTCTA CCTGCCTATT GCGGCCGCCA TGTACATGGC AGGCATTGAT 
GGGGAGAAGG AACACGCCAA TGCCCTGAAG ATCCTGATGG AGATGGGCGA GTTCTTCCAG 
GTCCAGGACG ACTACCTTGA TCTCTTTGGA GACCCCAGTG TGACGGGAAA GGTCGGCACT 
GACATCCAGG ACAACAAATG CAGCTGGCTG GTGGTTCAGT GTCTGCTACG AGCCTCTCCT 
CAACAGCGCC AGATCTTAGA GGAGAATTAT GGGCAGAAGG ACCCAGAAAA AGTGGCTCGG 
GTGAAAGCAC TGTATGAGGC GCTGGATCTG CAGTCTGCTT TCTTCAAGTA TGAGGAAGAC 
AGTTACAACC GCCTCAAGAG TCTCATAGAG CAGTGCTCTG CGCCCCTGCC CCCATCCATC 
TTCATGGAAC TTGCAAACAA GATCTACAAA CGGAGAAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Embryonic poly(A)-binding protein is required at the preantral stage of mouse folliculogenesis for oocyte-somatic communication.
Biology of reproduction96(2)341-351(2017 02)
Lowther KM,Favero F,Yang CR,Taylor HS,Seli E

A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo.
Journal of lipid research56(8)1551-9(2015 Aug)
?i?ecio?lu M,Budak H,Geffers L,?ankaya M,?iftci M,Thaller C,Eichele G,K?frevio?lu ??,?zdemir H

Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis.
PloS one9(8)e105674(2014)
Patra D,DeLassus E,Liang G,Sandell LJ

Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in mice.
Cardiovascular research97(3)490-9(2013 Mar)
Yang J,Mou Y,Wu T,Ye Y,Jiang JC,Zhao CZ,Zhu HH,Du CQ,Zhou L,Hu SJ