Jmjd6 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Jmjd6
Entrez Gene ID	107817
Full Name	jumonji domain containing 6
Synonyms	5730436I23Rik,D11Ertd195e,PSR,PtdSerR,Ptdsr,mKIAA0585
General protein information	Preferred Names jumonji domain containing 6 Names bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 apoptotic cell clearance receptor PtdSerR histone arginine demethylase JMJD6 jmjC domain-containing protein 6 jumonji domain-containing protein 6 lysyl-hydroxylase JMJD6 peptide-lysine 5-dioxygenase JMJD6 phosphatidylserine receptor
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11 E2\|11 81.49 cM
Summary	This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein functions in differentiation of multiple tissues during development, and in anti-inflammatory cytokine signaling. It was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that this protein does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001363363.1	NP_001350292.1	bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform 1
NM_033398.2	NP_203971.2	bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
XM_006531960.3	XP_006532023.1	bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform X1
XM_030245464.1	XP_030101324.1	bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform X1
NM_033398.3	NP_203971.2	bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform 2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Jmjd6	NP_001012143.2
Bos taurus (cattle)	JMJD6	NP_001029492.2
Mus musculus (house mouse)	Jmjd6	NP_203971.2
Homo sapiens (human)	JMJD6	NP_001074930.1
Canis lupus familiaris (dog)	JMJD6	XP_003639292.1
Gallus gallus (chicken)	JMJD6	NP_001025874.1
Drosophila melanogaster (fruit fly)	PSR	NP_001262832.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000158	XP_310981.3
Xenopus tropicalis (tropical clawed frog)	jmjd6	NP_001016203.1
Pan troglodytes (chimpanzee)	JMJD6	XP_001153530.1
Danio rerio (zebrafish)	jmjd6	NP_739567.2
Caenorhabditis elegans (roundworm)	psr-1	NP_001040940.1

Gene Ontology
Bibliography

Related articles in PubMed

Thymic epithelial cell-specific deletion of Jmjd6 reduces Aire protein expression and exacerbates disease development in a mouse model of autoimmune diabetes.
Yanagihara T, Tomino T, Uruno T, Fukui Y
Biochemical and biophysical research communications489(1)8-13(2017 07)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus.
Yanagihara T, Sanematsu F, Sato T, Uruno T, Duan X, Tomino T, Harada Y, Watanabe M, Wang Y, Tanaka Y, Nakanishi Y, Suyama M, Yoshinori F
Nature communications68820(2015 Nov)

Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6.
Hu YJ, Belaghzal H, Hsiao WY, Qi J, Bradner JE, Guertin DA, Sif S, Imbalzano AN
Nucleic acids research43(16)7790-804(2015 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TEC-specific deletion of Jmjd6 exacerbates development of autoimmune diabetes in a mouse model, which express both ovalbumin (OVA) under the control of the rat insulin gene promoter and OT-I T cell receptor specific for OVA peptide bound to major histocompatibility complex class I K(b) molecules.
Title: Thymic epithelial cell-specific deletion of Jmjd6 reduces Aire protein expression and exacerbates disease development in a mouse model of autoimmune diabetes.

Although Jmjd6 deficiency does not affect abundance of Aire transcript, the intron 2 of Aire gene is not effectively spliced out in the absence of Jmjd6, resulting in reduction of mature Aire protein and spontaneous multi-organ autoimmunity in mice.
Title: Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus.

The results indicate dual roles for JMJD6 in promoting adipogenic gene expression program by post-transcriptional regulation of C/EBPbeta and C/EBPdelta and direct transcriptional activation of Ppargamma2 and Cebpalpha during adipocyte differentiation.
Title: Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6.

histones are additional substrates of JMJD6 in vivo. Because 5-hydroxylation of lysyl residues inhibited N-acetylation and N-methylation by an acetyltransferase and a methyltransferase
Title: Lysyl 5-hydroxylation, a novel histone modification, by Jumonji domain containing 6 (JMJD6).

confirmed that Jmjd6 forms multimers and showed that nuclear localization of the protein involves association with a nucleic acid matrix
Title: Analysis of Jmjd6 cellular localization and testing for its involvement in histone demethylation.

The following Jmjd6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Jmjd6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu15641	NM_033398.3 Latest version!	Mus musculus jumonji domain containing 6 (Jmjd6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu45384	NM_001363363.1 Latest version!	Mus musculus jumonji domain containing 6 (Jmjd6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu45384	XM_006531960.3 Latest version!	Mus musculus jumonji domain containing 6 (Jmjd6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu85591	XM_030245464.1 Latest version!	Mus musculus jumonji domain containing 6 (Jmjd6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OMu15641	NM_033398.2	Mus musculus jumonji domain containing 6 (Jmjd6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Jmjd6 ( NM_033398.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_203971.2 Mus musculus jumonji domain containing 6 (Jmjd6), mRNA.

Price & Availability↑

CloneID	OMu15641
Clone ID Related Accession (Same CDS sequence)	NM_033398.2 , NM_033398.3
Accession Version	NM_033398.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1212bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Mus musculus(house mouse)
Product	bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL645542.13, CX210791.1 and BP769727.1. On Feb 16, 2007 this sequence version replaced NM_033398.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC056629.1, SRR1660815.489215.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACCACA AGAGCAAGAA GCGCATCCGC GAGGCCAAGC GAAGTGCGCG GCCGGAGCTC 
AAGGACTCGC TCGACTGGAC CCGGCACAAC TACTACGAGA GCTACCCGCT GAACCCCGCG 
GCCGTGCCGG ATAACGTGGA GAGAGCTGAT GCCTTACAGC TGTCGGTGAA AGAGTTCGTG 
GAGCGCTACG AGAGGCCTTA CAAGCCCGTG GTTCTGCTCA ATGCACAAGA GGGCTGGTCC 
GCACAGGAGA AATGGACTCT GGAGCGCCTC AAAAGGAAAT ACCGGAACCA GAAGTTCAAG 
TGCGGCGAGG ATAATGACGG CTACTCGGTT AAGATGAAGA TGAAGTACTA CATCGAGTAC 
ATGGAGAGCA CCCGCGATGA CAGTCCCCTT TACATCTTCG ATAGCAGCTA TGGCGAACAC 
CCCAAAAGAA GGAAACTTTT GGAAGACTAC AAGGTGCCCA AGTTTTTCAC AGATGATCTT 
TTCCAATACG CGGGGGAGAA ACGCAGACCC CCTTACAGGT GGTTTGTGAT GGGGCCACCG 
CGTTCTGGAA CTGGGATTCA CATCGACCCT CTGGGGACCA GTGCCTGGAA TGCCTTAGTT 
CAGGGTCACA AGCGGTGGTG CCTCTTCCCA ACAAACACAC CCAGAGAACT CATCAAGGTG 
ACCCGAGAAG AAGGAGGGAA CCAACAGGAT GAAGCAATTA CCTGGTTTAA TGTCATCTAT 
CCCCGGACAC AGCTTCCAAC CTGGCCACCT GAATTCAAAC CCCTGGAGAT ATTACAGAAA 
CCAGGAGAAA CTGTCTTTGT ACCAGGGGGC TGGTGGCATG TTGTCCTCAA CCTTGACACC 
ACCATTGCCA TCACCCAGAA CTTTGCCAGC AGCACCAACT TCCCTGTTGT GTGGCACAAG 
ACGGTAAGAG GGAGACCAAA GTTATCAAGG AAGTGGTATA GGATCTTGAA ACAGGAGCAC 
CCTGAGCTGG CAGTCCTGGC CGACGCAGTT GACCTCCAGG AGTCCACAGG CATTGCCTCT 
GACAGCTCCA GCGACTCTTC TAGCTCCTCT AGTTCCAGCT CGTCAGACTC GGACTCAGAG 
TGTGAATCTG GGTCAGAAGG TGATGGGACG ACACACCGCA GGAAGAAGAG GAGAACCTGC 
AGCATGGTGG GAAATGGGGA CACTACCTCC CAGGATGACT GTGTGAGCAA AGAGCGCAGC 
TCCTCCAGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_203971.2
CDS	257..1468
Translation	MNHKSKKRIREAKRSARPELKDSLDWTRHNYYESYPLNPAAVPDNVERADALQLSVKEFVERYERPYKPVVLLNAQEGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLEDYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTNTPRELIKVTREEGGNQQDEAITWFNVIYPRTQLPTWPPEFKPLEILQKPGETVFVPGGWWHVVLNLDTTIAITQNFASSTNFPVVWHKTVRGRPKLSRKWYRILKQEHPELAVLADAVDLQESTGIASDSSSDSSSSSSSSSSDSDSECESGSEGDGTTHRRKKRRTCSMVGNGDTTSQDDCVSKERSSSR

Target ORF information:

RefSeq Version	NM_033398.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus jumonji domain containing 6 (Jmjd6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033398.2

ORF Insert Sequence:

ATGAACCACA AGAGCAAGAA GCGCATCCGC GAGGCCAAGC GAAGTGCGCG GCCGGAGCTC 
AAGGACTCGC TCGACTGGAC CCGGCACAAC TACTACGAGA GCTACCCGCT GAACCCCGCG 
GCCGTGCCGG ATAACGTGGA GAGAGCTGAT GCCTTACAGC TGTCGGTGAA AGAGTTCGTG 
GAGCGCTACG AGAGGCCTTA CAAGCCCGTG GTTCTGCTCA ATGCACAAGA GGGCTGGTCC 
GCACAGGAGA AATGGACTCT GGAGCGCCTC AAAAGGAAAT ACCGGAACCA GAAGTTCAAG 
TGCGGCGAGG ATAATGACGG CTACTCGGTT AAGATGAAGA TGAAGTACTA CATCGAGTAC 
ATGGAGAGCA CCCGCGATGA CAGTCCCCTT TACATCTTCG ATAGCAGCTA TGGCGAACAC 
CCCAAAAGAA GGAAACTTTT GGAAGACTAC AAGGTGCCCA AGTTTTTCAC AGATGATCTT 
TTCCAATACG CGGGGGAGAA ACGCAGACCC CCTTACAGGT GGTTTGTGAT GGGGCCACCG 
CGTTCTGGAA CTGGGATTCA CATCGACCCT CTGGGGACCA GTGCCTGGAA TGCCTTAGTT 
CAGGGTCACA AGCGGTGGTG CCTCTTCCCA ACAAACACAC CCAGAGAACT CATCAAGGTG 
ACCCGAGAAG AAGGAGGGAA CCAACAGGAT GAAGCAATTA CCTGGTTTAA TGTCATCTAT 
CCCCGGACAC AGCTTCCAAC CTGGCCACCT GAATTCAAAC CCCTGGAGAT ATTACAGAAA 
CCAGGAGAAA CTGTCTTTGT ACCAGGGGGC TGGTGGCATG TTGTCCTCAA CCTTGACACC 
ACCATTGCCA TCACCCAGAA CTTTGCCAGC AGCACCAACT TCCCTGTTGT GTGGCACAAG 
ACGGTAAGAG GGAGACCAAA GTTATCAAGG AAGTGGTATA GGATCTTGAA ACAGGAGCAC 
CCTGAGCTGG CAGTCCTGGC CGACGCAGTT GACCTCCAGG AGTCCACAGG CATTGCCTCT 
GACAGCTCCA GCGACTCTTC TAGCTCCTCT AGTTCCAGCT CGTCAGACTC GGACTCAGAG 
TGTGAATCTG GGTCAGAAGG TGATGGGACG ACACACCGCA GGAAGAAGAG GAGAACCTGC 
AGCATGGTGG GAAATGGGGA CACTACCTCC CAGGATGACT GTGTGAGCAA AGAGCGCAGC 
TCCTCCAGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Jmjd6 ( NM_033398.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_203971.2 Mus musculus jumonji domain containing 6 (Jmjd6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu15641
Clone ID Related Accession (Same CDS sequence)	NM_033398.2 , NM_033398.3
Accession Version	NM_033398.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1212bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Mus musculus(house mouse)
Product	bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL645542.13, CX210791.1 and BP769727.1. On May 17, 2018 this sequence version replaced NM_033398.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC056629.1, SRR1660815.489215.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACCACA AGAGCAAGAA GCGCATCCGC GAGGCCAAGC GAAGTGCGCG GCCGGAGCTC 
AAGGACTCGC TCGACTGGAC CCGGCACAAC TACTACGAGA GCTACCCGCT GAACCCCGCG 
GCCGTGCCGG ATAACGTGGA GAGAGCTGAT GCCTTACAGC TGTCGGTGAA AGAGTTCGTG 
GAGCGCTACG AGAGGCCTTA CAAGCCCGTG GTTCTGCTCA ATGCACAAGA GGGCTGGTCC 
GCACAGGAGA AATGGACTCT GGAGCGCCTC AAAAGGAAAT ACCGGAACCA GAAGTTCAAG 
TGCGGCGAGG ATAATGACGG CTACTCGGTT AAGATGAAGA TGAAGTACTA CATCGAGTAC 
ATGGAGAGCA CCCGCGATGA CAGTCCCCTT TACATCTTCG ATAGCAGCTA TGGCGAACAC 
CCCAAAAGAA GGAAACTTTT GGAAGACTAC AAGGTGCCCA AGTTTTTCAC AGATGATCTT 
TTCCAATACG CGGGGGAGAA ACGCAGACCC CCTTACAGGT GGTTTGTGAT GGGGCCACCG 
CGTTCTGGAA CTGGGATTCA CATCGACCCT CTGGGGACCA GTGCCTGGAA TGCCTTAGTT 
CAGGGTCACA AGCGGTGGTG CCTCTTCCCA ACAAACACAC CCAGAGAACT CATCAAGGTG 
ACCCGAGAAG AAGGAGGGAA CCAACAGGAT GAAGCAATTA CCTGGTTTAA TGTCATCTAT 
CCCCGGACAC AGCTTCCAAC CTGGCCACCT GAATTCAAAC CCCTGGAGAT ATTACAGAAA 
CCAGGAGAAA CTGTCTTTGT ACCAGGGGGC TGGTGGCATG TTGTCCTCAA CCTTGACACC 
ACCATTGCCA TCACCCAGAA CTTTGCCAGC AGCACCAACT TCCCTGTTGT GTGGCACAAG 
ACGGTAAGAG GGAGACCAAA GTTATCAAGG AAGTGGTATA GGATCTTGAA ACAGGAGCAC 
CCTGAGCTGG CAGTCCTGGC CGACGCAGTT GACCTCCAGG AGTCCACAGG CATTGCCTCT 
GACAGCTCCA GCGACTCTTC TAGCTCCTCT AGTTCCAGCT CGTCAGACTC GGACTCAGAG 
TGTGAATCTG GGTCAGAAGG TGATGGGACG ACACACCGCA GGAAGAAGAG GAGAACCTGC 
AGCATGGTGG GAAATGGGGA CACTACCTCC CAGGATGACT GTGTGAGCAA AGAGCGCAGC 
TCCTCCAGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_203971.2
CDS	257..1468
Translation	MNHKSKKRIREAKRSARPELKDSLDWTRHNYYESYPLNPAAVPDNVERADALQLSVKEFVERYERPYKPVVLLNAQEGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLEDYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTNTPRELIKVTREEGGNQQDEAITWFNVIYPRTQLPTWPPEFKPLEILQKPGETVFVPGGWWHVVLNLDTTIAITQNFASSTNFPVVWHKTVRGRPKLSRKWYRILKQEHPELAVLADAVDLQESTGIASDSSSDSSSSSSSSSSDSDSECESGSEGDGTTHRRKKRRTCSMVGNGDTTSQDDCVSKERSSSR

Target ORF information:

RefSeq Version	NM_033398.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus jumonji domain containing 6 (Jmjd6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033398.3

ORF Insert Sequence:

ATGAACCACA AGAGCAAGAA GCGCATCCGC GAGGCCAAGC GAAGTGCGCG GCCGGAGCTC 
AAGGACTCGC TCGACTGGAC CCGGCACAAC TACTACGAGA GCTACCCGCT GAACCCCGCG 
GCCGTGCCGG ATAACGTGGA GAGAGCTGAT GCCTTACAGC TGTCGGTGAA AGAGTTCGTG 
GAGCGCTACG AGAGGCCTTA CAAGCCCGTG GTTCTGCTCA ATGCACAAGA GGGCTGGTCC 
GCACAGGAGA AATGGACTCT GGAGCGCCTC AAAAGGAAAT ACCGGAACCA GAAGTTCAAG 
TGCGGCGAGG ATAATGACGG CTACTCGGTT AAGATGAAGA TGAAGTACTA CATCGAGTAC 
ATGGAGAGCA CCCGCGATGA CAGTCCCCTT TACATCTTCG ATAGCAGCTA TGGCGAACAC 
CCCAAAAGAA GGAAACTTTT GGAAGACTAC AAGGTGCCCA AGTTTTTCAC AGATGATCTT 
TTCCAATACG CGGGGGAGAA ACGCAGACCC CCTTACAGGT GGTTTGTGAT GGGGCCACCG 
CGTTCTGGAA CTGGGATTCA CATCGACCCT CTGGGGACCA GTGCCTGGAA TGCCTTAGTT 
CAGGGTCACA AGCGGTGGTG CCTCTTCCCA ACAAACACAC CCAGAGAACT CATCAAGGTG 
ACCCGAGAAG AAGGAGGGAA CCAACAGGAT GAAGCAATTA CCTGGTTTAA TGTCATCTAT 
CCCCGGACAC AGCTTCCAAC CTGGCCACCT GAATTCAAAC CCCTGGAGAT ATTACAGAAA 
CCAGGAGAAA CTGTCTTTGT ACCAGGGGGC TGGTGGCATG TTGTCCTCAA CCTTGACACC 
ACCATTGCCA TCACCCAGAA CTTTGCCAGC AGCACCAACT TCCCTGTTGT GTGGCACAAG 
ACGGTAAGAG GGAGACCAAA GTTATCAAGG AAGTGGTATA GGATCTTGAA ACAGGAGCAC 
CCTGAGCTGG CAGTCCTGGC CGACGCAGTT GACCTCCAGG AGTCCACAGG CATTGCCTCT 
GACAGCTCCA GCGACTCTTC TAGCTCCTCT AGTTCCAGCT CGTCAGACTC GGACTCAGAG 
TGTGAATCTG GGTCAGAAGG TGATGGGACG ACACACCGCA GGAAGAAGAG GAGAACCTGC 
AGCATGGTGG GAAATGGGGA CACTACCTCC CAGGATGACT GTGTGAGCAA AGAGCGCAGC 
TCCTCCAGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Jmjd6 ( NM_001363363.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001350292.1 Mus musculus jumonji domain containing 6 (Jmjd6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu45384
Clone ID Related Accession (Same CDS sequence)	NM_001363363.1 , XM_006531960.3
Accession Version	NM_001363363.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1263bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Mus musculus(house mouse)
Product	bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL645542.13 and EF527405.1. On May 17, 2018 this sequence version replaced XM_006531960.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EF527405.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END##

ATGAACCACA AGAGCAAGAA GCGCATCCGC GAGGCCAAGC GAAGTGCGCG GCCGGAGCTC 
AAGGACTCGC TCGACTGGAC CCGGCACAAC TACTACGAGA GCTACCCGCT GAACCCCGCG 
GCCGTGCCGG ATAACGTGGA GAGAGCTGAT GCCTTACAGC TGTCGGTGAA AGAGTTCGTG 
GAGCGCTACG AGAGGCCTTA CAAGCCCGTG GTTCTGCTCA ATGCACAAGA GGGCTGGTCC 
GCACAGGAGA AATGGACTCT GGAGCGCCTC AAAAGGAAAT ACCGGAACCA GAAGTTCAAG 
TGCGGCGAGG ATAATGACGG CTACTCGGTT AAGATGAAGA TGAAGTACTA CATCGAGTAC 
ATGGAGAGCA CCCGCGATGA CAGTCCCCTT TACATCTTCG ATAGCAGCTA TGGCGAACAC 
CCCAAAAGAA GGAAACTTTT GGAAGACTAC AAGGTGCCCA AGTTTTTCAC AGATGATCTT 
TTCCAATACG CGGGGGAGAA ACGCAGACCC CCTTACAGGT GGTTTGTGAT GGGGCCACCG 
CGTTCTGGAA CTGGGATTCA CATCGACCCT CTGGGGACCA GTGCCTGGAA TGCCTTAGTT 
CAGGGTCACA AGCGGTGGTG CCTCTTCCCA ACAAACACAC CCAGAGAACT CATCAAGGTG 
ACCCGAGAAG AAGGAGGGAA CCAACAGGAT GAAGCAATTA CCTGGTTTAA TGTCATCTAT 
CCCCGGACAC AGCTTCCAAC CTGGCCACCT GAATTCAAAC CCCTGGAGAT ATTACAGAAA 
CCAGGAGAAA CTGTCTTTGT ACCAGGGGGC TGGTGGCATG TTGTCCTCAA CCTTGACACC 
ACCATTGCCA TCACCCAGAA CTTTGCCAGC AGCACCAACT TCCCTGTTGT GTGGCACAAG 
ACGATACAGC ACGGGCAGCG GCAGTGCAAG CCACCCCCAG CCACCCCGTG CCACTGTGTC 
CCAACCCTGA CCTGGAGGGA CCAGCTCTCG GGGATCTTGA AACAGGAGCA CCCTGAGCTG 
GCAGTCCTGG CCGACGCAGT TGACCTCCAG GAGTCCACAG GCATTGCCTC TGACAGCTCC 
AGCGACTCTT CTAGCTCCTC TAGTTCCAGC TCGTCAGACT CGGACTCAGA GTGTGAATCT 
GGGTCAGAAG GTGATGGGAC GACACACCGC AGGAAGAAGA GGAGAACCTG CAGCATGGTG 
GGAAATGGGG ACACTACCTC CCAGGATGAC TGTGTGAGCA AAGAGCGCAG CTCCTCCAGG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001350292.1
CDS	257..1519
Translation	MNHKSKKRIREAKRSARPELKDSLDWTRHNYYESYPLNPAAVPDNVERADALQLSVKEFVERYERPYKPVVLLNAQEGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLEDYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTNTPRELIKVTREEGGNQQDEAITWFNVIYPRTQLPTWPPEFKPLEILQKPGETVFVPGGWWHVVLNLDTTIAITQNFASSTNFPVVWHKTIQHGQRQCKPPPATPCHCVPTLTWRDQLSGILKQEHPELAVLADAVDLQESTGIASDSSSDSSSSSSSSSSDSDSECESGSEGDGTTHRRKKRRTCSMVGNGDTTSQDDCVSKERSSSR

Target ORF information:

RefSeq Version	NM_001363363.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus jumonji domain containing 6 (Jmjd6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001363363.1

ORF Insert Sequence:

ATGAACCACA AGAGCAAGAA GCGCATCCGC GAGGCCAAGC GAAGTGCGCG GCCGGAGCTC 
AAGGACTCGC TCGACTGGAC CCGGCACAAC TACTACGAGA GCTACCCGCT GAACCCCGCG 
GCCGTGCCGG ATAACGTGGA GAGAGCTGAT GCCTTACAGC TGTCGGTGAA AGAGTTCGTG 
GAGCGCTACG AGAGGCCTTA CAAGCCCGTG GTTCTGCTCA ATGCACAAGA GGGCTGGTCC 
GCACAGGAGA AATGGACTCT GGAGCGCCTC AAAAGGAAAT ACCGGAACCA GAAGTTCAAG 
TGCGGCGAGG ATAATGACGG CTACTCGGTT AAGATGAAGA TGAAGTACTA CATCGAGTAC 
ATGGAGAGCA CCCGCGATGA CAGTCCCCTT TACATCTTCG ATAGCAGCTA TGGCGAACAC 
CCCAAAAGAA GGAAACTTTT GGAAGACTAC AAGGTGCCCA AGTTTTTCAC AGATGATCTT 
TTCCAATACG CGGGGGAGAA ACGCAGACCC CCTTACAGGT GGTTTGTGAT GGGGCCACCG 
CGTTCTGGAA CTGGGATTCA CATCGACCCT CTGGGGACCA GTGCCTGGAA TGCCTTAGTT 
CAGGGTCACA AGCGGTGGTG CCTCTTCCCA ACAAACACAC CCAGAGAACT CATCAAGGTG 
ACCCGAGAAG AAGGAGGGAA CCAACAGGAT GAAGCAATTA CCTGGTTTAA TGTCATCTAT 
CCCCGGACAC AGCTTCCAAC CTGGCCACCT GAATTCAAAC CCCTGGAGAT ATTACAGAAA 
CCAGGAGAAA CTGTCTTTGT ACCAGGGGGC TGGTGGCATG TTGTCCTCAA CCTTGACACC 
ACCATTGCCA TCACCCAGAA CTTTGCCAGC AGCACCAACT TCCCTGTTGT GTGGCACAAG 
ACGATACAGC ACGGGCAGCG GCAGTGCAAG CCACCCCCAG CCACCCCGTG CCACTGTGTC 
CCAACCCTGA CCTGGAGGGA CCAGCTCTCG GGGATCTTGA AACAGGAGCA CCCTGAGCTG 
GCAGTCCTGG CCGACGCAGT TGACCTCCAG GAGTCCACAG GCATTGCCTC TGACAGCTCC 
AGCGACTCTT CTAGCTCCTC TAGTTCCAGC TCGTCAGACT CGGACTCAGA GTGTGAATCT 
GGGTCAGAAG GTGATGGGAC GACACACCGC AGGAAGAAGA GGAGAACCTG CAGCATGGTG 
GGAAATGGGG ACACTACCTC CCAGGATGAC TGTGTGAGCA AAGAGCGCAG CTCCTCCAGG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Jmjd6 ( XM_006531960.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006532023.1 Mus musculus jumonji domain containing 6 (Jmjd6), transcript variant X1, mRNA.

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CloneID	OMu45384
Clone ID Related Accession (Same CDS sequence)	NM_001363363.1 , XM_006531960.3
Accession Version	XM_006531960.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1263bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006531960.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACCACA AGAGCAAGAA GCGCATCCGC GAGGCCAAGC GAAGTGCGCG GCCGGAGCTC 
AAGGACTCGC TCGACTGGAC CCGGCACAAC TACTACGAGA GCTACCCGCT GAACCCCGCG 
GCCGTGCCGG ATAACGTGGA GAGAGCTGAT GCCTTACAGC TGTCGGTGAA AGAGTTCGTG 
GAGCGCTACG AGAGGCCTTA CAAGCCCGTG GTTCTGCTCA ATGCACAAGA GGGCTGGTCC 
GCACAGGAGA AATGGACTCT GGAGCGCCTC AAAAGGAAAT ACCGGAACCA GAAGTTCAAG 
TGCGGCGAGG ATAATGACGG CTACTCGGTT AAGATGAAGA TGAAGTACTA CATCGAGTAC 
ATGGAGAGCA CCCGCGATGA CAGTCCCCTT TACATCTTCG ATAGCAGCTA TGGCGAACAC 
CCCAAAAGAA GGAAACTTTT GGAAGACTAC AAGGTGCCCA AGTTTTTCAC AGATGATCTT 
TTCCAATACG CGGGGGAGAA ACGCAGACCC CCTTACAGGT GGTTTGTGAT GGGGCCACCG 
CGTTCTGGAA CTGGGATTCA CATCGACCCT CTGGGGACCA GTGCCTGGAA TGCCTTAGTT 
CAGGGTCACA AGCGGTGGTG CCTCTTCCCA ACAAACACAC CCAGAGAACT CATCAAGGTG 
ACCCGAGAAG AAGGAGGGAA CCAACAGGAT GAAGCAATTA CCTGGTTTAA TGTCATCTAT 
CCCCGGACAC AGCTTCCAAC CTGGCCACCT GAATTCAAAC CCCTGGAGAT ATTACAGAAA 
CCAGGAGAAA CTGTCTTTGT ACCAGGGGGC TGGTGGCATG TTGTCCTCAA CCTTGACACC 
ACCATTGCCA TCACCCAGAA CTTTGCCAGC AGCACCAACT TCCCTGTTGT GTGGCACAAG 
ACGATACAGC ACGGGCAGCG GCAGTGCAAG CCACCCCCAG CCACCCCGTG CCACTGTGTC 
CCAACCCTGA CCTGGAGGGA CCAGCTCTCG GGGATCTTGA AACAGGAGCA CCCTGAGCTG 
GCAGTCCTGG CCGACGCAGT TGACCTCCAG GAGTCCACAG GCATTGCCTC TGACAGCTCC 
AGCGACTCTT CTAGCTCCTC TAGTTCCAGC TCGTCAGACT CGGACTCAGA GTGTGAATCT 
GGGTCAGAAG GTGATGGGAC GACACACCGC AGGAAGAAGA GGAGAACCTG CAGCATGGTG 
GGAAATGGGG ACACTACCTC CCAGGATGAC TGTGTGAGCA AAGAGCGCAG CTCCTCCAGG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006532023.1
CDS	168..1430
Translation	MNHKSKKRIREAKRSARPELKDSLDWTRHNYYESYPLNPAAVPDNVERADALQLSVKEFVERYERPYKPVVLLNAQEGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLEDYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTNTPRELIKVTREEGGNQQDEAITWFNVIYPRTQLPTWPPEFKPLEILQKPGETVFVPGGWWHVVLNLDTTIAITQNFASSTNFPVVWHKTIQHGQRQCKPPPATPCHCVPTLTWRDQLSGILKQEHPELAVLADAVDLQESTGIASDSSSDSSSSSSSSSSDSDSECESGSEGDGTTHRRKKRRTCSMVGNGDTTSQDDCVSKERSSSR

Target ORF information:

RefSeq Version	XM_006531960.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus jumonji domain containing 6 (Jmjd6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006531960.3

ORF Insert Sequence:

ATGAACCACA AGAGCAAGAA GCGCATCCGC GAGGCCAAGC GAAGTGCGCG GCCGGAGCTC 
AAGGACTCGC TCGACTGGAC CCGGCACAAC TACTACGAGA GCTACCCGCT GAACCCCGCG 
GCCGTGCCGG ATAACGTGGA GAGAGCTGAT GCCTTACAGC TGTCGGTGAA AGAGTTCGTG 
GAGCGCTACG AGAGGCCTTA CAAGCCCGTG GTTCTGCTCA ATGCACAAGA GGGCTGGTCC 
GCACAGGAGA AATGGACTCT GGAGCGCCTC AAAAGGAAAT ACCGGAACCA GAAGTTCAAG 
TGCGGCGAGG ATAATGACGG CTACTCGGTT AAGATGAAGA TGAAGTACTA CATCGAGTAC 
ATGGAGAGCA CCCGCGATGA CAGTCCCCTT TACATCTTCG ATAGCAGCTA TGGCGAACAC 
CCCAAAAGAA GGAAACTTTT GGAAGACTAC AAGGTGCCCA AGTTTTTCAC AGATGATCTT 
TTCCAATACG CGGGGGAGAA ACGCAGACCC CCTTACAGGT GGTTTGTGAT GGGGCCACCG 
CGTTCTGGAA CTGGGATTCA CATCGACCCT CTGGGGACCA GTGCCTGGAA TGCCTTAGTT 
CAGGGTCACA AGCGGTGGTG CCTCTTCCCA ACAAACACAC CCAGAGAACT CATCAAGGTG 
ACCCGAGAAG AAGGAGGGAA CCAACAGGAT GAAGCAATTA CCTGGTTTAA TGTCATCTAT 
CCCCGGACAC AGCTTCCAAC CTGGCCACCT GAATTCAAAC CCCTGGAGAT ATTACAGAAA 
CCAGGAGAAA CTGTCTTTGT ACCAGGGGGC TGGTGGCATG TTGTCCTCAA CCTTGACACC 
ACCATTGCCA TCACCCAGAA CTTTGCCAGC AGCACCAACT TCCCTGTTGT GTGGCACAAG 
ACGATACAGC ACGGGCAGCG GCAGTGCAAG CCACCCCCAG CCACCCCGTG CCACTGTGTC 
CCAACCCTGA CCTGGAGGGA CCAGCTCTCG GGGATCTTGA AACAGGAGCA CCCTGAGCTG 
GCAGTCCTGG CCGACGCAGT TGACCTCCAG GAGTCCACAG GCATTGCCTC TGACAGCTCC 
AGCGACTCTT CTAGCTCCTC TAGTTCCAGC TCGTCAGACT CGGACTCAGA GTGTGAATCT 
GGGTCAGAAG GTGATGGGAC GACACACCGC AGGAAGAAGA GGAGAACCTG CAGCATGGTG 
GGAAATGGGG ACACTACCTC CCAGGATGAC TGTGTGAGCA AAGAGCGCAG CTCCTCCAGG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Jmjd6 ( XM_030245464.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030101324.1 Mus musculus jumonji domain containing 6 (Jmjd6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu85591
Clone ID Related Accession (Same CDS sequence)	XM_030245464.1
Accession Version	XM_030245464.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1152bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACCACA AGAGCAAGAA GCGCATCCGC GAGGCCAAGC GAAGTGCGCG GCCGGAGCTC 
AAGGACTCGC TCGACTGGAC CCGGCACAAC TACTACGAGA GCTACCCGCT GAACCCCGCG 
GCCGTGCCGG ATAACGTGGA GAGAGCTGAT GCCTTACAGC TGTCGGTGAA AGAGTTCGTG 
GAGCGCTACG AGAGGCCTTA CAAGCCCGTG GTTCTGCTCA ATGCACAAGA GGGCTGGTCC 
GCACAGGAGA AATGGACTCT GGAGCGCCTC AAAAGGAAAT ACCGGAACCA GAAGTTCAAG 
TGCGGCGAGG ATAATGACGG CTACTCGGTT AAGATGAAGA TGAAGTACTA CATCGAGTAC 
ATGGAGAGCA CCCGCGATGA CAGTCCCCTT TACATCTTCG ATAGCAGCTA TGGCGAACAC 
CCCAAAAGAA GGAAACTTTT GGAAGACTAC AAGGTGCCCA AGTTTTTCAC AGATGATCTT 
TTCCAATACG CGGGGGAGAA ACGCAGACCC CCTTACAGGT GGTTTGTGAT GGGGCCACCG 
CGTTCTGGAA CTGGGATTCA CATCGACCCT CTGGGGACCA GTGCCTGGAA TGCCTTAGTT 
CAGGGTCACA AGCGGTGGTG CCTCTTCCCA ACAAACACAC CCAGAGAACT CATCAAGGTG 
ACCCGAGAAG AAGGAGGGAA CCAACAGGAT GAAGCAATTA CCTGGTTTAA TGTCATCTAT 
CCCCGGACAC AGCTTCCAAC CTGGCCACCT GAATTCAAAC CCCTGGAGAT ATTACAGAAA 
CCAGGAGAAA CTGTCTTTGT ACCAGGGGGC TGGTGGCATG TTGTCCTCAA CCTTGACACC 
ACCATTGCCA TCACCCAGAA CTTTGCCAGC AGCACCAACT TCCCTGTTGT GTGGCACAAG 
ACGGTAAGAG GGAGACCAAA GTTATCAAGG AAGTGGTATA GGATCTTGAA ACAGGAGCAC 
CCTGAGCTGG CAGTCCTGGC CGACGCAGTT GACCTCCAGG AGTCCACAGG CATTGCCTCT 
GACAGCTCCA GCGACTCTTC TAGCTCCTCT AGTTCCAGCT CGTCAGACTC GGACTCAGAG 
GGTTTCTCTG TGTCGCCCCG GCTTTCCTGG ACCCCAGTCT GTAGACCAGG CTGGCCTCGA 
ATGCTGGATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030101324.1
CDS	365..1516
Translation	MNHKSKKRIREAKRSARPELKDSLDWTRHNYYESYPLNPAAVPDNVERADALQLSVKEFVERYERPYKPVVLLNAQEGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLEDYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTNTPRELIKVTREEGGNQQDEAITWFNVIYPRTQLPTWPPEFKPLEILQKPGETVFVPGGWWHVVLNLDTTIAITQNFASSTNFPVVWHKTVRGRPKLSRKWYRILKQEHPELAVLADAVDLQESTGIASDSSSDSSSSSSSSSSDSDSEGFSVSPRLSWTPVCRPGWPRMLD

Target ORF information:

RefSeq Version	XM_030245464.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus jumonji domain containing 6 (Jmjd6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030245464.1

ORF Insert Sequence:

ATGAACCACA AGAGCAAGAA GCGCATCCGC GAGGCCAAGC GAAGTGCGCG GCCGGAGCTC 
AAGGACTCGC TCGACTGGAC CCGGCACAAC TACTACGAGA GCTACCCGCT GAACCCCGCG 
GCCGTGCCGG ATAACGTGGA GAGAGCTGAT GCCTTACAGC TGTCGGTGAA AGAGTTCGTG 
GAGCGCTACG AGAGGCCTTA CAAGCCCGTG GTTCTGCTCA ATGCACAAGA GGGCTGGTCC 
GCACAGGAGA AATGGACTCT GGAGCGCCTC AAAAGGAAAT ACCGGAACCA GAAGTTCAAG 
TGCGGCGAGG ATAATGACGG CTACTCGGTT AAGATGAAGA TGAAGTACTA CATCGAGTAC 
ATGGAGAGCA CCCGCGATGA CAGTCCCCTT TACATCTTCG ATAGCAGCTA TGGCGAACAC 
CCCAAAAGAA GGAAACTTTT GGAAGACTAC AAGGTGCCCA AGTTTTTCAC AGATGATCTT 
TTCCAATACG CGGGGGAGAA ACGCAGACCC CCTTACAGGT GGTTTGTGAT GGGGCCACCG 
CGTTCTGGAA CTGGGATTCA CATCGACCCT CTGGGGACCA GTGCCTGGAA TGCCTTAGTT 
CAGGGTCACA AGCGGTGGTG CCTCTTCCCA ACAAACACAC CCAGAGAACT CATCAAGGTG 
ACCCGAGAAG AAGGAGGGAA CCAACAGGAT GAAGCAATTA CCTGGTTTAA TGTCATCTAT 
CCCCGGACAC AGCTTCCAAC CTGGCCACCT GAATTCAAAC CCCTGGAGAT ATTACAGAAA 
CCAGGAGAAA CTGTCTTTGT ACCAGGGGGC TGGTGGCATG TTGTCCTCAA CCTTGACACC 
ACCATTGCCA TCACCCAGAA CTTTGCCAGC AGCACCAACT TCCCTGTTGT GTGGCACAAG 
ACGGTAAGAG GGAGACCAAA GTTATCAAGG AAGTGGTATA GGATCTTGAA ACAGGAGCAC 
CCTGAGCTGG CAGTCCTGGC CGACGCAGTT GACCTCCAGG AGTCCACAGG CATTGCCTCT 
GACAGCTCCA GCGACTCTTC TAGCTCCTCT AGTTCCAGCT CGTCAGACTC GGACTCAGAG 
GGTTTCTCTG TGTCGCCCCG GCTTTCCTGG ACCCCAGTCT GTAGACCAGG CTGGCCTCGA 
ATGCTGGATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Thymic epithelial cell-specific deletion of Jmjd6 reduces Aire protein expression and exacerbates disease development in a mouse model of autoimmune diabetes.
Biochemical and biophysical research communications489(1)8-13(2017 07)
Yanagihara T,Tomino T,Uruno T,Fukui Y

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus.
Nature communications68820(2015 Nov)
Yanagihara T,Sanematsu F,Sato T,Uruno T,Duan X,Tomino T,Harada Y,Watanabe M,Wang Y,Tanaka Y,Nakanishi Y,Suyama M,Yoshinori F

Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6.
Nucleic acids research43(16)7790-804(2015 Sep)
Hu YJ,Belaghzal H,Hsiao WY,Qi J,Bradner JE,Guertin DA,Sif S,Imbalzano AN

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Jmjd6 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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