MBD3L1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MBD3L1
Entrez Gene ID	85509
Full Name	methyl-CpG binding domain protein 3 like 1
Synonyms	MBD3L
General protein information	Preferred Names methyl-CpG binding domain protein 3 like 1 Names methyl-CpG-binding domain protein 3-like 1 MBD3-like protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.2
Summary	This gene encodes a protein that is related to methyl-CpG-binding proteins but lacks the methyl-CpG binding domain. The protein is localized to discrete areas in the nucleus, and expression appears to be restricted to round spermatids, suggesting that the protein plays a role in the postmeiotic stages of male germ cell development. [provided by RefSeq, Jul 2008].
Disorder MIM:	607963

mRNA and Protein(s)

mRNA	Protein	Name
NM_145208.2	NP_660209.2	methyl-CpG-binding domain protein 3-like 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	MBD3L1	NP_660209.2
Pan troglodytes (chimpanzee)	MBD3L1	XP_003316115.1
	MBD3L1	XP_001095444.1
Canis lupus familiaris (dog)	MBD3L1	XP_003432911.1
Bos taurus (cattle)	MBD3L1	NP_001070554.1
Mus musculus (house mouse)	Mbd3l1	NP_082833.1
Rattus norvegicus (Norway rat)	Mbd3l1	NP_001100273.1

Gene Ontology
Bibliography

Related articles in PubMed

The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation.
Carmona-Mora P, Widagdo J, Tomasetig F, Canales CP, Cha Y, Lee W, Alshawaf A, Dottori M, Whan RM, Hardeman EC, Palmer SJ
Human genetics134(10)1099-115(2015 Oct)

Unique features of the anti-parallel, heterodimeric coiled-coil interaction between methyl-cytosine binding domain 2 (MBD2) homologues and GATA zinc finger domain containing 2A (GATAD2A/p66?).
Walavalkar NM, Gordon N, Williams DC Jr
The Journal of biological chemistry288(5)3419-27(2013 Feb)

MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex.
Jiang CL, Jin SG, Pfeifer GP
The Journal of biological chemistry279(50)52456-64(2004 Dec)

The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity.
Yao YL, Yang WM
The Journal of biological chemistry278(43)42560-8(2003 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These factors lead to a binding affinity hierarchy of p66alpha for the different MBD2 homologues (MBD2 approximately MBD3 > MBD3L1 approximately MBD3L2).
Title: Unique features of the anti-parallel, heterodimeric coiled-coil interaction between methyl-cytosine binding domain 2 (MBD2) homologues and GATA zinc finger domain containing 2A (GATAD2A/p66?).

interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex
Title: MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex.

The following MBD3L1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MBD3L1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu12824	NM_145208.2 Latest version!	Homo sapiens methyl-CpG binding domain protein 3 like 1 (MBD3L1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MBD3L1 ( NM_145208.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_660209.2 Homo sapiens methyl-CpG binding domain protein 3 like 1 (MBD3L1), mRNA.

Price & Availability↑

CloneID	OHu12824
Clone ID Related Accession (Same CDS sequence)	NM_145208.2
Accession Version	NM_145208.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 585bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	methyl-CpG-binding domain protein 3-like 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC112064.1 and AC008734.7. On Apr 10, 2009 this sequence version replaced NM_145208.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript is intronless :: BC112064.1, BC112058.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCAAGA GTTCACAGAG GAAGCAACGT GACTGTGTAA ACCAATGCAA ATCAAAGCCT 
GGCTTGAGCA CCTCAATCCC TTTGAGAATG TCCAGTTACA CATTCAAGAG GCCAGTAACG 
AGAATTACAC CCCATCCTGG CAATGAGGTC AGATACCATC AATGGGAGGA GAGCTTGGAG 
AAGCCTCAGC AGGTCTGCTG GCAGAGGAGA CTGCAGGGAC TCCAGGCTTA CAGCAGTGCA 
GGAGAACTTT CAAGCACTTT GGATCTTGCC AATACCTTGC AAAAACTTGT CCCTAGTTAC 
ACAGGTGGAT CTCTGCTGGA GGATCTTGCC AGTGGTCTGG AGCACTCCTG CCCCATGCCC 
CACCTTGCCT GCTCTTCAGA TGCGGTGGAG ATAATTCCTG CAGAGGGAGT GGGTATCTCG 
CAGCTCCTCT GCAAACAATT TCTGGTTACT GAGGAAGATA TCAGGAAACA GGAAGGGAAA 
GTGAAGACAG TCAGAGAGAG ACTCGCAATA GCACTGATTG CGGATGGACT CGCTAATGAG 
GCAGAGAAAG TGAGAGACCA AGAAGGCCGT CCTGAAAAAC GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_660209.2
CDS	87..671
Translation	MAKSSQRKQRDCVNQCKSKPGLSTSIPLRMSSYTFKRPVTRITPHPGNEVRYHQWEESLEKPQQVCWQRRLQGLQAYSSAGELSSTLDLANTLQKLVPSYTGGSLLEDLASGLEHSCPMPHLACSSDAVEIIPAEGVGISQLLCKQFLVTEEDIRKQEGKVKTVRERLAIALIADGLANEAEKVRDQEGRPEKR

Target ORF information:

RefSeq Version	NM_145208.2
Organism	Homo sapiens(human)
Definition	Homo sapiens methyl-CpG binding domain protein 3 like 1 (MBD3L1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145208.2

ORF Insert Sequence:

ATGGCCAAGA GTTCACAGAG GAAGCAACGT GACTGTGTAA ACCAATGCAA ATCAAAGCCT 
GGCTTGAGCA CCTCAATCCC TTTGAGAATG TCCAGTTACA CATTCAAGAG GCCAGTAACG 
AGAATTACAC CCCATCCTGG CAATGAGGTC AGATACCATC AATGGGAGGA GAGCTTGGAG 
AAGCCTCAGC AGGTCTGCTG GCAGAGGAGA CTGCAGGGAC TCCAGGCTTA CAGCAGTGCA 
GGAGAACTTT CAAGCACTTT GGATCTTGCC AATACCTTGC AAAAACTTGT CCCTAGTTAC 
ACAGGTGGAT CTCTGCTGGA GGATCTTGCC AGTGGTCTGG AGCACTCCTG CCCCATGCCC 
CACCTTGCCT GCTCTTCAGA TGCGGTGGAG ATAATTCCTG CAGAGGGAGT GGGTATCTCG 
CAGCTCCTCT GCAAACAATT TCTGGTTACT GAGGAAGATA TCAGGAAACA GGAAGGGAAA 
GTGAAGACAG TCAGAGAGAG ACTCGCAATA GCACTGATTG CGGATGGACT CGCTAATGAG 
GCAGAGAAAG TGAGAGACCA AGAAGGCCGT CCTGAAAAAC GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation.
Human genetics134(10)1099-115(2015 Oct)
Carmona-Mora P,Widagdo J,Tomasetig F,Canales CP,Cha Y,Lee W,Alshawaf A,Dottori M,Whan RM,Hardeman EC,Palmer SJ

Unique features of the anti-parallel, heterodimeric coiled-coil interaction between methyl-cytosine binding domain 2 (MBD2) homologues and GATA zinc finger domain containing 2A (GATAD2A/p66?).
The Journal of biological chemistry288(5)3419-27(2013 Feb)
Walavalkar NM,Gordon N,Williams DC Jr

MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex.
The Journal of biological chemistry279(50)52456-64(2004 Dec)
Jiang CL,Jin SG,Pfeifer GP

The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity.
The Journal of biological chemistry278(43)42560-8(2003 Oct)
Yao YL,Yang WM