FTMT cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FTMT
Entrez Gene ID	94033
Full Name	ferritin mitochondrial
Synonyms	MTF
General protein information	Preferred Names ferritin mitochondrial Names ferritin, mitochondrial ferritin H subunit mitochondrial ferritin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q23.1
Disorder MIM:	608847

mRNA and Protein(s)

mRNA	Protein	Name
NM_177478.1	NP_803431.1	ferritin, mitochondrial precursor
NM_177478.2	NP_803431.1	ferritin, mitochondrial precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	FTMT	XP_526991.2
Danio rerio (zebrafish)	zgc:173593	XP_005164115.1
Danio rerio (zebrafish)	zgc:198419	NP_001107131.1
Canis lupus familiaris (dog)	LOC608550	XP_003431636.2
Bos taurus (cattle)	FTMT	NP_001069658.1
Rattus norvegicus (Norway rat)	Ftmt	NP_001099606.1
Danio rerio (zebrafish)	LOC100006428	XP_001921731.1
Homo sapiens (human)	FTMT	NP_803431.1
Canis lupus familiaris (dog)	LOC481426	XP_003431602.2
Mus musculus (house mouse)	Ftmt	NP_080562.2
Danio rerio (zebrafish)	zgc:173594	NP_001103324.1
Danio rerio (zebrafish)	LOC558816	XP_687175.1
Danio rerio (zebrafish)	zgc:109934	NP_001018367.1
	FTMT	XP_001088733.1
Danio rerio (zebrafish)	zgc:92066	NP_001002378.1
Danio rerio (zebrafish)	zgc:194125	NP_001124139.1
Drosophila melanogaster (fruit fly)	Fer3HCH	NP_572854.1

Gene Ontology
Bibliography

Related articles in PubMed

Mitochondrial ferritin affects mitochondria by stabilizing HIF-1? in retinal pigment epithelium: implications for the pathophysiology of age-related macular degeneration.
Wang X, Yang H, Yanagisawa D, Bellier JP, Morino K, Zhao S, Liu P, Vigers P, Tooyama I
Neurobiology of aging47168-179(2016 Nov)

Characterization of human mitochondrial ferritin promoter: identification of transcription factors and evidences of epigenetic control.
Guaraldo M, Santambrogio P, Rovelli E, Di Savino A, Saglio G, Cittaro D, Roetto A, Levi S
Scientific reports633432(2016 Sep)

Mapping of mitochondrial ferritin in the brainstem of Macaca fascicularis.
Yang M, Yang H, Guan H, Bellier JP, Zhao S, Tooyama I
Neuroscience32892-106(2016 07)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Age-related increase is found in FtMt and hypoxia-inducible factor-1a (HIF-1a) in murine retinal pigment epithelium (RPE).HIF-1alpha stabilization reduced the protein level of the mature, functional form of mitochondrial ferritin.
Title: Mitochondrial ferritin affects mitochondria by stabilizing HIF-1? in retinal pigment epithelium: implications for the pathophysiology of age-related macular degeneration.

Study characterized a new human FtMt antibody, and with it created the first map of FtMt immunoreactivity in a monkey brainstem. This showed the widespread distribution of FtMt in various brainstem regions and co-localization with catecholaminergic neurons.
Title: Mapping of mitochondrial ferritin in the brainstem of Macaca fascicularis.

experimental overexpression of FTMT may modify mitochondrial iron availability and lead to ineffective erythropoiesis
Title: Effects of mitochondrial ferritin overexpression in normal and sideroblastic erythroid progenitors.

FtMt mutation may determine a condition similar to haploinsufficiency resulting in a reduced protection from iron-dependent oxidative stress in mitochondria
Title: Study of FTMT and ABCA4 genes in a patient affected by age-related macular degeneration: identification and analysis of new mutations.

MtF is involved in the pathology of Alzheimer's disease and may play a neuroprotective role against oxidative stress
Title: Expression and localization of mitochondrial ferritin mRNA in Alzheimer's disease cerebral cortex.

The following FTMT gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FTMT cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu55907	NM_177478.2 Latest version!	Homo sapiens ferritin mitochondrial (FTMT), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu55907	NM_177478.1	Homo sapiens ferritin mitochondrial (FTMT), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FTMT ( NM_177478.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_803431.1 Homo sapiens ferritin mitochondrial (FTMT), mRNA.

Price & Availability↑

CloneID	OHu55907
Clone ID Related Accession (Same CDS sequence)	NM_177478.1 , NM_177478.2
Accession Version	NM_177478.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 729bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-22
Organism	Homo sapiens(human)
Product	ferritin, mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC034419.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC034419.1, ERR279838.7296.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGCTGTCCT GCTTCAGGCT CCTCTCCAGG CACATCAGCC CTTCGCTGGC GTCTCTGCGC 
CCGGTGCGCT GCTGCTTCGC GCTCCCGCTG CGTTGGGCCC CGGGGCGCCC CTTGGACCCC 
AGGCAGATCG CCCCCCGCCG CCCCCTGGCC GCAGCCGCCT CCTCCCGGGA CCCTACCGGG 
CCCGCCGCCG GCCCCTCTCG GGTGCGCCAG AACTTCCACC CCGACTCCGA GGCTGCCATC 
AACCGCCAGA TCAACCTCGA GCTCTATGCG TCCTACGTGT ACTTGTCCAT GGCCTATTAC 
TTCTCCCGGG ATGACGTGGC CTTGAACAAC TTCTCCAGGT ATTTCCTTCA CCAGTCCCGG 
GAGGAGACCG AGCACGCGGA GAAGCTGATG AGGCTGCAGA ACCAGCGAGG AGGCCGGATC 
CGCCTGCAGG ACATCAAGAA GCCGGAACAG GACGACTGGG AAAGCGGGCT GCATGCCATG 
GAGTGTGCTC TACTCTTGGA AAAGAACGTG AACCAGTCGT TGCTGGAATT GCACGCTCTA 
GCCTCAGATA AAGGTGACCC CCATTTGTGC GATTTCCTGG AAACCTACTA CCTGAATGAG 
CAGGTGAAGT CTATCAAAGA ACTAGGTGAC CACGTGCACA ACTTAGTGAA GATGGGGGCC 
CCGGATGCTG GCCTGGCGGA GTACCTTTTT GACACACATA CCCTTGGAAA TGAAAACAAG 
CAGAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_803431.1
CDS	10..738
Translation	MLSCFRLLSRHISPSLASLRPVRCCFALPLRWAPGRPLDPRQIAPRRPLAAAASSRDPTGPAAGPSRVRQNFHPDSEAAINRQINLELYASYVYLSMAYYFSRDDVALNNFSRYFLHQSREETEHAEKLMRLQNQRGGRIRLQDIKKPEQDDWESGLHAMECALLLEKNVNQSLLELHALASDKGDPHLCDFLETYYLNEQVKSIKELGDHVHNLVKMGAPDAGLAEYLFDTHTLGNENKQN

Target ORF information:

RefSeq Version	NM_177478.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ferritin mitochondrial (FTMT), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177478.1

ORF Insert Sequence:

ATGCTGTCCT GCTTCAGGCT CCTCTCCAGG CACATCAGCC CTTCGCTGGC GTCTCTGCGC 
CCGGTGCGCT GCTGCTTCGC GCTCCCGCTG CGTTGGGCCC CGGGGCGCCC CTTGGACCCC 
AGGCAGATCG CCCCCCGCCG CCCCCTGGCC GCAGCCGCCT CCTCCCGGGA CCCTACCGGG 
CCCGCCGCCG GCCCCTCTCG GGTGCGCCAG AACTTCCACC CCGACTCCGA GGCTGCCATC 
AACCGCCAGA TCAACCTCGA GCTCTATGCG TCCTACGTGT ACTTGTCCAT GGCCTATTAC 
TTCTCCCGGG ATGACGTGGC CTTGAACAAC TTCTCCAGGT ATTTCCTTCA CCAGTCCCGG 
GAGGAGACCG AGCACGCGGA GAAGCTGATG AGGCTGCAGA ACCAGCGAGG AGGCCGGATC 
CGCCTGCAGG ACATCAAGAA GCCGGAACAG GACGACTGGG AAAGCGGGCT GCATGCCATG 
GAGTGTGCTC TACTCTTGGA AAAGAACGTG AACCAGTCGT TGCTGGAATT GCACGCTCTA 
GCCTCAGATA AAGGTGACCC CCATTTGTGC GATTTCCTGG AAACCTACTA CCTGAATGAG 
CAGGTGAAGT CTATCAAAGA ACTAGGTGAC CACGTGCACA ACTTAGTGAA GATGGGGGCC 
CCGGATGCTG GCCTGGCGGA GTACCTTTTT GACACACATA CCCTTGGAAA TGAAAACAAG 
CAGAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FTMT ( NM_177478.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_803431.1 Homo sapiens ferritin mitochondrial (FTMT), mRNA.

Price & Availability↑

CloneID	OHu55907
Clone ID Related Accession (Same CDS sequence)	NM_177478.1 , NM_177478.2
Accession Version	NM_177478.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 729bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	ferritin, mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC117523.2 and BC034419.1. On Nov 23, 2018 this sequence version replaced NM_177478.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC034419.1, ERR279838.7296.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000321339.3/ ENSP00000313691.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGTCCT GCTTCAGGCT CCTCTCCAGG CACATCAGCC CTTCGCTGGC GTCTCTGCGC 
CCGGTGCGCT GCTGCTTCGC GCTCCCGCTG CGTTGGGCCC CGGGGCGCCC CTTGGACCCC 
AGGCAGATCG CCCCCCGCCG CCCCCTGGCC GCAGCCGCCT CCTCCCGGGA CCCTACCGGG 
CCCGCCGCCG GCCCCTCTCG GGTGCGCCAG AACTTCCACC CCGACTCCGA GGCTGCCATC 
AACCGCCAGA TCAACCTCGA GCTCTATGCG TCCTACGTGT ACTTGTCCAT GGCCTATTAC 
TTCTCCCGGG ATGACGTGGC CTTGAACAAC TTCTCCAGGT ATTTCCTTCA CCAGTCCCGG 
GAGGAGACCG AGCACGCGGA GAAGCTGATG AGGCTGCAGA ACCAGCGAGG AGGCCGGATC 
CGCCTGCAGG ACATCAAGAA GCCGGAACAG GACGACTGGG AAAGCGGGCT GCATGCCATG 
GAGTGTGCTC TACTCTTGGA AAAGAACGTG AACCAGTCGT TGCTGGAATT GCACGCTCTA 
GCCTCAGATA AAGGTGACCC CCATTTGTGC GATTTCCTGG AAACCTACTA CCTGAATGAG 
CAGGTGAAGT CTATCAAAGA ACTAGGTGAC CACGTGCACA ACTTAGTGAA GATGGGGGCC 
CCGGATGCTG GCCTGGCGGA GTACCTTTTT GACACACATA CCCTTGGAAA TGAAAACAAG 
CAGAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_803431.1
CDS	83..811
Translation	MLSCFRLLSRHISPSLASLRPVRCCFALPLRWAPGRPLDPRQIAPRRPLAAAASSRDPTGPAAGPSRVRQNFHPDSEAAINRQINLELYASYVYLSMAYYFSRDDVALNNFSRYFLHQSREETEHAEKLMRLQNQRGGRIRLQDIKKPEQDDWESGLHAMECALLLEKNVNQSLLELHALASDKGDPHLCDFLETYYLNEQVKSIKELGDHVHNLVKMGAPDAGLAEYLFDTHTLGNENKQN

Target ORF information:

RefSeq Version	NM_177478.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ferritin mitochondrial (FTMT), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177478.2

ORF Insert Sequence:

ATGCTGTCCT GCTTCAGGCT CCTCTCCAGG CACATCAGCC CTTCGCTGGC GTCTCTGCGC 
CCGGTGCGCT GCTGCTTCGC GCTCCCGCTG CGTTGGGCCC CGGGGCGCCC CTTGGACCCC 
AGGCAGATCG CCCCCCGCCG CCCCCTGGCC GCAGCCGCCT CCTCCCGGGA CCCTACCGGG 
CCCGCCGCCG GCCCCTCTCG GGTGCGCCAG AACTTCCACC CCGACTCCGA GGCTGCCATC 
AACCGCCAGA TCAACCTCGA GCTCTATGCG TCCTACGTGT ACTTGTCCAT GGCCTATTAC 
TTCTCCCGGG ATGACGTGGC CTTGAACAAC TTCTCCAGGT ATTTCCTTCA CCAGTCCCGG 
GAGGAGACCG AGCACGCGGA GAAGCTGATG AGGCTGCAGA ACCAGCGAGG AGGCCGGATC 
CGCCTGCAGG ACATCAAGAA GCCGGAACAG GACGACTGGG AAAGCGGGCT GCATGCCATG 
GAGTGTGCTC TACTCTTGGA AAAGAACGTG AACCAGTCGT TGCTGGAATT GCACGCTCTA 
GCCTCAGATA AAGGTGACCC CCATTTGTGC GATTTCCTGG AAACCTACTA CCTGAATGAG 
CAGGTGAAGT CTATCAAAGA ACTAGGTGAC CACGTGCACA ACTTAGTGAA GATGGGGGCC 
CCGGATGCTG GCCTGGCGGA GTACCTTTTT GACACACATA CCCTTGGAAA TGAAAACAAG 
CAGAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mitochondrial ferritin affects mitochondria by stabilizing HIF-1? in retinal pigment epithelium: implications for the pathophysiology of age-related macular degeneration.
Neurobiology of aging47168-179(2016 Nov)
Wang X,Yang H,Yanagisawa D,Bellier JP,Morino K,Zhao S,Liu P,Vigers P,Tooyama I

Characterization of human mitochondrial ferritin promoter: identification of transcription factors and evidences of epigenetic control.
Scientific reports633432(2016 Sep)
Guaraldo M,Santambrogio P,Rovelli E,Di Savino A,Saglio G,Cittaro D,Roetto A,Levi S

Mapping of mitochondrial ferritin in the brainstem of Macaca fascicularis.
Neuroscience32892-106(2016 07)
Yang M,Yang H,Guan H,Bellier JP,Zhao S,Tooyama I