Txndc5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Txndc5
Entrez Gene ID	105245
Full Name	thioredoxin domain containing 5
Synonyms	AL022641,ERp46,PC-TRP
General protein information	Preferred Names thioredoxin domain containing 5 Names thioredoxin domain-containing protein 5 ER protein 46 endoplasmic reticulum protein ERp46 endoplasmic reticulum resident protein 46 plasma cell-specific thioredoxin-related protein thioredoxin-like protein p46
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13\|13 A3.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_145367.4	NP_663342.3	thioredoxin domain-containing protein 5 isoform 1 precursor
NM_001289599.1	NP_001276528.1	thioredoxin domain-containing protein 5 isoform 3
NM_001289598.1	NP_001276527.1	thioredoxin domain-containing protein 5 isoform 2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Txndc5	NP_663342.3
	TXNDC5	XP_002803633.1
Gallus gallus (chicken)	TXNDC5	NP_001006374.1
Drosophila melanogaster (fruit fly)	prtp	NP_572742.1
Canis lupus familiaris (dog)	TXNDC5	XP_005640077.1
Bos taurus (cattle)	TXNDC5	NP_001193661.1
Rattus norvegicus (Norway rat)	Txndc5	NP_001258259.1
Xenopus tropicalis (tropical clawed frog)	txndc5	NP_989186.1
Pan troglodytes (chimpanzee)	TXNDC5	XP_003311145.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000044	XP_311114.4
Homo sapiens (human)	TXNDC5	NP_110437.2
Danio rerio (zebrafish)	txndc5	NP_998181.1

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
Liu X, Jiao Y, Cao Y, Deng N, Ma Y, Hasty KA, Kang A, Chen H, Stuart JM, Gu W
BMC immunology17(1)25(2016 08)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

Investigate pathogenic mechanism of TXNDC5 in rheumatoid arthritis.
Wang L, Zheng Y, Xu H, Yan X, Chang X
PloS one8(1)e53301(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Hypoxia induced TXCNDC5 expression, which contributed to adiponectin expression, cytokine production and the cellular proliferation and migration of fibroblasts in rheumatoid arthritis.
Title: Investigate pathogenic mechanism of TXNDC5 in rheumatoid arthritis.

Txndc5 reflects the anti-steatotic properties of squalene and the sensitivity to lipid accumulation.
Title: Proteomics and gene expression analyses of squalene-supplemented mice identify microsomal thioredoxin domain-containing protein 5 changes associated with hepatic steatosis.

ERp46 plays a protective role in palmitic acid -induced cell apoptosis by decreasing the endoplasmic reticulum stress response and might be a novel target for anti-diabetic drugs.
Title: Role of ERp46 in ?-cell lipoapoptosis through endoplasmic reticulum stress pathway as well as the protective effect of exendin-4.

Potential role for TXNDC5 in resistance to nitrosative stress.
Title: Involvement of thioredoxin domain-containing 5 in resistance to nitrosative stress.

ERp46 may be an important component in the phenomenon of "glucose toxicity" involved in insulin production at the posttranslational level.
Title: ERp46 is reduced by high glucose and regulates insulin content in pancreatic beta-cells.

The following Txndc5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Txndc5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu58030	NM_001289599.1 Latest version!	Mus musculus thioredoxin domain containing 5 (Txndc5), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu57986	NM_145367.4 Latest version!	Mus musculus thioredoxin domain containing 5 (Txndc5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
OMu58009	NM_001289598.1 Latest version!	Mus musculus thioredoxin domain containing 5 (Txndc5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Txndc5 ( NM_001289599.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001276528.1 Mus musculus thioredoxin domain containing 5 (Txndc5), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu58030
Clone ID Related Accession (Same CDS sequence)	NM_001289599.1
Accession Version	NM_001289599.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1035bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Mus musculus(house mouse)
Product	thioredoxin domain-containing protein 5 isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK225017.1 and AY243534.1. Transcript Variant: This variant (3) contains a distinct 5' UTR and coding region and represents translation initiation at a novel AUG, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK225017.1, AK224981.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164138 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGTGGAC ACTGCCAGCG GCTGCAGCCA ACTTGGAATG ACCTGGGAGA CAAGTACAAC 
AGCATGGAGG ATGCCAAGGT CTACGTGGCC AAAGTGGACT GCACGGCTGA TTCCGACGTG 
TGCTCTGCCC AGGGAGTGCG AGGATACCCC ACCCTGAAGT TTTTTAAGCC TGGACAAGAA 
GCAGTGAAGT ACCAGGGTCC TAGAGACTTT GAAACACTGG AAAACTGGAT GCTGCAGACA 
CTGAACGAGG AGCCAGCCAC ACCGGAGCCG GAAGCGGAAC CACCCAGAGC CCCTGAGCTC 
AAACAGGGGT TGTATGAGCT CTCGGCCAAC AACTTTGAGC TGCATGTTTC TCAAGGCAAC 
CACTTTATCA AGTTCTTCGC TCCGTGGTGC GGTCACTGCA AAGCTCTGGC TCCAACCTGG 
GAGCAGCTGG CTCTGGGCCT TGAACATTCT GAAACCGTCA AGATTGGCAA GGTTGACTGC 
ACGCAGCACT ACGCTGTCTG CTCAGAGCAT CAGGTCAGAG GCTATCCAAC TCTGCTCTGG 
TTTCGAGATG GCAAGAAGGT GGATCAGTAC AAGGGAAAGC GGGACTTGGA GTCACTGAGA 
GACTATGTGC AGTCCCAGCT GCAGGGTTCA GAGGCAGCTC CGGAGACTGT TGAGCCGTCA 
GAGGCCCCAG TGATGGCTGC TGAGCCCACG GGTGACAAGG GCACTGTGCT GGCACTCACC 
GAGAAGAGCT TCGAGGACAC TATTGCACAG GGGATAACCT TCGTCAAGTT CTATGCTCCG 
TGGTGTGGCC ACTGTAAGAA TCTGGCTCCT ACCTGGGAGG AGCTCTCTAA AAAGGAATTC 
CCAGGCTTGT CAGATGTCAC CATCGCAGAA GTGGACTGCA CCGCTGAGCG CAATGTCTGC 
AGCAAGTACT CGGTACGAGG TTATCCCACG TTGCTGCTTT TCCGAGGAGG TGAAAAAGTG 
GGAGAACACA ACGGAGGTAG AGACCTCGAC TCCTTACACA GCTTTGTTCT GCGCCAGGCA 
AAGGATGAAC TATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001276528.1
CDS	239..1273
Translation	MCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTADSDVCSAQGVRGYPTLKFFKPGQEAVKYQGPRDFETLENWMLQTLNEEPATPEPEAEPPRAPELKQGLYELSANNFELHVSQGNHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYAVCSEHQVRGYPTLLWFRDGKKVDQYKGKRDLESLRDYVQSQLQGSEAAPETVEPSEAPVMAAEPTGDKGTVLALTEKSFEDTIAQGITFVKFYAPWCGHCKNLAPTWEELSKKEFPGLSDVTIAEVDCTAERNVCSKYSVRGYPTLLLFRGGEKVGEHNGGRDLDSLHSFVLRQAKDEL

Target ORF information:

RefSeq Version	NM_001289599.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus thioredoxin domain containing 5 (Txndc5), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001289599.1

ORF Insert Sequence:

ATGTGTGGAC ACTGCCAGCG GCTGCAGCCA ACTTGGAATG ACCTGGGAGA CAAGTACAAC 
AGCATGGAGG ATGCCAAGGT CTACGTGGCC AAAGTGGACT GCACGGCTGA TTCCGACGTG 
TGCTCTGCCC AGGGAGTGCG AGGATACCCC ACCCTGAAGT TTTTTAAGCC TGGACAAGAA 
GCAGTGAAGT ACCAGGGTCC TAGAGACTTT GAAACACTGG AAAACTGGAT GCTGCAGACA 
CTGAACGAGG AGCCAGCCAC ACCGGAGCCG GAAGCGGAAC CACCCAGAGC CCCTGAGCTC 
AAACAGGGGT TGTATGAGCT CTCGGCCAAC AACTTTGAGC TGCATGTTTC TCAAGGCAAC 
CACTTTATCA AGTTCTTCGC TCCGTGGTGC GGTCACTGCA AAGCTCTGGC TCCAACCTGG 
GAGCAGCTGG CTCTGGGCCT TGAACATTCT GAAACCGTCA AGATTGGCAA GGTTGACTGC 
ACGCAGCACT ACGCTGTCTG CTCAGAGCAT CAGGTCAGAG GCTATCCAAC TCTGCTCTGG 
TTTCGAGATG GCAAGAAGGT GGATCAGTAC AAGGGAAAGC GGGACTTGGA GTCACTGAGA 
GACTATGTGC AGTCCCAGCT GCAGGGTTCA GAGGCAGCTC CGGAGACTGT TGAGCCGTCA 
GAGGCCCCAG TGATGGCTGC TGAGCCCACG GGTGACAAGG GCACTGTGCT GGCACTCACC 
GAGAAGAGCT TCGAGGACAC TATTGCACAG GGGATAACCT TCGTCAAGTT CTATGCTCCG 
TGGTGTGGCC ACTGTAAGAA TCTGGCTCCT ACCTGGGAGG AGCTCTCTAA AAAGGAATTC 
CCAGGCTTGT CAGATGTCAC CATCGCAGAA GTGGACTGCA CCGCTGAGCG CAATGTCTGC 
AGCAAGTACT CGGTACGAGG TTATCCCACG TTGCTGCTTT TCCGAGGAGG TGAAAAAGTG 
GGAGAACACA ACGGAGGTAG AGACCTCGAC TCCTTACACA GCTTTGTTCT GCGCCAGGCA 
AAGGATGAAC TATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Txndc5 ( NM_145367.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_663342.3 Mus musculus thioredoxin domain containing 5 (Txndc5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu57986
Clone ID Related Accession (Same CDS sequence)	NM_145367.4
Accession Version	NM_145367.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1254bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Mus musculus(house mouse)
Product	thioredoxin domain-containing protein 5 isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK225023.1, AK224971.1 and AY243534.1. On Jan 24, 2014 this sequence version replaced NM_145367.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC016252.1, AK225023.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164138 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCCCGC GCCCAGGACG CCTCCTCCAG CCGCTGGCCG GGCTGCCGGC CCTGGCCACG 
CTCCTGCTGC TGCTCGGGGC GCGCAAAGGC GCCCGGGCCC AGGAGGTGGA AGCGGACAGC 
GGGGTCGAGC AGGACCCGCA CGCCAAGCAC CTGTATACGG CCGACATGTT CACGCACGGG 
ATCCAGAGCG CCGCGCACTT CGTCATGTTC TTCGCGCCCT GGTGTGGACA CTGCCAGCGG 
CTGCAGCCAA CTTGGAATGA CCTGGGAGAC AAGTACAACA GCATGGAGGA TGCCAAGGTC 
TACGTGGCCA AAGTGGACTG CACGGCTGAT TCCGACGTGT GCTCTGCCCA GGGAGTGCGA 
GGATACCCCA CCCTGAAGTT TTTTAAGCCT GGACAAGAAG CAGTGAAGTA CCAGGGTCCT 
AGAGACTTTG AAACACTGGA AAACTGGATG CTGCAGACAC TGAACGAGGA GCCAGCCACA 
CCGGAGCCGG AAGCGGAACC ACCCAGAGCC CCTGAGCTCA AACAGGGGTT GTATGAGCTC 
TCGGCCAACA ACTTTGAGCT GCATGTTTCT CAAGGCAACC ACTTTATCAA GTTCTTCGCT 
CCGTGGTGCG GTCACTGCAA AGCTCTGGCT CCAACCTGGG AGCAGCTGGC TCTGGGCCTT 
GAACATTCTG AAACCGTCAA GATTGGCAAG GTTGACTGCA CGCAGCACTA CGCTGTCTGC 
TCAGAGCATC AGGTCAGAGG CTATCCAACT CTGCTCTGGT TTCGAGATGG CAAGAAGGTG 
GATCAGTACA AGGGAAAGCG GGACTTGGAG TCACTGAGAG ACTATGTGCA GTCCCAGCTG 
CAGGGTTCAG AGGCAGCTCC GGAGACTGTT GAGCCGTCAG AGGCCCCAGT GATGGCTGCT 
GAGCCCACGG GTGACAAGGG CACTGTGCTG GCACTCACCG AGAAGAGCTT CGAGGACACT 
ATTGCACAGG GGATAACCTT CGTCAAGTTC TATGCTCCGT GGTGTGGCCA CTGTAAGAAT 
CTGGCTCCTA CCTGGGAGGA GCTCTCTAAA AAGGAATTCC CAGGCTTGTC AGATGTCACC 
ATCGCAGAAG TGGACTGCAC CGCTGAGCGC AATGTCTGCA GCAAGTACTC GGTACGAGGT 
TATCCCACGT TGCTGCTTTT CCGAGGAGGT GAAAAAGTGG GAGAACACAA CGGAGGTAGA 
GACCTCGACT CCTTACACAG CTTTGTTCTG CGCCAGGCAA AGGATGAACT ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_663342.3
CDS	77..1330
Translation	MPPRPGRLLQPLAGLPALATLLLLLGARKGARAQEVEADSGVEQDPHAKHLYTADMFTHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTADSDVCSAQGVRGYPTLKFFKPGQEAVKYQGPRDFETLENWMLQTLNEEPATPEPEAEPPRAPELKQGLYELSANNFELHVSQGNHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYAVCSEHQVRGYPTLLWFRDGKKVDQYKGKRDLESLRDYVQSQLQGSEAAPETVEPSEAPVMAAEPTGDKGTVLALTEKSFEDTIAQGITFVKFYAPWCGHCKNLAPTWEELSKKEFPGLSDVTIAEVDCTAERNVCSKYSVRGYPTLLLFRGGEKVGEHNGGRDLDSLHSFVLRQAKDEL

Target ORF information:

RefSeq Version	NM_145367.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus thioredoxin domain containing 5 (Txndc5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145367.4

ORF Insert Sequence:

ATGCCCCCGC GCCCAGGACG CCTCCTCCAG CCGCTGGCCG GGCTGCCGGC CCTGGCCACG 
CTCCTGCTGC TGCTCGGGGC GCGCAAAGGC GCCCGGGCCC AGGAGGTGGA AGCGGACAGC 
GGGGTCGAGC AGGACCCGCA CGCCAAGCAC CTGTATACGG CCGACATGTT CACGCACGGG 
ATCCAGAGCG CCGCGCACTT CGTCATGTTC TTCGCGCCCT GGTGTGGACA CTGCCAGCGG 
CTGCAGCCAA CTTGGAATGA CCTGGGAGAC AAGTACAACA GCATGGAGGA TGCCAAGGTC 
TACGTGGCCA AAGTGGACTG CACGGCTGAT TCCGACGTGT GCTCTGCCCA GGGAGTGCGA 
GGATACCCCA CCCTGAAGTT TTTTAAGCCT GGACAAGAAG CAGTGAAGTA CCAGGGTCCT 
AGAGACTTTG AAACACTGGA AAACTGGATG CTGCAGACAC TGAACGAGGA GCCAGCCACA 
CCGGAGCCGG AAGCGGAACC ACCCAGAGCC CCTGAGCTCA AACAGGGGTT GTATGAGCTC 
TCGGCCAACA ACTTTGAGCT GCATGTTTCT CAAGGCAACC ACTTTATCAA GTTCTTCGCT 
CCGTGGTGCG GTCACTGCAA AGCTCTGGCT CCAACCTGGG AGCAGCTGGC TCTGGGCCTT 
GAACATTCTG AAACCGTCAA GATTGGCAAG GTTGACTGCA CGCAGCACTA CGCTGTCTGC 
TCAGAGCATC AGGTCAGAGG CTATCCAACT CTGCTCTGGT TTCGAGATGG CAAGAAGGTG 
GATCAGTACA AGGGAAAGCG GGACTTGGAG TCACTGAGAG ACTATGTGCA GTCCCAGCTG 
CAGGGTTCAG AGGCAGCTCC GGAGACTGTT GAGCCGTCAG AGGCCCCAGT GATGGCTGCT 
GAGCCCACGG GTGACAAGGG CACTGTGCTG GCACTCACCG AGAAGAGCTT CGAGGACACT 
ATTGCACAGG GGATAACCTT CGTCAAGTTC TATGCTCCGT GGTGTGGCCA CTGTAAGAAT 
CTGGCTCCTA CCTGGGAGGA GCTCTCTAAA AAGGAATTCC CAGGCTTGTC AGATGTCACC 
ATCGCAGAAG TGGACTGCAC CGCTGAGCGC AATGTCTGCA GCAAGTACTC GGTACGAGGT 
TATCCCACGT TGCTGCTTTT CCGAGGAGGT GAAAAAGTGG GAGAACACAA CGGAGGTAGA 
GACCTCGACT CCTTACACAG CTTTGTTCTG CGCCAGGCAA AGGATGAACT ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Txndc5 ( NM_001289598.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001276527.1 Mus musculus thioredoxin domain containing 5 (Txndc5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu58009
Clone ID Related Accession (Same CDS sequence)	NM_001289598.1
Accession Version	NM_001289598.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 972bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Mus musculus(house mouse)
Product	thioredoxin domain-containing protein 5 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC154747.2, AK136046.1, AK224956.1 and AY243534.1. Transcript Variant: This variant (2) contains a distinct 5' UTR and represents translation initiation at an in-frame downstream AUG, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK225019.1, AK224956.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164138 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGATG CCAAGGTCTA CGTGGCCAAA GTGGACTGCA CGGCTGATTC CGACGTGTGC 
TCTGCCCAGG GAGTGCGAGG ATACCCCACC CTGAAGTTTT TTAAGCCTGG ACAAGAAGCA 
GTGAAGTACC AGGGTCCTAG AGACTTTGAA ACACTGGAAA ACTGGATGCT GCAGACACTG 
AACGAGGAGC CAGCCACACC GGAGCCGGAA GCGGAACCAC CCAGAGCCCC TGAGCTCAAA 
CAGGGGTTGT ATGAGCTCTC GGCCAACAAC TTTGAGCTGC ATGTTTCTCA AGGCAACCAC 
TTTATCAAGT TCTTCGCTCC GTGGTGCGGT CACTGCAAAG CTCTGGCTCC AACCTGGGAG 
CAGCTGGCTC TGGGCCTTGA ACATTCTGAA ACCGTCAAGA TTGGCAAGGT TGACTGCACG 
CAGCACTACG CTGTCTGCTC AGAGCATCAG GTCAGAGGCT ATCCAACTCT GCTCTGGTTT 
CGAGATGGCA AGAAGGTGGA TCAGTACAAG GGAAAGCGGG ACTTGGAGTC ACTGAGAGAC 
TATGTGCAGT CCCAGCTGCA GGGTTCAGAG GCAGCTCCGG AGACTGTTGA GCCGTCAGAG 
GCCCCAGTGA TGGCTGCTGA GCCCACGGGT GACAAGGGCA CTGTGCTGGC ACTCACCGAG 
AAGAGCTTCG AGGACACTAT TGCACAGGGG ATAACCTTCG TCAAGTTCTA TGCTCCGTGG 
TGTGGCCACT GTAAGAATCT GGCTCCTACC TGGGAGGAGC TCTCTAAAAA GGAATTCCCA 
GGCTTGTCAG ATGTCACCAT CGCAGAAGTG GACTGCACCG CTGAGCGCAA TGTCTGCAGC 
AAGTACTCGG TACGAGGTTA TCCCACGTTG CTGCTTTTCC GAGGAGGTGA AAAAGTGGGA 
GAACACAACG GAGGTAGAGA CCTCGACTCC TTACACAGCT TTGTTCTGCG CCAGGCAAAG 
GATGAACTAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001276527.1
CDS	335..1306
Translation	MEDAKVYVAKVDCTADSDVCSAQGVRGYPTLKFFKPGQEAVKYQGPRDFETLENWMLQTLNEEPATPEPEAEPPRAPELKQGLYELSANNFELHVSQGNHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYAVCSEHQVRGYPTLLWFRDGKKVDQYKGKRDLESLRDYVQSQLQGSEAAPETVEPSEAPVMAAEPTGDKGTVLALTEKSFEDTIAQGITFVKFYAPWCGHCKNLAPTWEELSKKEFPGLSDVTIAEVDCTAERNVCSKYSVRGYPTLLLFRGGEKVGEHNGGRDLDSLHSFVLRQAKDEL

Target ORF information:

RefSeq Version	NM_001289598.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus thioredoxin domain containing 5 (Txndc5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001289598.1

ORF Insert Sequence:

ATGGAGGATG CCAAGGTCTA CGTGGCCAAA GTGGACTGCA CGGCTGATTC CGACGTGTGC 
TCTGCCCAGG GAGTGCGAGG ATACCCCACC CTGAAGTTTT TTAAGCCTGG ACAAGAAGCA 
GTGAAGTACC AGGGTCCTAG AGACTTTGAA ACACTGGAAA ACTGGATGCT GCAGACACTG 
AACGAGGAGC CAGCCACACC GGAGCCGGAA GCGGAACCAC CCAGAGCCCC TGAGCTCAAA 
CAGGGGTTGT ATGAGCTCTC GGCCAACAAC TTTGAGCTGC ATGTTTCTCA AGGCAACCAC 
TTTATCAAGT TCTTCGCTCC GTGGTGCGGT CACTGCAAAG CTCTGGCTCC AACCTGGGAG 
CAGCTGGCTC TGGGCCTTGA ACATTCTGAA ACCGTCAAGA TTGGCAAGGT TGACTGCACG 
CAGCACTACG CTGTCTGCTC AGAGCATCAG GTCAGAGGCT ATCCAACTCT GCTCTGGTTT 
CGAGATGGCA AGAAGGTGGA TCAGTACAAG GGAAAGCGGG ACTTGGAGTC ACTGAGAGAC 
TATGTGCAGT CCCAGCTGCA GGGTTCAGAG GCAGCTCCGG AGACTGTTGA GCCGTCAGAG 
GCCCCAGTGA TGGCTGCTGA GCCCACGGGT GACAAGGGCA CTGTGCTGGC ACTCACCGAG 
AAGAGCTTCG AGGACACTAT TGCACAGGGG ATAACCTTCG TCAAGTTCTA TGCTCCGTGG 
TGTGGCCACT GTAAGAATCT GGCTCCTACC TGGGAGGAGC TCTCTAAAAA GGAATTCCCA 
GGCTTGTCAG ATGTCACCAT CGCAGAAGTG GACTGCACCG CTGAGCGCAA TGTCTGCAGC 
AAGTACTCGG TACGAGGTTA TCCCACGTTG CTGCTTTTCC GAGGAGGTGA AAAAGTGGGA 
GAACACAACG GAGGTAGAGA CCTCGACTCC TTACACAGCT TTGTTCTGCG CCAGGCAAAG 
GATGAACTAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
BMC immunology17(1)25(2016 08)
Liu X,Jiao Y,Cao Y,Deng N,Ma Y,Hasty KA,Kang A,Chen H,Stuart JM,Gu W

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

Investigate pathogenic mechanism of TXNDC5 in rheumatoid arthritis.
PloS one8(1)e53301(2013)
Wang L,Zheng Y,Xu H,Yan X,Chang X

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Txndc5 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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