DEPDC7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DEPDC7
Entrez Gene ID	91614
Full Name	DEP domain containing 7
Synonyms	TR2,dJ85M6.4
General protein information	Preferred Names DEP domain containing 7 Names DEP domain-containing protein 7 dJ85M6.4 (novel 58.3 KDA protein) novel 58.3 KDA protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p13
Disorder MIM:	612294

mRNA and Protein(s)

mRNA	Protein	Name
NM_001077242.2	NP_001070710.1	DEP domain-containing protein 7 isoform 1
NM_139160.2	NP_631899.2	DEP domain-containing protein 7 isoform 2
NM_001077242.1	NP_001070710.1	DEP domain-containing protein 7 isoform 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	DEPDC7	NP_001070710.1
Pan troglodytes (chimpanzee)	DEPDC7	XP_001143476.1
Bos taurus (cattle)	DEPDC7	NP_001179659.1
Xenopus tropicalis (tropical clawed frog)	depdc7	NP_001072183.1
Canis lupus familiaris (dog)	DEPDC7	XP_540553.3
Mus musculus (house mouse)	Depdc7	NP_659053.1
Rattus norvegicus (Norway rat)	Depdc7	NP_001025087.1
Danio rerio (zebrafish)	depdc7	NP_001038734.1
Gallus gallus (chicken)	DEPDC7	NP_001186335.1

Gene Ontology
Bibliography

Related articles in PubMed

DEPDC7 inhibits cell proliferation, migration and invasion in hepatoma cells.
Liao Z, Wang X, Wang X, Li L, Lin D
Oncology letters14(6)7332-7338(2017 Dec)

Construction and Identification of the RNAi Recombinant Lentiviral Vector Targeting Human DEPDC7 Gene.
Liao Z, Wang X, Lin D, Zou Q
Interdisciplinary sciences, computational life sciences9(3)350-356(2017 Sep)

Further evidence of DEPDC7 DNA hypomethylation in depression: A study in adult twins.
C?rdova-Palomera A, Fatj?-Vilas M, Palma-Gudiel H, Blasco-Fontecilla H, Kebir O, Fa?an?s L
European psychiatry : the journal of the Association of European Psychiatrists30(6)715-8(2015 Sep)

The Dishevelled, EGL-10 and pleckstrin (DEP) domain-containing protein DEPDC7 binds to CARMA2 and CARMA3 proteins, and regulates NF-?B activation.
D'Andrea EL, Ferravante A, Scudiero I, Zotti T, Reale C, Pizzulo M, De La Motte LR, De Maio C, Mazzone P, Telesio G, Vito P, Stilo R
PloS one9(12)e116062(2014)

A 7.5 Mb sequence-ready PAC contig and gene expression map of human chromosome 11p13-p14.1.
Gawin B, Niederf?hr A, Schumacher N, Hummerich H, Little PF, Gessler M
Genome research9(11)1074-86(1999 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

DEPDC7 hypomethylation in peripheral blood DNA may be associated with recent depressive symptomatology.
Title: Further evidence of DEPDC7 DNA hypomethylation in depression: A study in adult twins.

The study identified the DEP domain-containing protein DEPDC7 as cellular binding partner of CARMA2 and CARMA3 proteins.
Title: The Dishevelled, EGL-10 and pleckstrin (DEP) domain-containing protein DEPDC7 binds to CARMA2 and CARMA3 proteins, and regulates NF-?B activation.

The following DEPDC7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DEPDC7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30297	NM_001077242.2 Latest version!	Homo sapiens DEP domain containing 7 (DEPDC7), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu30392	NM_139160.2 Latest version!	Homo sapiens DEP domain containing 7 (DEPDC7), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$293.30 $419.00
View Old Accession Versions >>
OHu30297	NM_001077242.1	Homo sapiens DEP domain containing 7 (DEPDC7), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DEPDC7 ( NM_001077242.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001070710.1 Homo sapiens DEP domain containing 7 (DEPDC7), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu30297
Clone ID Related Accession (Same CDS sequence)	NM_001077242.2 , NM_001077242.1
Accession Version	NM_001077242.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1536bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-30
Organism	Homo sapiens(human)
Product	DEP domain-containing protein 7 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC030970.1 and AJ245600.1. On Nov 22, 2018 this sequence version replaced NM_001077242.1. Transcript Variant: This variant (1) represents the more frequently occurring transcript and it encodes the longer protein (isoform 1). ##Evidence-Data-START## Transcript exon combination :: SRR5189667.391689.1, BC030970.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000241051.8/ ENSP00000241051.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCACCG TGCAGGAGAA GGCTGCTGCG CTGAACCTCT CGGCTCTCCA CAGCCCCGCG 
CACAGGCCTC CGGGTTTCAG TGTAGCTCAG AAGCCATTTG GAGCCACGTA TGTATGGAGC 
AGCATCATAA ACACTCTTCA AACACAAGTG GAAGTGAAAA AACGAAGGCA CCGTTTAAAA 
CGACATAATG ACTGCTTTGT TGGTTCAGAA GCTGTGGATG TCATTTTTTC TCACCTAATT 
CAGAATAAGT ATTTTGGTGA TGTAGATATT CCTCGAGCCA AAGTGGTGAG AGTGTGTCAA 
GCGCTTATGG ACTACAAAGT ATTTGAAGCA GTTCCAACCA AAGTCTTTGG AAAAGACAAA 
AAACCTACAT TTGAAGATAG TAGTTGCAGC CTTTATAGAT TCACCACAAT ACCTAACCAA 
GACAGTCAGT TAGGCAAAGA GAACAAACTA TATTCACCTG CCAGGTATGC AGATGCATTA 
TTTAAGTCAT CCGATATCAG ATCAGCCAGT TTAGAGGACC TGTGGGAAAA TCTGAGTTTA 
AAGCCTGCCA ACTCCCCTCA TGTAAATATC TCTGCAACCT TGTCTCCACA AGTTATTAAT 
GAAGTGTGGC AAGAAGAAAC AATTGGGCGT CTACTACAAC TTGTAGACCT TCCACTTCTT 
GACTCCTTAC TGAAACAGCA AGAGGCTGTA CCTAAAATTC CTCAACCTAA GAGGCAGTCC 
ACCATGGTCA ACAGCAGTAA CTATCTGGAT CGAGGGATTC TCAAGGCTTA TAGTGACTCT 
CAGGAAGATG AGTGGCTCTC GGCAGCAATT GACTGTTTAG AATACCTTCC AGACCAAATG 
GTGGTGGAAA TAAGCAGAAG CTTTCCTGAG CAACCAGACC GAACAGACTT AGTGAAAGAA 
CTTCTGTTTG ATGCCATTGG CAGATATTAC AGTAGTAGGG AACCTCTGTT AAATCACTTA 
TCTGACGTTC ATAATGGAAT TGCAGAACTC TTAGTGAATG GGAAGACGGA AATAGCTTTA 
GAAGCTACCC AGCTCCTTCT AAAGCTTTTA GATTTCCAAA ATAGAGAAGA ATTTAGAAGA 
CTACTGTATT TCATGGCTGT TGCAGCAAAT CCTTCTGAGT TTAAATTACA GAAAGAAAGT 
GACAACCGAA TGGTTGTGAA AAGGATATTC TCAAAAGCTA TTGTTGACAA TAAAAATTTA 
TCCAAAGGCA AAACAGATCT TCTGGTACTC TTTTTAATGG ATCATCAGAA AGATGTTTTT 
AAGATTCCTG GAACTCTACA TAAAATTGTA AGTGTTAAGC TTATGGCCAT ACAGAACGGA 
AGAGATCCAA ATAGAGATGC AGGATATATT TATTGCCAGA GAATTGATCA ACGTGACTAT 
TCCAACAATA CAGAGAAGAC AACCAAAGAT GAGCTGTTGA ATTTACTAAA AACTCTTGAT 
GAGGATTCAA AACTTTCTGC CAAAGAGAAG AAAAAATTGC TAGGTCAATT CTATAAGTGT 
CACCCAGACA TCTTTATTGA GCATTTTGGA GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001070710.1
CDS	79..1614
Translation	MATVQEKAAALNLSALHSPAHRPPGFSVAQKPFGATYVWSSIINTLQTQVEVKKRRHRLKRHNDCFVGSEAVDVIFSHLIQNKYFGDVDIPRAKVVRVCQALMDYKVFEAVPTKVFGKDKKPTFEDSSCSLYRFTTIPNQDSQLGKENKLYSPARYADALFKSSDIRSASLEDLWENLSLKPANSPHVNISATLSPQVINEVWQEETIGRLLQLVDLPLLDSLLKQQEAVPKIPQPKRQSTMVNSSNYLDRGILKAYSDSQEDEWLSAAIDCLEYLPDQMVVEISRSFPEQPDRTDLVKELLFDAIGRYYSSREPLLNHLSDVHNGIAELLVNGKTEIALEATQLLLKLLDFQNREEFRRLLYFMAVAANPSEFKLQKESDNRMVVKRIFSKAIVDNKNLSKGKTDLLVLFLMDHQKDVFKIPGTLHKIVSVKLMAIQNGRDPNRDAGYIYCQRIDQRDYSNNTEKTTKDELLNLLKTLDEDSKLSAKEKKKLLGQFYKCHPDIFIEHFGD

Target ORF information:

RefSeq Version	NM_001077242.2
Organism	Homo sapiens(human)
Definition	Homo sapiens DEP domain containing 7 (DEPDC7), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001077242.2

ORF Insert Sequence:

ATGGCCACCG TGCAGGAGAA GGCTGCTGCG CTGAACCTCT CGGCTCTCCA CAGCCCCGCG 
CACAGGCCTC CGGGTTTCAG TGTAGCTCAG AAGCCATTTG GAGCCACGTA TGTATGGAGC 
AGCATCATAA ACACTCTTCA AACACAAGTG GAAGTGAAAA AACGAAGGCA CCGTTTAAAA 
CGACATAATG ACTGCTTTGT TGGTTCAGAA GCTGTGGATG TCATTTTTTC TCACCTAATT 
CAGAATAAGT ATTTTGGTGA TGTAGATATT CCTCGAGCCA AAGTGGTGAG AGTGTGTCAA 
GCGCTTATGG ACTACAAAGT ATTTGAAGCA GTTCCAACCA AAGTCTTTGG AAAAGACAAA 
AAACCTACAT TTGAAGATAG TAGTTGCAGC CTTTATAGAT TCACCACAAT ACCTAACCAA 
GACAGTCAGT TAGGCAAAGA GAACAAACTA TATTCACCTG CCAGGTATGC AGATGCATTA 
TTTAAGTCAT CCGATATCAG ATCAGCCAGT TTAGAGGACC TGTGGGAAAA TCTGAGTTTA 
AAGCCTGCCA ACTCCCCTCA TGTAAATATC TCTGCAACCT TGTCTCCACA AGTTATTAAT 
GAAGTGTGGC AAGAAGAAAC AATTGGGCGT CTACTACAAC TTGTAGACCT TCCACTTCTT 
GACTCCTTAC TGAAACAGCA AGAGGCTGTA CCTAAAATTC CTCAACCTAA GAGGCAGTCC 
ACCATGGTCA ACAGCAGTAA CTATCTGGAT CGAGGGATTC TCAAGGCTTA TAGTGACTCT 
CAGGAAGATG AGTGGCTCTC GGCAGCAATT GACTGTTTAG AATACCTTCC AGACCAAATG 
GTGGTGGAAA TAAGCAGAAG CTTTCCTGAG CAACCAGACC GAACAGACTT AGTGAAAGAA 
CTTCTGTTTG ATGCCATTGG CAGATATTAC AGTAGTAGGG AACCTCTGTT AAATCACTTA 
TCTGACGTTC ATAATGGAAT TGCAGAACTC TTAGTGAATG GGAAGACGGA AATAGCTTTA 
GAAGCTACCC AGCTCCTTCT AAAGCTTTTA GATTTCCAAA ATAGAGAAGA ATTTAGAAGA 
CTACTGTATT TCATGGCTGT TGCAGCAAAT CCTTCTGAGT TTAAATTACA GAAAGAAAGT 
GACAACCGAA TGGTTGTGAA AAGGATATTC TCAAAAGCTA TTGTTGACAA TAAAAATTTA 
TCCAAAGGCA AAACAGATCT TCTGGTACTC TTTTTAATGG ATCATCAGAA AGATGTTTTT 
AAGATTCCTG GAACTCTACA TAAAATTGTA AGTGTTAAGC TTATGGCCAT ACAGAACGGA 
AGAGATCCAA ATAGAGATGC AGGATATATT TATTGCCAGA GAATTGATCA ACGTGACTAT 
TCCAACAATA CAGAGAAGAC AACCAAAGAT GAGCTGTTGA ATTTACTAAA AACTCTTGAT 
GAGGATTCAA AACTTTCTGC CAAAGAGAAG AAAAAATTGC TAGGTCAATT CTATAAGTGT 
CACCCAGACA TCTTTATTGA GCATTTTGGA GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DEPDC7 ( NM_001077242.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001070710.1 Homo sapiens DEP domain containing 7 (DEPDC7), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu30297
Clone ID Related Accession (Same CDS sequence)	NM_001077242.2 , NM_001077242.1
Accession Version	NM_001077242.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1536bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	DEP domain-containing protein 7 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC030970.1 and AJ245600.1. Transcript Variant: This variant (1) represents the more frequently occurring transcript and it encodes the longer protein (isoform 1). ##Evidence-Data-START## Transcript exon combination :: BC030970.1, SRR1803614.205902.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCACCG TGCAGGAGAA GGCTGCTGCG CTGAACCTCT CGGCTCTCCA CAGCCCCGCG 
CACAGGCCTC CGGGTTTCAG TGTAGCTCAG AAGCCATTTG GAGCCACGTA TGTATGGAGC 
AGCATCATAA ACACTCTTCA AACACAAGTG GAAGTGAAAA AACGAAGGCA CCGTTTAAAA 
CGACATAATG ACTGCTTTGT TGGTTCAGAA GCTGTGGATG TCATTTTTTC TCACCTAATT 
CAGAATAAGT ATTTTGGTGA TGTAGATATT CCTCGAGCCA AAGTGGTGAG AGTGTGTCAA 
GCGCTTATGG ACTACAAAGT ATTTGAAGCA GTTCCAACCA AAGTCTTTGG AAAAGACAAA 
AAACCTACAT TTGAAGATAG TAGTTGCAGC CTTTATAGAT TCACCACAAT ACCTAACCAA 
GACAGTCAGT TAGGCAAAGA GAACAAACTA TATTCACCTG CCAGGTATGC AGATGCATTA 
TTTAAGTCAT CCGATATCAG ATCAGCCAGT TTAGAGGACC TGTGGGAAAA TCTGAGTTTA 
AAGCCTGCCA ACTCCCCTCA TGTAAATATC TCTGCAACCT TGTCTCCACA AGTTATTAAT 
GAAGTGTGGC AAGAAGAAAC AATTGGGCGT CTACTACAAC TTGTAGACCT TCCACTTCTT 
GACTCCTTAC TGAAACAGCA AGAGGCTGTA CCTAAAATTC CTCAACCTAA GAGGCAGTCC 
ACCATGGTCA ACAGCAGTAA CTATCTGGAT CGAGGGATTC TCAAGGCTTA TAGTGACTCT 
CAGGAAGATG AGTGGCTCTC GGCAGCAATT GACTGTTTAG AATACCTTCC AGACCAAATG 
GTGGTGGAAA TAAGCAGAAG CTTTCCTGAG CAACCAGACC GAACAGACTT AGTGAAAGAA 
CTTCTGTTTG ATGCCATTGG CAGATATTAC AGTAGTAGGG AACCTCTGTT AAATCACTTA 
TCTGACGTTC ATAATGGAAT TGCAGAACTC TTAGTGAATG GGAAGACGGA AATAGCTTTA 
GAAGCTACCC AGCTCCTTCT AAAGCTTTTA GATTTCCAAA ATAGAGAAGA ATTTAGAAGA 
CTACTGTATT TCATGGCTGT TGCAGCAAAT CCTTCTGAGT TTAAATTACA GAAAGAAAGT 
GACAACCGAA TGGTTGTGAA AAGGATATTC TCAAAAGCTA TTGTTGACAA TAAAAATTTA 
TCCAAAGGCA AAACAGATCT TCTGGTACTC TTTTTAATGG ATCATCAGAA AGATGTTTTT 
AAGATTCCTG GAACTCTACA TAAAATTGTA AGTGTTAAGC TTATGGCCAT ACAGAACGGA 
AGAGATCCAA ATAGAGATGC AGGATATATT TATTGCCAGA GAATTGATCA ACGTGACTAT 
TCCAACAATA CAGAGAAGAC AACCAAAGAT GAGCTGTTGA ATTTACTAAA AACTCTTGAT 
GAGGATTCAA AACTTTCTGC CAAAGAGAAG AAAAAATTGC TAGGTCAATT CTATAAGTGT 
CACCCAGACA TCTTTATTGA GCATTTTGGA GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001070710.1
CDS	93..1628
Translation	MATVQEKAAALNLSALHSPAHRPPGFSVAQKPFGATYVWSSIINTLQTQVEVKKRRHRLKRHNDCFVGSEAVDVIFSHLIQNKYFGDVDIPRAKVVRVCQALMDYKVFEAVPTKVFGKDKKPTFEDSSCSLYRFTTIPNQDSQLGKENKLYSPARYADALFKSSDIRSASLEDLWENLSLKPANSPHVNISATLSPQVINEVWQEETIGRLLQLVDLPLLDSLLKQQEAVPKIPQPKRQSTMVNSSNYLDRGILKAYSDSQEDEWLSAAIDCLEYLPDQMVVEISRSFPEQPDRTDLVKELLFDAIGRYYSSREPLLNHLSDVHNGIAELLVNGKTEIALEATQLLLKLLDFQNREEFRRLLYFMAVAANPSEFKLQKESDNRMVVKRIFSKAIVDNKNLSKGKTDLLVLFLMDHQKDVFKIPGTLHKIVSVKLMAIQNGRDPNRDAGYIYCQRIDQRDYSNNTEKTTKDELLNLLKTLDEDSKLSAKEKKKLLGQFYKCHPDIFIEHFGD

Target ORF information:

RefSeq Version	NM_001077242.1
Organism	Homo sapiens(human)
Definition	Homo sapiens DEP domain containing 7 (DEPDC7), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001077242.1

ORF Insert Sequence:

ATGGCCACCG TGCAGGAGAA GGCTGCTGCG CTGAACCTCT CGGCTCTCCA CAGCCCCGCG 
CACAGGCCTC CGGGTTTCAG TGTAGCTCAG AAGCCATTTG GAGCCACGTA TGTATGGAGC 
AGCATCATAA ACACTCTTCA AACACAAGTG GAAGTGAAAA AACGAAGGCA CCGTTTAAAA 
CGACATAATG ACTGCTTTGT TGGTTCAGAA GCTGTGGATG TCATTTTTTC TCACCTAATT 
CAGAATAAGT ATTTTGGTGA TGTAGATATT CCTCGAGCCA AAGTGGTGAG AGTGTGTCAA 
GCGCTTATGG ACTACAAAGT ATTTGAAGCA GTTCCAACCA AAGTCTTTGG AAAAGACAAA 
AAACCTACAT TTGAAGATAG TAGTTGCAGC CTTTATAGAT TCACCACAAT ACCTAACCAA 
GACAGTCAGT TAGGCAAAGA GAACAAACTA TATTCACCTG CCAGGTATGC AGATGCATTA 
TTTAAGTCAT CCGATATCAG ATCAGCCAGT TTAGAGGACC TGTGGGAAAA TCTGAGTTTA 
AAGCCTGCCA ACTCCCCTCA TGTAAATATC TCTGCAACCT TGTCTCCACA AGTTATTAAT 
GAAGTGTGGC AAGAAGAAAC AATTGGGCGT CTACTACAAC TTGTAGACCT TCCACTTCTT 
GACTCCTTAC TGAAACAGCA AGAGGCTGTA CCTAAAATTC CTCAACCTAA GAGGCAGTCC 
ACCATGGTCA ACAGCAGTAA CTATCTGGAT CGAGGGATTC TCAAGGCTTA TAGTGACTCT 
CAGGAAGATG AGTGGCTCTC GGCAGCAATT GACTGTTTAG AATACCTTCC AGACCAAATG 
GTGGTGGAAA TAAGCAGAAG CTTTCCTGAG CAACCAGACC GAACAGACTT AGTGAAAGAA 
CTTCTGTTTG ATGCCATTGG CAGATATTAC AGTAGTAGGG AACCTCTGTT AAATCACTTA 
TCTGACGTTC ATAATGGAAT TGCAGAACTC TTAGTGAATG GGAAGACGGA AATAGCTTTA 
GAAGCTACCC AGCTCCTTCT AAAGCTTTTA GATTTCCAAA ATAGAGAAGA ATTTAGAAGA 
CTACTGTATT TCATGGCTGT TGCAGCAAAT CCTTCTGAGT TTAAATTACA GAAAGAAAGT 
GACAACCGAA TGGTTGTGAA AAGGATATTC TCAAAAGCTA TTGTTGACAA TAAAAATTTA 
TCCAAAGGCA AAACAGATCT TCTGGTACTC TTTTTAATGG ATCATCAGAA AGATGTTTTT 
AAGATTCCTG GAACTCTACA TAAAATTGTA AGTGTTAAGC TTATGGCCAT ACAGAACGGA 
AGAGATCCAA ATAGAGATGC AGGATATATT TATTGCCAGA GAATTGATCA ACGTGACTAT 
TCCAACAATA CAGAGAAGAC AACCAAAGAT GAGCTGTTGA ATTTACTAAA AACTCTTGAT 
GAGGATTCAA AACTTTCTGC CAAAGAGAAG AAAAAATTGC TAGGTCAATT CTATAAGTGT 
CACCCAGACA TCTTTATTGA GCATTTTGGA GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DEPDC7 ( NM_139160.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_631899.2 Homo sapiens DEP domain containing 7 (DEPDC7), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu30392
Clone ID Related Accession (Same CDS sequence)	NM_139160.2
Accession Version	NM_139160.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1509bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-30
Organism	Homo sapiens(human)
Product	DEP domain-containing protein 7 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC107939.5, AJ245600.1 and BC030970.1. On Oct 17, 2006 this sequence version replaced NM_139160.1. Transcript Variant: This variant (2) includes a different segment for the 5' UTR and 5' CDS, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct N-terminus when it is compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AF447588.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2145122 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGAGGTT TATGTGAGTT CTACTGGCAG GAATTTGGCA TAAAAGGTTT CAGTGTAGCT 
CAGAAGCCAT TTGGAGCCAC GTATGTATGG AGCAGCATCA TAAACACTCT TCAAACACAA 
GTGGAAGTGA AAAAACGAAG GCACCGTTTA AAACGACATA ATGACTGCTT TGTTGGTTCA 
GAAGCTGTGG ATGTCATTTT TTCTCACCTA ATTCAGAATA AGTATTTTGG TGATGTAGAT 
ATTCCTCGAG CCAAAGTGGT GAGAGTGTGT CAAGCGCTTA TGGACTACAA AGTATTTGAA 
GCAGTTCCAA CCAAAGTCTT TGGAAAAGAC AAAAAACCTA CATTTGAAGA TAGTAGTTGC 
AGCCTTTATA GATTCACCAC AATACCTAAC CAAGACAGTC AGTTAGGCAA AGAGAACAAA 
CTATATTCAC CTGCCAGGTA TGCAGATGCA TTATTTAAGT CATCCGATAT CAGATCAGCC 
AGTTTAGAGG ACCTGTGGGA AAATCTGAGT TTAAAGCCTG CCAACTCCCC TCATGTAAAT 
ATCTCTGCAA CCTTGTCTCC ACAAGTTATT AATGAAGTGT GGCAAGAAGA AACAATTGGG 
CGTCTACTAC AACTTGTAGA CCTTCCACTT CTTGACTCCT TACTGAAACA GCAAGAGGCT 
GTACCTAAAA TTCCTCAACC TAAGAGGCAG TCCACCATGG TCAACAGCAG TAACTATCTG 
GATCGAGGGA TTCTCAAGGC TTATAGTGAC TCTCAGGAAG ATGAGTGGCT CTCGGCAGCA 
ATTGACTGTT TAGAATACCT TCCAGACCAA ATGGTGGTGG AAATAAGCAG AAGCTTTCCT 
GAGCAACCAG ACCGAACAGA CTTAGTGAAA GAACTTCTGT TTGATGCCAT TGGCAGATAT 
TACAGTAGTA GGGAACCTCT GTTAAATCAC TTATCTGACG TTCATAATGG AATTGCAGAA 
CTCTTAGTGA ATGGGAAGAC GGAAATAGCT TTAGAAGCTA CCCAGCTCCT TCTAAAGCTT 
TTAGATTTCC AAAATAGAGA AGAATTTAGA AGACTACTGT ATTTCATGGC TGTTGCAGCA 
AATCCTTCTG AGTTTAAATT ACAGAAAGAA AGTGACAACC GAATGGTTGT GAAAAGGATA 
TTCTCAAAAG CTATTGTTGA CAATAAAAAT TTATCCAAAG GCAAAACAGA TCTTCTGGTA 
CTCTTTTTAA TGGATCATCA GAAAGATGTT TTTAAGATTC CTGGAACTCT ACATAAAATT 
GTAAGTGTTA AGCTTATGGC CATACAGAAC GGAAGAGATC CAAATAGAGA TGCAGGATAT 
ATTTATTGCC AGAGAATTGA TCAACGTGAC TATTCCAACA ATACAGAGAA GACAACCAAA 
GATGAGCTGT TGAATTTACT AAAAACTCTT GATGAGGATT CAAAACTTTC TGCCAAAGAG 
AAGAAAAAAT TGCTAGGTCA ATTCTATAAG TGTCACCCAG ACATCTTTAT TGAGCATTTT 
GGAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_631899.2
CDS	359..1867
Translation	MRGLCEFYWQEFGIKGFSVAQKPFGATYVWSSIINTLQTQVEVKKRRHRLKRHNDCFVGSEAVDVIFSHLIQNKYFGDVDIPRAKVVRVCQALMDYKVFEAVPTKVFGKDKKPTFEDSSCSLYRFTTIPNQDSQLGKENKLYSPARYADALFKSSDIRSASLEDLWENLSLKPANSPHVNISATLSPQVINEVWQEETIGRLLQLVDLPLLDSLLKQQEAVPKIPQPKRQSTMVNSSNYLDRGILKAYSDSQEDEWLSAAIDCLEYLPDQMVVEISRSFPEQPDRTDLVKELLFDAIGRYYSSREPLLNHLSDVHNGIAELLVNGKTEIALEATQLLLKLLDFQNREEFRRLLYFMAVAANPSEFKLQKESDNRMVVKRIFSKAIVDNKNLSKGKTDLLVLFLMDHQKDVFKIPGTLHKIVSVKLMAIQNGRDPNRDAGYIYCQRIDQRDYSNNTEKTTKDELLNLLKTLDEDSKLSAKEKKKLLGQFYKCHPDIFIEHFGD

Target ORF information:

RefSeq Version	NM_139160.2
Organism	Homo sapiens(human)
Definition	Homo sapiens DEP domain containing 7 (DEPDC7), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_139160.2

ORF Insert Sequence:

ATGAGAGGTT TATGTGAGTT CTACTGGCAG GAATTTGGCA TAAAAGGTTT CAGTGTAGCT 
CAGAAGCCAT TTGGAGCCAC GTATGTATGG AGCAGCATCA TAAACACTCT TCAAACACAA 
GTGGAAGTGA AAAAACGAAG GCACCGTTTA AAACGACATA ATGACTGCTT TGTTGGTTCA 
GAAGCTGTGG ATGTCATTTT TTCTCACCTA ATTCAGAATA AGTATTTTGG TGATGTAGAT 
ATTCCTCGAG CCAAAGTGGT GAGAGTGTGT CAAGCGCTTA TGGACTACAA AGTATTTGAA 
GCAGTTCCAA CCAAAGTCTT TGGAAAAGAC AAAAAACCTA CATTTGAAGA TAGTAGTTGC 
AGCCTTTATA GATTCACCAC AATACCTAAC CAAGACAGTC AGTTAGGCAA AGAGAACAAA 
CTATATTCAC CTGCCAGGTA TGCAGATGCA TTATTTAAGT CATCCGATAT CAGATCAGCC 
AGTTTAGAGG ACCTGTGGGA AAATCTGAGT TTAAAGCCTG CCAACTCCCC TCATGTAAAT 
ATCTCTGCAA CCTTGTCTCC ACAAGTTATT AATGAAGTGT GGCAAGAAGA AACAATTGGG 
CGTCTACTAC AACTTGTAGA CCTTCCACTT CTTGACTCCT TACTGAAACA GCAAGAGGCT 
GTACCTAAAA TTCCTCAACC TAAGAGGCAG TCCACCATGG TCAACAGCAG TAACTATCTG 
GATCGAGGGA TTCTCAAGGC TTATAGTGAC TCTCAGGAAG ATGAGTGGCT CTCGGCAGCA 
ATTGACTGTT TAGAATACCT TCCAGACCAA ATGGTGGTGG AAATAAGCAG AAGCTTTCCT 
GAGCAACCAG ACCGAACAGA CTTAGTGAAA GAACTTCTGT TTGATGCCAT TGGCAGATAT 
TACAGTAGTA GGGAACCTCT GTTAAATCAC TTATCTGACG TTCATAATGG AATTGCAGAA 
CTCTTAGTGA ATGGGAAGAC GGAAATAGCT TTAGAAGCTA CCCAGCTCCT TCTAAAGCTT 
TTAGATTTCC AAAATAGAGA AGAATTTAGA AGACTACTGT ATTTCATGGC TGTTGCAGCA 
AATCCTTCTG AGTTTAAATT ACAGAAAGAA AGTGACAACC GAATGGTTGT GAAAAGGATA 
TTCTCAAAAG CTATTGTTGA CAATAAAAAT TTATCCAAAG GCAAAACAGA TCTTCTGGTA 
CTCTTTTTAA TGGATCATCA GAAAGATGTT TTTAAGATTC CTGGAACTCT ACATAAAATT 
GTAAGTGTTA AGCTTATGGC CATACAGAAC GGAAGAGATC CAAATAGAGA TGCAGGATAT 
ATTTATTGCC AGAGAATTGA TCAACGTGAC TATTCCAACA ATACAGAGAA GACAACCAAA 
GATGAGCTGT TGAATTTACT AAAAACTCTT GATGAGGATT CAAAACTTTC TGCCAAAGAG 
AAGAAAAAAT TGCTAGGTCA ATTCTATAAG TGTCACCCAG ACATCTTTAT TGAGCATTTT 
GGAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

DEPDC7 inhibits cell proliferation, migration and invasion in hepatoma cells.
Oncology letters14(6)7332-7338(2017 Dec)
Liao Z,Wang X,Wang X,Li L,Lin D

Construction and Identification of the RNAi Recombinant Lentiviral Vector Targeting Human DEPDC7 Gene.
Interdisciplinary sciences, computational life sciences9(3)350-356(2017 Sep)
Liao Z,Wang X,Lin D,Zou Q

Further evidence of DEPDC7 DNA hypomethylation in depression: A study in adult twins.
European psychiatry : the journal of the Association of European Psychiatrists30(6)715-8(2015 Sep)
C?rdova-Palomera A,Fatj?-Vilas M,Palma-Gudiel H,Blasco-Fontecilla H,Kebir O,Fa?an?s L

The Dishevelled, EGL-10 and pleckstrin (DEP) domain-containing protein DEPDC7 binds to CARMA2 and CARMA3 proteins, and regulates NF-?B activation.
PloS one9(12)e116062(2014)
D'Andrea EL,Ferravante A,Scudiero I,Zotti T,Reale C,Pizzulo M,De La Motte LR,De Maio C,Mazzone P,Telesio G,Vito P,Stilo R

A 7.5 Mb sequence-ready PAC contig and gene expression map of human chromosome 11p13-p14.1.
Genome research9(11)1074-86(1999 Nov)
Gawin B,Niederf?hr A,Schumacher N,Hummerich H,Little PF,Gessler M

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DEPDC7 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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