CD70 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CD70
Entrez Gene ID	970
Full Name	CD70 molecule
Synonyms	CD27-L,CD27L,CD27LG,TNFSF7,TNLG8A
General protein information	Preferred Names CD70 molecule Names CD70 antigen CD27 ligand Ki-24 antigen surface antigen CD70 tumor necrosis factor ligand 8A tumor necrosis factor ligand superfamily member 7
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.3
Summary	The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008].
Disorder MIM:	602840

mRNA and Protein(s)

mRNA	Protein	Name
NM_001330332.2	NP_001317261.1	CD70 antigen isoform 2
NM_001252.5	NP_001243.1	CD70 antigen isoform 1
NM_001330332.1	NP_001317261.1	CD70 antigen isoform 2
NM_001252.4	NP_001243.1	CD70 antigen isoform 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CD70	XP_002688954.3
Mus musculus (house mouse)	Cd70	NP_035747.1
	CD70	XP_001088935.1
Canis lupus familiaris (dog)	CD70	XP_542136.3
Rattus norvegicus (Norway rat)	Cd70	NP_001100348.1
Homo sapiens (human)	CD70	NP_001243.1

Gene Ontology
Bibliography

Related articles in PubMed

CD70, a novel target of CAR T-cell therapy for gliomas.
Jin L, Ge H, Long Y, Yang C, Chang YE, Mu L, Sayour EJ, De Leon G, Wang QJ, Yang JC, Kubilis PS, Bao H, Xia S, Lu D, Kong Y, Hu L, Shang Y, Jiang C, Nie J, Li S, Gu Y, Sun J, Mitchell DA, Lin Z, Huang J
Neuro-oncology20(1)55-65(2018 Jan)

Phase I Dose-Escalation Study of the Anti-CD70 Antibody ARGX-110 in Advanced Malignancies.
Aftimos P, Rolfo C, Rottey S, Offner F, Bron D, Maerevoet M, Soria JC, Moshir M, Dreier T, Van Rompaey L, Michot JM, Silence K, Hultberg A, Gandini D, de Haard H, Ribrag V, Peeters M, Thibault A, Leupin N, Awada A
Clinical cancer research : an official journal of the American Association for Cancer Research23(21)6411-6420(2017 Nov)

Expression of CD70 (CD27L) Is Associated With Epithelioid and Sarcomatous Features in IDH-Wild-Type Glioblastoma.
Pratt D, Pittaluga S, Palisoc M, Fetsch P, Xi L, Raffeld M, Gilbert MR, Quezado M
Journal of neuropathology and experimental neurology76(8)697-708(2017 Aug)

Down-regulation of MBD4 contributes to hypomethylation and overexpression of CD70 in CD4
Liao W, Li M, Wu H, Jia S, Zhang N, Dai Y, Zhao M, Lu Q
Clinical epigenetics9104(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study demonstrated that Expression of CD70 (CD27L) Is Associated With Epithelioid and Sarcomatous Features in IDH-Wild-Type Glioblastoma.
Title: Expression of CD70 (CD27L) Is Associated With Epithelioid and Sarcomatous Features in IDH-Wild-Type Glioblastoma.

CD27 is engaged by CD70 cross-presented by other AML blasts or stem/progenitor cells in a paracrine manner.
Title: CD70/CD27 signaling promotes blast stemness and is a viable therapeutic target in acute myeloid leukemia.

the CD70-CD27 pathway appears to be a crucial component of EBV-specific T cell immunity and more generally for the immune surveillance of B cells and may be a target for immunotherapy of B cell malignancies.
Title: Inherited CD70 deficiency in humans reveals a critical role for the CD70-CD27 pathway in immunity to Epstein-Barr virus infection.

human CD70-CD27 interactions therefore play a nonredundant role in T and B cell-mediated immunity, especially for protection against EBV and humoral immunity.
Title: Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency.

Both monomeric and trimeric forms of CD70 were detected in tumour cell membrane fractions, whereas cytoplasmic fractions contained almost exclusively monomeric CD70
Title: Melanoma-expressed CD70 is involved in invasion and metastasis.

The following CD70 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CD70 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu100630	NM_001330332.2 Latest version!	Homo sapiens CD70 molecule (CD70), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu23687	NM_001252.5 Latest version!	Homo sapiens CD70 molecule (CD70), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu100630	NM_001330332.1	Homo sapiens CD70 molecule (CD70), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu23687	NM_001252.4	Homo sapiens CD70 molecule (CD70), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CD70 ( NM_001330332.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001317261.1 Homo sapiens CD70 molecule (CD70), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu100630
Clone ID Related Accession (Same CDS sequence)	NM_001330332.2 , NM_001330332.1
Accession Version	NM_001330332.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	CD70 antigen isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC008760.7 and AK298467.1. On May 31, 2019 this sequence version replaced NM_001330332.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.346676.1, AK298467.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2152719 [ECO:0000348] ##Evidence-Data-END##

ATGCCGGAGG AGGGTTCGGG CTGCTCGGTG CGGCGCAGGC CCTATGGGTG CGTCCTGCGG 
GCTGCTTTGG TCCCATTGGT CGCGGGCTTG GTGATCTGCC TCGTGGTGTG CATCCAGCGC 
TTCGCACAGG CTCAGCAGCA GCTGCCGCTC GAGTCACTTG GGTGGGACGT AGCTGAGCTG 
CAGCTGAATC ACACAGGACC TCAGCAGGAC CCCAGGCTAT ACTGGCAGGG GGGCCCAGCA 
CTGGGCCGCT CCTTCCTGCA TGGACCAGAG CTGGACAAGG GGCAGCTACG TATCCATCGT 
GATGGCATCT ACATGGTACA CATCCAGGTG ACGCTGGCCA TCTGCTCCTC CACGACGGCC 
TCCAGGCACC ACCCCACCAC CCTGGCCGTG GGAATCTGCT CTCCCGCCTC CCGTAGCATC 
AGCCTGCTGC GTCTCAGCTT CCACCAAGGG CTTTTTGGAT TTTGGAACTG GGGACTCAAA 
GTCAAGTGCT TCTTACGGCA TTTAATATGG ACTGCACACT GTTTTATCCC ATTAACTCAG 
CTCGTGTTCA TGCAAGCCCT ACAAAGCTGG AGGAATCATC ATTGTTCCCA TTTCACAGAT 
GAGGAAAACA GAGGCGTAAA CCGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001317261.1
CDS	149..775
Translation	MPEEGSGCSVRRRPYGCVLRAALVPLVAGLVICLVVCIQRFAQAQQQLPLESLGWDVAELQLNHTGPQQDPRLYWQGGPALGRSFLHGPELDKGQLRIHRDGIYMVHIQVTLAICSSTTASRHHPTTLAVGICSPASRSISLLRLSFHQGLFGFWNWGLKVKCFLRHLIWTAHCFIPLTQLVFMQALQSWRNHHCSHFTDEENRGVNR

Target ORF information:

RefSeq Version	NM_001330332.2
Organism	Homo sapiens(human)
Definition	Homo sapiens CD70 molecule (CD70), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001330332.2

ORF Insert Sequence:

ATGCCGGAGG AGGGTTCGGG CTGCTCGGTG CGGCGCAGGC CCTATGGGTG CGTCCTGCGG 
GCTGCTTTGG TCCCATTGGT CGCGGGCTTG GTGATCTGCC TCGTGGTGTG CATCCAGCGC 
TTCGCACAGG CTCAGCAGCA GCTGCCGCTC GAGTCACTTG GGTGGGACGT AGCTGAGCTG 
CAGCTGAATC ACACAGGACC TCAGCAGGAC CCCAGGCTAT ACTGGCAGGG GGGCCCAGCA 
CTGGGCCGCT CCTTCCTGCA TGGACCAGAG CTGGACAAGG GGCAGCTACG TATCCATCGT 
GATGGCATCT ACATGGTACA CATCCAGGTG ACGCTGGCCA TCTGCTCCTC CACGACGGCC 
TCCAGGCACC ACCCCACCAC CCTGGCCGTG GGAATCTGCT CTCCCGCCTC CCGTAGCATC 
AGCCTGCTGC GTCTCAGCTT CCACCAAGGG CTTTTTGGAT TTTGGAACTG GGGACTCAAA 
GTCAAGTGCT TCTTACGGCA TTTAATATGG ACTGCACACT GTTTTATCCC ATTAACTCAG 
CTCGTGTTCA TGCAAGCCCT ACAAAGCTGG AGGAATCATC ATTGTTCCCA TTTCACAGAT 
GAGGAAAACA GAGGCGTAAA CCGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD70 ( NM_001330332.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001317261.1 Homo sapiens CD70 molecule (CD70), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu100630
Clone ID Related Accession (Same CDS sequence)	NM_001330332.2 , NM_001330332.1
Accession Version	NM_001330332.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-25
Organism	Homo sapiens(human)
Product	CD70 antigen isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC008760.7 and AK298467.1. On Aug 23, 2016 this sequence version replaced XM_017027523.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.346676.1, AK298467.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2152719 [ECO:0000348] ##Evidence-Data-END##

ATGCCGGAGG AGGGTTCGGG CTGCTCGGTG CGGCGCAGGC CCTATGGGTG CGTCCTGCGG 
GCTGCTTTGG TCCCATTGGT CGCGGGCTTG GTGATCTGCC TCGTGGTGTG CATCCAGCGC 
TTCGCACAGG CTCAGCAGCA GCTGCCGCTC GAGTCACTTG GGTGGGACGT AGCTGAGCTG 
CAGCTGAATC ACACAGGACC TCAGCAGGAC CCCAGGCTAT ACTGGCAGGG GGGCCCAGCA 
CTGGGCCGCT CCTTCCTGCA TGGACCAGAG CTGGACAAGG GGCAGCTACG TATCCATCGT 
GATGGCATCT ACATGGTACA CATCCAGGTG ACGCTGGCCA TCTGCTCCTC CACGACGGCC 
TCCAGGCACC ACCCCACCAC CCTGGCCGTG GGAATCTGCT CTCCCGCCTC CCGTAGCATC 
AGCCTGCTGC GTCTCAGCTT CCACCAAGGG CTTTTTGGAT TTTGGAACTG GGGACTCAAA 
GTCAAGTGCT TCTTACGGCA TTTAATATGG ACTGCACACT GTTTTATCCC ATTAACTCAG 
CTCGTGTTCA TGCAAGCCCT ACAAAGCTGG AGGAATCATC ATTGTTCCCA TTTCACAGAT 
GAGGAAAACA GAGGCGTAAA CCGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001317261.1
CDS	151..777
Translation	MPEEGSGCSVRRRPYGCVLRAALVPLVAGLVICLVVCIQRFAQAQQQLPLESLGWDVAELQLNHTGPQQDPRLYWQGGPALGRSFLHGPELDKGQLRIHRDGIYMVHIQVTLAICSSTTASRHHPTTLAVGICSPASRSISLLRLSFHQGLFGFWNWGLKVKCFLRHLIWTAHCFIPLTQLVFMQALQSWRNHHCSHFTDEENRGVNR

Target ORF information:

RefSeq Version	NM_001330332.1
Organism	Homo sapiens(human)
Definition	Homo sapiens CD70 molecule (CD70), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001330332.1

ORF Insert Sequence:

ATGCCGGAGG AGGGTTCGGG CTGCTCGGTG CGGCGCAGGC CCTATGGGTG CGTCCTGCGG 
GCTGCTTTGG TCCCATTGGT CGCGGGCTTG GTGATCTGCC TCGTGGTGTG CATCCAGCGC 
TTCGCACAGG CTCAGCAGCA GCTGCCGCTC GAGTCACTTG GGTGGGACGT AGCTGAGCTG 
CAGCTGAATC ACACAGGACC TCAGCAGGAC CCCAGGCTAT ACTGGCAGGG GGGCCCAGCA 
CTGGGCCGCT CCTTCCTGCA TGGACCAGAG CTGGACAAGG GGCAGCTACG TATCCATCGT 
GATGGCATCT ACATGGTACA CATCCAGGTG ACGCTGGCCA TCTGCTCCTC CACGACGGCC 
TCCAGGCACC ACCCCACCAC CCTGGCCGTG GGAATCTGCT CTCCCGCCTC CCGTAGCATC 
AGCCTGCTGC GTCTCAGCTT CCACCAAGGG CTTTTTGGAT TTTGGAACTG GGGACTCAAA 
GTCAAGTGCT TCTTACGGCA TTTAATATGG ACTGCACACT GTTTTATCCC ATTAACTCAG 
CTCGTGTTCA TGCAAGCCCT ACAAAGCTGG AGGAATCATC ATTGTTCCCA TTTCACAGAT 
GAGGAAAACA GAGGCGTAAA CCGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD70 ( NM_001252.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001243.1 Homo sapiens CD70 molecule (CD70), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23687
Clone ID Related Accession (Same CDS sequence)	NM_001252.5 , NM_001252.4
Accession Version	NM_001252.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	CD70 antigen isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC008760.7 and KC877696.1. On Nov 23, 2018 this sequence version replaced NM_001252.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L08096.1, SRR1163657.324732.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000245903.4/ ENSP00000245903.2 RefSeq Select criteria :: based on expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCGGAGG AGGGTTCGGG CTGCTCGGTG CGGCGCAGGC CCTATGGGTG CGTCCTGCGG 
GCTGCTTTGG TCCCATTGGT CGCGGGCTTG GTGATCTGCC TCGTGGTGTG CATCCAGCGC 
TTCGCACAGG CTCAGCAGCA GCTGCCGCTC GAGTCACTTG GGTGGGACGT AGCTGAGCTG 
CAGCTGAATC ACACAGGACC TCAGCAGGAC CCCAGGCTAT ACTGGCAGGG GGGCCCAGCA 
CTGGGCCGCT CCTTCCTGCA TGGACCAGAG CTGGACAAGG GGCAGCTACG TATCCATCGT 
GATGGCATCT ACATGGTACA CATCCAGGTG ACGCTGGCCA TCTGCTCCTC CACGACGGCC 
TCCAGGCACC ACCCCACCAC CCTGGCCGTG GGAATCTGCT CTCCCGCCTC CCGTAGCATC 
AGCCTGCTGC GTCTCAGCTT CCACCAAGGT TGTACCATTG CCTCCCAGCG CCTGACGCCC 
CTGGCCCGAG GGGACACACT CTGCACCAAC CTCACTGGGA CACTTTTGCC TTCCCGAAAC 
ACTGATGAGA CCTTCTTTGG AGTGCAGTGG GTGCGCCCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001243.1
CDS	149..730
Translation	MPEEGSGCSVRRRPYGCVLRAALVPLVAGLVICLVVCIQRFAQAQQQLPLESLGWDVAELQLNHTGPQQDPRLYWQGGPALGRSFLHGPELDKGQLRIHRDGIYMVHIQVTLAICSSTTASRHHPTTLAVGICSPASRSISLLRLSFHQGCTIASQRLTPLARGDTLCTNLTGTLLPSRNTDETFFGVQWVRP

Target ORF information:

RefSeq Version	NM_001252.5
Organism	Homo sapiens(human)
Definition	Homo sapiens CD70 molecule (CD70), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001252.5

ORF Insert Sequence:

ATGCCGGAGG AGGGTTCGGG CTGCTCGGTG CGGCGCAGGC CCTATGGGTG CGTCCTGCGG 
GCTGCTTTGG TCCCATTGGT CGCGGGCTTG GTGATCTGCC TCGTGGTGTG CATCCAGCGC 
TTCGCACAGG CTCAGCAGCA GCTGCCGCTC GAGTCACTTG GGTGGGACGT AGCTGAGCTG 
CAGCTGAATC ACACAGGACC TCAGCAGGAC CCCAGGCTAT ACTGGCAGGG GGGCCCAGCA 
CTGGGCCGCT CCTTCCTGCA TGGACCAGAG CTGGACAAGG GGCAGCTACG TATCCATCGT 
GATGGCATCT ACATGGTACA CATCCAGGTG ACGCTGGCCA TCTGCTCCTC CACGACGGCC 
TCCAGGCACC ACCCCACCAC CCTGGCCGTG GGAATCTGCT CTCCCGCCTC CCGTAGCATC 
AGCCTGCTGC GTCTCAGCTT CCACCAAGGT TGTACCATTG CCTCCCAGCG CCTGACGCCC 
CTGGCCCGAG GGGACACACT CTGCACCAAC CTCACTGGGA CACTTTTGCC TTCCCGAAAC 
ACTGATGAGA CCTTCTTTGG AGTGCAGTGG GTGCGCCCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD70 ( NM_001252.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001243.1 Homo sapiens CD70 molecule (CD70), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23687
Clone ID Related Accession (Same CDS sequence)	NM_001252.5 , NM_001252.4
Accession Version	NM_001252.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	CD70 antigen isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC008760.7 and KC877696.1. On Jan 17, 2014 this sequence version replaced NM_001252.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L08096.1, SRR1163657.324732.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGGAGG AGGGTTCGGG CTGCTCGGTG CGGCGCAGGC CCTATGGGTG CGTCCTGCGG 
GCTGCTTTGG TCCCATTGGT CGCGGGCTTG GTGATCTGCC TCGTGGTGTG CATCCAGCGC 
TTCGCACAGG CTCAGCAGCA GCTGCCGCTC GAGTCACTTG GGTGGGACGT AGCTGAGCTG 
CAGCTGAATC ACACAGGACC TCAGCAGGAC CCCAGGCTAT ACTGGCAGGG GGGCCCAGCA 
CTGGGCCGCT CCTTCCTGCA TGGACCAGAG CTGGACAAGG GGCAGCTACG TATCCATCGT 
GATGGCATCT ACATGGTACA CATCCAGGTG ACGCTGGCCA TCTGCTCCTC CACGACGGCC 
TCCAGGCACC ACCCCACCAC CCTGGCCGTG GGAATCTGCT CTCCCGCCTC CCGTAGCATC 
AGCCTGCTGC GTCTCAGCTT CCACCAAGGT TGTACCATTG CCTCCCAGCG CCTGACGCCC 
CTGGCCCGAG GGGACACACT CTGCACCAAC CTCACTGGGA CACTTTTGCC TTCCCGAAAC 
ACTGATGAGA CCTTCTTTGG AGTGCAGTGG GTGCGCCCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001243.1
CDS	151..732
Translation	MPEEGSGCSVRRRPYGCVLRAALVPLVAGLVICLVVCIQRFAQAQQQLPLESLGWDVAELQLNHTGPQQDPRLYWQGGPALGRSFLHGPELDKGQLRIHRDGIYMVHIQVTLAICSSTTASRHHPTTLAVGICSPASRSISLLRLSFHQGCTIASQRLTPLARGDTLCTNLTGTLLPSRNTDETFFGVQWVRP

Target ORF information:

RefSeq Version	NM_001252.4
Organism	Homo sapiens(human)
Definition	Homo sapiens CD70 molecule (CD70), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001252.4

ORF Insert Sequence:

ATGCCGGAGG AGGGTTCGGG CTGCTCGGTG CGGCGCAGGC CCTATGGGTG CGTCCTGCGG 
GCTGCTTTGG TCCCATTGGT CGCGGGCTTG GTGATCTGCC TCGTGGTGTG CATCCAGCGC 
TTCGCACAGG CTCAGCAGCA GCTGCCGCTC GAGTCACTTG GGTGGGACGT AGCTGAGCTG 
CAGCTGAATC ACACAGGACC TCAGCAGGAC CCCAGGCTAT ACTGGCAGGG GGGCCCAGCA 
CTGGGCCGCT CCTTCCTGCA TGGACCAGAG CTGGACAAGG GGCAGCTACG TATCCATCGT 
GATGGCATCT ACATGGTACA CATCCAGGTG ACGCTGGCCA TCTGCTCCTC CACGACGGCC 
TCCAGGCACC ACCCCACCAC CCTGGCCGTG GGAATCTGCT CTCCCGCCTC CCGTAGCATC 
AGCCTGCTGC GTCTCAGCTT CCACCAAGGT TGTACCATTG CCTCCCAGCG CCTGACGCCC 
CTGGCCCGAG GGGACACACT CTGCACCAAC CTCACTGGGA CACTTTTGCC TTCCCGAAAC 
ACTGATGAGA CCTTCTTTGG AGTGCAGTGG GTGCGCCCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CD70, a novel target of CAR T-cell therapy for gliomas.
Neuro-oncology20(1)55-65(2018 Jan)
Jin L,Ge H,Long Y,Yang C,Chang YE,Mu L,Sayour EJ,De Leon G,Wang QJ,Yang JC,Kubilis PS,Bao H,Xia S,Lu D,Kong Y,Hu L,Shang Y,Jiang C,Nie J,Li S,Gu Y,Sun J,Mitchell DA,Lin Z,Huang J

Phase I Dose-Escalation Study of the Anti-CD70 Antibody ARGX-110 in Advanced Malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research23(21)6411-6420(2017 Nov)
Aftimos P,Rolfo C,Rottey S,Offner F,Bron D,Maerevoet M,Soria JC,Moshir M,Dreier T,Van Rompaey L,Michot JM,Silence K,Hultberg A,Gandini D,de Haard H,Ribrag V,Peeters M,Thibault A,Leupin N,Awada A

Expression of CD70 (CD27L) Is Associated With Epithelioid and Sarcomatous Features in IDH-Wild-Type Glioblastoma.
Journal of neuropathology and experimental neurology76(8)697-708(2017 Aug)
Pratt D,Pittaluga S,Palisoc M,Fetsch P,Xi L,Raffeld M,Gilbert MR,Quezado M

Down-regulation of MBD4 contributes to hypomethylation and overexpression of CD70 in CD4
Clinical epigenetics9104(2017)
Liao W,Li M,Wu H,Jia S,Zhang N,Dai Y,Zhao M,Lu Q

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CD70 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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