HMGN5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HMGN5
Entrez Gene ID	79366
Full Name	high mobility group nucleosome binding domain 5
Synonyms	NBP-45,NSBP1
General protein information	Preferred Names high mobility group nucleosome binding domain 5 Names high mobility group nucleosome-binding domain-containing protein 5 nucleosomal binding protein 1 nucleosome-binding protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq21.1
Summary	This gene encodes a nuclear protein with similarities to the high mobility group proteins, HMG14 and HMG17, which suggests that this protein may function as a nucleosomal binding and transcriptional activating protein. [provided by RefSeq, Sep 2009].
Disorder MIM:	300385

mRNA and Protein(s)

mRNA	Protein	Name
NM_030763.2	NP_110390.1	high mobility group nucleosome-binding domain-containing protein 5
XM_006724688.3	XP_006724751.1	high mobility group nucleosome-binding domain-containing protein 5 isoform X1
XM_017029840.1	XP_016885329.1	high mobility group nucleosome-binding domain-containing protein 5 isoform X3
NM_030763.3	NP_110390.1	high mobility group nucleosome-binding domain-containing protein 5
XM_017029839.1	XP_016885328.1	high mobility group nucleosome-binding domain-containing protein 5 isoform X2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	HMGN5	XP_001144951.2
Homo sapiens (human)	HMGN5	NP_110390.1
	LOC709253	XP_001103630.1
Bos taurus (cattle)	HMGN5	XP_002699982.3

Gene Ontology
Bibliography

Related articles in PubMed

Silencing HMGN5 suppresses cell growth and promotes chemosensitivity in esophageal squamous cell carcinoma.
Liu X, Ma W, Yan Y, Wu S
Journal of biochemical and molecular toxicology31(12)(2017 Dec)

Overexpression of microRNA-495 suppresses the proliferation and invasion and induces the apoptosis of osteosarcoma cells by targeting high-mobility group nucleosome-binding domain 5.
Jiang W, Zheng J, Yu T, Wang J
Oncology reports38(2)1099-1107(2017 Aug)

MicroRNA-140-5p regulates osteosarcoma chemoresistance by targeting HMGN5 and autophagy.
Meng Y, Gao R, Ma J, Zhao J, Xu E, Wang C, Zhou X
Scientific reports7(1)416(2017 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

NSBP1 was highly expressed in NSCLC cells. NSBP1 siRNA knockdown suppressed NSCLC cell proliferation and invasion. miR326 has a putative binding site in the NSBP1 3'UTR. NSBP1 overexpression abolished miR326 inhibition of cyclin B1 and MMP9 expression.
Title: Suppression of nucleosome-binding protein 1 by miR-326 impedes cell proliferation and invasion in non-small cell lung cancer cells.

Decreased miR-340 expression may contribute to the development and progression of prostate cancer through a mechanism that involves HMGN5.
Title: microRNA-340 Suppresses Tumorigenic Potential of Prostate Cancer Cells by Targeting High-Mobility Group Nucleosome-Binding Domain 5.

HMGN5 overexpression is correlated with advanced pathological grade and poorer prognosis in meningiomas
Title: HMGN5 blockade by siRNA enhances apoptosis, suppresses invasion and increases chemosensitivity to temozolomide in meningiomas.

Our data first time identified miR-186 as the upstream regulator of NSBP1
Title: MiR-186 suppresses the growth and metastasis of bladder cancer by targeting NSBP1.

High HMGN5 expression is associated with urothelial bladder cancer.
Title: Knockdown of HMGN5 suppresses the viability and invasion of human urothelial bladder cancer 5637 cells in vitro and in vivo.

The following HMGN5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HMGN5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18639	NM_030763.3 Latest version!	Homo sapiens high mobility group nucleosome binding domain 5 (HMGN5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu54222	XM_006724688.3 Latest version!	Homo sapiens high mobility group nucleosome binding domain 5 (HMGN5), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
OHu54223	XM_017029839.1 Latest version!	Homo sapiens high mobility group nucleosome binding domain 5 (HMGN5), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
OHu54224	XM_017029840.1 Latest version!	Homo sapiens high mobility group nucleosome binding domain 5 (HMGN5), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
View Old Accession Versions >>
OHu18639	NM_030763.2	Homo sapiens high mobility group nucleosome binding domain 5 (HMGN5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HMGN5 ( NM_030763.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_110390.1 Homo sapiens high mobility group nucleosome binding domain 5 (HMGN5), mRNA.

Price & Availability↑

CloneID	OHu18639
Clone ID Related Accession (Same CDS sequence)	NM_030763.2 , NM_030763.3
Accession Version	NM_030763.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 849bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	high mobility group nucleosome-binding domain-containing protein 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK094058.1, DA745749.1 and AF250329.1. This sequence is a reference standard in the RefSeqGene project. On Jul 16, 2009 this sequence version replaced NM_030763.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK094058.1, SRR1660805.260956.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCAAAA GAAAGGCTGC AGGTCAAGGT GATATGAGGC AGGAGCCAAA GAGAAGATCT 
GCCAGGTTGT CTGCTATGCT TGTGCCAGTT ACACCAGAGG TGAAGCCTAA AAGAACATCA 
AGTTCAAGGA AAATGAAGAC AAAAAGTGAT ATGATGGAAG AAAACATAGA TACAAGTGCC 
CAAGCAGTTG CTGAAACCAA GCAAGAAGCA GTTGTTGAAG AAGACTACAA TGAAAATGCT 
AAAAATGGAG AAGCCAAAAT TACAGAGGCA CCAGCTTCTG AAAAAGAAAT TGTGGAAGTA 
AAAGAAGAAA ATATTGAAGA TGCCACAGAA AAGGGAGGAG AAAAGAAAGA AGCAGTGGCA 
GCAGAAGTAA AAAATGAAGA AGAAGATCAG AAAGAAGATG AAGAAGATCA AAACGAAGAG 
AAAGGGGAAG CTGGAAAAGA AGACAAAGAT GAAAAAGGGG AAGAAGATGG AAAAGAGGAT 
AAAAATGGAA ATGAGAAAGG AGAAGATGCA AAAGAGAAAG AAGATGGAAA AAAAGGTGAA 
GACGGAAAAG GAAATGGAGA AGATGGAAAA GAGAAAGGAG AAGATGAAAA AGAGGAAGAA 
GACAGAAAAG AAACAGGAGA TGGAAAAGAG AATGAAGATG GAAAAGAGAA GGGAGATAAA 
AAAGAGGGGA AAGATGTAAA AGTCAAAGAA GATGAAAAAG AGAGAGAAGA TGGAAAAGAA 
GATGAAGGTG GAAATGAGGA AGAAGCTGGA AAAGAGAAAG AAGATTTAAA AGAAGAGGAA 
GAAGGAAAAG AGGAAGATGA GATCAAAGAA GATGATGGAA AAAAAGAGGA GCCACAGAGT 
ATTGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_110390.1
CDS	330..1178
Translation	MPKRKAAGQGDMRQEPKRRSARLSAMLVPVTPEVKPKRTSSSRKMKTKSDMMEENIDTSAQAVAETKQEAVVEEDYNENAKNGEAKITEAPASEKEIVEVKEENIEDATEKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDGKKGEDGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDGKEKGDKKEGKDVKVKEDEKEREDGKEDEGGNEEEAGKEKEDLKEEEEGKEEDEIKEDDGKKEEPQSIV

Target ORF information:

RefSeq Version	NM_030763.2
Organism	Homo sapiens(human)
Definition	Homo sapiens high mobility group nucleosome binding domain 5 (HMGN5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030763.2

ORF Insert Sequence:

ATGCCCAAAA GAAAGGCTGC AGGTCAAGGT GATATGAGGC AGGAGCCAAA GAGAAGATCT 
GCCAGGTTGT CTGCTATGCT TGTGCCAGTT ACACCAGAGG TGAAGCCTAA AAGAACATCA 
AGTTCAAGGA AAATGAAGAC AAAAAGTGAT ATGATGGAAG AAAACATAGA TACAAGTGCC 
CAAGCAGTTG CTGAAACCAA GCAAGAAGCA GTTGTTGAAG AAGACTACAA TGAAAATGCT 
AAAAATGGAG AAGCCAAAAT TACAGAGGCA CCAGCTTCTG AAAAAGAAAT TGTGGAAGTA 
AAAGAAGAAA ATATTGAAGA TGCCACAGAA AAGGGAGGAG AAAAGAAAGA AGCAGTGGCA 
GCAGAAGTAA AAAATGAAGA AGAAGATCAG AAAGAAGATG AAGAAGATCA AAACGAAGAG 
AAAGGGGAAG CTGGAAAAGA AGACAAAGAT GAAAAAGGGG AAGAAGATGG AAAAGAGGAT 
AAAAATGGAA ATGAGAAAGG AGAAGATGCA AAAGAGAAAG AAGATGGAAA AAAAGGTGAA 
GACGGAAAAG GAAATGGAGA AGATGGAAAA GAGAAAGGAG AAGATGAAAA AGAGGAAGAA 
GACAGAAAAG AAACAGGAGA TGGAAAAGAG AATGAAGATG GAAAAGAGAA GGGAGATAAA 
AAAGAGGGGA AAGATGTAAA AGTCAAAGAA GATGAAAAAG AGAGAGAAGA TGGAAAAGAA 
GATGAAGGTG GAAATGAGGA AGAAGCTGGA AAAGAGAAAG AAGATTTAAA AGAAGAGGAA 
GAAGGAAAAG AGGAAGATGA GATCAAAGAA GATGATGGAA AAAAAGAGGA GCCACAGAGT 
ATTGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HMGN5 ( NM_030763.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_110390.1 Homo sapiens high mobility group nucleosome binding domain 5 (HMGN5), mRNA.

Price & Availability↑

CloneID	OHu18639
Clone ID Related Accession (Same CDS sequence)	NM_030763.2 , NM_030763.3
Accession Version	NM_030763.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 849bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-10
Organism	Homo sapiens(human)
Product	high mobility group nucleosome-binding domain-containing protein 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK094058.1, DA745749.1, AF250329.1 and AL391294.16. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_030763.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK094058.1, SRR1803611.480579.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000358130.7/ ENSP00000350848.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCCAAAA GAAAGGCTGC AGGTCAAGGT GATATGAGGC AGGAGCCAAA GAGAAGATCT 
GCCAGGTTGT CTGCTATGCT TGTGCCAGTT ACACCAGAGG TGAAGCCTAA AAGAACATCA 
AGTTCAAGGA AAATGAAGAC AAAAAGTGAT ATGATGGAAG AAAACATAGA TACAAGTGCC 
CAAGCAGTTG CTGAAACCAA GCAAGAAGCA GTTGTTGAAG AAGACTACAA TGAAAATGCT 
AAAAATGGAG AAGCCAAAAT TACAGAGGCA CCAGCTTCTG AAAAAGAAAT TGTGGAAGTA 
AAAGAAGAAA ATATTGAAGA TGCCACAGAA AAGGGAGGAG AAAAGAAAGA AGCAGTGGCA 
GCAGAAGTAA AAAATGAAGA AGAAGATCAG AAAGAAGATG AAGAAGATCA AAACGAAGAG 
AAAGGGGAAG CTGGAAAAGA AGACAAAGAT GAAAAAGGGG AAGAAGATGG AAAAGAGGAT 
AAAAATGGAA ATGAGAAAGG AGAAGATGCA AAAGAGAAAG AAGATGGAAA AAAAGGTGAA 
GACGGAAAAG GAAATGGAGA AGATGGAAAA GAGAAAGGAG AAGATGAAAA AGAGGAAGAA 
GACAGAAAAG AAACAGGAGA TGGAAAAGAG AATGAAGATG GAAAAGAGAA GGGAGATAAA 
AAAGAGGGGA AAGATGTAAA AGTCAAAGAA GATGAAAAAG AGAGAGAAGA TGGAAAAGAA 
GATGAAGGTG GAAATGAGGA AGAAGCTGGA AAAGAGAAAG AAGATTTAAA AGAAGAGGAA 
GAAGGAAAAG AGGAAGATGA GATCAAAGAA GATGATGGAA AAAAAGAGGA GCCACAGAGT 
ATTGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_110390.1
CDS	301..1149
Translation	MPKRKAAGQGDMRQEPKRRSARLSAMLVPVTPEVKPKRTSSSRKMKTKSDMMEENIDTSAQAVAETKQEAVVEEDYNENAKNGEAKITEAPASEKEIVEVKEENIEDATEKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDGKKGEDGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDGKEKGDKKEGKDVKVKEDEKEREDGKEDEGGNEEEAGKEKEDLKEEEEGKEEDEIKEDDGKKEEPQSIV

Target ORF information:

RefSeq Version	NM_030763.3
Organism	Homo sapiens(human)
Definition	Homo sapiens high mobility group nucleosome binding domain 5 (HMGN5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030763.3

ORF Insert Sequence:

ATGCCCAAAA GAAAGGCTGC AGGTCAAGGT GATATGAGGC AGGAGCCAAA GAGAAGATCT 
GCCAGGTTGT CTGCTATGCT TGTGCCAGTT ACACCAGAGG TGAAGCCTAA AAGAACATCA 
AGTTCAAGGA AAATGAAGAC AAAAAGTGAT ATGATGGAAG AAAACATAGA TACAAGTGCC 
CAAGCAGTTG CTGAAACCAA GCAAGAAGCA GTTGTTGAAG AAGACTACAA TGAAAATGCT 
AAAAATGGAG AAGCCAAAAT TACAGAGGCA CCAGCTTCTG AAAAAGAAAT TGTGGAAGTA 
AAAGAAGAAA ATATTGAAGA TGCCACAGAA AAGGGAGGAG AAAAGAAAGA AGCAGTGGCA 
GCAGAAGTAA AAAATGAAGA AGAAGATCAG AAAGAAGATG AAGAAGATCA AAACGAAGAG 
AAAGGGGAAG CTGGAAAAGA AGACAAAGAT GAAAAAGGGG AAGAAGATGG AAAAGAGGAT 
AAAAATGGAA ATGAGAAAGG AGAAGATGCA AAAGAGAAAG AAGATGGAAA AAAAGGTGAA 
GACGGAAAAG GAAATGGAGA AGATGGAAAA GAGAAAGGAG AAGATGAAAA AGAGGAAGAA 
GACAGAAAAG AAACAGGAGA TGGAAAAGAG AATGAAGATG GAAAAGAGAA GGGAGATAAA 
AAAGAGGGGA AAGATGTAAA AGTCAAAGAA GATGAAAAAG AGAGAGAAGA TGGAAAAGAA 
GATGAAGGTG GAAATGAGGA AGAAGCTGGA AAAGAGAAAG AAGATTTAAA AGAAGAGGAA 
GAAGGAAAAG AGGAAGATGA GATCAAAGAA GATGATGGAA AAAAAGAGGA GCCACAGAGT 
ATTGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HMGN5 ( XM_006724688.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_006724751.1 Homo sapiens high mobility group nucleosome binding domain 5 (HMGN5), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu54222
Clone ID Related Accession (Same CDS sequence)	XM_006724688.3
Accession Version	XM_006724688.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 852bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	high mobility group nucleosome-binding domain-containing protein 5 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006724688.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCAAAA GAAAGGCTGC AGGTCAAGGT GATATGAGGC AGGAGCCAAA GAGAAGATCT 
GCCAGGTTGT CTGCTCAGAT GCTTGTGCCA GTTACACCAG AGGTGAAGCC TAAAAGAACA 
TCAAGTTCAA GGAAAATGAA GACAAAAAGT GATATGATGG AAGAAAACAT AGATACAAGT 
GCCCAAGCAG TTGCTGAAAC CAAGCAAGAA GCAGTTGTTG AAGAAGACTA CAATGAAAAT 
GCTAAAAATG GAGAAGCCAA AATTACAGAG GCACCAGCTT CTGAAAAAGA AATTGTGGAA 
GTAAAAGAAG AAAATATTGA AGATGCCACA GAAAAGGGAG GAGAAAAGAA AGAAGCAGTG 
GCAGCAGAAG TAAAAAATGA AGAAGAAGAT CAGAAAGAAG ATGAAGAAGA TCAAAACGAA 
GAGAAAGGGG AAGCTGGAAA AGAAGACAAA GATGAAAAAG GGGAAGAAGA TGGAAAAGAG 
GATAAAAATG GAAATGAGAA AGGAGAAGAT GCAAAAGAGA AAGAAGATGG AAAAAAAGGT 
GAAGACGGAA AAGGAAATGG AGAAGATGGA AAAGAGAAAG GAGAAGATGA AAAAGAGGAA 
GAAGACAGAA AAGAAACAGG AGATGGAAAA GAGAATGAAG ATGGAAAAGA GAAGGGAGAT 
AAAAAAGAGG GGAAAGATGT AAAAGTCAAA GAAGATGAAA AAGAGAGAGA AGATGGAAAA 
GAAGATGAAG GTGGAAATGA GGAAGAAGCT GGAAAAGAGA AAGAAGATTT AAAAGAAGAG 
GAAGAAGGAA AAGAGGAAGA TGAGATCAAA GAAGATGATG GAAAAAAAGA GGAGCCACAG 
AGTATTGTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006724751.1
CDS	277..1128
Translation	MPKRKAAGQGDMRQEPKRRSARLSAQMLVPVTPEVKPKRTSSSRKMKTKSDMMEENIDTSAQAVAETKQEAVVEEDYNENAKNGEAKITEAPASEKEIVEVKEENIEDATEKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDGKKGEDGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDGKEKGDKKEGKDVKVKEDEKEREDGKEDEGGNEEEAGKEKEDLKEEEEGKEEDEIKEDDGKKEEPQSIV

Target ORF information:

RefSeq Version	XM_006724688.3
Organism	Homo sapiens(human)
Definition	Homo sapiens high mobility group nucleosome binding domain 5 (HMGN5), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006724688.3

ORF Insert Sequence:

ATGCCCAAAA GAAAGGCTGC AGGTCAAGGT GATATGAGGC AGGAGCCAAA GAGAAGATCT 
GCCAGGTTGT CTGCTCAGAT GCTTGTGCCA GTTACACCAG AGGTGAAGCC TAAAAGAACA 
TCAAGTTCAA GGAAAATGAA GACAAAAAGT GATATGATGG AAGAAAACAT AGATACAAGT 
GCCCAAGCAG TTGCTGAAAC CAAGCAAGAA GCAGTTGTTG AAGAAGACTA CAATGAAAAT 
GCTAAAAATG GAGAAGCCAA AATTACAGAG GCACCAGCTT CTGAAAAAGA AATTGTGGAA 
GTAAAAGAAG AAAATATTGA AGATGCCACA GAAAAGGGAG GAGAAAAGAA AGAAGCAGTG 
GCAGCAGAAG TAAAAAATGA AGAAGAAGAT CAGAAAGAAG ATGAAGAAGA TCAAAACGAA 
GAGAAAGGGG AAGCTGGAAA AGAAGACAAA GATGAAAAAG GGGAAGAAGA TGGAAAAGAG 
GATAAAAATG GAAATGAGAA AGGAGAAGAT GCAAAAGAGA AAGAAGATGG AAAAAAAGGT 
GAAGACGGAA AAGGAAATGG AGAAGATGGA AAAGAGAAAG GAGAAGATGA AAAAGAGGAA 
GAAGACAGAA AAGAAACAGG AGATGGAAAA GAGAATGAAG ATGGAAAAGA GAAGGGAGAT 
AAAAAAGAGG GGAAAGATGT AAAAGTCAAA GAAGATGAAA AAGAGAGAGA AGATGGAAAA 
GAAGATGAAG GTGGAAATGA GGAAGAAGCT GGAAAAGAGA AAGAAGATTT AAAAGAAGAG 
GAAGAAGGAA AAGAGGAAGA TGAGATCAAA GAAGATGATG GAAAAAAAGA GGAGCCACAG 
AGTATTGTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HMGN5 ( XM_017029839.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016885328.1 Homo sapiens high mobility group nucleosome binding domain 5 (HMGN5), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu54223
Clone ID Related Accession (Same CDS sequence)	XM_017029839.1
Accession Version	XM_017029839.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	high mobility group nucleosome-binding domain-containing protein 5 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCAAAA GAAAGCCAAA GAGAAGATCT GCCAGGTTGT CTGCTCAGAT GCTTGTGCCA 
GTTACACCAG AGGTGAAGCC TAAAAGAACA TCAAGTTCAA GGAAAATGAA GACAAAAAGT 
GATATGATGG AAGAAAACAT AGATACAAGT GCCCAAGCAG TTGCTGAAAC CAAGCAAGAA 
GCAGTTGTTG AAGAAGACTA CAATGAAAAT GCTAAAAATG GAGAAGCCAA AATTACAGAG 
GCACCAGCTT CTGAAAAAGA AATTGTGGAA GTAAAAGAAG AAAATATTGA AGATGCCACA 
GAAAAGGGAG GAGAAAAGAA AGAAGCAGTG GCAGCAGAAG TAAAAAATGA AGAAGAAGAT 
CAGAAAGAAG ATGAAGAAGA TCAAAACGAA GAGAAAGGGG AAGCTGGAAA AGAAGACAAA 
GATGAAAAAG GGGAAGAAGA TGGAAAAGAG GATAAAAATG GAAATGAGAA AGGAGAAGAT 
GCAAAAGAGA AAGAAGATGG AAAAAAAGGT GAAGACGGAA AAGGAAATGG AGAAGATGGA 
AAAGAGAAAG GAGAAGATGA AAAAGAGGAA GAAGACAGAA AAGAAACAGG AGATGGAAAA 
GAGAATGAAG ATGGAAAAGA GAAGGGAGAT AAAAAAGAGG GGAAAGATGT AAAAGTCAAA 
GAAGATGAAA AAGAGAGAGA AGATGGAAAA GAAGATGAAG GTGGAAATGA GGAAGAAGCT 
GGAAAAGAGA AAGAAGATTT AAAAGAAGAG GAAGAAGGAA AAGAGGAAGA TGAGATCAAA 
GAAGATGATG GAAAAAAAGA GGAGCCACAG AGTATTGTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016885328.1
CDS	187..1008
Translation	MPKRKPKRRSARLSAQMLVPVTPEVKPKRTSSSRKMKTKSDMMEENIDTSAQAVAETKQEAVVEEDYNENAKNGEAKITEAPASEKEIVEVKEENIEDATEKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDGKKGEDGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDGKEKGDKKEGKDVKVKEDEKEREDGKEDEGGNEEEAGKEKEDLKEEEEGKEEDEIKEDDGKKEEPQSIV

Target ORF information:

RefSeq Version	XM_017029839.1
Organism	Homo sapiens(human)
Definition	Homo sapiens high mobility group nucleosome binding domain 5 (HMGN5), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017029839.1

ORF Insert Sequence:

ATGCCCAAAA GAAAGCCAAA GAGAAGATCT GCCAGGTTGT CTGCTCAGAT GCTTGTGCCA 
GTTACACCAG AGGTGAAGCC TAAAAGAACA TCAAGTTCAA GGAAAATGAA GACAAAAAGT 
GATATGATGG AAGAAAACAT AGATACAAGT GCCCAAGCAG TTGCTGAAAC CAAGCAAGAA 
GCAGTTGTTG AAGAAGACTA CAATGAAAAT GCTAAAAATG GAGAAGCCAA AATTACAGAG 
GCACCAGCTT CTGAAAAAGA AATTGTGGAA GTAAAAGAAG AAAATATTGA AGATGCCACA 
GAAAAGGGAG GAGAAAAGAA AGAAGCAGTG GCAGCAGAAG TAAAAAATGA AGAAGAAGAT 
CAGAAAGAAG ATGAAGAAGA TCAAAACGAA GAGAAAGGGG AAGCTGGAAA AGAAGACAAA 
GATGAAAAAG GGGAAGAAGA TGGAAAAGAG GATAAAAATG GAAATGAGAA AGGAGAAGAT 
GCAAAAGAGA AAGAAGATGG AAAAAAAGGT GAAGACGGAA AAGGAAATGG AGAAGATGGA 
AAAGAGAAAG GAGAAGATGA AAAAGAGGAA GAAGACAGAA AAGAAACAGG AGATGGAAAA 
GAGAATGAAG ATGGAAAAGA GAAGGGAGAT AAAAAAGAGG GGAAAGATGT AAAAGTCAAA 
GAAGATGAAA AAGAGAGAGA AGATGGAAAA GAAGATGAAG GTGGAAATGA GGAAGAAGCT 
GGAAAAGAGA AAGAAGATTT AAAAGAAGAG GAAGAAGGAA AAGAGGAAGA TGAGATCAAA 
GAAGATGATG GAAAAAAAGA GGAGCCACAG AGTATTGTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HMGN5 ( XM_017029840.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016885329.1 Homo sapiens high mobility group nucleosome binding domain 5 (HMGN5), transcript variant X3, mRNA.

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CloneID	OHu54224
Clone ID Related Accession (Same CDS sequence)	XM_017029840.1
Accession Version	XM_017029840.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 819bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	high mobility group nucleosome-binding domain-containing protein 5 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCAAAA GAAAGCCAAA GAGAAGATCT GCCAGGTTGT CTGCTATGCT TGTGCCAGTT 
ACACCAGAGG TGAAGCCTAA AAGAACATCA AGTTCAAGGA AAATGAAGAC AAAAAGTGAT 
ATGATGGAAG AAAACATAGA TACAAGTGCC CAAGCAGTTG CTGAAACCAA GCAAGAAGCA 
GTTGTTGAAG AAGACTACAA TGAAAATGCT AAAAATGGAG AAGCCAAAAT TACAGAGGCA 
CCAGCTTCTG AAAAAGAAAT TGTGGAAGTA AAAGAAGAAA ATATTGAAGA TGCCACAGAA 
AAGGGAGGAG AAAAGAAAGA AGCAGTGGCA GCAGAAGTAA AAAATGAAGA AGAAGATCAG 
AAAGAAGATG AAGAAGATCA AAACGAAGAG AAAGGGGAAG CTGGAAAAGA AGACAAAGAT 
GAAAAAGGGG AAGAAGATGG AAAAGAGGAT AAAAATGGAA ATGAGAAAGG AGAAGATGCA 
AAAGAGAAAG AAGATGGAAA AAAAGGTGAA GACGGAAAAG GAAATGGAGA AGATGGAAAA 
GAGAAAGGAG AAGATGAAAA AGAGGAAGAA GACAGAAAAG AAACAGGAGA TGGAAAAGAG 
AATGAAGATG GAAAAGAGAA GGGAGATAAA AAAGAGGGGA AAGATGTAAA AGTCAAAGAA 
GATGAAAAAG AGAGAGAAGA TGGAAAAGAA GATGAAGGTG GAAATGAGGA AGAAGCTGGA 
AAAGAGAAAG AAGATTTAAA AGAAGAGGAA GAAGGAAAAG AGGAAGATGA GATCAAAGAA 
GATGATGGAA AAAAAGAGGA GCCACAGAGT ATTGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016885329.1
CDS	184..1002
Translation	MPKRKPKRRSARLSAMLVPVTPEVKPKRTSSSRKMKTKSDMMEENIDTSAQAVAETKQEAVVEEDYNENAKNGEAKITEAPASEKEIVEVKEENIEDATEKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDGKKGEDGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDGKEKGDKKEGKDVKVKEDEKEREDGKEDEGGNEEEAGKEKEDLKEEEEGKEEDEIKEDDGKKEEPQSIV

Target ORF information:

RefSeq Version	XM_017029840.1
Organism	Homo sapiens(human)
Definition	Homo sapiens high mobility group nucleosome binding domain 5 (HMGN5), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017029840.1

ORF Insert Sequence:

ATGCCCAAAA GAAAGCCAAA GAGAAGATCT GCCAGGTTGT CTGCTATGCT TGTGCCAGTT 
ACACCAGAGG TGAAGCCTAA AAGAACATCA AGTTCAAGGA AAATGAAGAC AAAAAGTGAT 
ATGATGGAAG AAAACATAGA TACAAGTGCC CAAGCAGTTG CTGAAACCAA GCAAGAAGCA 
GTTGTTGAAG AAGACTACAA TGAAAATGCT AAAAATGGAG AAGCCAAAAT TACAGAGGCA 
CCAGCTTCTG AAAAAGAAAT TGTGGAAGTA AAAGAAGAAA ATATTGAAGA TGCCACAGAA 
AAGGGAGGAG AAAAGAAAGA AGCAGTGGCA GCAGAAGTAA AAAATGAAGA AGAAGATCAG 
AAAGAAGATG AAGAAGATCA AAACGAAGAG AAAGGGGAAG CTGGAAAAGA AGACAAAGAT 
GAAAAAGGGG AAGAAGATGG AAAAGAGGAT AAAAATGGAA ATGAGAAAGG AGAAGATGCA 
AAAGAGAAAG AAGATGGAAA AAAAGGTGAA GACGGAAAAG GAAATGGAGA AGATGGAAAA 
GAGAAAGGAG AAGATGAAAA AGAGGAAGAA GACAGAAAAG AAACAGGAGA TGGAAAAGAG 
AATGAAGATG GAAAAGAGAA GGGAGATAAA AAAGAGGGGA AAGATGTAAA AGTCAAAGAA 
GATGAAAAAG AGAGAGAAGA TGGAAAAGAA GATGAAGGTG GAAATGAGGA AGAAGCTGGA 
AAAGAGAAAG AAGATTTAAA AGAAGAGGAA GAAGGAAAAG AGGAAGATGA GATCAAAGAA 
GATGATGGAA AAAAAGAGGA GCCACAGAGT ATTGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Silencing HMGN5 suppresses cell growth and promotes chemosensitivity in esophageal squamous cell carcinoma.
Journal of biochemical and molecular toxicology31(12)(2017 Dec)
Liu X,Ma W,Yan Y,Wu S

Overexpression of microRNA-495 suppresses the proliferation and invasion and induces the apoptosis of osteosarcoma cells by targeting high-mobility group nucleosome-binding domain 5.
Oncology reports38(2)1099-1107(2017 Aug)
Jiang W,Zheng J,Yu T,Wang J

MicroRNA-140-5p regulates osteosarcoma chemoresistance by targeting HMGN5 and autophagy.
Scientific reports7(1)416(2017 Mar)
Meng Y,Gao R,Ma J,Zhao J,Xu E,Wang C,Zhou X