CAV3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CAV3
Entrez Gene ID	859
Full Name	caveolin 3
Synonyms	LGMD1C,LQT9,VIP-21,VIP21
General protein information	Preferred Names caveolin 3 Names caveolin-3 M-caveolin cavolin 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3p25.3
Summary	This gene encodes a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites. [provided by RefSeq, Jul 2008].
Disorder MIM:	601253
Disorder Html:	Muscular dystrophy, limb-girdle, type IC, 607801 (3); Rippling muscle disease, 606072 (3); Creatine phosphokinase, elevated serum, 123320 (3); Myopathy, distal, Tateyama type, 614321 (3); Cardiomyopathy, familial hypertrophic, 192600 (3); Long QT syndrome 9, 611818 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001234.4	NP_001225.1	caveolin-3
NM_001234.5	NP_001225.1	caveolin-3
NM_033337.3	NP_203123.1	caveolin-3
NM_033337.2	NP_203123.1	caveolin-3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CAV3	XP_001144093.2
Mus musculus (house mouse)	Cav3	NP_031643.1
Danio rerio (zebrafish)	cav3	NP_991301.1
	CAV3	XP_001097615.1
Bos taurus (cattle)	CAV3	NP_001040023.1
Homo sapiens (human)	CAV3	NP_203123.1
Canis lupus familiaris (dog)	CAV3	XP_541786.2
Xenopus tropicalis (tropical clawed frog)	cav3.1	NP_001096498.1
Rattus norvegicus (Norway rat)	Cav3	NP_062028.1
Gallus gallus (chicken)	CAV3	NP_989701.1

Gene Ontology
Bibliography

Related articles in PubMed

Inward Rectifier Potassium Channels (Kir2.x) and Caveolin-3 Domain-Specific Interaction: Implications for Purkinje Cell-Dependent Ventricular Arrhythmias.
Vaidyanathan R, Van Ert H, Haq KT, Morotti S, Esch S, McCune EC, Grandi E, Eckhardt LL
Circulation. Arrhythmia and electrophysiology11(1)e005800(2018 Jan)

Functional interaction of the two-pore domain potassium channel TASK-1 and caveolin-3.
Kang C, Hernandez VA, Hu K
Biochimica et biophysica acta1864(10)1537-1544(2017 10)

The expression of the rare caveolin-3 variant T78M alters cardiac ion channels function and membrane excitability.
Campostrini G, Bonzanni M, Lissoni A, Bazzini C, Milanesi R, Vezzoli E, Francolini M, Baruscotti M, Bucchi A, Rivolta I, Fantini M, Severi S, Cappato R, Crotti L, J Schwartz P, DiFrancesco D, Barbuti A
Cardiovascular research113(10)1256-1265(2017 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

our study indicates that TASK-1 is functionally regulated by caveolin-3, possibly via association with each other on the cell surface. These results point out a novel mechanism in the regulation of TASK-1.
Title: Functional interaction of the two-pore domain potassium channel TASK-1 and caveolin-3.

Our results indicate that HCN4 channel function is modulated by cav-3. LQTS-associated mutations of cav-3 differentially influence pacemaker current properties indicating a pathophysiological role in clinical manifestations.
Title: Long-QT syndrome-associated caveolin-3 mutations differentially regulate the hyperpolarization-activated cyclic nucleotide gated channel 4.

The Cav3 P104L mutation of limb girdle muscular dystrophy-1C leads to disordered glucose metabolism in muscle cells.
Title: The Caveolin-3 P104L mutation of LGMD-1C leads to disordered glucose metabolism in muscle cells.

The caveolin 3 G56S variant is not a clearly pathogenic mutation, but may influence cellular functions and morphologies resulting in an increased cellular vulnerability in terms of a modifying factor.
Title: The Caveolin-3 G56S sequence variant of unknown significance: Muscle biopsy findings and functional cell biological analysis.

This study demonstrated that the Caveolin-3 is aberrantly expressed in skeletal muscle cells in myasthenia gravis.
Title: Caveolin-3 is aberrantly expressed in skeletal muscle cells in myasthenia gravis.

The following CAV3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CAV3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21738	NM_001234.5 Latest version!	Homo sapiens caveolin 3 (CAV3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu21738	NM_033337.3 Latest version!	Homo sapiens caveolin 3 (CAV3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu21738	NM_001234.4	Homo sapiens caveolin 3 (CAV3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu21738	NM_033337.2	Homo sapiens caveolin 3 (CAV3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CAV3 ( NM_001234.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001225.1 Homo sapiens caveolin 3 (CAV3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu21738
Clone ID Related Accession (Same CDS sequence)	NM_001234.4 , NM_001234.5 , NM_033337.3 , NM_033337.2
Accession Version	NM_001234.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 456bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	caveolin-3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK291892.1, Y14747.1, AC068312.5 and AA993189.1. On Nov 9, 2011 this sequence version replaced NM_001234.3. Transcript Variant: This variant (2) is shorter than variant 1, since it lacks a differentially spliced intron located in the 3' UTR, but both transcripts encode identical proteins. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y14747.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149178, SAMEA2154361 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGGCAG AAGAGCACAC AGATCTCGAG GCCCAGATCG TCAAGGATAT CCACTGCAAG 
GAGATTGACC TGGTGAACCG AGACCCCAAG AACATTAACG AGGACATAGT CAAGGTGGAT 
TTTGAAGACG TGATCGCAGA GCCTGTGGGC ACCTACAGCT TTGACGGCGT GTGGAAGGTG 
AGCTACACCA CCTTCACTGT CTCCAAGTAC TGGTGCTACC GTCTGTTGTC CACGCTGCTG 
GGCGTCCCAC TGGCCCTGCT CTGGGGCTTC CTGTTCGCCT GCATCTCCTT CTGCCACATC 
TGGGCGGTGG TGCCATGCAT TAAGAGCTAC CTGATCGAGA TCCAGTGCAT CAGCCACATC 
TACTCACTCT GCATCCGCAC CTTCTGCAAC CCACTCTTCG CGGCCCTGGG CCAGGTCTGC 
AGCAGCATCA AGGTGGTGCT GCGGAAGGAG GTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001225.1
CDS	78..533
Translation	MMAEEHTDLEAQIVKDIHCKEIDLVNRDPKNINEDIVKVDFEDVIAEPVGTYSFDGVWKVSYTTFTVSKYWCYRLLSTLLGVPLALLWGFLFACISFCHIWAVVPCIKSYLIEIQCISHIYSLCIRTFCNPLFAALGQVCSSIKVVLRKEV

Target ORF information:

RefSeq Version	NM_001234.4
Organism	Homo sapiens(human)
Definition	Homo sapiens caveolin 3 (CAV3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001234.4

ORF Insert Sequence:

ATGATGGCAG AAGAGCACAC AGATCTCGAG GCCCAGATCG TCAAGGATAT CCACTGCAAG 
GAGATTGACC TGGTGAACCG AGACCCCAAG AACATTAACG AGGACATAGT CAAGGTGGAT 
TTTGAAGACG TGATCGCAGA GCCTGTGGGC ACCTACAGCT TTGACGGCGT GTGGAAGGTG 
AGCTACACCA CCTTCACTGT CTCCAAGTAC TGGTGCTACC GTCTGTTGTC CACGCTGCTG 
GGCGTCCCAC TGGCCCTGCT CTGGGGCTTC CTGTTCGCCT GCATCTCCTT CTGCCACATC 
TGGGCGGTGG TGCCATGCAT TAAGAGCTAC CTGATCGAGA TCCAGTGCAT CAGCCACATC 
TACTCACTCT GCATCCGCAC CTTCTGCAAC CCACTCTTCG CGGCCCTGGG CCAGGTCTGC 
AGCAGCATCA AGGTGGTGCT GCGGAAGGAG GTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CAV3 ( NM_001234.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001225.1 Homo sapiens caveolin 3 (CAV3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu21738
Clone ID Related Accession (Same CDS sequence)	NM_001234.4 , NM_001234.5 , NM_033337.3 , NM_033337.2
Accession Version	NM_001234.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 456bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Homo sapiens(human)
Product	caveolin-3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK291892.1, Y14747.1, AC068312.5 and AA993189.1. On Jun 2, 2019 this sequence version replaced NM_001234.4. Transcript Variant: This variant (2) is shorter than variant 1, since it lacks a differentially spliced intron located in the 3' UTR, but both transcripts encode identical proteins. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189655.163089.1, Y14747.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149178, SAMEA2154361 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGGCAG AAGAGCACAC AGATCTCGAG GCCCAGATCG TCAAGGATAT CCACTGCAAG 
GAGATTGACC TGGTGAACCG AGACCCCAAG AACATTAACG AGGACATAGT CAAGGTGGAT 
TTTGAAGACG TGATCGCAGA GCCTGTGGGC ACCTACAGCT TTGACGGCGT GTGGAAGGTG 
AGCTACACCA CCTTCACTGT CTCCAAGTAC TGGTGCTACC GTCTGTTGTC CACGCTGCTG 
GGCGTCCCAC TGGCCCTGCT CTGGGGCTTC CTGTTCGCCT GCATCTCCTT CTGCCACATC 
TGGGCGGTGG TGCCATGCAT TAAGAGCTAC CTGATCGAGA TCCAGTGCAT CAGCCACATC 
TACTCACTCT GCATCCGCAC CTTCTGCAAC CCACTCTTCG CGGCCCTGGG CCAGGTCTGC 
AGCAGCATCA AGGTGGTGCT GCGGAAGGAG GTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001225.1
CDS	76..531
Translation	MMAEEHTDLEAQIVKDIHCKEIDLVNRDPKNINEDIVKVDFEDVIAEPVGTYSFDGVWKVSYTTFTVSKYWCYRLLSTLLGVPLALLWGFLFACISFCHIWAVVPCIKSYLIEIQCISHIYSLCIRTFCNPLFAALGQVCSSIKVVLRKEV

Target ORF information:

RefSeq Version	NM_001234.5
Organism	Homo sapiens(human)
Definition	Homo sapiens caveolin 3 (CAV3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001234.5

ORF Insert Sequence:

ATGATGGCAG AAGAGCACAC AGATCTCGAG GCCCAGATCG TCAAGGATAT CCACTGCAAG 
GAGATTGACC TGGTGAACCG AGACCCCAAG AACATTAACG AGGACATAGT CAAGGTGGAT 
TTTGAAGACG TGATCGCAGA GCCTGTGGGC ACCTACAGCT TTGACGGCGT GTGGAAGGTG 
AGCTACACCA CCTTCACTGT CTCCAAGTAC TGGTGCTACC GTCTGTTGTC CACGCTGCTG 
GGCGTCCCAC TGGCCCTGCT CTGGGGCTTC CTGTTCGCCT GCATCTCCTT CTGCCACATC 
TGGGCGGTGG TGCCATGCAT TAAGAGCTAC CTGATCGAGA TCCAGTGCAT CAGCCACATC 
TACTCACTCT GCATCCGCAC CTTCTGCAAC CCACTCTTCG CGGCCCTGGG CCAGGTCTGC 
AGCAGCATCA AGGTGGTGCT GCGGAAGGAG GTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CAV3 ( NM_033337.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_203123.1 Homo sapiens caveolin 3 (CAV3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21738
Clone ID Related Accession (Same CDS sequence)	NM_001234.4 , NM_001234.5 , NM_033337.3 , NM_033337.2
Accession Version	NM_033337.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 456bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Homo sapiens(human)
Product	caveolin-3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK291892.1, BC102033.1, BX114193.1 and AA993189.1. On Aug 31, 2019 this sequence version replaced NM_033337.2. Transcript Variant: This variant (1) is longer than variant 2, since it includes a differentially spliced intron located in the 3' UTR, but both transcripts encode identical proteins. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF043101.1, DA898993.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATGGCAG AAGAGCACAC AGATCTCGAG GCCCAGATCG TCAAGGATAT CCACTGCAAG 
GAGATTGACC TGGTGAACCG AGACCCCAAG AACATTAACG AGGACATAGT CAAGGTGGAT 
TTTGAAGACG TGATCGCAGA GCCTGTGGGC ACCTACAGCT TTGACGGCGT GTGGAAGGTG 
AGCTACACCA CCTTCACTGT CTCCAAGTAC TGGTGCTACC GTCTGTTGTC CACGCTGCTG 
GGCGTCCCAC TGGCCCTGCT CTGGGGCTTC CTGTTCGCCT GCATCTCCTT CTGCCACATC 
TGGGCGGTGG TGCCATGCAT TAAGAGCTAC CTGATCGAGA TCCAGTGCAT CAGCCACATC 
TACTCACTCT GCATCCGCAC CTTCTGCAAC CCACTCTTCG CGGCCCTGGG CCAGGTCTGC 
AGCAGCATCA AGGTGGTGCT GCGGAAGGAG GTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_203123.1
CDS	76..531
Translation	MMAEEHTDLEAQIVKDIHCKEIDLVNRDPKNINEDIVKVDFEDVIAEPVGTYSFDGVWKVSYTTFTVSKYWCYRLLSTLLGVPLALLWGFLFACISFCHIWAVVPCIKSYLIEIQCISHIYSLCIRTFCNPLFAALGQVCSSIKVVLRKEV

Target ORF information:

RefSeq Version	NM_033337.3
Organism	Homo sapiens(human)
Definition	Homo sapiens caveolin 3 (CAV3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033337.3

ORF Insert Sequence:

ATGATGGCAG AAGAGCACAC AGATCTCGAG GCCCAGATCG TCAAGGATAT CCACTGCAAG 
GAGATTGACC TGGTGAACCG AGACCCCAAG AACATTAACG AGGACATAGT CAAGGTGGAT 
TTTGAAGACG TGATCGCAGA GCCTGTGGGC ACCTACAGCT TTGACGGCGT GTGGAAGGTG 
AGCTACACCA CCTTCACTGT CTCCAAGTAC TGGTGCTACC GTCTGTTGTC CACGCTGCTG 
GGCGTCCCAC TGGCCCTGCT CTGGGGCTTC CTGTTCGCCT GCATCTCCTT CTGCCACATC 
TGGGCGGTGG TGCCATGCAT TAAGAGCTAC CTGATCGAGA TCCAGTGCAT CAGCCACATC 
TACTCACTCT GCATCCGCAC CTTCTGCAAC CCACTCTTCG CGGCCCTGGG CCAGGTCTGC 
AGCAGCATCA AGGTGGTGCT GCGGAAGGAG GTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CAV3 ( NM_033337.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_203123.1 Homo sapiens caveolin 3 (CAV3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21738
Clone ID Related Accession (Same CDS sequence)	NM_001234.4 , NM_001234.5 , NM_033337.3 , NM_033337.2
Accession Version	NM_033337.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 456bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-25
Organism	Homo sapiens(human)
Product	caveolin-3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK291892.1, BC102033.1, BX114193.1 and AA993189.1. This sequence is a reference standard in the RefSeqGene project. On Jun 23, 2010 this sequence version replaced NM_033337.1. Transcript Variant: This variant (1) is longer than variant 2, since it includes a differentially spliced intron located in the 3' UTR, but both transcripts encode identical proteins. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA897474.1, AF043101.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMEA2146236 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATGGCAG AAGAGCACAC AGATCTCGAG GCCCAGATCG TCAAGGATAT CCACTGCAAG 
GAGATTGACC TGGTGAACCG AGACCCCAAG AACATTAACG AGGACATAGT CAAGGTGGAT 
TTTGAAGACG TGATCGCAGA GCCTGTGGGC ACCTACAGCT TTGACGGCGT GTGGAAGGTG 
AGCTACACCA CCTTCACTGT CTCCAAGTAC TGGTGCTACC GTCTGTTGTC CACGCTGCTG 
GGCGTCCCAC TGGCCCTGCT CTGGGGCTTC CTGTTCGCCT GCATCTCCTT CTGCCACATC 
TGGGCGGTGG TGCCATGCAT TAAGAGCTAC CTGATCGAGA TCCAGTGCAT CAGCCACATC 
TACTCACTCT GCATCCGCAC CTTCTGCAAC CCACTCTTCG CGGCCCTGGG CCAGGTCTGC 
AGCAGCATCA AGGTGGTGCT GCGGAAGGAG GTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_203123.1
CDS	78..533
Translation	MMAEEHTDLEAQIVKDIHCKEIDLVNRDPKNINEDIVKVDFEDVIAEPVGTYSFDGVWKVSYTTFTVSKYWCYRLLSTLLGVPLALLWGFLFACISFCHIWAVVPCIKSYLIEIQCISHIYSLCIRTFCNPLFAALGQVCSSIKVVLRKEV

Target ORF information:

RefSeq Version	NM_033337.2
Organism	Homo sapiens(human)
Definition	Homo sapiens caveolin 3 (CAV3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033337.2

ORF Insert Sequence:

ATGATGGCAG AAGAGCACAC AGATCTCGAG GCCCAGATCG TCAAGGATAT CCACTGCAAG 
GAGATTGACC TGGTGAACCG AGACCCCAAG AACATTAACG AGGACATAGT CAAGGTGGAT 
TTTGAAGACG TGATCGCAGA GCCTGTGGGC ACCTACAGCT TTGACGGCGT GTGGAAGGTG 
AGCTACACCA CCTTCACTGT CTCCAAGTAC TGGTGCTACC GTCTGTTGTC CACGCTGCTG 
GGCGTCCCAC TGGCCCTGCT CTGGGGCTTC CTGTTCGCCT GCATCTCCTT CTGCCACATC 
TGGGCGGTGG TGCCATGCAT TAAGAGCTAC CTGATCGAGA TCCAGTGCAT CAGCCACATC 
TACTCACTCT GCATCCGCAC CTTCTGCAAC CCACTCTTCG CGGCCCTGGG CCAGGTCTGC 
AGCAGCATCA AGGTGGTGCT GCGGAAGGAG GTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inward Rectifier Potassium Channels (Kir2.x) and Caveolin-3 Domain-Specific Interaction: Implications for Purkinje Cell-Dependent Ventricular Arrhythmias.
Circulation. Arrhythmia and electrophysiology11(1)e005800(2018 Jan)
Vaidyanathan R,Van Ert H,Haq KT,Morotti S,Esch S,McCune EC,Grandi E,Eckhardt LL

Functional interaction of the two-pore domain potassium channel TASK-1 and caveolin-3.
Biochimica et biophysica acta1864(10)1537-1544(2017 10)
Kang C,Hernandez VA,Hu K

The expression of the rare caveolin-3 variant T78M alters cardiac ion channels function and membrane excitability.
Cardiovascular research113(10)1256-1265(2017 Aug)
Campostrini G,Bonzanni M,Lissoni A,Bazzini C,Milanesi R,Vezzoli E,Francolini M,Baruscotti M,Bucchi A,Rivolta I,Fantini M,Severi S,Cappato R,Crotti L,J Schwartz P,DiFrancesco D,Barbuti A

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CAV3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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見積依頼

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電話

FAX

オンラインフォーム