FAAP24 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FAAP24
Entrez Gene ID	91442
Full Name	Fanconi anemia core complex associated protein 24
Synonyms	C19orf40
General protein information	Preferred Names Fanconi anemia core complex associated protein 24 Names Fanconi anemia core complex-associated protein 24 Fanconi anemia-associated protein of 24 kDa
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.11
Summary	FAAP24 is a component of the Fanconi anemia (FA) core complex (see MIM 227650), which plays a crucial role in DNA damage response (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008].
Disorder MIM:	610884

mRNA and Protein(s)

mRNA	Protein	Name
NM_152266.5	NP_689479.1	Fanconi anemia core complex-associated protein 24 isoform 1
NM_001300978.1	NP_001287907.1	Fanconi anemia core complex-associated protein 24 isoform 2
XM_005259393.3	XP_005259450.1	Fanconi anemia core complex-associated protein 24 isoform X1
NM_152266.4	NP_689479.1	Fanconi anemia core complex-associated protein 24 isoform 1
NM_001300978.2	NP_001287907.1	Fanconi anemia core complex-associated protein 24 isoform 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	C19orf40	NP_689479.1
Xenopus tropicalis (tropical clawed frog)	c19orf40	NP_001016122.1
Bos taurus (cattle)	C18H19orf40	NP_001039527.1
Mus musculus (house mouse)	C230052I12Rik	NP_848758.1
Canis lupus familiaris (dog)	C1H19orf40	XP_533705.3
Rattus norvegicus (Norway rat)	RGD1564719	NP_001102805.1
Pan troglodytes (chimpanzee)	C19H19orf40	XP_512569.3
Gallus gallus (chicken)	C11H19ORF40	NP_001264524.1
Danio rerio (zebrafish)	zgc:162267	NP_001082992.1

Gene Ontology
Bibliography

Related articles in PubMed

Fatal Lymphoproliferative Disease in Two Siblings Lacking Functional FAAP24.
Daschkey S, Bienemann K, Schuster V, Kreth HW, Linka RM, H?nscheid A, Fritz G, Johannes C, Fleckenstein B, Kempkes B, Gombert M, Ginzel S, Borkhardt A
Journal of clinical immunology36(7)684-92(2016 Oct)

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

Structural insights into the functions of the FANCM-FAAP24 complex in DNA repair.
Yang H, Zhang T, Tao Y, Wang F, Tong L, Ding J
Nucleic acids research41(22)10573-83(2013 Dec)

Structure analysis of FAAP24 reveals single-stranded DNA-binding activity and domain functions in DNA damage response.
Wang Y, Han X, Wu F, Leung JW, Lowery MG, Do H, Chen J, Shi C, Tian C, Li L, Gong W
Cell research23(10)1215-28(2013 Oct)

Architecture and DNA recognition elements of the Fanconi anemia FANCM-FAAP24 complex.
Coulthard R, Deans AJ, Swuec P, Bowles M, Costa A, West SC, McDonald NQ
Structure (London, England : 1993)21(9)1648-58(2013 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This is the first report of an FAAP24 loss of function mutation found in human patients with EBV-associated lymphoproliferation.
Title: Fatal Lymphoproliferative Disease in Two Siblings Lacking Functional FAAP24.

Results show that the first HhH motif of FAAP24 is a potential binding site for DNA, which plays a critical role in targeting FANCM-FAAP24 to chromatin.
Title: Structural insights into the functions of the FANCM-FAAP24 complex in DNA repair.

These results demonstrate dual roles of FAAP24 in DNA damage response against crosslinking lesions, one through the formation of FANCM/FAAP24 heterodimer and the other via its ssDNA-binding activity required in optimized checkpoint activation.
Title: Structure analysis of FAAP24 reveals single-stranded DNA-binding activity and domain functions in DNA damage response.

Crystal structure of the FANCM-FAAP24 complex.
Title: Architecture and DNA recognition elements of the Fanconi anemia FANCM-FAAP24 complex.

FANCM and FAAP24 play multiple, while not fully epistatic, roles in maintaining genomic integrity.
Title: FANCM and FAAP24 maintain genome stability via cooperative as well as unique functions.

The following FAAP24 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FAAP24 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17530	NM_152266.5 Latest version!	Homo sapiens FA core complex associated protein 24 (FAAP24), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu52589	NM_001300978.2 Latest version!	Homo sapiens FA core complex associated protein 24 (FAAP24), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu52588	XM_005259393.3 Latest version!	Homo sapiens FA core complex associated protein 24 (FAAP24), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu17530	NM_152266.4	Homo sapiens FA core complex associated protein 24 (FAAP24), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu52589	NM_001300978.1	Homo sapiens FA core complex associated protein 24 (FAAP24), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FAAP24 ( NM_152266.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_689479.1 Homo sapiens FA core complex associated protein 24 (FAAP24), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17530
Clone ID Related Accession (Same CDS sequence)	NM_152266.5 , NM_152266.4
Accession Version	NM_152266.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 648bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	Fanconi anemia core complex-associated protein 24 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CD690094.1, AK128668.1, CN368337.1, BX390218.2, BC020247.1, BM679170.1 and AC011449.6. On May 17, 2019 this sequence version replaced NM_152266.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK128668.1, SRR5189667.156605.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000588258.6/ ENSP00000466121.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAAAAGA ACCCCCCTGA TGATACGGGC CCCGTGCACG TGCCTTTGGG GCATATTGTG 
GCCAATGAGA AATGGCGCGG GTCACAGCTG GCGCAGGAGA TGCAAGGGAA AATTAAGCTC 
ATTTTCGAGG ATGGCTTGAC ACCAGACTTT TATCTGTCGA ACAGATGCTG CATTCTTTAT 
GTCACCGAAG CTGATTTGGT GGCAGGAAAT GGCTACAGAA AGAGGCTTGT TCGGGTTAGA 
AATTCCAATA ATCTTAAAGG AATTGTAGTC GTTGAAAAAA CCCGGATGAG TGAACAATAC 
TTCCCAGCCC TACAGAAGTT TACTGTGCTG GACCTTGGAA TGGTGCTGCT TCCAGTGGCC 
AGCCAGATGG AAGCATCCTG CCTCGTCATC CAGTTGGTTC AAGAGCAAAC CAAAGAGCCC 
AGTAAGAACC CTCTTCTCGG GAAGAAACGG GCCCTGCTGC TGTCTGAGCC TTCGCTCCTT 
CGAACCGTGC AGCAGATCCC AGGAGTTGGA AAAGTTAAAG CTCCCCTTCT CCTCCAGAAG 
TTTCCAAGCA TCCAGCAACT GAGTAATGCT TCCATTGGGG AACTGGAGCA GGTGGTCGGA 
CAAGCAGTGG CACAGCAGAT CCATGCCTTC TTCACGCAGC CCAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_689479.1
CDS	119..766
Translation	MEKNPPDDTGPVHVPLGHIVANEKWRGSQLAQEMQGKIKLIFEDGLTPDFYLSNRCCILYVTEADLVAGNGYRKRLVRVRNSNNLKGIVVVEKTRMSEQYFPALQKFTVLDLGMVLLPVASQMEASCLVIQLVQEQTKEPSKNPLLGKKRALLLSEPSLLRTVQQIPGVGKVKAPLLLQKFPSIQQLSNASIGELEQVVGQAVAQQIHAFFTQPR

Target ORF information:

RefSeq Version	NM_152266.5
Organism	Homo sapiens(human)
Definition	Homo sapiens FA core complex associated protein 24 (FAAP24), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152266.5

ORF Insert Sequence:

ATGGAAAAGA ACCCCCCTGA TGATACGGGC CCCGTGCACG TGCCTTTGGG GCATATTGTG 
GCCAATGAGA AATGGCGCGG GTCACAGCTG GCGCAGGAGA TGCAAGGGAA AATTAAGCTC 
ATTTTCGAGG ATGGCTTGAC ACCAGACTTT TATCTGTCGA ACAGATGCTG CATTCTTTAT 
GTCACCGAAG CTGATTTGGT GGCAGGAAAT GGCTACAGAA AGAGGCTTGT TCGGGTTAGA 
AATTCCAATA ATCTTAAAGG AATTGTAGTC GTTGAAAAAA CCCGGATGAG TGAACAATAC 
TTCCCAGCCC TACAGAAGTT TACTGTGCTG GACCTTGGAA TGGTGCTGCT TCCAGTGGCC 
AGCCAGATGG AAGCATCCTG CCTCGTCATC CAGTTGGTTC AAGAGCAAAC CAAAGAGCCC 
AGTAAGAACC CTCTTCTCGG GAAGAAACGG GCCCTGCTGC TGTCTGAGCC TTCGCTCCTT 
CGAACCGTGC AGCAGATCCC AGGAGTTGGA AAAGTTAAAG CTCCCCTTCT CCTCCAGAAG 
TTTCCAAGCA TCCAGCAACT GAGTAATGCT TCCATTGGGG AACTGGAGCA GGTGGTCGGA 
CAAGCAGTGG CACAGCAGAT CCATGCCTTC TTCACGCAGC CCAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FAAP24 ( NM_152266.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_689479.1 Homo sapiens FA core complex associated protein 24 (FAAP24), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17530
Clone ID Related Accession (Same CDS sequence)	NM_152266.5 , NM_152266.4
Accession Version	NM_152266.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 648bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-29
Organism	Homo sapiens(human)
Product	Fanconi anemia core complex-associated protein 24 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CD690094.1, AK128668.1, CN368337.1, BX390218.2, BC020247.1 and BM679170.1. On Jul 17, 2014 this sequence version replaced NM_152266.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI829252.1, AK128668.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAAAGA ACCCCCCTGA TGATACGGGC CCCGTGCACG TGCCTTTGGG GCATATTGTG 
GCCAATGAGA AATGGCGCGG GTCACAGCTG GCGCAGGAGA TGCAAGGGAA AATTAAGCTC 
ATTTTCGAGG ATGGCTTGAC ACCAGACTTT TATCTGTCGA ACAGATGCTG CATTCTTTAT 
GTCACCGAAG CTGATTTGGT GGCAGGAAAT GGCTACAGAA AGAGGCTTGT TCGGGTTAGA 
AATTCCAATA ATCTTAAAGG AATTGTAGTC GTTGAAAAAA CCCGGATGAG TGAACAATAC 
TTCCCAGCCC TACAGAAGTT TACTGTGCTG GACCTTGGAA TGGTGCTGCT TCCAGTGGCC 
AGCCAGATGG AAGCATCCTG CCTCGTCATC CAGTTGGTTC AAGAGCAAAC CAAAGAGCCC 
AGTAAGAACC CTCTTCTCGG GAAGAAACGG GCCCTGCTGC TGTCTGAGCC TTCGCTCCTT 
CGAACCGTGC AGCAGATCCC AGGAGTTGGA AAAGTTAAAG CTCCCCTTCT CCTCCAGAAG 
TTTCCAAGCA TCCAGCAACT GAGTAATGCT TCCATTGGGG AACTGGAGCA GGTGGTCGGA 
CAAGCAGTGG CACAGCAGAT CCATGCCTTC TTCACGCAGC CCAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_689479.1
CDS	144..791
Translation	MEKNPPDDTGPVHVPLGHIVANEKWRGSQLAQEMQGKIKLIFEDGLTPDFYLSNRCCILYVTEADLVAGNGYRKRLVRVRNSNNLKGIVVVEKTRMSEQYFPALQKFTVLDLGMVLLPVASQMEASCLVIQLVQEQTKEPSKNPLLGKKRALLLSEPSLLRTVQQIPGVGKVKAPLLLQKFPSIQQLSNASIGELEQVVGQAVAQQIHAFFTQPR

Target ORF information:

RefSeq Version	NM_152266.4
Organism	Homo sapiens(human)
Definition	Homo sapiens FA core complex associated protein 24 (FAAP24), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152266.4

ORF Insert Sequence:

ATGGAAAAGA ACCCCCCTGA TGATACGGGC CCCGTGCACG TGCCTTTGGG GCATATTGTG 
GCCAATGAGA AATGGCGCGG GTCACAGCTG GCGCAGGAGA TGCAAGGGAA AATTAAGCTC 
ATTTTCGAGG ATGGCTTGAC ACCAGACTTT TATCTGTCGA ACAGATGCTG CATTCTTTAT 
GTCACCGAAG CTGATTTGGT GGCAGGAAAT GGCTACAGAA AGAGGCTTGT TCGGGTTAGA 
AATTCCAATA ATCTTAAAGG AATTGTAGTC GTTGAAAAAA CCCGGATGAG TGAACAATAC 
TTCCCAGCCC TACAGAAGTT TACTGTGCTG GACCTTGGAA TGGTGCTGCT TCCAGTGGCC 
AGCCAGATGG AAGCATCCTG CCTCGTCATC CAGTTGGTTC AAGAGCAAAC CAAAGAGCCC 
AGTAAGAACC CTCTTCTCGG GAAGAAACGG GCCCTGCTGC TGTCTGAGCC TTCGCTCCTT 
CGAACCGTGC AGCAGATCCC AGGAGTTGGA AAAGTTAAAG CTCCCCTTCT CCTCCAGAAG 
TTTCCAAGCA TCCAGCAACT GAGTAATGCT TCCATTGGGG AACTGGAGCA GGTGGTCGGA 
CAAGCAGTGG CACAGCAGAT CCATGCCTTC TTCACGCAGC CCAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FAAP24 ( NM_001300978.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001287907.1 Homo sapiens FA core complex associated protein 24 (FAAP24), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu52589
Clone ID Related Accession (Same CDS sequence)	NM_001300978.1 , NM_001300978.2
Accession Version	NM_001300978.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 363bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-29
Organism	Homo sapiens(human)
Product	Fanconi anemia core complex-associated protein 24 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CD690094.1, CN368337.1, AK128668.1, BX390218.2, BC020247.1 and BM679170.1. On Jul 17, 2014 this sequence version replaced XM_005259394.1. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CN368337.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTGAAC AATACTTCCC AGCCCTACAG AAGTTTACTG TGCTGGACCT TGGAATGGTG 
CTGCTTCCAG TGGCCAGCCA GATGGAAGCA TCCTGCCTCG TCATCCAGTT GGTTCAAGAG 
CAAACCAAAG AGCCCAGTAA GAACCCTCTT CTCGGGAAGA AACGGGCCCT GCTGCTGTCT 
GAGCCTTCGC TCCTTCGAAC CGTGCAGCAG ATCCCAGGAG TTGGAAAAGT TAAAGCTCCC 
CTTCTCCTCC AGAAGTTTCC AAGCATCCAG CAACTGAGTA ATGCTTCCAT TGGGGAACTG 
GAGCAGGTGG TCGGACAAGC AGTGGCACAG CAGATCCATG CCTTCTTCAC GCAGCCCAGG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001287907.1
CDS	173..535
Translation	MSEQYFPALQKFTVLDLGMVLLPVASQMEASCLVIQLVQEQTKEPSKNPLLGKKRALLLSEPSLLRTVQQIPGVGKVKAPLLLQKFPSIQQLSNASIGELEQVVGQAVAQQIHAFFTQPR

Target ORF information:

RefSeq Version	NM_001300978.1
Organism	Homo sapiens(human)
Definition	Homo sapiens FA core complex associated protein 24 (FAAP24), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001300978.1

ORF Insert Sequence:

ATGAGTGAAC AATACTTCCC AGCCCTACAG AAGTTTACTG TGCTGGACCT TGGAATGGTG 
CTGCTTCCAG TGGCCAGCCA GATGGAAGCA TCCTGCCTCG TCATCCAGTT GGTTCAAGAG 
CAAACCAAAG AGCCCAGTAA GAACCCTCTT CTCGGGAAGA AACGGGCCCT GCTGCTGTCT 
GAGCCTTCGC TCCTTCGAAC CGTGCAGCAG ATCCCAGGAG TTGGAAAAGT TAAAGCTCCC 
CTTCTCCTCC AGAAGTTTCC AAGCATCCAG CAACTGAGTA ATGCTTCCAT TGGGGAACTG 
GAGCAGGTGG TCGGACAAGC AGTGGCACAG CAGATCCATG CCTTCTTCAC GCAGCCCAGG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FAAP24 ( NM_001300978.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001287907.1 Homo sapiens FA core complex associated protein 24 (FAAP24), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu52589
Clone ID Related Accession (Same CDS sequence)	NM_001300978.1 , NM_001300978.2
Accession Version	NM_001300978.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 363bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-30
Organism	Homo sapiens(human)
Product	Fanconi anemia core complex-associated protein 24 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CD690094.1, CN368337.1, AK128668.1, BX390218.2, BC020247.1, BM679170.1 and AC011449.6. On May 31, 2019 this sequence version replaced NM_001300978.1. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CN368337.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTGAAC AATACTTCCC AGCCCTACAG AAGTTTACTG TGCTGGACCT TGGAATGGTG 
CTGCTTCCAG TGGCCAGCCA GATGGAAGCA TCCTGCCTCG TCATCCAGTT GGTTCAAGAG 
CAAACCAAAG AGCCCAGTAA GAACCCTCTT CTCGGGAAGA AACGGGCCCT GCTGCTGTCT 
GAGCCTTCGC TCCTTCGAAC CGTGCAGCAG ATCCCAGGAG TTGGAAAAGT TAAAGCTCCC 
CTTCTCCTCC AGAAGTTTCC AAGCATCCAG CAACTGAGTA ATGCTTCCAT TGGGGAACTG 
GAGCAGGTGG TCGGACAAGC AGTGGCACAG CAGATCCATG CCTTCTTCAC GCAGCCCAGG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001287907.1
CDS	148..510
Translation	MSEQYFPALQKFTVLDLGMVLLPVASQMEASCLVIQLVQEQTKEPSKNPLLGKKRALLLSEPSLLRTVQQIPGVGKVKAPLLLQKFPSIQQLSNASIGELEQVVGQAVAQQIHAFFTQPR

Target ORF information:

RefSeq Version	NM_001300978.2
Organism	Homo sapiens(human)
Definition	Homo sapiens FA core complex associated protein 24 (FAAP24), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001300978.2

ORF Insert Sequence:

ATGAGTGAAC AATACTTCCC AGCCCTACAG AAGTTTACTG TGCTGGACCT TGGAATGGTG 
CTGCTTCCAG TGGCCAGCCA GATGGAAGCA TCCTGCCTCG TCATCCAGTT GGTTCAAGAG 
CAAACCAAAG AGCCCAGTAA GAACCCTCTT CTCGGGAAGA AACGGGCCCT GCTGCTGTCT 
GAGCCTTCGC TCCTTCGAAC CGTGCAGCAG ATCCCAGGAG TTGGAAAAGT TAAAGCTCCC 
CTTCTCCTCC AGAAGTTTCC AAGCATCCAG CAACTGAGTA ATGCTTCCAT TGGGGAACTG 
GAGCAGGTGG TCGGACAAGC AGTGGCACAG CAGATCCATG CCTTCTTCAC GCAGCCCAGG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FAAP24 ( XM_005259393.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005259450.1 Homo sapiens FA core complex associated protein 24 (FAAP24), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu52588
Clone ID Related Accession (Same CDS sequence)	XM_005259393.3
Accession Version	XM_005259393.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 519bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	Fanconi anemia core complex-associated protein 24 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005259393.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGCGGG TCACAGCTGG CGCAGGAGAT GCAAGATGCT GCATTCTTTA TGTCACCGAA 
GCTGATTTGG TGGCAGGAAA TGGCTACAGA AAGAGGCTTG TTCGGGTTAG AAATTCCAAT 
AATCTTAAAG GAATTGTAGT CGTTGAAAAA ACCCGGATGA GTGAACAATA CTTCCCAGCC 
CTACAGAAGT TTACTGTGCT GGACCTTGGA ATGGTGCTGC TTCCAGTGGC CAGCCAGATG 
GAAGCATCCT GCCTCGTCAT CCAGTTGGTT CAAGAGCAAA CCAAAGAGCC CAGTAAGAAC 
CCTCTTCTCG GGAAGAAACG GGCCCTGCTG CTGTCTGAGC CTTCGCTCCT TCGAACCGTG 
CAGCAGATCC CAGGAGTTGG AAAAGTTAAA GCTCCCCTTC TCCTCCAGAA GTTTCCAAGC 
ATCCAGCAAC TGAGTAATGC TTCCATTGGG GAACTGGAGC AGGTGGTCGG ACAAGCAGTG 
GCACAGCAGA TCCATGCCTT CTTCACGCAG CCCAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005259450.1
CDS	220..738
Translation	MARVTAGAGDARCCILYVTEADLVAGNGYRKRLVRVRNSNNLKGIVVVEKTRMSEQYFPALQKFTVLDLGMVLLPVASQMEASCLVIQLVQEQTKEPSKNPLLGKKRALLLSEPSLLRTVQQIPGVGKVKAPLLLQKFPSIQQLSNASIGELEQVVGQAVAQQIHAFFTQPR

Target ORF information:

RefSeq Version	XM_005259393.3
Organism	Homo sapiens(human)
Definition	Homo sapiens FA core complex associated protein 24 (FAAP24), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005259393.3

ORF Insert Sequence:

ATGGCGCGGG TCACAGCTGG CGCAGGAGAT GCAAGATGCT GCATTCTTTA TGTCACCGAA 
GCTGATTTGG TGGCAGGAAA TGGCTACAGA AAGAGGCTTG TTCGGGTTAG AAATTCCAAT 
AATCTTAAAG GAATTGTAGT CGTTGAAAAA ACCCGGATGA GTGAACAATA CTTCCCAGCC 
CTACAGAAGT TTACTGTGCT GGACCTTGGA ATGGTGCTGC TTCCAGTGGC CAGCCAGATG 
GAAGCATCCT GCCTCGTCAT CCAGTTGGTT CAAGAGCAAA CCAAAGAGCC CAGTAAGAAC 
CCTCTTCTCG GGAAGAAACG GGCCCTGCTG CTGTCTGAGC CTTCGCTCCT TCGAACCGTG 
CAGCAGATCC CAGGAGTTGG AAAAGTTAAA GCTCCCCTTC TCCTCCAGAA GTTTCCAAGC 
ATCCAGCAAC TGAGTAATGC TTCCATTGGG GAACTGGAGC AGGTGGTCGG ACAAGCAGTG 
GCACAGCAGA TCCATGCCTT CTTCACGCAG CCCAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Fatal Lymphoproliferative Disease in Two Siblings Lacking Functional FAAP24.
Journal of clinical immunology36(7)684-92(2016 Oct)
Daschkey S,Bienemann K,Schuster V,Kreth HW,Linka RM,H?nscheid A,Fritz G,Johannes C,Fleckenstein B,Kempkes B,Gombert M,Ginzel S,Borkhardt A

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M

Structural insights into the functions of the FANCM-FAAP24 complex in DNA repair.
Nucleic acids research41(22)10573-83(2013 Dec)
Yang H,Zhang T,Tao Y,Wang F,Tong L,Ding J

Structure analysis of FAAP24 reveals single-stranded DNA-binding activity and domain functions in DNA damage response.
Cell research23(10)1215-28(2013 Oct)
Wang Y,Han X,Wu F,Leung JW,Lowery MG,Do H,Chen J,Shi C,Tian C,Li L,Gong W

Architecture and DNA recognition elements of the Fanconi anemia FANCM-FAAP24 complex.
Structure (London, England : 1993)21(9)1648-58(2013 Sep)
Coulthard R,Deans AJ,Swuec P,Bowles M,Costa A,West SC,McDonald NQ

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FAAP24 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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