Cavin3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cavin3
Entrez Gene ID	109042
Full Name	caveolae associated 3
Synonyms	3110015B12Rik,6330514M23Rik,Prkcdbp,SRBC
General protein information	Preferred Names caveolae associated 3 Names caveolae-associated protein 3 cavin-3 protein kinase C, delta binding protein serum deprivation response factor-related gene product that binds to C-kinase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 E3

mRNA and Protein(s)

mRNA	Protein	Name
NM_028444.1	NP_082720.1	caveolae-associated protein 3

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Prkcdbp	NP_604444.1
Canis lupus familiaris (dog)	PRKCDBP	XP_534035.2
Mus musculus (house mouse)	Prkcdbp	NP_082720.1
Homo sapiens (human)	PRKCDBP	NP_659477.2
Bos taurus (cattle)	PRKCDBP	NP_001076870.1
Pan troglodytes (chimpanzee)	PRKCDBP	XP_003951859.1
	LOC712799	XP_002808124.1

Gene Ontology
Bibliography

Related articles in PubMed

Cavin-3 (PRKCDBP) deficiency reduces the density of caveolae in smooth muscle.
Zhu B, Sw?rd K, Ekman M, Uvelius B, Rippe C
Cell and tissue research368(3)591-602(2017 06)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression.
West DB, Engelhard EK, Adkisson M, Nava AJ, Kirov JV, Cipollone A, Willis B, Rapp J, de Jong PJ, Lloyd KC
PLoS genetics12(2)e1005691(2016 Feb)

Cavin3 interacts with cavin1 and caveolin1 to increase surface dynamics of caveolae.
Mohan J, Mor?n B, Larsson E, Holst MR, Lundmark R
Journal of cell science128(5)979-91(2015 Mar)

Cavin-3 knockout mice show that cavin-3 is not essential for caveolae formation, for maintenance of body composition, or for glucose tolerance.
Liu L, Hansen CG, Honeyman BJ, Nichols BJ, Pilch PF
PloS one9(7)e102935(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The roles of cavins 2 and 3 in caveolar morphogenesis in vivo, are reported.
Title: Deletion of cavin genes reveals tissue-specific mechanisms for morphogenesis of endothelial caveolae.

The following Cavin3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cavin3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22166	NM_028444.1 Latest version!	Mus musculus caveolae associated 3 (Cavin3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cavin3 ( NM_028444.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_082720.1 Mus musculus caveolae associated 3 (Cavin3), mRNA.

Price & Availability↑

CloneID	OMu22166
Clone ID Related Accession (Same CDS sequence)	NM_028444.1
Accession Version	NM_028444.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 783bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Mus musculus(house mouse)
Product	caveolae-associated protein 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC009660.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC009660.1, BI408052.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGGGGAGA GCGCACTGGA GCCCGGACCT GTGCCTGAGA CGCCCGCAGG GGGTCCGGTG 
CACGCAGTCA CCGTGGTGAC CTTGCTGGAG AAATTGGCCA CCATGCTGGA GGCTCTGCGG 
GAGCGGCAAG GCGGCCTGGC TGAGAGGCAG GGCGGCCTGG CGGGCTCCGT GCGTCGCATA 
CAGAGTGGCC TGGGTGCGCT GAGTCGCAGC CACGACACCA CCAGCAACAC ACTGACGCAG 
CTGCTGGCCA AGGCGGAGCG CGTGGGCTCG CACGCCGACG CAGCCCAGGA GCGGGCCGTG 
CGTCGCGCTG CTCAGGTGCA GCGGTTGGAG GCCAACCACG GGCTGCTGGT GGCGCGCGGG 
AAGCTGCACG TCCTGCTCTT CAAGGAGGAG ACTGAAATTC CAGCCCGCGC CTTCCAGAAA 
GTCCCAGAGC TCTTGGGTCC GGAGGACCAG TTGGTGCTGG GCCCAGATCA GCCAGAGGAT 
GAAGTTGGAG AGAGTTCTGA AGAGGAGCCA GTGGAGTCCA GGGCTCAGCG GCTGCGCCGC 
ACTGGTTTAC AGAAAGTTCA AAGCCTGAAA AGGGCTCTTT CCAGTCGTAA AGCAGCACAG 
CCCACACCAG TCAAGCCGCC ACGCGTAGGG CCTGTCCGGA GCTCTGAAGG CCCATCAGAA 
GGCCAGCCTG CAGCTCAGCC TGAAATGGAG TCCGAGCTCG AGACTGCCCT GGAGCCAGAA 
CCTCCTCAAC CTACCAAGGA AGATCCTGAG AAACCCGTGC TTCAAATAGA GAGCGCAGCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_082720.1
CDS	39..821
Translation	MGESALEPGPVPETPAGGPVHAVTVVTLLEKLATMLEALRERQGGLAERQGGLAGSVRRIQSGLGALSRSHDTTSNTLTQLLAKAERVGSHADAAQERAVRRAAQVQRLEANHGLLVARGKLHVLLFKEETEIPARAFQKVPELLGPEDQLVLGPDQPEDEVGESSEEEPVESRAQRLRRTGLQKVQSLKRALSSRKAAQPTPVKPPRVGPVRSSEGPSEGQPAAQPEMESELETALEPEPPQPTKEDPEKPVLQIESAA

Target ORF information:

RefSeq Version	NM_028444.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus caveolae associated 3 (Cavin3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_028444.1

ORF Insert Sequence:

ATGGGGGAGA GCGCACTGGA GCCCGGACCT GTGCCTGAGA CGCCCGCAGG GGGTCCGGTG 
CACGCAGTCA CCGTGGTGAC CTTGCTGGAG AAATTGGCCA CCATGCTGGA GGCTCTGCGG 
GAGCGGCAAG GCGGCCTGGC TGAGAGGCAG GGCGGCCTGG CGGGCTCCGT GCGTCGCATA 
CAGAGTGGCC TGGGTGCGCT GAGTCGCAGC CACGACACCA CCAGCAACAC ACTGACGCAG 
CTGCTGGCCA AGGCGGAGCG CGTGGGCTCG CACGCCGACG CAGCCCAGGA GCGGGCCGTG 
CGTCGCGCTG CTCAGGTGCA GCGGTTGGAG GCCAACCACG GGCTGCTGGT GGCGCGCGGG 
AAGCTGCACG TCCTGCTCTT CAAGGAGGAG ACTGAAATTC CAGCCCGCGC CTTCCAGAAA 
GTCCCAGAGC TCTTGGGTCC GGAGGACCAG TTGGTGCTGG GCCCAGATCA GCCAGAGGAT 
GAAGTTGGAG AGAGTTCTGA AGAGGAGCCA GTGGAGTCCA GGGCTCAGCG GCTGCGCCGC 
ACTGGTTTAC AGAAAGTTCA AAGCCTGAAA AGGGCTCTTT CCAGTCGTAA AGCAGCACAG 
CCCACACCAG TCAAGCCGCC ACGCGTAGGG CCTGTCCGGA GCTCTGAAGG CCCATCAGAA 
GGCCAGCCTG CAGCTCAGCC TGAAATGGAG TCCGAGCTCG AGACTGCCCT GGAGCCAGAA 
CCTCCTCAAC CTACCAAGGA AGATCCTGAG AAACCCGTGC TTCAAATAGA GAGCGCAGCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cavin-3 (PRKCDBP) deficiency reduces the density of caveolae in smooth muscle.
Cell and tissue research368(3)591-602(2017 06)
Zhu B,Sw?rd K,Ekman M,Uvelius B,Rippe C

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression.
PLoS genetics12(2)e1005691(2016 Feb)
West DB,Engelhard EK,Adkisson M,Nava AJ,Kirov JV,Cipollone A,Willis B,Rapp J,de Jong PJ,Lloyd KC

Cavin3 interacts with cavin1 and caveolin1 to increase surface dynamics of caveolae.
Journal of cell science128(5)979-91(2015 Mar)
Mohan J,Mor?n B,Larsson E,Holst MR,Lundmark R

Cavin-3 knockout mice show that cavin-3 is not essential for caveolae formation, for maintenance of body composition, or for glucose tolerance.
PloS one9(7)e102935(2014)
Liu L,Hansen CG,Honeyman BJ,Nichols BJ,Pilch PF