VAV1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	VAV1
Entrez Gene ID	7409
Full Name	vav guanine nucleotide exchange factor 1
Synonyms	VAV
General protein information	Preferred Names vav guanine nucleotide exchange factor 1 Names proto-oncogene vav vav 1 guanine nucleotide exchange factor vav 1 oncogene
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.3
Summary	This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012].
Disorder MIM:	164875

mRNA and Protein(s)

mRNA	Protein	Name
NM_005428.3	NP_005419.2	proto-oncogene vav isoform 1
NM_001258207.2	NP_001245136.1	proto-oncogene vav isoform 3
XM_005259642.1	XP_005259699.1	proto-oncogene vav isoform X1
NM_001258206.2	NP_001245135.1	proto-oncogene vav isoform 2
NM_001258206.1	NP_001245135.1	proto-oncogene vav isoform 2
NM_005428.4	NP_005419.2	proto-oncogene vav isoform 1
NM_001258207.1	NP_001245136.1	proto-oncogene vav isoform 3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	VAV1	XP_512321.3
Xenopus tropicalis (tropical clawed frog)	LOC100497964	XP_002940062.1
Homo sapiens (human)	VAV1	NP_005419.2
Drosophila melanogaster (fruit fly)	vav	NP_728235.1
Mus musculus (house mouse)	Vav1	NP_035821.3
Rattus norvegicus (Norway rat)	Vav1	NP_036891.2
Canis lupus familiaris (dog)	VAV1	XP_005633021.1
Bos taurus (cattle)	VAV1	NP_001071542.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010292	XP_319489.4

Gene Ontology
Bibliography

Related articles in PubMed

A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.
Robles-Valero J, Lorenzo-Mart?n LF, Menacho-M?rquez M, Fern?ndez-Pisonero I, Abad A, Cam?s M, Toribio ML, Espinosa L, Bigas A, Bustelo XR
Cancer cell32(5)608-623.e9(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that GEF Vav1 possesses tumor-suppressor functions in immature T cells.
Title: A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.

TGFbeta induced the dissociation of DNMT1 from the VAV1 promoter, leading to demethylation and the subsequent ectopic expression of VAV1 in cancer cells via a SMAD4-dependent mechanism
Title: TGF? promotes mesenchymal phenotype of pancreatic cancer cells, in part, through epigenetic activation of VAV1.

Vav1 expression is increased in esophageal squamous cell carcinoma, indicates poor prognosis, and can serve as a candidate molecular prognostic marker.
Title: Vav1 expression is increased in esophageal squamous cell carcinoma and indicates poor prognosis.

Polymorphisms of VAV1 gene is associated with Rheumatoid arthritis.
Title: VAV1 regulates experimental autoimmune arthritis and is associated with anti-CCP negative rheumatoid arthritis.

Our results suggest the existence of a Vav1/PU.1/miR-142-3p network that supports all-trans retinoic acid -induced differentiation in acute promyelocytic leukemia -derived cells
Title: A network including PU.1, Vav1 and miR-142-3p sustains ATRA-induced differentiation of acute promyelocytic leukemia cells - a short report.

The following VAV1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the VAV1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20003	NM_005428.4 Latest version!	Homo sapiens vav guanine nucleotide exchange factor 1 (VAV1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$339.50-$475.30 $679.00
OHu19981	NM_001258206.2 Latest version!	Homo sapiens vav guanine nucleotide exchange factor 1 (VAV1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
OHu20225	NM_001258207.2 Latest version!	Homo sapiens vav guanine nucleotide exchange factor 1 (VAV1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
OHu51797	XM_005259642.1 Latest version!	Homo sapiens vav guanine nucleotide exchange factor 1 (VAV1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
View Old Accession Versions >>
OHu19981	NM_001258206.1	Homo sapiens vav guanine nucleotide exchange factor 1 (VAV1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
OHu20003	NM_005428.3	Homo sapiens vav guanine nucleotide exchange factor 1 (VAV1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
OHu20225	NM_001258207.1	Homo sapiens vav guanine nucleotide exchange factor 1 (VAV1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

VAV1 ( NM_005428.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005419.2 Homo sapiens vav guanine nucleotide exchange factor 1 (VAV1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20003
Clone ID Related Accession (Same CDS sequence)	NM_005428.3 , NM_005428.4
Accession Version	NM_005428.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2538bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	proto-oncogene vav isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC408645.1, AK313307.1 and BC013361.2. On Nov 23, 2018 this sequence version replaced NM_005428.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.108247.1, SRR1660805.210017.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000602142.6/ ENSP00000472929.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGCTGT GGCGCCAATG CACCCACTGG CTCATCCAGT GCCGGGTGCT GCCGCCCAGC 
CACCGCGTGA CCTGGGATGG GGCTCAGGTG TGTGAACTGG CCCAGGCCCT CCGGGATGGT 
GTCCTTCTGT GTCAGCTGCT TAACAACCTG CTACCCCATG CCATCAACCT GCGTGAGGTC 
AACCTGCGCC CCCAGATGTC CCAGTTCCTG TGCCTTAAGA ACATTAGAAC CTTCCTGTCC 
ACCTGCTGTG AGAAGTTCGG CCTCAAGCGG AGCGAGCTCT TCGAAGCCTT TGACCTCTTC 
GATGTGCAGG ATTTTGGCAA GGTCATCTAC ACCCTGTCTG CTCTGTCCTG GACCCCGATC 
GCCCAGAACA GGGGGATCAT GCCCTTCCCC ACCGAGGAGG AGAGTGTAGG TGATGAAGAC 
ATCTACAGTG GCCTGTCCGA CCAGATCGAC GACACGGTGG AGGAGGATGA GGACCTGTAT 
GACTGCGTGG AGAATGAGGA GGCGGAAGGC GACGAGATCT ATGAGGACCT CATGCGCTCG 
GAGCCCGTGT CCATGCCGCC CAAGATGACA GAGTATGACA AGCGCTGCTG CTGCCTGCGG 
GAGATCCAGC AGACGGAGGA GAAGTACACT GACACGCTGG GCTCCATCCA GCAGCATTTC 
TTGAAGCCCC TGCAACGGTT CCTGAAACCT CAAGACATTG AGATCATCTT TATCAACATT 
GAGGACCTGC TTCGTGTTCA TACTCACTTC CTAAAGGAGA TGAAGGAAGC CCTGGGCACC 
CCTGGCGCAG CCAATCTCTA CCAGGTCTTC ATCAAATACA AGGAGAGGTT CCTCGTCTAT 
GGCCGCTACT GCAGCCAGGT GGAGTCAGCC AGCAAACACC TGGACCGTGT GGCCGCAGCC 
CGGGAGGACG TGCAGATGAA GCTGGAGGAA TGTTCTCAGA GAGCCAACAA CGGGAGGTTC 
ACCCTGCGGG ACCTGCTGAT GGTGCCTATG CAGCGAGTTC TCAAATATCA CCTCCTTCTC 
CAGGAGCTGG TGAAACACAC GCAGGAGGCG ATGGAGAAGG AGAACCTGCG GCTGGCCCTG 
GATGCCATGA GGGACCTGGC TCAGTGCGTG AACGAGGTCA AGCGAGACAA CGAGACACTG 
CGACAGATCA CCAATTTCCA GCTGTCCATT GAGAACCTGG ACCAGTCTCT GGCTCACTAT 
GGCCGGCCCA AGATCGACGG GGAACTCAAG ATCACCTCGG TGGAACGGCG CTCCAAGATG 
GACAGGTATG CCTTCCTGCT CGACAAAGCT CTACTCATCT GTAAGCGCAG GGGAGACTCC 
TATGACCTCA AGGACTTTGT AAACCTGCAC AGCTTCCAGG TTCGGGATGA CTCTTCAGGA 
GACCGAGACA ACAAGAAGTG GAGCCACATG TTCCTCCTGA TCGAGGACCA AGGTGCCCAG 
GGCTATGAGC TGTTCTTCAA GACAAGAGAA TTGAAGAAGA AGTGGATGGA GCAGTTTGAG 
ATGGCCATCT CCAACATCTA TCCGGAGAAT GCCACCGCCA ACGGGCATGA CTTCCAGATG 
TTCTCCTTTG AGGAGACCAC ATCCTGCAAG GCCTGTCAGA TGCTGCTTAG AGGTACCTTC 
TATCAGGGCT ACCGCTGCCA TCGGTGCCGG GCATCTGCAC ACAAGGAGTG TCTGGGGAGG 
GTCCCTCCAT GTGGCCGACA TGGGCAAGAT TTCCCAGGAA CTATGAAGAA GGACAAACTA 
CATCGCAGGG CTCAGGACAA AAAGAGGAAT GAGCTGGGTC TGCCCAAGAT GGAGGTGTTT 
CAGGAATACT ACGGGCTTCC TCCACCCCCT GGAGCCATTG GACCCTTTCT ACGGCTCAAC 
CCTGGAGACA TTGTGGAGCT CACGAAGGCT GAGGCTGAAC AGAACTGGTG GGAGGGCAGA 
AATACATCTA CTAATGAAAT TGGCTGGTTT CCTTGTAACA GGGTGAAGCC CTATGTCCAT 
GGCCCTCCTC AGGACCTGTC TGTTCATCTC TGGTACGCAG GCCCCATGGA GCGGGCAGGG 
GCAGAGAGCA TCCTGGCCAA CCGCTCGGAC GGGACTTTCT TGGTGCGGCA GAGGGTGAAG 
GATGCAGCAG AATTTGCCAT CAGCATTAAA TATAACGTCG AGGTCAAGCA CATTAAAATC 
ATGACAGCAG AAGGACTGTA CCGGATCACA GAGAAAAAGG CTTTCCGGGG GCTTACGGAG 
CTGGTGGAGT TTTACCAGCA GAACTCTCTA AAGGATTGCT TCAAGTCTCT GGACACCACC 
TTGCAGTTCC CCTTCAAGGA GCCTGAAAAG AGAACCATCA GCAGGCCAGC AGTGGGAAGC 
ACAAAGTATT TTGGCACAGC CAAAGCCCGC TATGACTTCT GCGCCCGAGA CCGATCAGAG 
CTGTCGCTCA AGGAGGGTGA CATCATCAAG ATCCTTAACA AGAAGGGACA GCAAGGCTGG 
TGGCGAGGGG AGATCTATGG CCGGGTTGGC TGGTTCCCTG CCAACTACGT GGAGGAAGAT 
TATTCTGAAT ACTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005419.2
CDS	101..2638
Translation	MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVFQEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVHGPPQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEEDYSEYC

Target ORF information:

RefSeq Version	NM_005428.4
Organism	Homo sapiens(human)
Definition	Homo sapiens vav guanine nucleotide exchange factor 1 (VAV1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005428.4

ORF Insert Sequence:

ATGGAGCTGT GGCGCCAATG CACCCACTGG CTCATCCAGT GCCGGGTGCT GCCGCCCAGC 
CACCGCGTGA CCTGGGATGG GGCTCAGGTG TGTGAACTGG CCCAGGCCCT CCGGGATGGT 
GTCCTTCTGT GTCAGCTGCT TAACAACCTG CTACCCCATG CCATCAACCT GCGTGAGGTC 
AACCTGCGCC CCCAGATGTC CCAGTTCCTG TGCCTTAAGA ACATTAGAAC CTTCCTGTCC 
ACCTGCTGTG AGAAGTTCGG CCTCAAGCGG AGCGAGCTCT TCGAAGCCTT TGACCTCTTC 
GATGTGCAGG ATTTTGGCAA GGTCATCTAC ACCCTGTCTG CTCTGTCCTG GACCCCGATC 
GCCCAGAACA GGGGGATCAT GCCCTTCCCC ACCGAGGAGG AGAGTGTAGG TGATGAAGAC 
ATCTACAGTG GCCTGTCCGA CCAGATCGAC GACACGGTGG AGGAGGATGA GGACCTGTAT 
GACTGCGTGG AGAATGAGGA GGCGGAAGGC GACGAGATCT ATGAGGACCT CATGCGCTCG 
GAGCCCGTGT CCATGCCGCC CAAGATGACA GAGTATGACA AGCGCTGCTG CTGCCTGCGG 
GAGATCCAGC AGACGGAGGA GAAGTACACT GACACGCTGG GCTCCATCCA GCAGCATTTC 
TTGAAGCCCC TGCAACGGTT CCTGAAACCT CAAGACATTG AGATCATCTT TATCAACATT 
GAGGACCTGC TTCGTGTTCA TACTCACTTC CTAAAGGAGA TGAAGGAAGC CCTGGGCACC 
CCTGGCGCAG CCAATCTCTA CCAGGTCTTC ATCAAATACA AGGAGAGGTT CCTCGTCTAT 
GGCCGCTACT GCAGCCAGGT GGAGTCAGCC AGCAAACACC TGGACCGTGT GGCCGCAGCC 
CGGGAGGACG TGCAGATGAA GCTGGAGGAA TGTTCTCAGA GAGCCAACAA CGGGAGGTTC 
ACCCTGCGGG ACCTGCTGAT GGTGCCTATG CAGCGAGTTC TCAAATATCA CCTCCTTCTC 
CAGGAGCTGG TGAAACACAC GCAGGAGGCG ATGGAGAAGG AGAACCTGCG GCTGGCCCTG 
GATGCCATGA GGGACCTGGC TCAGTGCGTG AACGAGGTCA AGCGAGACAA CGAGACACTG 
CGACAGATCA CCAATTTCCA GCTGTCCATT GAGAACCTGG ACCAGTCTCT GGCTCACTAT 
GGCCGGCCCA AGATCGACGG GGAACTCAAG ATCACCTCGG TGGAACGGCG CTCCAAGATG 
GACAGGTATG CCTTCCTGCT CGACAAAGCT CTACTCATCT GTAAGCGCAG GGGAGACTCC 
TATGACCTCA AGGACTTTGT AAACCTGCAC AGCTTCCAGG TTCGGGATGA CTCTTCAGGA 
GACCGAGACA ACAAGAAGTG GAGCCACATG TTCCTCCTGA TCGAGGACCA AGGTGCCCAG 
GGCTATGAGC TGTTCTTCAA GACAAGAGAA TTGAAGAAGA AGTGGATGGA GCAGTTTGAG 
ATGGCCATCT CCAACATCTA TCCGGAGAAT GCCACCGCCA ACGGGCATGA CTTCCAGATG 
TTCTCCTTTG AGGAGACCAC ATCCTGCAAG GCCTGTCAGA TGCTGCTTAG AGGTACCTTC 
TATCAGGGCT ACCGCTGCCA TCGGTGCCGG GCATCTGCAC ACAAGGAGTG TCTGGGGAGG 
GTCCCTCCAT GTGGCCGACA TGGGCAAGAT TTCCCAGGAA CTATGAAGAA GGACAAACTA 
CATCGCAGGG CTCAGGACAA AAAGAGGAAT GAGCTGGGTC TGCCCAAGAT GGAGGTGTTT 
CAGGAATACT ACGGGCTTCC TCCACCCCCT GGAGCCATTG GACCCTTTCT ACGGCTCAAC 
CCTGGAGACA TTGTGGAGCT CACGAAGGCT GAGGCTGAAC AGAACTGGTG GGAGGGCAGA 
AATACATCTA CTAATGAAAT TGGCTGGTTT CCTTGTAACA GGGTGAAGCC CTATGTCCAT 
GGCCCTCCTC AGGACCTGTC TGTTCATCTC TGGTACGCAG GCCCCATGGA GCGGGCAGGG 
GCAGAGAGCA TCCTGGCCAA CCGCTCGGAC GGGACTTTCT TGGTGCGGCA GAGGGTGAAG 
GATGCAGCAG AATTTGCCAT CAGCATTAAA TATAACGTCG AGGTCAAGCA CATTAAAATC 
ATGACAGCAG AAGGACTGTA CCGGATCACA GAGAAAAAGG CTTTCCGGGG GCTTACGGAG 
CTGGTGGAGT TTTACCAGCA GAACTCTCTA AAGGATTGCT TCAAGTCTCT GGACACCACC 
TTGCAGTTCC CCTTCAAGGA GCCTGAAAAG AGAACCATCA GCAGGCCAGC AGTGGGAAGC 
ACAAAGTATT TTGGCACAGC CAAAGCCCGC TATGACTTCT GCGCCCGAGA CCGATCAGAG 
CTGTCGCTCA AGGAGGGTGA CATCATCAAG ATCCTTAACA AGAAGGGACA GCAAGGCTGG 
TGGCGAGGGG AGATCTATGG CCGGGTTGGC TGGTTCCCTG CCAACTACGT GGAGGAAGAT 
TATTCTGAAT ACTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VAV1 ( NM_001258206.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001245135.1 Homo sapiens vav guanine nucleotide exchange factor 1 (VAV1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu19981
Clone ID Related Accession (Same CDS sequence)	NM_001258206.2 , NM_001258206.1
Accession Version	NM_001258206.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2472bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	proto-oncogene vav isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC408645.1, AK225710.1 and BC013361.2. On May 31, 2019 this sequence version replaced NM_001258206.1. Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK225710.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2153307 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCTGT GGCGCCAATG CACCCACTGG CTCATCCAGT GCCGGGTGCT GCCGCCCAGC 
CACCGCGTGA CCTGGGATGG GGCTCAGGTG TGTGAACTGG CCCAGGCCCT CCGGGATGGT 
GTCCTTCTGT GTCAGCTGCT TAACAACCTG CTACCCCATG CCATCAACCT GCGTGAGGTC 
AACCTGCGCC CCCAGATGTC CCAGTTCCTG TGCCTTAAGA ACATTAGAAC CTTCCTGTCC 
ACCTGCTGTG AGAAGTTCGG CCTCAAGCGG AGCGAGCTCT TCGAAGCCTT TGACCTCTTC 
GATGTGCAGG ATTTTGGCAA GGTCATCTAC ACCCTGTCTG CTCTGTCCTG GACCCCGATC 
GCCCAGAACA GGGGGATCAT GCCCTTCCCC ACCGAGGAGG AGAGTGTAGG TGATGAAGAC 
ATCTACAGTG GCCTGTCCGA CCAGATCGAC GACACGGTGG AGGAGGATGA GGACCTGTAT 
GACTGCGTGG AGAATGAGGA GGCGGAAGGC GACGAGATCT ATGAGGACCT CATGCGCTCG 
GAGCCCGTGT CCATGCCGCC CAAGATGACA GAGTATGACA AGCGCTGCTG CTGCCTGCGG 
GAGATCCAGC AGACGGAGGA GAAGTACACT GACACGCTGG GCTCCATCCA GCAGCATTTC 
TTGAAGCCCC TGCAACGGTT CCTGAAACCT CAAGACATTG AGATCATCTT TATCAACATT 
GAGGACCTGC TTCGTGTTCA TACTCACTTC CTAAAGGAGA TGAAGGAAGC CCTGGGCACC 
CCTGGCGCAG CCAATCTCTA CCAGGTCTTC ATCAAATACA AGGAGAGGTT CCTCGTCTAT 
GGCCGCTACT GCAGCCAGGT GGAGTCAGCC AGCAAACACC TGGACCGTGT GGCCGCAGCC 
CGGGAGGACG TGCAGATGAA GCTGGAGGAA TGTTCTCAGA GAGCCAACAA CGGGAGGTTC 
ACCCTGCGGG ACCTGCTGAT GGTGCCTATG CAGCGAGTTC TCAAATATCA CCTCCTTCTC 
CAGGAGCTGG TGAAACACAC GCAGGAGGCG ATGGAGAAGG AGAACCTGCG GCTGGCCCTG 
GATGCCATGA GGGACCTGGC TCAGTGCGTG AACGAGGTCA AGCGAGACAA CGAGACACTG 
CGACAGATCA CCAATTTCCA GCTGTCCATT GAGAACCTGG ACCAGTCTCT GGCTCACTAT 
GGCCGGCCCA AGATCGACGG GGAACTCAAG ATCACCTCGG TGGAACGGCG CTCCAAGATG 
GACAGGTATG CCTTCCTGCT CGACAAAGCT CTACTCATCT GTAAGCGCAG GGGAGACTCC 
TATGACCTCA AGGACTTTGT AAACCTGCAC AGCTTCCAGG TTCGGGATGA CTCTTCAGGA 
GACCGAGACA ACAAGAAGTG GAGCCACATG TTCCTCCTGA TCGAGGACCA AGGTGCCCAG 
GGCTATGAGC TGTTCTTCAA GACAAGAGAA TTGAAGAAGA AGTGGATGGA GCAGTTTGAG 
ATGGCCATCT CCAACATCTA TCCGGAGAAT GCCACCGCCA ACGGGCATGA CTTCCAGATG 
TTCTCCTTTG AGGAGACCAC ATCCTGCAAG GCCTGTCAGA TGCTGCTTAG AGGTACCTTC 
TATCAGGGCT ACCGCTGCCA TCGGTGCCGG GCATCTGCAC ACAAGGAGTG TCTGGGGAGG 
GTCCCTCCAT GTGGCCGACA TGGGCAAGAT TTCCCAGGAA CTATGAAGAA GGACAAACTA 
CATCGCAGGG CTCAGGACAA AAAGAGGAAT GAGCTGGGTC TGCCCAAGAT GGAGGTGTTT 
CAGGAATACT ACGGGCTTCC TCCACCCCCT GGAGCCATTG GACCCTTTCT ACGGCTCAAC 
CCTGGAGACA TTGTGGAGCT CACGAAGGCT GAGGCTGAAC AGAACTGGTG GGAGGGCCCT 
CCTCAGGACC TGTCTGTTCA TCTCTGGTAC GCAGGCCCCA TGGAGCGGGC AGGGGCAGAG 
AGCATCCTGG CCAACCGCTC GGACGGGACT TTCTTGGTGC GGCAGAGGGT GAAGGATGCA 
GCAGAATTTG CCATCAGCAT TAAATATAAC GTCGAGGTCA AGCACATTAA AATCATGACA 
GCAGAAGGAC TGTACCGGAT CACAGAGAAA AAGGCTTTCC GGGGGCTTAC GGAGCTGGTG 
GAGTTTTACC AGCAGAACTC TCTAAAGGAT TGCTTCAAGT CTCTGGACAC CACCTTGCAG 
TTCCCCTTCA AGGAGCCTGA AAAGAGAACC ATCAGCAGGC CAGCAGTGGG AAGCACAAAG 
TATTTTGGCA CAGCCAAAGC CCGCTATGAC TTCTGCGCCC GAGACCGATC AGAGCTGTCG 
CTCAAGGAGG GTGACATCAT CAAGATCCTT AACAAGAAGG GACAGCAAGG CTGGTGGCGA 
GGGGAGATCT ATGGCCGGGT TGGCTGGTTC CCTGCCAACT ACGTGGAGGA AGATTATTCT 
GAATACTGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001245135.1
CDS	101..2572
Translation	MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVFQEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGPPQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEEDYSEYC

Target ORF information:

RefSeq Version	NM_001258206.2
Organism	Homo sapiens(human)
Definition	Homo sapiens vav guanine nucleotide exchange factor 1 (VAV1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001258206.2

ORF Insert Sequence:

ATGGAGCTGT GGCGCCAATG CACCCACTGG CTCATCCAGT GCCGGGTGCT GCCGCCCAGC 
CACCGCGTGA CCTGGGATGG GGCTCAGGTG TGTGAACTGG CCCAGGCCCT CCGGGATGGT 
GTCCTTCTGT GTCAGCTGCT TAACAACCTG CTACCCCATG CCATCAACCT GCGTGAGGTC 
AACCTGCGCC CCCAGATGTC CCAGTTCCTG TGCCTTAAGA ACATTAGAAC CTTCCTGTCC 
ACCTGCTGTG AGAAGTTCGG CCTCAAGCGG AGCGAGCTCT TCGAAGCCTT TGACCTCTTC 
GATGTGCAGG ATTTTGGCAA GGTCATCTAC ACCCTGTCTG CTCTGTCCTG GACCCCGATC 
GCCCAGAACA GGGGGATCAT GCCCTTCCCC ACCGAGGAGG AGAGTGTAGG TGATGAAGAC 
ATCTACAGTG GCCTGTCCGA CCAGATCGAC GACACGGTGG AGGAGGATGA GGACCTGTAT 
GACTGCGTGG AGAATGAGGA GGCGGAAGGC GACGAGATCT ATGAGGACCT CATGCGCTCG 
GAGCCCGTGT CCATGCCGCC CAAGATGACA GAGTATGACA AGCGCTGCTG CTGCCTGCGG 
GAGATCCAGC AGACGGAGGA GAAGTACACT GACACGCTGG GCTCCATCCA GCAGCATTTC 
TTGAAGCCCC TGCAACGGTT CCTGAAACCT CAAGACATTG AGATCATCTT TATCAACATT 
GAGGACCTGC TTCGTGTTCA TACTCACTTC CTAAAGGAGA TGAAGGAAGC CCTGGGCACC 
CCTGGCGCAG CCAATCTCTA CCAGGTCTTC ATCAAATACA AGGAGAGGTT CCTCGTCTAT 
GGCCGCTACT GCAGCCAGGT GGAGTCAGCC AGCAAACACC TGGACCGTGT GGCCGCAGCC 
CGGGAGGACG TGCAGATGAA GCTGGAGGAA TGTTCTCAGA GAGCCAACAA CGGGAGGTTC 
ACCCTGCGGG ACCTGCTGAT GGTGCCTATG CAGCGAGTTC TCAAATATCA CCTCCTTCTC 
CAGGAGCTGG TGAAACACAC GCAGGAGGCG ATGGAGAAGG AGAACCTGCG GCTGGCCCTG 
GATGCCATGA GGGACCTGGC TCAGTGCGTG AACGAGGTCA AGCGAGACAA CGAGACACTG 
CGACAGATCA CCAATTTCCA GCTGTCCATT GAGAACCTGG ACCAGTCTCT GGCTCACTAT 
GGCCGGCCCA AGATCGACGG GGAACTCAAG ATCACCTCGG TGGAACGGCG CTCCAAGATG 
GACAGGTATG CCTTCCTGCT CGACAAAGCT CTACTCATCT GTAAGCGCAG GGGAGACTCC 
TATGACCTCA AGGACTTTGT AAACCTGCAC AGCTTCCAGG TTCGGGATGA CTCTTCAGGA 
GACCGAGACA ACAAGAAGTG GAGCCACATG TTCCTCCTGA TCGAGGACCA AGGTGCCCAG 
GGCTATGAGC TGTTCTTCAA GACAAGAGAA TTGAAGAAGA AGTGGATGGA GCAGTTTGAG 
ATGGCCATCT CCAACATCTA TCCGGAGAAT GCCACCGCCA ACGGGCATGA CTTCCAGATG 
TTCTCCTTTG AGGAGACCAC ATCCTGCAAG GCCTGTCAGA TGCTGCTTAG AGGTACCTTC 
TATCAGGGCT ACCGCTGCCA TCGGTGCCGG GCATCTGCAC ACAAGGAGTG TCTGGGGAGG 
GTCCCTCCAT GTGGCCGACA TGGGCAAGAT TTCCCAGGAA CTATGAAGAA GGACAAACTA 
CATCGCAGGG CTCAGGACAA AAAGAGGAAT GAGCTGGGTC TGCCCAAGAT GGAGGTGTTT 
CAGGAATACT ACGGGCTTCC TCCACCCCCT GGAGCCATTG GACCCTTTCT ACGGCTCAAC 
CCTGGAGACA TTGTGGAGCT CACGAAGGCT GAGGCTGAAC AGAACTGGTG GGAGGGCCCT 
CCTCAGGACC TGTCTGTTCA TCTCTGGTAC GCAGGCCCCA TGGAGCGGGC AGGGGCAGAG 
AGCATCCTGG CCAACCGCTC GGACGGGACT TTCTTGGTGC GGCAGAGGGT GAAGGATGCA 
GCAGAATTTG CCATCAGCAT TAAATATAAC GTCGAGGTCA AGCACATTAA AATCATGACA 
GCAGAAGGAC TGTACCGGAT CACAGAGAAA AAGGCTTTCC GGGGGCTTAC GGAGCTGGTG 
GAGTTTTACC AGCAGAACTC TCTAAAGGAT TGCTTCAAGT CTCTGGACAC CACCTTGCAG 
TTCCCCTTCA AGGAGCCTGA AAAGAGAACC ATCAGCAGGC CAGCAGTGGG AAGCACAAAG 
TATTTTGGCA CAGCCAAAGC CCGCTATGAC TTCTGCGCCC GAGACCGATC AGAGCTGTCG 
CTCAAGGAGG GTGACATCAT CAAGATCCTT AACAAGAAGG GACAGCAAGG CTGGTGGCGA 
GGGGAGATCT ATGGCCGGGT TGGCTGGTTC CCTGCCAACT ACGTGGAGGA AGATTATTCT 
GAATACTGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VAV1 ( NM_001258206.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001245135.1 Homo sapiens vav guanine nucleotide exchange factor 1 (VAV1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu19981
Clone ID Related Accession (Same CDS sequence)	NM_001258206.2 , NM_001258206.1
Accession Version	NM_001258206.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2472bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-09
Organism	Homo sapiens(human)
Product	proto-oncogene vav isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC408645.1, AK225710.1, BC013361.2 and AW105491.1. Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK225710.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2153307 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCTGT GGCGCCAATG CACCCACTGG CTCATCCAGT GCCGGGTGCT GCCGCCCAGC 
CACCGCGTGA CCTGGGATGG GGCTCAGGTG TGTGAACTGG CCCAGGCCCT CCGGGATGGT 
GTCCTTCTGT GTCAGCTGCT TAACAACCTG CTACCCCATG CCATCAACCT GCGTGAGGTC 
AACCTGCGCC CCCAGATGTC CCAGTTCCTG TGCCTTAAGA ACATTAGAAC CTTCCTGTCC 
ACCTGCTGTG AGAAGTTCGG CCTCAAGCGG AGCGAGCTCT TCGAAGCCTT TGACCTCTTC 
GATGTGCAGG ATTTTGGCAA GGTCATCTAC ACCCTGTCTG CTCTGTCCTG GACCCCGATC 
GCCCAGAACA GGGGGATCAT GCCCTTCCCC ACCGAGGAGG AGAGTGTAGG TGATGAAGAC 
ATCTACAGTG GCCTGTCCGA CCAGATCGAC GACACGGTGG AGGAGGATGA GGACCTGTAT 
GACTGCGTGG AGAATGAGGA GGCGGAAGGC GACGAGATCT ATGAGGACCT CATGCGCTCG 
GAGCCCGTGT CCATGCCGCC CAAGATGACA GAGTATGACA AGCGCTGCTG CTGCCTGCGG 
GAGATCCAGC AGACGGAGGA GAAGTACACT GACACGCTGG GCTCCATCCA GCAGCATTTC 
TTGAAGCCCC TGCAACGGTT CCTGAAACCT CAAGACATTG AGATCATCTT TATCAACATT 
GAGGACCTGC TTCGTGTTCA TACTCACTTC CTAAAGGAGA TGAAGGAAGC CCTGGGCACC 
CCTGGCGCAG CCAATCTCTA CCAGGTCTTC ATCAAATACA AGGAGAGGTT CCTCGTCTAT 
GGCCGCTACT GCAGCCAGGT GGAGTCAGCC AGCAAACACC TGGACCGTGT GGCCGCAGCC 
CGGGAGGACG TGCAGATGAA GCTGGAGGAA TGTTCTCAGA GAGCCAACAA CGGGAGGTTC 
ACCCTGCGGG ACCTGCTGAT GGTGCCTATG CAGCGAGTTC TCAAATATCA CCTCCTTCTC 
CAGGAGCTGG TGAAACACAC GCAGGAGGCG ATGGAGAAGG AGAACCTGCG GCTGGCCCTG 
GATGCCATGA GGGACCTGGC TCAGTGCGTG AACGAGGTCA AGCGAGACAA CGAGACACTG 
CGACAGATCA CCAATTTCCA GCTGTCCATT GAGAACCTGG ACCAGTCTCT GGCTCACTAT 
GGCCGGCCCA AGATCGACGG GGAACTCAAG ATCACCTCGG TGGAACGGCG CTCCAAGATG 
GACAGGTATG CCTTCCTGCT CGACAAAGCT CTACTCATCT GTAAGCGCAG GGGAGACTCC 
TATGACCTCA AGGACTTTGT AAACCTGCAC AGCTTCCAGG TTCGGGATGA CTCTTCAGGA 
GACCGAGACA ACAAGAAGTG GAGCCACATG TTCCTCCTGA TCGAGGACCA AGGTGCCCAG 
GGCTATGAGC TGTTCTTCAA GACAAGAGAA TTGAAGAAGA AGTGGATGGA GCAGTTTGAG 
ATGGCCATCT CCAACATCTA TCCGGAGAAT GCCACCGCCA ACGGGCATGA CTTCCAGATG 
TTCTCCTTTG AGGAGACCAC ATCCTGCAAG GCCTGTCAGA TGCTGCTTAG AGGTACCTTC 
TATCAGGGCT ACCGCTGCCA TCGGTGCCGG GCATCTGCAC ACAAGGAGTG TCTGGGGAGG 
GTCCCTCCAT GTGGCCGACA TGGGCAAGAT TTCCCAGGAA CTATGAAGAA GGACAAACTA 
CATCGCAGGG CTCAGGACAA AAAGAGGAAT GAGCTGGGTC TGCCCAAGAT GGAGGTGTTT 
CAGGAATACT ACGGGCTTCC TCCACCCCCT GGAGCCATTG GACCCTTTCT ACGGCTCAAC 
CCTGGAGACA TTGTGGAGCT CACGAAGGCT GAGGCTGAAC AGAACTGGTG GGAGGGCCCT 
CCTCAGGACC TGTCTGTTCA TCTCTGGTAC GCAGGCCCCA TGGAGCGGGC AGGGGCAGAG 
AGCATCCTGG CCAACCGCTC GGACGGGACT TTCTTGGTGC GGCAGAGGGT GAAGGATGCA 
GCAGAATTTG CCATCAGCAT TAAATATAAC GTCGAGGTCA AGCACATTAA AATCATGACA 
GCAGAAGGAC TGTACCGGAT CACAGAGAAA AAGGCTTTCC GGGGGCTTAC GGAGCTGGTG 
GAGTTTTACC AGCAGAACTC TCTAAAGGAT TGCTTCAAGT CTCTGGACAC CACCTTGCAG 
TTCCCCTTCA AGGAGCCTGA AAAGAGAACC ATCAGCAGGC CAGCAGTGGG AAGCACAAAG 
TATTTTGGCA CAGCCAAAGC CCGCTATGAC TTCTGCGCCC GAGACCGATC AGAGCTGTCG 
CTCAAGGAGG GTGACATCAT CAAGATCCTT AACAAGAAGG GACAGCAAGG CTGGTGGCGA 
GGGGAGATCT ATGGCCGGGT TGGCTGGTTC CCTGCCAACT ACGTGGAGGA AGATTATTCT 
GAATACTGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001245135.1
CDS	141..2612
Translation	MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVFQEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGPPQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEEDYSEYC

Target ORF information:

RefSeq Version	NM_001258206.1
Organism	Homo sapiens(human)
Definition	Homo sapiens vav guanine nucleotide exchange factor 1 (VAV1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001258206.1

ORF Insert Sequence:

ATGGAGCTGT GGCGCCAATG CACCCACTGG CTCATCCAGT GCCGGGTGCT GCCGCCCAGC 
CACCGCGTGA CCTGGGATGG GGCTCAGGTG TGTGAACTGG CCCAGGCCCT CCGGGATGGT 
GTCCTTCTGT GTCAGCTGCT TAACAACCTG CTACCCCATG CCATCAACCT GCGTGAGGTC 
AACCTGCGCC CCCAGATGTC CCAGTTCCTG TGCCTTAAGA ACATTAGAAC CTTCCTGTCC 
ACCTGCTGTG AGAAGTTCGG CCTCAAGCGG AGCGAGCTCT TCGAAGCCTT TGACCTCTTC 
GATGTGCAGG ATTTTGGCAA GGTCATCTAC ACCCTGTCTG CTCTGTCCTG GACCCCGATC 
GCCCAGAACA GGGGGATCAT GCCCTTCCCC ACCGAGGAGG AGAGTGTAGG TGATGAAGAC 
ATCTACAGTG GCCTGTCCGA CCAGATCGAC GACACGGTGG AGGAGGATGA GGACCTGTAT 
GACTGCGTGG AGAATGAGGA GGCGGAAGGC GACGAGATCT ATGAGGACCT CATGCGCTCG 
GAGCCCGTGT CCATGCCGCC CAAGATGACA GAGTATGACA AGCGCTGCTG CTGCCTGCGG 
GAGATCCAGC AGACGGAGGA GAAGTACACT GACACGCTGG GCTCCATCCA GCAGCATTTC 
TTGAAGCCCC TGCAACGGTT CCTGAAACCT CAAGACATTG AGATCATCTT TATCAACATT 
GAGGACCTGC TTCGTGTTCA TACTCACTTC CTAAAGGAGA TGAAGGAAGC CCTGGGCACC 
CCTGGCGCAG CCAATCTCTA CCAGGTCTTC ATCAAATACA AGGAGAGGTT CCTCGTCTAT 
GGCCGCTACT GCAGCCAGGT GGAGTCAGCC AGCAAACACC TGGACCGTGT GGCCGCAGCC 
CGGGAGGACG TGCAGATGAA GCTGGAGGAA TGTTCTCAGA GAGCCAACAA CGGGAGGTTC 
ACCCTGCGGG ACCTGCTGAT GGTGCCTATG CAGCGAGTTC TCAAATATCA CCTCCTTCTC 
CAGGAGCTGG TGAAACACAC GCAGGAGGCG ATGGAGAAGG AGAACCTGCG GCTGGCCCTG 
GATGCCATGA GGGACCTGGC TCAGTGCGTG AACGAGGTCA AGCGAGACAA CGAGACACTG 
CGACAGATCA CCAATTTCCA GCTGTCCATT GAGAACCTGG ACCAGTCTCT GGCTCACTAT 
GGCCGGCCCA AGATCGACGG GGAACTCAAG ATCACCTCGG TGGAACGGCG CTCCAAGATG 
GACAGGTATG CCTTCCTGCT CGACAAAGCT CTACTCATCT GTAAGCGCAG GGGAGACTCC 
TATGACCTCA AGGACTTTGT AAACCTGCAC AGCTTCCAGG TTCGGGATGA CTCTTCAGGA 
GACCGAGACA ACAAGAAGTG GAGCCACATG TTCCTCCTGA TCGAGGACCA AGGTGCCCAG 
GGCTATGAGC TGTTCTTCAA GACAAGAGAA TTGAAGAAGA AGTGGATGGA GCAGTTTGAG 
ATGGCCATCT CCAACATCTA TCCGGAGAAT GCCACCGCCA ACGGGCATGA CTTCCAGATG 
TTCTCCTTTG AGGAGACCAC ATCCTGCAAG GCCTGTCAGA TGCTGCTTAG AGGTACCTTC 
TATCAGGGCT ACCGCTGCCA TCGGTGCCGG GCATCTGCAC ACAAGGAGTG TCTGGGGAGG 
GTCCCTCCAT GTGGCCGACA TGGGCAAGAT TTCCCAGGAA CTATGAAGAA GGACAAACTA 
CATCGCAGGG CTCAGGACAA AAAGAGGAAT GAGCTGGGTC TGCCCAAGAT GGAGGTGTTT 
CAGGAATACT ACGGGCTTCC TCCACCCCCT GGAGCCATTG GACCCTTTCT ACGGCTCAAC 
CCTGGAGACA TTGTGGAGCT CACGAAGGCT GAGGCTGAAC AGAACTGGTG GGAGGGCCCT 
CCTCAGGACC TGTCTGTTCA TCTCTGGTAC GCAGGCCCCA TGGAGCGGGC AGGGGCAGAG 
AGCATCCTGG CCAACCGCTC GGACGGGACT TTCTTGGTGC GGCAGAGGGT GAAGGATGCA 
GCAGAATTTG CCATCAGCAT TAAATATAAC GTCGAGGTCA AGCACATTAA AATCATGACA 
GCAGAAGGAC TGTACCGGAT CACAGAGAAA AAGGCTTTCC GGGGGCTTAC GGAGCTGGTG 
GAGTTTTACC AGCAGAACTC TCTAAAGGAT TGCTTCAAGT CTCTGGACAC CACCTTGCAG 
TTCCCCTTCA AGGAGCCTGA AAAGAGAACC ATCAGCAGGC CAGCAGTGGG AAGCACAAAG 
TATTTTGGCA CAGCCAAAGC CCGCTATGAC TTCTGCGCCC GAGACCGATC AGAGCTGTCG 
CTCAAGGAGG GTGACATCAT CAAGATCCTT AACAAGAAGG GACAGCAAGG CTGGTGGCGA 
GGGGAGATCT ATGGCCGGGT TGGCTGGTTC CCTGCCAACT ACGTGGAGGA AGATTATTCT 
GAATACTGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VAV1 ( NM_005428.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005419.2 Homo sapiens vav guanine nucleotide exchange factor 1 (VAV1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20003
Clone ID Related Accession (Same CDS sequence)	NM_005428.3 , NM_005428.4
Accession Version	NM_005428.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2538bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	proto-oncogene vav isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC408645.1, AK313307.1, BC013361.2 and AW105491.1. On Apr 19, 2012 this sequence version replaced NM_005428.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.210017.1, SRR1163655.108247.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCTGT GGCGCCAATG CACCCACTGG CTCATCCAGT GCCGGGTGCT GCCGCCCAGC 
CACCGCGTGA CCTGGGATGG GGCTCAGGTG TGTGAACTGG CCCAGGCCCT CCGGGATGGT 
GTCCTTCTGT GTCAGCTGCT TAACAACCTG CTACCCCATG CCATCAACCT GCGTGAGGTC 
AACCTGCGCC CCCAGATGTC CCAGTTCCTG TGCCTTAAGA ACATTAGAAC CTTCCTGTCC 
ACCTGCTGTG AGAAGTTCGG CCTCAAGCGG AGCGAGCTCT TCGAAGCCTT TGACCTCTTC 
GATGTGCAGG ATTTTGGCAA GGTCATCTAC ACCCTGTCTG CTCTGTCCTG GACCCCGATC 
GCCCAGAACA GGGGGATCAT GCCCTTCCCC ACCGAGGAGG AGAGTGTAGG TGATGAAGAC 
ATCTACAGTG GCCTGTCCGA CCAGATCGAC GACACGGTGG AGGAGGATGA GGACCTGTAT 
GACTGCGTGG AGAATGAGGA GGCGGAAGGC GACGAGATCT ATGAGGACCT CATGCGCTCG 
GAGCCCGTGT CCATGCCGCC CAAGATGACA GAGTATGACA AGCGCTGCTG CTGCCTGCGG 
GAGATCCAGC AGACGGAGGA GAAGTACACT GACACGCTGG GCTCCATCCA GCAGCATTTC 
TTGAAGCCCC TGCAACGGTT CCTGAAACCT CAAGACATTG AGATCATCTT TATCAACATT 
GAGGACCTGC TTCGTGTTCA TACTCACTTC CTAAAGGAGA TGAAGGAAGC CCTGGGCACC 
CCTGGCGCAG CCAATCTCTA CCAGGTCTTC ATCAAATACA AGGAGAGGTT CCTCGTCTAT 
GGCCGCTACT GCAGCCAGGT GGAGTCAGCC AGCAAACACC TGGACCGTGT GGCCGCAGCC 
CGGGAGGACG TGCAGATGAA GCTGGAGGAA TGTTCTCAGA GAGCCAACAA CGGGAGGTTC 
ACCCTGCGGG ACCTGCTGAT GGTGCCTATG CAGCGAGTTC TCAAATATCA CCTCCTTCTC 
CAGGAGCTGG TGAAACACAC GCAGGAGGCG ATGGAGAAGG AGAACCTGCG GCTGGCCCTG 
GATGCCATGA GGGACCTGGC TCAGTGCGTG AACGAGGTCA AGCGAGACAA CGAGACACTG 
CGACAGATCA CCAATTTCCA GCTGTCCATT GAGAACCTGG ACCAGTCTCT GGCTCACTAT 
GGCCGGCCCA AGATCGACGG GGAACTCAAG ATCACCTCGG TGGAACGGCG CTCCAAGATG 
GACAGGTATG CCTTCCTGCT CGACAAAGCT CTACTCATCT GTAAGCGCAG GGGAGACTCC 
TATGACCTCA AGGACTTTGT AAACCTGCAC AGCTTCCAGG TTCGGGATGA CTCTTCAGGA 
GACCGAGACA ACAAGAAGTG GAGCCACATG TTCCTCCTGA TCGAGGACCA AGGTGCCCAG 
GGCTATGAGC TGTTCTTCAA GACAAGAGAA TTGAAGAAGA AGTGGATGGA GCAGTTTGAG 
ATGGCCATCT CCAACATCTA TCCGGAGAAT GCCACCGCCA ACGGGCATGA CTTCCAGATG 
TTCTCCTTTG AGGAGACCAC ATCCTGCAAG GCCTGTCAGA TGCTGCTTAG AGGTACCTTC 
TATCAGGGCT ACCGCTGCCA TCGGTGCCGG GCATCTGCAC ACAAGGAGTG TCTGGGGAGG 
GTCCCTCCAT GTGGCCGACA TGGGCAAGAT TTCCCAGGAA CTATGAAGAA GGACAAACTA 
CATCGCAGGG CTCAGGACAA AAAGAGGAAT GAGCTGGGTC TGCCCAAGAT GGAGGTGTTT 
CAGGAATACT ACGGGCTTCC TCCACCCCCT GGAGCCATTG GACCCTTTCT ACGGCTCAAC 
CCTGGAGACA TTGTGGAGCT CACGAAGGCT GAGGCTGAAC AGAACTGGTG GGAGGGCAGA 
AATACATCTA CTAATGAAAT TGGCTGGTTT CCTTGTAACA GGGTGAAGCC CTATGTCCAT 
GGCCCTCCTC AGGACCTGTC TGTTCATCTC TGGTACGCAG GCCCCATGGA GCGGGCAGGG 
GCAGAGAGCA TCCTGGCCAA CCGCTCGGAC GGGACTTTCT TGGTGCGGCA GAGGGTGAAG 
GATGCAGCAG AATTTGCCAT CAGCATTAAA TATAACGTCG AGGTCAAGCA CATTAAAATC 
ATGACAGCAG AAGGACTGTA CCGGATCACA GAGAAAAAGG CTTTCCGGGG GCTTACGGAG 
CTGGTGGAGT TTTACCAGCA GAACTCTCTA AAGGATTGCT TCAAGTCTCT GGACACCACC 
TTGCAGTTCC CCTTCAAGGA GCCTGAAAAG AGAACCATCA GCAGGCCAGC AGTGGGAAGC 
ACAAAGTATT TTGGCACAGC CAAAGCCCGC TATGACTTCT GCGCCCGAGA CCGATCAGAG 
CTGTCGCTCA AGGAGGGTGA CATCATCAAG ATCCTTAACA AGAAGGGACA GCAAGGCTGG 
TGGCGAGGGG AGATCTATGG CCGGGTTGGC TGGTTCCCTG CCAACTACGT GGAGGAAGAT 
TATTCTGAAT ACTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005419.2
CDS	141..2678
Translation	MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVFQEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVHGPPQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEEDYSEYC

Target ORF information:

RefSeq Version	NM_005428.3
Organism	Homo sapiens(human)
Definition	Homo sapiens vav guanine nucleotide exchange factor 1 (VAV1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005428.3

ORF Insert Sequence:

ATGGAGCTGT GGCGCCAATG CACCCACTGG CTCATCCAGT GCCGGGTGCT GCCGCCCAGC 
CACCGCGTGA CCTGGGATGG GGCTCAGGTG TGTGAACTGG CCCAGGCCCT CCGGGATGGT 
GTCCTTCTGT GTCAGCTGCT TAACAACCTG CTACCCCATG CCATCAACCT GCGTGAGGTC 
AACCTGCGCC CCCAGATGTC CCAGTTCCTG TGCCTTAAGA ACATTAGAAC CTTCCTGTCC 
ACCTGCTGTG AGAAGTTCGG CCTCAAGCGG AGCGAGCTCT TCGAAGCCTT TGACCTCTTC 
GATGTGCAGG ATTTTGGCAA GGTCATCTAC ACCCTGTCTG CTCTGTCCTG GACCCCGATC 
GCCCAGAACA GGGGGATCAT GCCCTTCCCC ACCGAGGAGG AGAGTGTAGG TGATGAAGAC 
ATCTACAGTG GCCTGTCCGA CCAGATCGAC GACACGGTGG AGGAGGATGA GGACCTGTAT 
GACTGCGTGG AGAATGAGGA GGCGGAAGGC GACGAGATCT ATGAGGACCT CATGCGCTCG 
GAGCCCGTGT CCATGCCGCC CAAGATGACA GAGTATGACA AGCGCTGCTG CTGCCTGCGG 
GAGATCCAGC AGACGGAGGA GAAGTACACT GACACGCTGG GCTCCATCCA GCAGCATTTC 
TTGAAGCCCC TGCAACGGTT CCTGAAACCT CAAGACATTG AGATCATCTT TATCAACATT 
GAGGACCTGC TTCGTGTTCA TACTCACTTC CTAAAGGAGA TGAAGGAAGC CCTGGGCACC 
CCTGGCGCAG CCAATCTCTA CCAGGTCTTC ATCAAATACA AGGAGAGGTT CCTCGTCTAT 
GGCCGCTACT GCAGCCAGGT GGAGTCAGCC AGCAAACACC TGGACCGTGT GGCCGCAGCC 
CGGGAGGACG TGCAGATGAA GCTGGAGGAA TGTTCTCAGA GAGCCAACAA CGGGAGGTTC 
ACCCTGCGGG ACCTGCTGAT GGTGCCTATG CAGCGAGTTC TCAAATATCA CCTCCTTCTC 
CAGGAGCTGG TGAAACACAC GCAGGAGGCG ATGGAGAAGG AGAACCTGCG GCTGGCCCTG 
GATGCCATGA GGGACCTGGC TCAGTGCGTG AACGAGGTCA AGCGAGACAA CGAGACACTG 
CGACAGATCA CCAATTTCCA GCTGTCCATT GAGAACCTGG ACCAGTCTCT GGCTCACTAT 
GGCCGGCCCA AGATCGACGG GGAACTCAAG ATCACCTCGG TGGAACGGCG CTCCAAGATG 
GACAGGTATG CCTTCCTGCT CGACAAAGCT CTACTCATCT GTAAGCGCAG GGGAGACTCC 
TATGACCTCA AGGACTTTGT AAACCTGCAC AGCTTCCAGG TTCGGGATGA CTCTTCAGGA 
GACCGAGACA ACAAGAAGTG GAGCCACATG TTCCTCCTGA TCGAGGACCA AGGTGCCCAG 
GGCTATGAGC TGTTCTTCAA GACAAGAGAA TTGAAGAAGA AGTGGATGGA GCAGTTTGAG 
ATGGCCATCT CCAACATCTA TCCGGAGAAT GCCACCGCCA ACGGGCATGA CTTCCAGATG 
TTCTCCTTTG AGGAGACCAC ATCCTGCAAG GCCTGTCAGA TGCTGCTTAG AGGTACCTTC 
TATCAGGGCT ACCGCTGCCA TCGGTGCCGG GCATCTGCAC ACAAGGAGTG TCTGGGGAGG 
GTCCCTCCAT GTGGCCGACA TGGGCAAGAT TTCCCAGGAA CTATGAAGAA GGACAAACTA 
CATCGCAGGG CTCAGGACAA AAAGAGGAAT GAGCTGGGTC TGCCCAAGAT GGAGGTGTTT 
CAGGAATACT ACGGGCTTCC TCCACCCCCT GGAGCCATTG GACCCTTTCT ACGGCTCAAC 
CCTGGAGACA TTGTGGAGCT CACGAAGGCT GAGGCTGAAC AGAACTGGTG GGAGGGCAGA 
AATACATCTA CTAATGAAAT TGGCTGGTTT CCTTGTAACA GGGTGAAGCC CTATGTCCAT 
GGCCCTCCTC AGGACCTGTC TGTTCATCTC TGGTACGCAG GCCCCATGGA GCGGGCAGGG 
GCAGAGAGCA TCCTGGCCAA CCGCTCGGAC GGGACTTTCT TGGTGCGGCA GAGGGTGAAG 
GATGCAGCAG AATTTGCCAT CAGCATTAAA TATAACGTCG AGGTCAAGCA CATTAAAATC 
ATGACAGCAG AAGGACTGTA CCGGATCACA GAGAAAAAGG CTTTCCGGGG GCTTACGGAG 
CTGGTGGAGT TTTACCAGCA GAACTCTCTA AAGGATTGCT TCAAGTCTCT GGACACCACC 
TTGCAGTTCC CCTTCAAGGA GCCTGAAAAG AGAACCATCA GCAGGCCAGC AGTGGGAAGC 
ACAAAGTATT TTGGCACAGC CAAAGCCCGC TATGACTTCT GCGCCCGAGA CCGATCAGAG 
CTGTCGCTCA AGGAGGGTGA CATCATCAAG ATCCTTAACA AGAAGGGACA GCAAGGCTGG 
TGGCGAGGGG AGATCTATGG CCGGGTTGGC TGGTTCCCTG CCAACTACGT GGAGGAAGAT 
TATTCTGAAT ACTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VAV1 ( NM_001258207.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001245136.1 Homo sapiens vav guanine nucleotide exchange factor 1 (VAV1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu20225
Clone ID Related Accession (Same CDS sequence)	NM_001258207.2 , NM_001258207.1
Accession Version	NM_001258207.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2442bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	proto-oncogene vav isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC408645.1, AK301128.1 and BC013361.2. On May 31, 2019 this sequence version replaced NM_001258207.1. Transcript Variant: This variant (3) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK301128.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCTGT GGCGCCAATG CACCCACTGG CTCATCCAGT GCCGGGTGCT GCCGCCCAGC 
CACCGCGTGA CCTGGGATGG GGCTCAGGTG TGTGAACTGG CCCAGGCCCT CCGGGATGGT 
GTCCTTCTGT GTCAGCTGCT TAACAACCTG CTACCCCATG CCATCAACCT GCGTGAGGTC 
AACCTGCGCC CCCAGATGTC CCAGTTCCTG TGCCTTAAGA ACATTAGAAC CTTCCTGTCC 
ACCTGCTGTG AGAAGTTCGG CCTCAAGCGG AGCGAGCTCT TCGAAGCCTT TGACCTCTTC 
GATGTGCAGG ATTTTGGCAA GGTCATCTAC ACCCTGTCTG CTCTGTCCTG GACCCCGATC 
GCCCAGAACA GGGGGATCAT GCCCTTCCCC ACCGAGGAGG AGAGTGTAGG TGATGAAGAC 
ATCTACAGTG GCCTGTCCGA CCAGATCGAC GACACGGTGG AGGAGGATGA GGACCTGTAT 
GACTGCGTGG AGAATGAGGA GGCGGAAGGC GACGAGATCT ATGAGGACCT CATGCGCTCG 
GAGCCCGTGT CCATGCCGCA TTTCTTGAAG CCCCTGCAAC GGTTCCTGAA ACCTCAAGAC 
ATTGAGATCA TCTTTATCAA CATTGAGGAC CTGCTTCGTG TTCATACTCA CTTCCTAAAG 
GAGATGAAGG AAGCCCTGGG CACCCCTGGC GCAGCCAATC TCTACCAGGT CTTCATCAAA 
TACAAGGAGA GGTTCCTCGT CTATGGCCGC TACTGCAGCC AGGTGGAGTC AGCCAGCAAA 
CACCTGGACC GTGTGGCCGC AGCCCGGGAG GACGTGCAGA TGAAGCTGGA GGAATGTTCT 
CAGAGAGCCA ACAACGGGAG GTTCACCCTG CGGGACCTGC TGATGGTGCC TATGCAGCGA 
GTTCTCAAAT ATCACCTCCT TCTCCAGGAG CTGGTGAAAC ACACGCAGGA GGCGATGGAG 
AAGGAGAACC TGCGGCTGGC CCTGGATGCC ATGAGGGACC TGGCTCAGTG CGTGAACGAG 
GTCAAGCGAG ACAACGAGAC ACTGCGACAG ATCACCAATT TCCAGCTGTC CATTGAGAAC 
CTGGACCAGT CTCTGGCTCA CTATGGCCGG CCCAAGATCG ACGGGGAACT CAAGATCACC 
TCGGTGGAAC GGCGCTCCAA GATGGACAGG TATGCCTTCC TGCTCGACAA AGCTCTACTC 
ATCTGTAAGC GCAGGGGAGA CTCCTATGAC CTCAAGGACT TTGTAAACCT GCACAGCTTC 
CAGGTTCGGG ATGACTCTTC AGGAGACCGA GACAACAAGA AGTGGAGCCA CATGTTCCTC 
CTGATCGAGG ACCAAGGTGC CCAGGGCTAT GAGCTGTTCT TCAAGACAAG AGAATTGAAG 
AAGAAGTGGA TGGAGCAGTT TGAGATGGCC ATCTCCAACA TCTATCCGGA GAATGCCACC 
GCCAACGGGC ATGACTTCCA GATGTTCTCC TTTGAGGAGA CCACATCCTG CAAGGCCTGT 
CAGATGCTGC TTAGAGGTAC CTTCTATCAG GGCTACCGCT GCCATCGGTG CCGGGCATCT 
GCACACAAGG AGTGTCTGGG GAGGGTCCCT CCATGTGGCC GACATGGGCA AGATTTCCCA 
GGAACTATGA AGAAGGACAA ACTACATCGC AGGGCTCAGG ACAAAAAGAG GAATGAGCTG 
GGTCTGCCCA AGATGGAGGT GTTTCAGGAA TACTACGGGC TTCCTCCACC CCCTGGAGCC 
ATTGGACCCT TTCTACGGCT CAACCCTGGA GACATTGTGG AGCTCACGAA GGCTGAGGCT 
GAACAGAACT GGTGGGAGGG CAGAAATACA TCTACTAATG AAATTGGCTG GTTTCCTTGT 
AACAGGGTGA AGCCCTATGT CCATGGCCCT CCTCAGGACC TGTCTGTTCA TCTCTGGTAC 
GCAGGCCCCA TGGAGCGGGC AGGGGCAGAG AGCATCCTGG CCAACCGCTC GGACGGGACT 
TTCTTGGTGC GGCAGAGGGT GAAGGATGCA GCAGAATTTG CCATCAGCAT TAAATATAAC 
GTCGAGGTCA AGCACATTAA AATCATGACA GCAGAAGGAC TGTACCGGAT CACAGAGAAA 
AAGGCTTTCC GGGGGCTTAC GGAGCTGGTG GAGTTTTACC AGCAGAACTC TCTAAAGGAT 
TGCTTCAAGT CTCTGGACAC CACCTTGCAG TTCCCCTTCA AGGAGCCTGA AAAGAGAACC 
ATCAGCAGGC CAGCAGTGGG AAGCACAAAG TATTTTGGCA CAGCCAAAGC CCGCTATGAC 
TTCTGCGCCC GAGACCGATC AGAGCTGTCG CTCAAGGAGG GTGACATCAT CAAGATCCTT 
AACAAGAAGG GACAGCAAGG CTGGTGGCGA GGGGAGATCT ATGGCCGGGT TGGCTGGTTC 
CCTGCCAACT ACGTGGAGGA AGATTATTCT GAATACTGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001245136.1
CDS	101..2542
Translation	MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVFQEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVHGPPQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEEDYSEYC

Target ORF information:

RefSeq Version	NM_001258207.2
Organism	Homo sapiens(human)
Definition	Homo sapiens vav guanine nucleotide exchange factor 1 (VAV1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001258207.2

ORF Insert Sequence:

ATGGAGCTGT GGCGCCAATG CACCCACTGG CTCATCCAGT GCCGGGTGCT GCCGCCCAGC 
CACCGCGTGA CCTGGGATGG GGCTCAGGTG TGTGAACTGG CCCAGGCCCT CCGGGATGGT 
GTCCTTCTGT GTCAGCTGCT TAACAACCTG CTACCCCATG CCATCAACCT GCGTGAGGTC 
AACCTGCGCC CCCAGATGTC CCAGTTCCTG TGCCTTAAGA ACATTAGAAC CTTCCTGTCC 
ACCTGCTGTG AGAAGTTCGG CCTCAAGCGG AGCGAGCTCT TCGAAGCCTT TGACCTCTTC 
GATGTGCAGG ATTTTGGCAA GGTCATCTAC ACCCTGTCTG CTCTGTCCTG GACCCCGATC 
GCCCAGAACA GGGGGATCAT GCCCTTCCCC ACCGAGGAGG AGAGTGTAGG TGATGAAGAC 
ATCTACAGTG GCCTGTCCGA CCAGATCGAC GACACGGTGG AGGAGGATGA GGACCTGTAT 
GACTGCGTGG AGAATGAGGA GGCGGAAGGC GACGAGATCT ATGAGGACCT CATGCGCTCG 
GAGCCCGTGT CCATGCCGCA TTTCTTGAAG CCCCTGCAAC GGTTCCTGAA ACCTCAAGAC 
ATTGAGATCA TCTTTATCAA CATTGAGGAC CTGCTTCGTG TTCATACTCA CTTCCTAAAG 
GAGATGAAGG AAGCCCTGGG CACCCCTGGC GCAGCCAATC TCTACCAGGT CTTCATCAAA 
TACAAGGAGA GGTTCCTCGT CTATGGCCGC TACTGCAGCC AGGTGGAGTC AGCCAGCAAA 
CACCTGGACC GTGTGGCCGC AGCCCGGGAG GACGTGCAGA TGAAGCTGGA GGAATGTTCT 
CAGAGAGCCA ACAACGGGAG GTTCACCCTG CGGGACCTGC TGATGGTGCC TATGCAGCGA 
GTTCTCAAAT ATCACCTCCT TCTCCAGGAG CTGGTGAAAC ACACGCAGGA GGCGATGGAG 
AAGGAGAACC TGCGGCTGGC CCTGGATGCC ATGAGGGACC TGGCTCAGTG CGTGAACGAG 
GTCAAGCGAG ACAACGAGAC ACTGCGACAG ATCACCAATT TCCAGCTGTC CATTGAGAAC 
CTGGACCAGT CTCTGGCTCA CTATGGCCGG CCCAAGATCG ACGGGGAACT CAAGATCACC 
TCGGTGGAAC GGCGCTCCAA GATGGACAGG TATGCCTTCC TGCTCGACAA AGCTCTACTC 
ATCTGTAAGC GCAGGGGAGA CTCCTATGAC CTCAAGGACT TTGTAAACCT GCACAGCTTC 
CAGGTTCGGG ATGACTCTTC AGGAGACCGA GACAACAAGA AGTGGAGCCA CATGTTCCTC 
CTGATCGAGG ACCAAGGTGC CCAGGGCTAT GAGCTGTTCT TCAAGACAAG AGAATTGAAG 
AAGAAGTGGA TGGAGCAGTT TGAGATGGCC ATCTCCAACA TCTATCCGGA GAATGCCACC 
GCCAACGGGC ATGACTTCCA GATGTTCTCC TTTGAGGAGA CCACATCCTG CAAGGCCTGT 
CAGATGCTGC TTAGAGGTAC CTTCTATCAG GGCTACCGCT GCCATCGGTG CCGGGCATCT 
GCACACAAGG AGTGTCTGGG GAGGGTCCCT CCATGTGGCC GACATGGGCA AGATTTCCCA 
GGAACTATGA AGAAGGACAA ACTACATCGC AGGGCTCAGG ACAAAAAGAG GAATGAGCTG 
GGTCTGCCCA AGATGGAGGT GTTTCAGGAA TACTACGGGC TTCCTCCACC CCCTGGAGCC 
ATTGGACCCT TTCTACGGCT CAACCCTGGA GACATTGTGG AGCTCACGAA GGCTGAGGCT 
GAACAGAACT GGTGGGAGGG CAGAAATACA TCTACTAATG AAATTGGCTG GTTTCCTTGT 
AACAGGGTGA AGCCCTATGT CCATGGCCCT CCTCAGGACC TGTCTGTTCA TCTCTGGTAC 
GCAGGCCCCA TGGAGCGGGC AGGGGCAGAG AGCATCCTGG CCAACCGCTC GGACGGGACT 
TTCTTGGTGC GGCAGAGGGT GAAGGATGCA GCAGAATTTG CCATCAGCAT TAAATATAAC 
GTCGAGGTCA AGCACATTAA AATCATGACA GCAGAAGGAC TGTACCGGAT CACAGAGAAA 
AAGGCTTTCC GGGGGCTTAC GGAGCTGGTG GAGTTTTACC AGCAGAACTC TCTAAAGGAT 
TGCTTCAAGT CTCTGGACAC CACCTTGCAG TTCCCCTTCA AGGAGCCTGA AAAGAGAACC 
ATCAGCAGGC CAGCAGTGGG AAGCACAAAG TATTTTGGCA CAGCCAAAGC CCGCTATGAC 
TTCTGCGCCC GAGACCGATC AGAGCTGTCG CTCAAGGAGG GTGACATCAT CAAGATCCTT 
AACAAGAAGG GACAGCAAGG CTGGTGGCGA GGGGAGATCT ATGGCCGGGT TGGCTGGTTC 
CCTGCCAACT ACGTGGAGGA AGATTATTCT GAATACTGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VAV1 ( NM_001258207.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001245136.1 Homo sapiens vav guanine nucleotide exchange factor 1 (VAV1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu20225
Clone ID Related Accession (Same CDS sequence)	NM_001258207.2 , NM_001258207.1
Accession Version	NM_001258207.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2442bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-09
Organism	Homo sapiens(human)
Product	proto-oncogene vav isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC408645.1, AK301128.1, BC013361.2 and AW105491.1. Transcript Variant: This variant (3) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK301128.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCTGT GGCGCCAATG CACCCACTGG CTCATCCAGT GCCGGGTGCT GCCGCCCAGC 
CACCGCGTGA CCTGGGATGG GGCTCAGGTG TGTGAACTGG CCCAGGCCCT CCGGGATGGT 
GTCCTTCTGT GTCAGCTGCT TAACAACCTG CTACCCCATG CCATCAACCT GCGTGAGGTC 
AACCTGCGCC CCCAGATGTC CCAGTTCCTG TGCCTTAAGA ACATTAGAAC CTTCCTGTCC 
ACCTGCTGTG AGAAGTTCGG CCTCAAGCGG AGCGAGCTCT TCGAAGCCTT TGACCTCTTC 
GATGTGCAGG ATTTTGGCAA GGTCATCTAC ACCCTGTCTG CTCTGTCCTG GACCCCGATC 
GCCCAGAACA GGGGGATCAT GCCCTTCCCC ACCGAGGAGG AGAGTGTAGG TGATGAAGAC 
ATCTACAGTG GCCTGTCCGA CCAGATCGAC GACACGGTGG AGGAGGATGA GGACCTGTAT 
GACTGCGTGG AGAATGAGGA GGCGGAAGGC GACGAGATCT ATGAGGACCT CATGCGCTCG 
GAGCCCGTGT CCATGCCGCA TTTCTTGAAG CCCCTGCAAC GGTTCCTGAA ACCTCAAGAC 
ATTGAGATCA TCTTTATCAA CATTGAGGAC CTGCTTCGTG TTCATACTCA CTTCCTAAAG 
GAGATGAAGG AAGCCCTGGG CACCCCTGGC GCAGCCAATC TCTACCAGGT CTTCATCAAA 
TACAAGGAGA GGTTCCTCGT CTATGGCCGC TACTGCAGCC AGGTGGAGTC AGCCAGCAAA 
CACCTGGACC GTGTGGCCGC AGCCCGGGAG GACGTGCAGA TGAAGCTGGA GGAATGTTCT 
CAGAGAGCCA ACAACGGGAG GTTCACCCTG CGGGACCTGC TGATGGTGCC TATGCAGCGA 
GTTCTCAAAT ATCACCTCCT TCTCCAGGAG CTGGTGAAAC ACACGCAGGA GGCGATGGAG 
AAGGAGAACC TGCGGCTGGC CCTGGATGCC ATGAGGGACC TGGCTCAGTG CGTGAACGAG 
GTCAAGCGAG ACAACGAGAC ACTGCGACAG ATCACCAATT TCCAGCTGTC CATTGAGAAC 
CTGGACCAGT CTCTGGCTCA CTATGGCCGG CCCAAGATCG ACGGGGAACT CAAGATCACC 
TCGGTGGAAC GGCGCTCCAA GATGGACAGG TATGCCTTCC TGCTCGACAA AGCTCTACTC 
ATCTGTAAGC GCAGGGGAGA CTCCTATGAC CTCAAGGACT TTGTAAACCT GCACAGCTTC 
CAGGTTCGGG ATGACTCTTC AGGAGACCGA GACAACAAGA AGTGGAGCCA CATGTTCCTC 
CTGATCGAGG ACCAAGGTGC CCAGGGCTAT GAGCTGTTCT TCAAGACAAG AGAATTGAAG 
AAGAAGTGGA TGGAGCAGTT TGAGATGGCC ATCTCCAACA TCTATCCGGA GAATGCCACC 
GCCAACGGGC ATGACTTCCA GATGTTCTCC TTTGAGGAGA CCACATCCTG CAAGGCCTGT 
CAGATGCTGC TTAGAGGTAC CTTCTATCAG GGCTACCGCT GCCATCGGTG CCGGGCATCT 
GCACACAAGG AGTGTCTGGG GAGGGTCCCT CCATGTGGCC GACATGGGCA AGATTTCCCA 
GGAACTATGA AGAAGGACAA ACTACATCGC AGGGCTCAGG ACAAAAAGAG GAATGAGCTG 
GGTCTGCCCA AGATGGAGGT GTTTCAGGAA TACTACGGGC TTCCTCCACC CCCTGGAGCC 
ATTGGACCCT TTCTACGGCT CAACCCTGGA GACATTGTGG AGCTCACGAA GGCTGAGGCT 
GAACAGAACT GGTGGGAGGG CAGAAATACA TCTACTAATG AAATTGGCTG GTTTCCTTGT 
AACAGGGTGA AGCCCTATGT CCATGGCCCT CCTCAGGACC TGTCTGTTCA TCTCTGGTAC 
GCAGGCCCCA TGGAGCGGGC AGGGGCAGAG AGCATCCTGG CCAACCGCTC GGACGGGACT 
TTCTTGGTGC GGCAGAGGGT GAAGGATGCA GCAGAATTTG CCATCAGCAT TAAATATAAC 
GTCGAGGTCA AGCACATTAA AATCATGACA GCAGAAGGAC TGTACCGGAT CACAGAGAAA 
AAGGCTTTCC GGGGGCTTAC GGAGCTGGTG GAGTTTTACC AGCAGAACTC TCTAAAGGAT 
TGCTTCAAGT CTCTGGACAC CACCTTGCAG TTCCCCTTCA AGGAGCCTGA AAAGAGAACC 
ATCAGCAGGC CAGCAGTGGG AAGCACAAAG TATTTTGGCA CAGCCAAAGC CCGCTATGAC 
TTCTGCGCCC GAGACCGATC AGAGCTGTCG CTCAAGGAGG GTGACATCAT CAAGATCCTT 
AACAAGAAGG GACAGCAAGG CTGGTGGCGA GGGGAGATCT ATGGCCGGGT TGGCTGGTTC 
CCTGCCAACT ACGTGGAGGA AGATTATTCT GAATACTGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001245136.1
CDS	141..2582
Translation	MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVFQEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVHGPPQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEEDYSEYC

Target ORF information:

RefSeq Version	NM_001258207.1
Organism	Homo sapiens(human)
Definition	Homo sapiens vav guanine nucleotide exchange factor 1 (VAV1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001258207.1

ORF Insert Sequence:

ATGGAGCTGT GGCGCCAATG CACCCACTGG CTCATCCAGT GCCGGGTGCT GCCGCCCAGC 
CACCGCGTGA CCTGGGATGG GGCTCAGGTG TGTGAACTGG CCCAGGCCCT CCGGGATGGT 
GTCCTTCTGT GTCAGCTGCT TAACAACCTG CTACCCCATG CCATCAACCT GCGTGAGGTC 
AACCTGCGCC CCCAGATGTC CCAGTTCCTG TGCCTTAAGA ACATTAGAAC CTTCCTGTCC 
ACCTGCTGTG AGAAGTTCGG CCTCAAGCGG AGCGAGCTCT TCGAAGCCTT TGACCTCTTC 
GATGTGCAGG ATTTTGGCAA GGTCATCTAC ACCCTGTCTG CTCTGTCCTG GACCCCGATC 
GCCCAGAACA GGGGGATCAT GCCCTTCCCC ACCGAGGAGG AGAGTGTAGG TGATGAAGAC 
ATCTACAGTG GCCTGTCCGA CCAGATCGAC GACACGGTGG AGGAGGATGA GGACCTGTAT 
GACTGCGTGG AGAATGAGGA GGCGGAAGGC GACGAGATCT ATGAGGACCT CATGCGCTCG 
GAGCCCGTGT CCATGCCGCA TTTCTTGAAG CCCCTGCAAC GGTTCCTGAA ACCTCAAGAC 
ATTGAGATCA TCTTTATCAA CATTGAGGAC CTGCTTCGTG TTCATACTCA CTTCCTAAAG 
GAGATGAAGG AAGCCCTGGG CACCCCTGGC GCAGCCAATC TCTACCAGGT CTTCATCAAA 
TACAAGGAGA GGTTCCTCGT CTATGGCCGC TACTGCAGCC AGGTGGAGTC AGCCAGCAAA 
CACCTGGACC GTGTGGCCGC AGCCCGGGAG GACGTGCAGA TGAAGCTGGA GGAATGTTCT 
CAGAGAGCCA ACAACGGGAG GTTCACCCTG CGGGACCTGC TGATGGTGCC TATGCAGCGA 
GTTCTCAAAT ATCACCTCCT TCTCCAGGAG CTGGTGAAAC ACACGCAGGA GGCGATGGAG 
AAGGAGAACC TGCGGCTGGC CCTGGATGCC ATGAGGGACC TGGCTCAGTG CGTGAACGAG 
GTCAAGCGAG ACAACGAGAC ACTGCGACAG ATCACCAATT TCCAGCTGTC CATTGAGAAC 
CTGGACCAGT CTCTGGCTCA CTATGGCCGG CCCAAGATCG ACGGGGAACT CAAGATCACC 
TCGGTGGAAC GGCGCTCCAA GATGGACAGG TATGCCTTCC TGCTCGACAA AGCTCTACTC 
ATCTGTAAGC GCAGGGGAGA CTCCTATGAC CTCAAGGACT TTGTAAACCT GCACAGCTTC 
CAGGTTCGGG ATGACTCTTC AGGAGACCGA GACAACAAGA AGTGGAGCCA CATGTTCCTC 
CTGATCGAGG ACCAAGGTGC CCAGGGCTAT GAGCTGTTCT TCAAGACAAG AGAATTGAAG 
AAGAAGTGGA TGGAGCAGTT TGAGATGGCC ATCTCCAACA TCTATCCGGA GAATGCCACC 
GCCAACGGGC ATGACTTCCA GATGTTCTCC TTTGAGGAGA CCACATCCTG CAAGGCCTGT 
CAGATGCTGC TTAGAGGTAC CTTCTATCAG GGCTACCGCT GCCATCGGTG CCGGGCATCT 
GCACACAAGG AGTGTCTGGG GAGGGTCCCT CCATGTGGCC GACATGGGCA AGATTTCCCA 
GGAACTATGA AGAAGGACAA ACTACATCGC AGGGCTCAGG ACAAAAAGAG GAATGAGCTG 
GGTCTGCCCA AGATGGAGGT GTTTCAGGAA TACTACGGGC TTCCTCCACC CCCTGGAGCC 
ATTGGACCCT TTCTACGGCT CAACCCTGGA GACATTGTGG AGCTCACGAA GGCTGAGGCT 
GAACAGAACT GGTGGGAGGG CAGAAATACA TCTACTAATG AAATTGGCTG GTTTCCTTGT 
AACAGGGTGA AGCCCTATGT CCATGGCCCT CCTCAGGACC TGTCTGTTCA TCTCTGGTAC 
GCAGGCCCCA TGGAGCGGGC AGGGGCAGAG AGCATCCTGG CCAACCGCTC GGACGGGACT 
TTCTTGGTGC GGCAGAGGGT GAAGGATGCA GCAGAATTTG CCATCAGCAT TAAATATAAC 
GTCGAGGTCA AGCACATTAA AATCATGACA GCAGAAGGAC TGTACCGGAT CACAGAGAAA 
AAGGCTTTCC GGGGGCTTAC GGAGCTGGTG GAGTTTTACC AGCAGAACTC TCTAAAGGAT 
TGCTTCAAGT CTCTGGACAC CACCTTGCAG TTCCCCTTCA AGGAGCCTGA AAAGAGAACC 
ATCAGCAGGC CAGCAGTGGG AAGCACAAAG TATTTTGGCA CAGCCAAAGC CCGCTATGAC 
TTCTGCGCCC GAGACCGATC AGAGCTGTCG CTCAAGGAGG GTGACATCAT CAAGATCCTT 
AACAAGAAGG GACAGCAAGG CTGGTGGCGA GGGGAGATCT ATGGCCGGGT TGGCTGGTTC 
CCTGCCAACT ACGTGGAGGA AGATTATTCT GAATACTGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VAV1 ( XM_005259642.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_005259699.1 Homo sapiens vav guanine nucleotide exchange factor 1 (VAV1), transcript variant X1, mRNA.

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CloneID	OHu51797
Clone ID Related Accession (Same CDS sequence)	XM_005259642.1
Accession Version	XM_005259642.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2466bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	proto-oncogene vav isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCTGT GGCGCCAATG CACCCACTGG CTCATCCAGT GCCGGGTGCT GCCGCCCAGC 
CACCGCGTGA CCTGGGATGG GGCTCAGGTG TGTGAACTGG CCCAGGCCCT CCGGGATGGT 
GTCCTTCTGT GTCAGCTGCT TAACAACCTG CTACCCCATG CCATCAACCT GCGTGAGGTC 
AACCTGCGCC CCCAGATGTC CCAGTTCCTG TGCCTTAAGA ACATTAGAAC CTTCCTGTCC 
ACCTGCTGTG AGAAGTTCGG CCTCAAGCGG AGCGAGCTCT TCGAAGCCTT TGACCTCTTC 
GATGTGCAGG ATTTTGGCAA GGTCATCTAC ACCCTGTCTG CTCTGTCCTG GACCCCGATC 
GCCCAGAACA GGGGGATCAT GCCCTTCCCC ACCGAGGAGG AGAGTGTAGG TGATGAAGAC 
ATCTACAGTG GCCTGTCCGA CCAGATCGAC GACACGGTGG AGGAGGATGA GGACCTGTAT 
GACTGCGTGG AGAATGAGGA GGCGGAAGGC GACGAGATCT ATGAGGACCT CATGCGCTCG 
GAGCCCGTGT CCATGCCGCC CAAGATGACA GAGTATGACA AGCGCTGCTG CTGCCTGCGG 
GAGATCCAGC AGACGGAGGA GAAGTACACT GACACGCTGG GCTCCATCCA GCAGCATTTC 
TTGAAGCCCC TGCAACGGTT CCTGAAACCT CAAGACATTG AGATCATCTT TATCAACATT 
GAGGACCTGC TTCGTGTTCA TACTCACTTC CTAAAGGAGA TGAAGGAAGC CCTGGGCACC 
CCTGGCGCAG CCAATCTCTA CCAGGTCTTC ATCAAATACA AGGAGAGGTT CCTCGTCTAT 
GGCCGCTACT GCAGCCAGGT GGAGTCAGCC AGCAAACACC TGGACCGTGT GGCCGCAGCC 
CGGGAGGACG TGCAGATGAA GCTGGAGGAA TGTTCTCAGA GAGCCAACAA CGGGAGGTTC 
ACCCTGCGGG ACCTGCTGAT GGTGCCTATG CAGCGAGTTC TCAAATATCA CCTCCTTCTC 
CAGGAGCTGG TGAAACACAC GCAGGAGGCG ATGGAGAAGG AGAACCTGCG GCTGGCCCTG 
GATGCCATGA GGGACCTGGC TCAGTGCGTG AACGAGGTCA AGCGAGACAA CGAGACACTG 
CGACAGATCA CCAATTTCCA GCTGTCCATT GAGAACCTGG ACCAGTCTCT GGCTCACTAT 
GGCCGGCCCA AGATCGACGG GGAACTCAAG ATCACCTCGG TGGAACGGCG CTCCAAGATG 
GACAGGTATG CCTTCCTGCT CGACAAAGCT CTACTCATCT GTAAGCGCAG GGGAGACTCC 
TATGACCTCA AGGACTTTGT AAACCTGCAC AGCTTCCAGG TTCGGGATGA CTCTTCAGGA 
GACCGAGACA ACAAGAAGTG GAGCCACATG TTCCTCCTGA TCGAGGACCA AGGTGCCCAG 
GGCTATGAGC TGTTCTTCAA GACAAGAGAA TTGAAGAAGA AGTGGATGGA GCAGTTTGAG 
ATGGCCATCT CCAACATCTA TCCGGAGAAT GCCACCGCCA ACGGGCATGA CTTCCAGATG 
TTCTCCTTTG AGGAGACCAC ATCCTGCAAG GCCTGTCAGA TGCTGCTTAG AGGTACCTTC 
TATCAGGGCT ACCGCTGCCA TCGGTGCCGG GCATCTGCAC ACAAGGAGTG TCTGGGGAGG 
GTCCCTCCAT GTGGCCGACA TGGGCAAGAT TTCCCAGGAA CTATGAAGAA GGACAAACTA 
CATCGCAGGG CTCAGGACAA AAAGAGGAAT GAGCTGGGTC TGCCCAAGAT GGAGGTGTTT 
CAGGAATACT ACGGGCTTCC TCCACCCCCT GGAGCCATTG GACCCTTTCT ACGGCTCAAC 
CCTGGAGACA TTGTGGAGCT CACGAAGGCT GAGGCTGAAC AGAACTGGTG GGAGGGCAGA 
AATACATCTA CTAATGAAAT TGGCTGGTTT CCTTGTAACA GGGTGAAGCC CTATGTCCAT 
GGCCCTCCTC AGGACCTGTC TGTTCATCTC TGGTACGCAG GCCCCATGGA GCGGGCAGGG 
GCAGAGAGCA TCCTGGCCAA CCGCTCGGAC GGGACTTTCT TGGTGCGGCA GAGGGTGAAG 
GATGCAGCAG AATTTGCCAT CAGCATTAAA TATAACGTCG AGGTCAAGCA CATTAAAATC 
ATGACAGCAG AAGGACTGTA CCGGATCACA GAGAAAAAGG CTTTCCGGGG GCTTACGTGG 
GAAGCACAAA GTATTTTGGC ACAGCCAAAG CCCGCTATGA CTTCTGCGCC CGAGACCGAT 
CAGAGCTGTC GCTCAAGGAG GGTGACATCA TCAAGATCCT TAACAAGAAG GGACAGCAAG 
GCTGGTGGCG AGGGGAGATC TATGGCCGGG TTGGCTGGTT CCCTGCCAAC TACGTGGAGG 
AAGATTATTC TGAATACTGC TGAGCCCTGG TGCCTTGGCA GAGAGACGAG AAACTCCAGG 
CTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005259699.1
CDS	101..2566
Translation	MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVFQEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVHGPPQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEGLYRITEKKAFRGLTWEAQSILAQPKPAMTSAPETDQSCRSRRVTSSRSLTRRDSKAGGEGRSMAGLAGSLPTTWRKIILNTAEPWCLGRETRNSRL

Target ORF information:

RefSeq Version	XM_005259642.1
Organism	Homo sapiens(human)
Definition	Homo sapiens vav guanine nucleotide exchange factor 1 (VAV1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005259642.1

ORF Insert Sequence:

ATGGAGCTGT GGCGCCAATG CACCCACTGG CTCATCCAGT GCCGGGTGCT GCCGCCCAGC 
CACCGCGTGA CCTGGGATGG GGCTCAGGTG TGTGAACTGG CCCAGGCCCT CCGGGATGGT 
GTCCTTCTGT GTCAGCTGCT TAACAACCTG CTACCCCATG CCATCAACCT GCGTGAGGTC 
AACCTGCGCC CCCAGATGTC CCAGTTCCTG TGCCTTAAGA ACATTAGAAC CTTCCTGTCC 
ACCTGCTGTG AGAAGTTCGG CCTCAAGCGG AGCGAGCTCT TCGAAGCCTT TGACCTCTTC 
GATGTGCAGG ATTTTGGCAA GGTCATCTAC ACCCTGTCTG CTCTGTCCTG GACCCCGATC 
GCCCAGAACA GGGGGATCAT GCCCTTCCCC ACCGAGGAGG AGAGTGTAGG TGATGAAGAC 
ATCTACAGTG GCCTGTCCGA CCAGATCGAC GACACGGTGG AGGAGGATGA GGACCTGTAT 
GACTGCGTGG AGAATGAGGA GGCGGAAGGC GACGAGATCT ATGAGGACCT CATGCGCTCG 
GAGCCCGTGT CCATGCCGCC CAAGATGACA GAGTATGACA AGCGCTGCTG CTGCCTGCGG 
GAGATCCAGC AGACGGAGGA GAAGTACACT GACACGCTGG GCTCCATCCA GCAGCATTTC 
TTGAAGCCCC TGCAACGGTT CCTGAAACCT CAAGACATTG AGATCATCTT TATCAACATT 
GAGGACCTGC TTCGTGTTCA TACTCACTTC CTAAAGGAGA TGAAGGAAGC CCTGGGCACC 
CCTGGCGCAG CCAATCTCTA CCAGGTCTTC ATCAAATACA AGGAGAGGTT CCTCGTCTAT 
GGCCGCTACT GCAGCCAGGT GGAGTCAGCC AGCAAACACC TGGACCGTGT GGCCGCAGCC 
CGGGAGGACG TGCAGATGAA GCTGGAGGAA TGTTCTCAGA GAGCCAACAA CGGGAGGTTC 
ACCCTGCGGG ACCTGCTGAT GGTGCCTATG CAGCGAGTTC TCAAATATCA CCTCCTTCTC 
CAGGAGCTGG TGAAACACAC GCAGGAGGCG ATGGAGAAGG AGAACCTGCG GCTGGCCCTG 
GATGCCATGA GGGACCTGGC TCAGTGCGTG AACGAGGTCA AGCGAGACAA CGAGACACTG 
CGACAGATCA CCAATTTCCA GCTGTCCATT GAGAACCTGG ACCAGTCTCT GGCTCACTAT 
GGCCGGCCCA AGATCGACGG GGAACTCAAG ATCACCTCGG TGGAACGGCG CTCCAAGATG 
GACAGGTATG CCTTCCTGCT CGACAAAGCT CTACTCATCT GTAAGCGCAG GGGAGACTCC 
TATGACCTCA AGGACTTTGT AAACCTGCAC AGCTTCCAGG TTCGGGATGA CTCTTCAGGA 
GACCGAGACA ACAAGAAGTG GAGCCACATG TTCCTCCTGA TCGAGGACCA AGGTGCCCAG 
GGCTATGAGC TGTTCTTCAA GACAAGAGAA TTGAAGAAGA AGTGGATGGA GCAGTTTGAG 
ATGGCCATCT CCAACATCTA TCCGGAGAAT GCCACCGCCA ACGGGCATGA CTTCCAGATG 
TTCTCCTTTG AGGAGACCAC ATCCTGCAAG GCCTGTCAGA TGCTGCTTAG AGGTACCTTC 
TATCAGGGCT ACCGCTGCCA TCGGTGCCGG GCATCTGCAC ACAAGGAGTG TCTGGGGAGG 
GTCCCTCCAT GTGGCCGACA TGGGCAAGAT TTCCCAGGAA CTATGAAGAA GGACAAACTA 
CATCGCAGGG CTCAGGACAA AAAGAGGAAT GAGCTGGGTC TGCCCAAGAT GGAGGTGTTT 
CAGGAATACT ACGGGCTTCC TCCACCCCCT GGAGCCATTG GACCCTTTCT ACGGCTCAAC 
CCTGGAGACA TTGTGGAGCT CACGAAGGCT GAGGCTGAAC AGAACTGGTG GGAGGGCAGA 
AATACATCTA CTAATGAAAT TGGCTGGTTT CCTTGTAACA GGGTGAAGCC CTATGTCCAT 
GGCCCTCCTC AGGACCTGTC TGTTCATCTC TGGTACGCAG GCCCCATGGA GCGGGCAGGG 
GCAGAGAGCA TCCTGGCCAA CCGCTCGGAC GGGACTTTCT TGGTGCGGCA GAGGGTGAAG 
GATGCAGCAG AATTTGCCAT CAGCATTAAA TATAACGTCG AGGTCAAGCA CATTAAAATC 
ATGACAGCAG AAGGACTGTA CCGGATCACA GAGAAAAAGG CTTTCCGGGG GCTTACGTGG 
GAAGCACAAA GTATTTTGGC ACAGCCAAAG CCCGCTATGA CTTCTGCGCC CGAGACCGAT 
CAGAGCTGTC GCTCAAGGAG GGTGACATCA TCAAGATCCT TAACAAGAAG GGACAGCAAG 
GCTGGTGGCG AGGGGAGATC TATGGCCGGG TTGGCTGGTT CCCTGCCAAC TACGTGGAGG 
AAGATTATTC TGAATACTGC TGAGCCCTGG TGCCTTGGCA GAGAGACGAG AAACTCCAGG 
CTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.
Cancer cell32(5)608-623.e9(2017 Nov)
Robles-Valero J,Lorenzo-Mart?n LF,Menacho-M?rquez M,Fern?ndez-Pisonero I,Abad A,Cam?s M,Toribio ML,Espinosa L,Bigas A,Bustelo XR

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VAV1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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