XPNPEP2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	XPNPEP2
Entrez Gene ID	7512
Full Name	X-prolyl aminopeptidase 2
Synonyms	AEACEI,APP2
General protein information	Preferred Names X-prolyl aminopeptidase 2 Names xaa-Pro aminopeptidase 2 X-Pro aminopeptidase 2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound aminoacylproline aminopeptidase mAmP membrane-bound APP membrane-bound AmP membrane-bound aminopeptidase P
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq26.1
Summary	Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes. [provided by RefSeq, Jul 2008].
Disorder MIM:	300145
Disorder Html:	{Angioedema induced by ACE inhibitors, susceptibility to}, 300909 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_003399.6	NP_003390.4	xaa-Pro aminopeptidase 2 precursor
NM_003399.5	NP_003390.4	xaa-Pro aminopeptidase 2 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Xpnpep2	NP_573476.2
Gallus gallus (chicken)	XPNPEP2	XP_420139.4
Bos taurus (cattle)	XPNPEP2	NP_001192484.1
Rattus norvegicus (Norway rat)	Xpnpep2	NP_476496.1
Xenopus tropicalis (tropical clawed frog)	xpnpep2	XP_002940335.2
Homo sapiens (human)	XPNPEP2	NP_003390.4
Pan troglodytes (chimpanzee)	XPNPEP2	XP_521256.3
	XPNPEP2	XP_001091201.1
Canis lupus familiaris (dog)	XPNPEP2	XP_549245.3
Danio rerio (zebrafish)	xpnpep2	NP_957326.1

Gene Ontology
Bibliography

Related articles in PubMed

XPNPEP2 is overexpressed in cervical cancer and promotes cervical cancer metastasis.
Cheng T, Wei R, Jiang G, Zhou Y, Lv M, Dai Y, Yuan Y, Luo D, Ma D, Li F, Xi L
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(7)1010428317717122(2017 Jul)

Hereditary angioedema with F12 mutation: Clinical features and enzyme polymorphisms in 9 Southwestern Spanish families.
Pi?ero-Saavedra M, Gonz?lez-Quevedo T, Saenz de San Pedro B, Alcaraz C, Bobadilla-Gonz?lez P, Fern?ndez-Vieira L, Hinojosa B, Garc?a-Lozano R
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology117(5)520-526(2016 11)

The development of a novel molecular assay examining the role of aminopeptidase P polymorphisms in acute hypotensive transfusion reactions.
Hui Y, Wu Y, Tormey CA
Archives of pathology & laboratory medicine137(1)96-9(2013 Jan)

A functional XPNPEP2 promoter haplotype leads to reduced plasma aminopeptidase P and increased risk of ACE inhibitor-induced angioedema.
Cilia La Corte AL, Carter AM, Rice GI, Duan QL, Rouleau GA, Adam A, Grant PJ, Hooper NM
Human mutation32(11)1326-31(2011 Nov)

Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS.
Zhang Y, Li Y, Qiu F, Qiu Z
Electrophoresis31(23-24)3797-807(2010 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

we demonstrated that XPNPEP2 had significant effects on the metastasis of xenografted tumors in vivo. Collectively, our findings identify the novel function of XPNPEP2 in the metastasis of cervical cancer and suggest that XPNPEP2 could be a novel potential therapeutic target for the treatment of cervical cancer
Title: XPNPEP2 is overexpressed in cervical cancer and promotes cervical cancer metastasis.

The XPNPEP2 c-2399A and the ACE insertion/deletion polymorphisms analyzed in a population of patients with hereditary angioedema with F12 mutation were not a major determinant of disease expression.
Title: Hereditary angioedema with F12 mutation: Clinical features and enzyme polymorphisms in 9 Southwestern Spanish families.

A C-2399A SNP assay was applied to patients with acute hypotensive transfusion reactions. In a pilot study, 2 patients (50%) were found to possess C-2399A polymorphisms. One was found to be homozygous, and the other was heterozygous.
Title: The development of a novel molecular assay examining the role of aminopeptidase P polymorphisms in acute hypotensive transfusion reactions.

the genetic regulation of the XPNPEP2 gene and identify the genetic factors contributing to variance in plasma aminopeptidase P activity and ACEi-angioedema (XPNPEP2)
Title: A functional XPNPEP2 promoter haplotype leads to reduced plasma aminopeptidase P and increased risk of ACE inhibitor-induced angioedema.

Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough.

The following XPNPEP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the XPNPEP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19512	NM_003399.6 Latest version!	Homo sapiens X-prolyl aminopeptidase 2 (XPNPEP2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
View Old Accession Versions >>
OHu19512	NM_003399.5	Homo sapiens X-prolyl aminopeptidase 2 (XPNPEP2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

XPNPEP2 ( NM_003399.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_003390.4 Homo sapiens X-prolyl aminopeptidase 2 (XPNPEP2), mRNA.

Price & Availability↑

CloneID	OHu19512
Clone ID Related Accession (Same CDS sequence)	NM_003399.6 , NM_003399.5
Accession Version	NM_003399.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2025bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	xaa-Pro aminopeptidase 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U90724.2, BP270314.1, CD617070.1, BX386512.2, BF830085.1, AL023653.1 and BQ224207.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_003399.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC126174.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000371106.4/ ENSP00000360147.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCCGGG CTCACTGGGG CTGCTGCCCC TGGCTGGTCC TCCTCTGTGC TTGTGCCTGG 
GGCCACACAA AGCCAGTGGA CCTTGGAGGG CAGGATGTGA GAAACTGTTC CACCAACCCC 
CCTTACCTTC CAGTTACTGT GGTCAATACC ACAATGTCAC TCACAGCCCT CCGCCAGCAG 
ATGCAGACCC AGAATCTCTC AGCCTACATC ATCCCAGGCA CAGATGCTCA CATGAACGAG 
TACATCGGCC AACATGACGA GAGGCGTGCG TGGATTACAG GCTTTACAGG GTCTGCAGGA 
ACTGCAGTGG TGACTATGAA GAAAGCAGCT GTCTGGACCG ACAGTCGCTA CTGGACTCAG 
GCTGAGCGGC AGATGGACTG CAACTGGGAG CTCCATAAGG AAGTTGGCAC CACTCCTATT 
GTCACCTGGC TCCTCACCGA GATTCCTGCT GGAGGGCGTG TGGGTTTTGA CCCCTTCCTC 
TTGTCCATTG ACACCTGGGA GAGTTATGAT CTGGCCCTCC AAGGCTCTAA CAGACAGCTG 
GTGTCCATCA CAACCAATCT TGTGGACCTG GTATGGGGAT CAGAGAGGCC ACCGGTTCCA 
AATCAACCCA TTTATGCCCT GCAGGAGGCA TTCACAGGGA GCACTTGGCA GGAGAAAGTA 
TCTGGCGTCC GAAGCCAGAT GCAGAAGCAT CAAAAGGTCC CGACTGCCGT CCTTCTGTCG 
GCGCTTGAGG AGACGGCCTG GCTCTTCAAC CTTCGAGCCA GTGACATCCC CTATAACCCC 
TTCTTCTATT CCTACACGCT GCTCACAGAC TCTTCTATTA GGTTGTTTGC AAACAAGAGT 
CGCTTTAGCT CCGAAACCTT GAGCTATCTG AACTCCAGTT GCACAGGCCC CATGTGTGTG 
CAAATCGAGG ATTACAGCCA AGTTCGTGAC AGCATCCAGG CCTACTCATT GGGAGATGTG 
AGGATCTGGA TTGGGACCAG CTATACCATG TATGGGATCT ATGAAATGAT ACCCAAGGAG 
AAACTCGTGA CAGACACCTA CTCCCCAGTG ATGATGACCA AGGCAGTGAA GAACAGCAAG 
GAGCAGGCCC TCCTCAAGGC CAGCCACGTG CGGGACGCTG TGGCTGTGAT CCGGTACTTG 
GTCTGGCTGG AGAAGAACGT GCCCAAAGGC ACAGTGGATG AGTTCTCGGG GGCAGAGATC 
GTGGACAAGT TCCGAGGAGA AGAACAGTTC TCCTCCGGAC CCAGTTTTGA AACCATCTCT 
GCTAGTGGTC TGAATGCTGC CCTGGCCCAC TACAGCCCGA CCAAGGAGCT GAACCGCAAG 
CTGTCCTCAG ATGAGATGTA CCTGCTGGAC TCTGGGGGGC AGTACTGGGA CGGGACCACA 
GACATCACCA GAACAGTCCA CTGGGGCACC CCCTCTGCCT TCCAGAAGGA GGCATACACC 
CGTGTGCTGA TAGGAAATAT TGACCTGTCC AGGCTCATCT TTCCCGCTGC TACATCAGGG 
CGAATGGTGG AGGCCTTTGC CCGCAGAGCC TTGTGGGATG CTGGTCTCAA TTATGGTCAT 
GGGACAGGCC ACGGCATTGG CAACTTCCTG TGTGTGCATG AGTGGCCAGT GGGATTCCAG 
TCCAACAACA TCGCTATGGC CAAGGGCATG TTCACTTCCA TTGAACCTGG TTACTATAAG 
GATGGAGAAT TTGGGATCCG TCTCGAAGAT GTGGCTCTCG TGGTAGAAGC AAAGACCAAG 
TACCCAGGGA GCTACCTGAC CTTTGAAGTG GTATCATTTG TGCCCTATGA CCGGAACCTC 
ATCGATGTCA GCCTGCTGTC TCCCGAGCAT CTCCAGTACC TGAATCGCTA CTACCAGACC 
ATCCGGGAGA AGGTGGGTCC AGAGCTGCAG AGGCGCCAGC TACTAGAGGA GTTCGAGTGG 
CTTCAACAGC ACACAGAGCC CCTGGCCGCC AGGGCCCCAG ACACCGCCTC CTGGGCCTCT 
GTGTTAGTGG TCTCCACCCT TGCCATCCTT GGCTGGAGTG TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003390.4
CDS	236..2260
Translation	MARAHWGCCPWLVLLCACAWGHTKPVDLGGQDVRNCSTNPPYLPVTVVNTTMSLTALRQQMQTQNLSAYIIPGTDAHMNEYIGQHDERRAWITGFTGSAGTAVVTMKKAAVWTDSRYWTQAERQMDCNWELHKEVGTTPIVTWLLTEIPAGGRVGFDPFLLSIDTWESYDLALQGSNRQLVSITTNLVDLVWGSERPPVPNQPIYALQEAFTGSTWQEKVSGVRSQMQKHQKVPTAVLLSALEETAWLFNLRASDIPYNPFFYSYTLLTDSSIRLFANKSRFSSETLSYLNSSCTGPMCVQIEDYSQVRDSIQAYSLGDVRIWIGTSYTMYGIYEMIPKEKLVTDTYSPVMMTKAVKNSKEQALLKASHVRDAVAVIRYLVWLEKNVPKGTVDEFSGAEIVDKFRGEEQFSSGPSFETISASGLNAALAHYSPTKELNRKLSSDEMYLLDSGGQYWDGTTDITRTVHWGTPSAFQKEAYTRVLIGNIDLSRLIFPAATSGRMVEAFARRALWDAGLNYGHGTGHGIGNFLCVHEWPVGFQSNNIAMAKGMFTSIEPGYYKDGEFGIRLEDVALVVEAKTKYPGSYLTFEVVSFVPYDRNLIDVSLLSPEHLQYLNRYYQTIREKVGPELQRRQLLEEFEWLQQHTEPLAARAPDTASWASVLVVSTLAILGWSV

Target ORF information:

RefSeq Version	NM_003399.6
Organism	Homo sapiens(human)
Definition	Homo sapiens X-prolyl aminopeptidase 2 (XPNPEP2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003399.6

ORF Insert Sequence:

ATGGCCCGGG CTCACTGGGG CTGCTGCCCC TGGCTGGTCC TCCTCTGTGC TTGTGCCTGG 
GGCCACACAA AGCCAGTGGA CCTTGGAGGG CAGGATGTGA GAAACTGTTC CACCAACCCC 
CCTTACCTTC CAGTTACTGT GGTCAATACC ACAATGTCAC TCACAGCCCT CCGCCAGCAG 
ATGCAGACCC AGAATCTCTC AGCCTACATC ATCCCAGGCA CAGATGCTCA CATGAACGAG 
TACATCGGCC AACATGACGA GAGGCGTGCG TGGATTACAG GCTTTACAGG GTCTGCAGGA 
ACTGCAGTGG TGACTATGAA GAAAGCAGCT GTCTGGACCG ACAGTCGCTA CTGGACTCAG 
GCTGAGCGGC AGATGGACTG CAACTGGGAG CTCCATAAGG AAGTTGGCAC CACTCCTATT 
GTCACCTGGC TCCTCACCGA GATTCCTGCT GGAGGGCGTG TGGGTTTTGA CCCCTTCCTC 
TTGTCCATTG ACACCTGGGA GAGTTATGAT CTGGCCCTCC AAGGCTCTAA CAGACAGCTG 
GTGTCCATCA CAACCAATCT TGTGGACCTG GTATGGGGAT CAGAGAGGCC ACCGGTTCCA 
AATCAACCCA TTTATGCCCT GCAGGAGGCA TTCACAGGGA GCACTTGGCA GGAGAAAGTA 
TCTGGCGTCC GAAGCCAGAT GCAGAAGCAT CAAAAGGTCC CGACTGCCGT CCTTCTGTCG 
GCGCTTGAGG AGACGGCCTG GCTCTTCAAC CTTCGAGCCA GTGACATCCC CTATAACCCC 
TTCTTCTATT CCTACACGCT GCTCACAGAC TCTTCTATTA GGTTGTTTGC AAACAAGAGT 
CGCTTTAGCT CCGAAACCTT GAGCTATCTG AACTCCAGTT GCACAGGCCC CATGTGTGTG 
CAAATCGAGG ATTACAGCCA AGTTCGTGAC AGCATCCAGG CCTACTCATT GGGAGATGTG 
AGGATCTGGA TTGGGACCAG CTATACCATG TATGGGATCT ATGAAATGAT ACCCAAGGAG 
AAACTCGTGA CAGACACCTA CTCCCCAGTG ATGATGACCA AGGCAGTGAA GAACAGCAAG 
GAGCAGGCCC TCCTCAAGGC CAGCCACGTG CGGGACGCTG TGGCTGTGAT CCGGTACTTG 
GTCTGGCTGG AGAAGAACGT GCCCAAAGGC ACAGTGGATG AGTTCTCGGG GGCAGAGATC 
GTGGACAAGT TCCGAGGAGA AGAACAGTTC TCCTCCGGAC CCAGTTTTGA AACCATCTCT 
GCTAGTGGTC TGAATGCTGC CCTGGCCCAC TACAGCCCGA CCAAGGAGCT GAACCGCAAG 
CTGTCCTCAG ATGAGATGTA CCTGCTGGAC TCTGGGGGGC AGTACTGGGA CGGGACCACA 
GACATCACCA GAACAGTCCA CTGGGGCACC CCCTCTGCCT TCCAGAAGGA GGCATACACC 
CGTGTGCTGA TAGGAAATAT TGACCTGTCC AGGCTCATCT TTCCCGCTGC TACATCAGGG 
CGAATGGTGG AGGCCTTTGC CCGCAGAGCC TTGTGGGATG CTGGTCTCAA TTATGGTCAT 
GGGACAGGCC ACGGCATTGG CAACTTCCTG TGTGTGCATG AGTGGCCAGT GGGATTCCAG 
TCCAACAACA TCGCTATGGC CAAGGGCATG TTCACTTCCA TTGAACCTGG TTACTATAAG 
GATGGAGAAT TTGGGATCCG TCTCGAAGAT GTGGCTCTCG TGGTAGAAGC AAAGACCAAG 
TACCCAGGGA GCTACCTGAC CTTTGAAGTG GTATCATTTG TGCCCTATGA CCGGAACCTC 
ATCGATGTCA GCCTGCTGTC TCCCGAGCAT CTCCAGTACC TGAATCGCTA CTACCAGACC 
ATCCGGGAGA AGGTGGGTCC AGAGCTGCAG AGGCGCCAGC TACTAGAGGA GTTCGAGTGG 
CTTCAACAGC ACACAGAGCC CCTGGCCGCC AGGGCCCCAG ACACCGCCTC CTGGGCCTCT 
GTGTTAGTGG TCTCCACCCT TGCCATCCTT GGCTGGAGTG TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

XPNPEP2 ( NM_003399.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_003390.4 Homo sapiens X-prolyl aminopeptidase 2 (XPNPEP2), mRNA.

Price & Availability↑

CloneID	OHu19512
Clone ID Related Accession (Same CDS sequence)	NM_003399.6 , NM_003399.5
Accession Version	NM_003399.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2025bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	xaa-Pro aminopeptidase 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U90724.2, BP270314.1, CD617070.1, BX386512.2, BF830085.1, AL023653.1 and BQ224207.1. This sequence is a reference standard in the RefSeqGene project. On Apr 21, 2006 this sequence version replaced NM_003399.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC126174.1, U90724.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCGGG CTCACTGGGG CTGCTGCCCC TGGCTGGTCC TCCTCTGTGC TTGTGCCTGG 
GGCCACACAA AGCCAGTGGA CCTTGGAGGG CAGGATGTGA GAAACTGTTC CACCAACCCC 
CCTTACCTTC CAGTTACTGT GGTCAATACC ACAATGTCAC TCACAGCCCT CCGCCAGCAG 
ATGCAGACCC AGAATCTCTC AGCCTACATC ATCCCAGGCA CAGATGCTCA CATGAACGAG 
TACATCGGCC AACATGACGA GAGGCGTGCG TGGATTACAG GCTTTACAGG GTCTGCAGGA 
ACTGCAGTGG TGACTATGAA GAAAGCAGCT GTCTGGACCG ACAGTCGCTA CTGGACTCAG 
GCTGAGCGGC AGATGGACTG CAACTGGGAG CTCCATAAGG AAGTTGGCAC CACTCCTATT 
GTCACCTGGC TCCTCACCGA GATTCCTGCT GGAGGGCGTG TGGGTTTTGA CCCCTTCCTC 
TTGTCCATTG ACACCTGGGA GAGTTATGAT CTGGCCCTCC AAGGCTCTAA CAGACAGCTG 
GTGTCCATCA CAACCAATCT TGTGGACCTG GTATGGGGAT CAGAGAGGCC ACCGGTTCCA 
AATCAACCCA TTTATGCCCT GCAGGAGGCA TTCACAGGGA GCACTTGGCA GGAGAAAGTA 
TCTGGCGTCC GAAGCCAGAT GCAGAAGCAT CAAAAGGTCC CGACTGCCGT CCTTCTGTCG 
GCGCTTGAGG AGACGGCCTG GCTCTTCAAC CTTCGAGCCA GTGACATCCC CTATAACCCC 
TTCTTCTATT CCTACACGCT GCTCACAGAC TCTTCTATTA GGTTGTTTGC AAACAAGAGT 
CGCTTTAGCT CCGAAACCTT GAGCTATCTG AACTCCAGTT GCACAGGCCC CATGTGTGTG 
CAAATCGAGG ATTACAGCCA AGTTCGTGAC AGCATCCAGG CCTACTCATT GGGAGATGTG 
AGGATCTGGA TTGGGACCAG CTATACCATG TATGGGATCT ATGAAATGAT ACCCAAGGAG 
AAACTCGTGA CAGACACCTA CTCCCCAGTG ATGATGACCA AGGCAGTGAA GAACAGCAAG 
GAGCAGGCCC TCCTCAAGGC CAGCCACGTG CGGGACGCTG TGGCTGTGAT CCGGTACTTG 
GTCTGGCTGG AGAAGAACGT GCCCAAAGGC ACAGTGGATG AGTTCTCGGG GGCAGAGATC 
GTGGACAAGT TCCGAGGAGA AGAACAGTTC TCCTCCGGAC CCAGTTTTGA AACCATCTCT 
GCTAGTGGTC TGAATGCTGC CCTGGCCCAC TACAGCCCGA CCAAGGAGCT GAACCGCAAG 
CTGTCCTCAG ATGAGATGTA CCTGCTGGAC TCTGGGGGGC AGTACTGGGA CGGGACCACA 
GACATCACCA GAACAGTCCA CTGGGGCACC CCCTCTGCCT TCCAGAAGGA GGCATACACC 
CGTGTGCTGA TAGGAAATAT TGACCTGTCC AGGCTCATCT TTCCCGCTGC TACATCAGGG 
CGAATGGTGG AGGCCTTTGC CCGCAGAGCC TTGTGGGATG CTGGTCTCAA TTATGGTCAT 
GGGACAGGCC ACGGCATTGG CAACTTCCTG TGTGTGCATG AGTGGCCAGT GGGATTCCAG 
TCCAACAACA TCGCTATGGC CAAGGGCATG TTCACTTCCA TTGAACCTGG TTACTATAAG 
GATGGAGAAT TTGGGATCCG TCTCGAAGAT GTGGCTCTCG TGGTAGAAGC AAAGACCAAG 
TACCCAGGGA GCTACCTGAC CTTTGAAGTG GTATCATTTG TGCCCTATGA CCGGAACCTC 
ATCGATGTCA GCCTGCTGTC TCCCGAGCAT CTCCAGTACC TGAATCGCTA CTACCAGACC 
ATCCGGGAGA AGGTGGGTCC AGAGCTGCAG AGGCGCCAGC TACTAGAGGA GTTCGAGTGG 
CTTCAACAGC ACACAGAGCC CCTGGCCGCC AGGGCCCCAG ACACCGCCTC CTGGGCCTCT 
GTGTTAGTGG TCTCCACCCT TGCCATCCTT GGCTGGAGTG TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003390.4
CDS	245..2269
Translation	MARAHWGCCPWLVLLCACAWGHTKPVDLGGQDVRNCSTNPPYLPVTVVNTTMSLTALRQQMQTQNLSAYIIPGTDAHMNEYIGQHDERRAWITGFTGSAGTAVVTMKKAAVWTDSRYWTQAERQMDCNWELHKEVGTTPIVTWLLTEIPAGGRVGFDPFLLSIDTWESYDLALQGSNRQLVSITTNLVDLVWGSERPPVPNQPIYALQEAFTGSTWQEKVSGVRSQMQKHQKVPTAVLLSALEETAWLFNLRASDIPYNPFFYSYTLLTDSSIRLFANKSRFSSETLSYLNSSCTGPMCVQIEDYSQVRDSIQAYSLGDVRIWIGTSYTMYGIYEMIPKEKLVTDTYSPVMMTKAVKNSKEQALLKASHVRDAVAVIRYLVWLEKNVPKGTVDEFSGAEIVDKFRGEEQFSSGPSFETISASGLNAALAHYSPTKELNRKLSSDEMYLLDSGGQYWDGTTDITRTVHWGTPSAFQKEAYTRVLIGNIDLSRLIFPAATSGRMVEAFARRALWDAGLNYGHGTGHGIGNFLCVHEWPVGFQSNNIAMAKGMFTSIEPGYYKDGEFGIRLEDVALVVEAKTKYPGSYLTFEVVSFVPYDRNLIDVSLLSPEHLQYLNRYYQTIREKVGPELQRRQLLEEFEWLQQHTEPLAARAPDTASWASVLVVSTLAILGWSV

Target ORF information:

RefSeq Version	NM_003399.5
Organism	Homo sapiens(human)
Definition	Homo sapiens X-prolyl aminopeptidase 2 (XPNPEP2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003399.5

ORF Insert Sequence:

ATGGCCCGGG CTCACTGGGG CTGCTGCCCC TGGCTGGTCC TCCTCTGTGC TTGTGCCTGG 
GGCCACACAA AGCCAGTGGA CCTTGGAGGG CAGGATGTGA GAAACTGTTC CACCAACCCC 
CCTTACCTTC CAGTTACTGT GGTCAATACC ACAATGTCAC TCACAGCCCT CCGCCAGCAG 
ATGCAGACCC AGAATCTCTC AGCCTACATC ATCCCAGGCA CAGATGCTCA CATGAACGAG 
TACATCGGCC AACATGACGA GAGGCGTGCG TGGATTACAG GCTTTACAGG GTCTGCAGGA 
ACTGCAGTGG TGACTATGAA GAAAGCAGCT GTCTGGACCG ACAGTCGCTA CTGGACTCAG 
GCTGAGCGGC AGATGGACTG CAACTGGGAG CTCCATAAGG AAGTTGGCAC CACTCCTATT 
GTCACCTGGC TCCTCACCGA GATTCCTGCT GGAGGGCGTG TGGGTTTTGA CCCCTTCCTC 
TTGTCCATTG ACACCTGGGA GAGTTATGAT CTGGCCCTCC AAGGCTCTAA CAGACAGCTG 
GTGTCCATCA CAACCAATCT TGTGGACCTG GTATGGGGAT CAGAGAGGCC ACCGGTTCCA 
AATCAACCCA TTTATGCCCT GCAGGAGGCA TTCACAGGGA GCACTTGGCA GGAGAAAGTA 
TCTGGCGTCC GAAGCCAGAT GCAGAAGCAT CAAAAGGTCC CGACTGCCGT CCTTCTGTCG 
GCGCTTGAGG AGACGGCCTG GCTCTTCAAC CTTCGAGCCA GTGACATCCC CTATAACCCC 
TTCTTCTATT CCTACACGCT GCTCACAGAC TCTTCTATTA GGTTGTTTGC AAACAAGAGT 
CGCTTTAGCT CCGAAACCTT GAGCTATCTG AACTCCAGTT GCACAGGCCC CATGTGTGTG 
CAAATCGAGG ATTACAGCCA AGTTCGTGAC AGCATCCAGG CCTACTCATT GGGAGATGTG 
AGGATCTGGA TTGGGACCAG CTATACCATG TATGGGATCT ATGAAATGAT ACCCAAGGAG 
AAACTCGTGA CAGACACCTA CTCCCCAGTG ATGATGACCA AGGCAGTGAA GAACAGCAAG 
GAGCAGGCCC TCCTCAAGGC CAGCCACGTG CGGGACGCTG TGGCTGTGAT CCGGTACTTG 
GTCTGGCTGG AGAAGAACGT GCCCAAAGGC ACAGTGGATG AGTTCTCGGG GGCAGAGATC 
GTGGACAAGT TCCGAGGAGA AGAACAGTTC TCCTCCGGAC CCAGTTTTGA AACCATCTCT 
GCTAGTGGTC TGAATGCTGC CCTGGCCCAC TACAGCCCGA CCAAGGAGCT GAACCGCAAG 
CTGTCCTCAG ATGAGATGTA CCTGCTGGAC TCTGGGGGGC AGTACTGGGA CGGGACCACA 
GACATCACCA GAACAGTCCA CTGGGGCACC CCCTCTGCCT TCCAGAAGGA GGCATACACC 
CGTGTGCTGA TAGGAAATAT TGACCTGTCC AGGCTCATCT TTCCCGCTGC TACATCAGGG 
CGAATGGTGG AGGCCTTTGC CCGCAGAGCC TTGTGGGATG CTGGTCTCAA TTATGGTCAT 
GGGACAGGCC ACGGCATTGG CAACTTCCTG TGTGTGCATG AGTGGCCAGT GGGATTCCAG 
TCCAACAACA TCGCTATGGC CAAGGGCATG TTCACTTCCA TTGAACCTGG TTACTATAAG 
GATGGAGAAT TTGGGATCCG TCTCGAAGAT GTGGCTCTCG TGGTAGAAGC AAAGACCAAG 
TACCCAGGGA GCTACCTGAC CTTTGAAGTG GTATCATTTG TGCCCTATGA CCGGAACCTC 
ATCGATGTCA GCCTGCTGTC TCCCGAGCAT CTCCAGTACC TGAATCGCTA CTACCAGACC 
ATCCGGGAGA AGGTGGGTCC AGAGCTGCAG AGGCGCCAGC TACTAGAGGA GTTCGAGTGG 
CTTCAACAGC ACACAGAGCC CCTGGCCGCC AGGGCCCCAG ACACCGCCTC CTGGGCCTCT 
GTGTTAGTGG TCTCCACCCT TGCCATCCTT GGCTGGAGTG TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

XPNPEP2 is overexpressed in cervical cancer and promotes cervical cancer metastasis.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(7)1010428317717122(2017 Jul)
Cheng T,Wei R,Jiang G,Zhou Y,Lv M,Dai Y,Yuan Y,Luo D,Ma D,Li F,Xi L

Hereditary angioedema with F12 mutation: Clinical features and enzyme polymorphisms in 9 Southwestern Spanish families.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology117(5)520-526(2016 11)
Pi?ero-Saavedra M,Gonz?lez-Quevedo T,Saenz de San Pedro B,Alcaraz C,Bobadilla-Gonz?lez P,Fern?ndez-Vieira L,Hinojosa B,Garc?a-Lozano R

The development of a novel molecular assay examining the role of aminopeptidase P polymorphisms in acute hypotensive transfusion reactions.
Archives of pathology & laboratory medicine137(1)96-9(2013 Jan)
Hui Y,Wu Y,Tormey CA

A functional XPNPEP2 promoter haplotype leads to reduced plasma aminopeptidase P and increased risk of ACE inhibitor-induced angioedema.
Human mutation32(11)1326-31(2011 Nov)
Cilia La Corte AL,Carter AM,Rice GI,Duan QL,Rouleau GA,Adam A,Grant PJ,Hooper NM

Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS.
Electrophoresis31(23-24)3797-807(2010 Dec)
Zhang Y,Li Y,Qiu F,Qiu Z

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XPNPEP2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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