PGLYRP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PGLYRP1
Entrez Gene ID	8993
Full Name	peptidoglycan recognition protein 1
Synonyms	PGLYRP,PGRP,PGRP-S,PGRPS,TAG7,TNFSF3L
General protein information	Preferred Names peptidoglycan recognition protein 1 Names peptidoglycan recognition protein 1 TNF superfamily, member 3 (LTB)-like (peptidoglycan recognition protein)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.32
Disorder MIM:	604963

mRNA and Protein(s)

mRNA	Protein	Name
NM_005091.3	NP_005082.1	peptidoglycan recognition protein 1 precursor
NM_005091.2	NP_005082.1	peptidoglycan recognition protein 1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	PGLYRP1	NP_005082.1
	LOC718480	XP_001103121.1
Canis lupus familiaris (dog)	PGLYRP1	XP_855038.1
Pan troglodytes (chimpanzee)	PGLYRP1	XP_003316525.1
Bos taurus (cattle)	PGLYRP1	NP_776998.1
Mus musculus (house mouse)	Pglyrp1	NP_033428.1
Rattus norvegicus (Norway rat)	Pglyrp1	NP_445825.1
Danio rerio (zebrafish)	pglyrp5	NP_001037786.1

Gene Ontology
Bibliography

Related articles in PubMed

Innate immunity protein Tag7 (PGRP-S) activates lymphocytes capable of Fasl-Fas-dependent contact killing of virus-infected cells.
Sharapova TN, Ivanova OK, Prasolov VS, Romanova EA, Sashchenko LP, Yashin DV
IUBMB life69(12)971-977(2017 Dec)

Innate Immunity Protein Tag7 Induces 3 Distinct Populations of Cytotoxic Cells That Use Different Mechanisms to Exhibit Their Antitumor Activity on Human Leukocyte Antigen-Deficient Cancer Cells.
Sharapova TN, Ivanova OK, Soshnikova NV, Romanova EA, Sashchenko LP, Yashin DV
Journal of innate immunity9(6)598-608(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The interaction of Fas receptor with FasL leads to an activation of the Tag7-Hsp70 complex in the lymphocyte membrane fraction, and here FasL acts as a receptor that induces intracellular signaling in lymphocytes.An interaction of the MicA stress ligand with the NKG2D receptor is necessary for the release of this cytotoxic complex
Title: FasL and the NKG2D receptor are required for the secretion of the Tag7/PGRP-S-Hsp70 complex by the cytotoxic CD8

interaction of Tag7-Hsp70 with the TNFR1 receptor triggered a certain sequence of events: at first, it activated RIP1 kinase, and later on, increased intracellular concentration of capital ES, Cyrillicsmall a, Cyrillic(2+) ions and an activation of calpains, which led to the permeabilization of the lysosomal membranes
Title: The Tag7-Hsp70 cytotoxic complex induces tumor cell necroptosis via permeabilisation of lysosomes and mitochondria.

Tag7, can bind to the TNFR1 receptor, thereby inhibiting the cytotoxic actions of the Tag7-Hsp70 complex and TNF-alpha, an acquired immunity cytokine.
Title: Tag7 (PGLYRP1) in Complex with Hsp70 Induces Alternative Cytotoxic Processes in Tumor Cells via TNFR1 Receptor.

The role for PGLYRP1 as a TREM-1 activator provides a new mechanism by which bacteria can trigger myeloid cells, linking two known, but previously unrelated, pathways in innate immunity.
Title: Cutting Edge: identification of neutrophil PGLYRP1 as a ligand for TREM-1.

Tag7-Mts1 complex causes chemotactic migration of lymphocytes, with NK cells being a preferred target.
Title: A new role for PGRP-S (Tag7) in immune defense: lymphocyte migration is induced by a chemoattractant complex of Tag7 with Mts1.

The following PGLYRP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PGLYRP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu55575	NM_005091.3 Latest version!	Homo sapiens peptidoglycan recognition protein 1 (PGLYRP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu55575	NM_005091.2	Homo sapiens peptidoglycan recognition protein 1 (PGLYRP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PGLYRP1 ( NM_005091.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005082.1 Homo sapiens peptidoglycan recognition protein 1 (PGLYRP1), mRNA.

Price & Availability↑

CloneID	OHu55575
Clone ID Related Accession (Same CDS sequence)	NM_005091.3 , NM_005091.2
Accession Version	NM_005091.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 591bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-03
Organism	Homo sapiens(human)
Product	peptidoglycan recognition protein 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DN998360.1 and AF242517.1. On Nov 24, 2018 this sequence version replaced NM_005091.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF242517.1, AY358936.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154529 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000008938.5/ ENSP00000008938.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCCCGCC GCTCTATGCT GCTTGCCTGG GCTCTCCCCA GCCTCCTTCG ACTCGGAGCG 
GCTCAGGAGA CAGAAGACCC GGCCTGCTGC AGCCCCATAG TGCCCCGGAA CGAGTGGAAG 
GCCCTGGCAT CAGAGTGCGC CCAGCACCTG AGCCTGCCCT TACGCTATGT GGTGGTATCG 
CACACGGCGG GCAGCAGCTG CAACACCCCC GCCTCGTGCC AGCAGCAGGC CCGGAATGTG 
CAGCACTACC ACATGAAGAC ACTGGGCTGG TGCGACGTGG GCTACAACTT CCTGATTGGA 
GAAGACGGGC TCGTATACGA GGGCCGTGGC TGGAACTTCA CGGGTGCCCA CTCAGGTCAC 
TTATGGAACC CCATGTCCAT TGGCATCAGC TTCATGGGCA ACTACATGGA TCGGGTGCCC 
ACACCCCAGG CCATCCGGGC AGCCCAGGGT CTACTGGCCT GCGGTGTGGC TCAGGGAGCC 
CTGAGGTCCA ACTATGTGCT CAAAGGACAC CGGGATGTGC AGCGTACACT CTCTCCAGGC 
AACCAGCTCT ACCACCTCAT CCAGAATTGG CCACACTACC GCTCCCCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005082.1
CDS	33..623
Translation	MSRRSMLLAWALPSLLRLGAAQETEDPACCSPIVPRNEWKALASECAQHLSLPLRYVVVSHTAGSSCNTPASCQQQARNVQHYHMKTLGWCDVGYNFLIGEDGLVYEGRGWNFTGAHSGHLWNPMSIGISFMGNYMDRVPTPQAIRAAQGLLACGVAQGALRSNYVLKGHRDVQRTLSPGNQLYHLIQNWPHYRSP

Target ORF information:

RefSeq Version	NM_005091.3
Organism	Homo sapiens(human)
Definition	Homo sapiens peptidoglycan recognition protein 1 (PGLYRP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005091.3

ORF Insert Sequence:

ATGTCCCGCC GCTCTATGCT GCTTGCCTGG GCTCTCCCCA GCCTCCTTCG ACTCGGAGCG 
GCTCAGGAGA CAGAAGACCC GGCCTGCTGC AGCCCCATAG TGCCCCGGAA CGAGTGGAAG 
GCCCTGGCAT CAGAGTGCGC CCAGCACCTG AGCCTGCCCT TACGCTATGT GGTGGTATCG 
CACACGGCGG GCAGCAGCTG CAACACCCCC GCCTCGTGCC AGCAGCAGGC CCGGAATGTG 
CAGCACTACC ACATGAAGAC ACTGGGCTGG TGCGACGTGG GCTACAACTT CCTGATTGGA 
GAAGACGGGC TCGTATACGA GGGCCGTGGC TGGAACTTCA CGGGTGCCCA CTCAGGTCAC 
TTATGGAACC CCATGTCCAT TGGCATCAGC TTCATGGGCA ACTACATGGA TCGGGTGCCC 
ACACCCCAGG CCATCCGGGC AGCCCAGGGT CTACTGGCCT GCGGTGTGGC TCAGGGAGCC 
CTGAGGTCCA ACTATGTGCT CAAAGGACAC CGGGATGTGC AGCGTACACT CTCTCCAGGC 
AACCAGCTCT ACCACCTCAT CCAGAATTGG CCACACTACC GCTCCCCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PGLYRP1 ( NM_005091.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005082.1 Homo sapiens peptidoglycan recognition protein 1 (PGLYRP1), mRNA.

Price & Availability↑

CloneID	OHu55575
Clone ID Related Accession (Same CDS sequence)	NM_005091.3 , NM_005091.2
Accession Version	NM_005091.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 591bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-09
Organism	Homo sapiens(human)
Product	peptidoglycan recognition protein 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DN998360.1 and AF242517.1. On Mar 25, 2010 this sequence version replaced NM_005091.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF242517.1, AY358936.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154529 [ECO:0000348] ##Evidence-Data-END##

ATGTCCCGCC GCTCTATGCT GCTTGCCTGG GCTCTCCCCA GCCTCCTTCG ACTCGGAGCG 
GCTCAGGAGA CAGAAGACCC GGCCTGCTGC AGCCCCATAG TGCCCCGGAA CGAGTGGAAG 
GCCCTGGCAT CAGAGTGCGC CCAGCACCTG AGCCTGCCCT TACGCTATGT GGTGGTATCG 
CACACGGCGG GCAGCAGCTG CAACACCCCC GCCTCGTGCC AGCAGCAGGC CCGGAATGTG 
CAGCACTACC ACATGAAGAC ACTGGGCTGG TGCGACGTGG GCTACAACTT CCTGATTGGA 
GAAGACGGGC TCGTATACGA GGGCCGTGGC TGGAACTTCA CGGGTGCCCA CTCAGGTCAC 
TTATGGAACC CCATGTCCAT TGGCATCAGC TTCATGGGCA ACTACATGGA TCGGGTGCCC 
ACACCCCAGG CCATCCGGGC AGCCCAGGGT CTACTGGCCT GCGGTGTGGC TCAGGGAGCC 
CTGAGGTCCA ACTATGTGCT CAAAGGACAC CGGGATGTGC AGCGTACACT CTCTCCAGGC 
AACCAGCTCT ACCACCTCAT CCAGAATTGG CCACACTACC GCTCCCCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005082.1
CDS	278..868
Translation	MSRRSMLLAWALPSLLRLGAAQETEDPACCSPIVPRNEWKALASECAQHLSLPLRYVVVSHTAGSSCNTPASCQQQARNVQHYHMKTLGWCDVGYNFLIGEDGLVYEGRGWNFTGAHSGHLWNPMSIGISFMGNYMDRVPTPQAIRAAQGLLACGVAQGALRSNYVLKGHRDVQRTLSPGNQLYHLIQNWPHYRSP

Target ORF information:

RefSeq Version	NM_005091.2
Organism	Homo sapiens(human)
Definition	Homo sapiens peptidoglycan recognition protein 1 (PGLYRP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005091.2

ORF Insert Sequence:

ATGTCCCGCC GCTCTATGCT GCTTGCCTGG GCTCTCCCCA GCCTCCTTCG ACTCGGAGCG 
GCTCAGGAGA CAGAAGACCC GGCCTGCTGC AGCCCCATAG TGCCCCGGAA CGAGTGGAAG 
GCCCTGGCAT CAGAGTGCGC CCAGCACCTG AGCCTGCCCT TACGCTATGT GGTGGTATCG 
CACACGGCGG GCAGCAGCTG CAACACCCCC GCCTCGTGCC AGCAGCAGGC CCGGAATGTG 
CAGCACTACC ACATGAAGAC ACTGGGCTGG TGCGACGTGG GCTACAACTT CCTGATTGGA 
GAAGACGGGC TCGTATACGA GGGCCGTGGC TGGAACTTCA CGGGTGCCCA CTCAGGTCAC 
TTATGGAACC CCATGTCCAT TGGCATCAGC TTCATGGGCA ACTACATGGA TCGGGTGCCC 
ACACCCCAGG CCATCCGGGC AGCCCAGGGT CTACTGGCCT GCGGTGTGGC TCAGGGAGCC 
CTGAGGTCCA ACTATGTGCT CAAAGGACAC CGGGATGTGC AGCGTACACT CTCTCCAGGC 
AACCAGCTCT ACCACCTCAT CCAGAATTGG CCACACTACC GCTCCCCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Innate immunity protein Tag7 (PGRP-S) activates lymphocytes capable of Fasl-Fas-dependent contact killing of virus-infected cells.
IUBMB life69(12)971-977(2017 Dec)
Sharapova TN,Ivanova OK,Prasolov VS,Romanova EA,Sashchenko LP,Yashin DV

Innate Immunity Protein Tag7 Induces 3 Distinct Populations of Cytotoxic Cells That Use Different Mechanisms to Exhibit Their Antitumor Activity on Human Leukocyte Antigen-Deficient Cancer Cells.
Journal of innate immunity9(6)598-608(2017)
Sharapova TN,Ivanova OK,Soshnikova NV,Romanova EA,Sashchenko LP,Yashin DV