NR2F1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NR2F1
Entrez Gene ID	7025
Full Name	nuclear receptor subfamily 2 group F member 1
Synonyms	BBOAS,BBSOAS,COUP-TFI,EAR-3,EAR3,ERBAL3,NR2F2,SVP44,TCFCOUP1,TFCOUP1
General protein information	Preferred Names nuclear receptor subfamily 2 group F member 1 Names COUP transcription factor 1 COUP transcription factor I COUP-TF I COUP-TF1 V-erbA-related protein 3 chicken ovalbumin upstream promoter-transcription factor I transcription factor COUP 1 (chicken ovalbumin upstream promoter 1, v-erb-a homolog-like 3)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q15
Summary	The protein encoded by this gene is a nuclear hormone receptor and transcriptional regulator. The encoded protein acts as a homodimer and binds to 5'-AGGTCA-3' repeats. Defects in this gene are a cause of Bosch-Boonstra optic atrophy syndrome (BBOAS). [provided by RefSeq, Apr 2014].
Disorder MIM:	132890
Disorder Html:	Bosch-Boonstra-Schaaf optic atrophy syndrome, 615722 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_005654.5	NP_005645.1	COUP transcription factor 1
NM_005654.6	NP_005645.1	COUP transcription factor 1
XM_017009797.1	XP_016865286.1	COUP transcription factor 1 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	NR2F1	NP_005645.1
Canis lupus familiaris (dog)	NR2F1	XP_848884.2
Rattus norvegicus (Norway rat)	Nr2f1	NP_112392.1
Mus musculus (house mouse)	Nr2f1	NP_034281.2
Danio rerio (zebrafish)	nr2f1a	NP_571255.1
	NR2F1	XP_001089115.2
Bos taurus (cattle)	NR2F1	NP_786998.1
Caenorhabditis elegans (roundworm)	unc-55	NP_001122482.2
Pan troglodytes (chimpanzee)	NR2F1	XP_517657.3
Gallus gallus (chicken)	LOC100859519	XP_004949459.1
Xenopus tropicalis (tropical clawed frog)	nr2f1	NP_001093677.1

Gene Ontology
Bibliography

Related articles in PubMed

Novel
Kaiwar C, Zimmermann MT, Ferber MJ, Niu Z, Urrutia RA, Klee EW, Babovic-Vuksanovic D
Cold Spring Harbor molecular case studies3(6)(2017 Nov)

The Transcription Factors COUP-TFI and COUP-TFII have Distinct Roles in Arealisation and GABAergic Interneuron Specification in the Early Human Fetal Telencephalon.
Alzu'bi A, Lindsay SJ, Harkin LF, McIntyre J, Lisgo SN, Clowry GJ
Cerebral cortex (New York, N.Y. : 1991)27(10)4971-4987(2017 Oct)

The expanding clinical phenotype of Bosch-Boonstra-Schaaf optic atrophy syndrome: 20 new cases and possible genotype-phenotype correlations.
Chen CA, Bosch DG, Cho MT, Rosenfeld JA, Shinawi M, Lewis RA, Mann J, Jayakar P, Payne K, Walsh L, Moss T, Schreiber A, Schoonveld C, Monaghan KG, Elmslie F, Douglas G, Boonstra FN, Millan F, Cremers FP, McKnight D, Richard G, Juusola J, Kendall F, Ramsey K, Anyane-Yeboa K, Malkin E, Chung WK, Niyazov D, Pascual JM, Walkiewicz M, Veluchamy V, Li C, Hisama FM, de Vries BB, Schaaf C
Genetics in medicine : official journal of the American College of Medical Genetics18(11)1143-1150(2016 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Bosch-Boonstra-Schaaf optic atrophy syndrome (BBSOAS)encompasses a broad range of clinical phenotypes. Functional studies help determine the severity of novel NR2F1 variants. Some genotype-phenotype correlations seem to exist, with missense mutations in the DNA-binding domain causing the most severe phenotypes
Title: The expanding clinical phenotype of Bosch-Boonstra-Schaaf optic atrophy syndrome: 20 new cases and possible genotype-phenotype correlations.

COUP-TFII is expressed in a diverse subset of GABAergic interneurons predominantly innervating small dendritic shafts originating from both interneurons and pyramidal cells.
Title: Molecular and Electrophysiological Characterization of GABAergic Interneurons Expressing the Transcription Factor COUP-TFII in the Adult Human Temporal Cortex.

our mechanistic in vitro assays and in vivo results suggest that a reduction in chemokine CXCL12 expression, with an enhancement of CXCR4 expression, provoked by COUP-TFI, could be associated with an increase in the invasive potential of breast cancer
Title: COUP-TFI modifies CXCL12 and CXCR4 expression by activating EGF signaling and stimulates breast cancer cell migration.

NR2F1 has an important role in the development of the visual system and that haploinsuffiency can lead to optic atrophy with intellectual impairment.
Title: NR2F1 mutations cause optic atrophy with intellectual disability.

Interaction of NSD1 with the NR2E/F subfamily including COUP-TFI, COUP-TFII, EAR2 and TLX requires an F/YSXXLXXL/Y motif. Interactions of NSD1 with liganded NRs require an overlapping LXXLL motif.
Title: A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.

The following NR2F1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NR2F1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23866	NM_005654.6 Latest version!	Homo sapiens nuclear receptor subfamily 2 group F member 1 (NR2F1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu96037	XM_017009797.1 Latest version!	Homo sapiens nuclear receptor subfamily 2 group F member 1 (NR2F1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu23866	NM_005654.5	Homo sapiens nuclear receptor subfamily 2 group F member 1 (NR2F1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NR2F1 ( NM_005654.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_005645.1 Homo sapiens nuclear receptor subfamily 2 group F member 1 (NR2F1), mRNA.

Price & Availability↑

CloneID	OHu23866
Clone ID Related Accession (Same CDS sequence)	NM_005654.5 , NM_005654.6
Accession Version	NM_005654.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1272bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-17
Organism	Homo sapiens(human)
Product	COUP transcription factor 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC017493.1, AC106818.2 and AF087978.1. This sequence is a reference standard in the RefSeqGene project. On Apr 22, 2014 this sequence version replaced NM_005654.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC017493.1, SRR1660805.121230.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAATGG TAGTTAGCAG CTGGCGAGAT CCGCAGGACG ACGTGGCCGG GGGCAACCCC 
GGCGGCCCCA ACCCCGCAGC GCAGGCGGCC CGCGGCGGCG GCGGCGGCGC CGGCGAGCAG 
CAGCAGCAGG CGGGCTCGGG CGCGCCGCAC ACGCCGCAGA CCCCGGGCCA GCCCGGAGCG 
CCCGCCACCC CCGGCACGGC GGGGGACAAG GGCCAGGGCC CGCCCGGTTC GGGCCAGAGC 
CAGCAGCACA TCGAGTGCGT GGTGTGCGGG GACAAGTCGA GCGGCAAGCA CTACGGCCAA 
TTCACCTGCG AGGGCTGCAA AAGTTTCTTC AAGAGGAGCG TCCGCAGGAA CTTAACTTAC 
ACATGCCGTG CCAACAGGAA CTGTCCCATC GACCAGCACC ACCGCAACCA GTGCCAATAC 
TGCCGCCTCA AGAAGTGCCT CAAAGTGGGC ATGAGGCGGG AAGCGGTTCA GCGAGGAAGA 
ATGCCTCCAA CCCAGCCCAA TCCAGGCCAG TACGCACTCA CCAACGGGGA CCCCCTCAAC 
GGCCACTGCT ACCTGTCCGG CTACATCTCG CTGCTGCTGC GCGCCGAGCC CTACCCCACG 
TCGCGCTACG GCAGCCAGTG CATGCAGCCC AACAACATTA TGGGCATCGA GAACATCTGC 
GAGCTGGCCG CGCGCCTGCT CTTCAGCGCC GTCGAGTGGG CCCGCAACAT CCCCTTCTTC 
CCGGATCTGC AGATCACCGA CCAGGTGTCC CTGCTACGCC TCACCTGGAG CGAGCTGTTC 
GTGCTCAACG CGGCCCAGTG CTCTATGCCG CTGCACGTGG CGCCGTTGCT GGCCGCCGCC 
GGCCTGCATG CCTCGCCCAT GTCTGCCGAC CGCGTCGTGG CCTTCATGGA CCACATCCGC 
ATCTTCCAGG AGCAGGTGGA GAAGCTCAAG GCGCTACACG TCGACTCAGC CGAGTACAGC 
TGCCTCAAAG CCATCGTGCT GTTCACGTCA GACGCCTGTG GCCTGTCGGA TGCGGCCCAC 
ATCGAGAGCC TGCAGGAGAA GTCGCAGTGC GCACTGGAGG AGTACGTGAG GAGCCAGTAC 
CCCAACCAGC CCAGCCGTTT TGGCAAACTG CTGCTGCGAC TGCCCTCGCT GCGCACCGTG 
TCCTCCTCCG TCATCGAGCA GCTCTTCTTC GTCCGTTTGG TAGGTAAAAC CCCCATCGAA 
ACTCTCATCC GCGATATGTT ACTGTCTGGG AGCAGCTTCA ACTGGCCTTA CATGTCCATC 
CAGTGCTCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005645.1
CDS	1688..2959
Translation	MAMVVSSWRDPQDDVAGGNPGGPNPAAQAARGGGGGAGEQQQQAGSGAPHTPQTPGQPGAPATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSIQCS

Target ORF information:

RefSeq Version	NM_005654.5
Organism	Homo sapiens(human)
Definition	Homo sapiens nuclear receptor subfamily 2 group F member 1 (NR2F1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005654.5

ORF Insert Sequence:

ATGGCAATGG TAGTTAGCAG CTGGCGAGAT CCGCAGGACG ACGTGGCCGG GGGCAACCCC 
GGCGGCCCCA ACCCCGCAGC GCAGGCGGCC CGCGGCGGCG GCGGCGGCGC CGGCGAGCAG 
CAGCAGCAGG CGGGCTCGGG CGCGCCGCAC ACGCCGCAGA CCCCGGGCCA GCCCGGAGCG 
CCCGCCACCC CCGGCACGGC GGGGGACAAG GGCCAGGGCC CGCCCGGTTC GGGCCAGAGC 
CAGCAGCACA TCGAGTGCGT GGTGTGCGGG GACAAGTCGA GCGGCAAGCA CTACGGCCAA 
TTCACCTGCG AGGGCTGCAA AAGTTTCTTC AAGAGGAGCG TCCGCAGGAA CTTAACTTAC 
ACATGCCGTG CCAACAGGAA CTGTCCCATC GACCAGCACC ACCGCAACCA GTGCCAATAC 
TGCCGCCTCA AGAAGTGCCT CAAAGTGGGC ATGAGGCGGG AAGCGGTTCA GCGAGGAAGA 
ATGCCTCCAA CCCAGCCCAA TCCAGGCCAG TACGCACTCA CCAACGGGGA CCCCCTCAAC 
GGCCACTGCT ACCTGTCCGG CTACATCTCG CTGCTGCTGC GCGCCGAGCC CTACCCCACG 
TCGCGCTACG GCAGCCAGTG CATGCAGCCC AACAACATTA TGGGCATCGA GAACATCTGC 
GAGCTGGCCG CGCGCCTGCT CTTCAGCGCC GTCGAGTGGG CCCGCAACAT CCCCTTCTTC 
CCGGATCTGC AGATCACCGA CCAGGTGTCC CTGCTACGCC TCACCTGGAG CGAGCTGTTC 
GTGCTCAACG CGGCCCAGTG CTCTATGCCG CTGCACGTGG CGCCGTTGCT GGCCGCCGCC 
GGCCTGCATG CCTCGCCCAT GTCTGCCGAC CGCGTCGTGG CCTTCATGGA CCACATCCGC 
ATCTTCCAGG AGCAGGTGGA GAAGCTCAAG GCGCTACACG TCGACTCAGC CGAGTACAGC 
TGCCTCAAAG CCATCGTGCT GTTCACGTCA GACGCCTGTG GCCTGTCGGA TGCGGCCCAC 
ATCGAGAGCC TGCAGGAGAA GTCGCAGTGC GCACTGGAGG AGTACGTGAG GAGCCAGTAC 
CCCAACCAGC CCAGCCGTTT TGGCAAACTG CTGCTGCGAC TGCCCTCGCT GCGCACCGTG 
TCCTCCTCCG TCATCGAGCA GCTCTTCTTC GTCCGTTTGG TAGGTAAAAC CCCCATCGAA 
ACTCTCATCC GCGATATGTT ACTGTCTGGG AGCAGCTTCA ACTGGCCTTA CATGTCCATC 
CAGTGCTCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NR2F1 ( NM_005654.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_005645.1 Homo sapiens nuclear receptor subfamily 2 group F member 1 (NR2F1), mRNA.

Price & Availability↑

CloneID	OHu23866
Clone ID Related Accession (Same CDS sequence)	NM_005654.5 , NM_005654.6
Accession Version	NM_005654.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1272bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	COUP transcription factor 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC106818.2, BC017493.1 and AF087978.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_005654.5. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC017493.1, SRR3476690.165042.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000327111.8/ ENSP00000325819.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAATGG TAGTTAGCAG CTGGCGAGAT CCGCAGGACG ACGTGGCCGG GGGCAACCCC 
GGCGGCCCCA ACCCCGCAGC GCAGGCGGCC CGCGGCGGCG GCGGCGGCGC CGGCGAGCAG 
CAGCAGCAGG CGGGCTCGGG CGCGCCGCAC ACGCCGCAGA CCCCGGGCCA GCCCGGAGCG 
CCCGCCACCC CCGGCACGGC GGGGGACAAG GGCCAGGGCC CGCCCGGTTC GGGCCAGAGC 
CAGCAGCACA TCGAGTGCGT GGTGTGCGGG GACAAGTCGA GCGGCAAGCA CTACGGCCAA 
TTCACCTGCG AGGGCTGCAA AAGTTTCTTC AAGAGGAGCG TCCGCAGGAA CTTAACTTAC 
ACATGCCGTG CCAACAGGAA CTGTCCCATC GACCAGCACC ACCGCAACCA GTGCCAATAC 
TGCCGCCTCA AGAAGTGCCT CAAAGTGGGC ATGAGGCGGG AAGCGGTTCA GCGAGGAAGA 
ATGCCTCCAA CCCAGCCCAA TCCAGGCCAG TACGCACTCA CCAACGGGGA CCCCCTCAAC 
GGCCACTGCT ACCTGTCCGG CTACATCTCG CTGCTGCTGC GCGCCGAGCC CTACCCCACG 
TCGCGCTACG GCAGCCAGTG CATGCAGCCC AACAACATTA TGGGCATCGA GAACATCTGC 
GAGCTGGCCG CGCGCCTGCT CTTCAGCGCC GTCGAGTGGG CCCGCAACAT CCCCTTCTTC 
CCGGATCTGC AGATCACCGA CCAGGTGTCC CTGCTACGCC TCACCTGGAG CGAGCTGTTC 
GTGCTCAACG CGGCCCAGTG CTCTATGCCG CTGCACGTGG CGCCGTTGCT GGCCGCCGCC 
GGCCTGCATG CCTCGCCCAT GTCTGCCGAC CGCGTCGTGG CCTTCATGGA CCACATCCGC 
ATCTTCCAGG AGCAGGTGGA GAAGCTCAAG GCGCTACACG TCGACTCAGC CGAGTACAGC 
TGCCTCAAAG CCATCGTGCT GTTCACGTCA GACGCCTGTG GCCTGTCGGA TGCGGCCCAC 
ATCGAGAGCC TGCAGGAGAA GTCGCAGTGC GCACTGGAGG AGTACGTGAG GAGCCAGTAC 
CCCAACCAGC CCAGCCGTTT TGGCAAACTG CTGCTGCGAC TGCCCTCGCT GCGCACCGTG 
TCCTCCTCCG TCATCGAGCA GCTCTTCTTC GTCCGTTTGG TAGGTAAAAC CCCCATCGAA 
ACTCTCATCC GCGATATGTT ACTGTCTGGG AGCAGCTTCA ACTGGCCTTA CATGTCCATC 
CAGTGCTCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005645.1
CDS	1803..3074
Translation	MAMVVSSWRDPQDDVAGGNPGGPNPAAQAARGGGGGAGEQQQQAGSGAPHTPQTPGQPGAPATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSIQCS

Target ORF information:

RefSeq Version	NM_005654.6
Organism	Homo sapiens(human)
Definition	Homo sapiens nuclear receptor subfamily 2 group F member 1 (NR2F1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005654.6

ORF Insert Sequence:

ATGGCAATGG TAGTTAGCAG CTGGCGAGAT CCGCAGGACG ACGTGGCCGG GGGCAACCCC 
GGCGGCCCCA ACCCCGCAGC GCAGGCGGCC CGCGGCGGCG GCGGCGGCGC CGGCGAGCAG 
CAGCAGCAGG CGGGCTCGGG CGCGCCGCAC ACGCCGCAGA CCCCGGGCCA GCCCGGAGCG 
CCCGCCACCC CCGGCACGGC GGGGGACAAG GGCCAGGGCC CGCCCGGTTC GGGCCAGAGC 
CAGCAGCACA TCGAGTGCGT GGTGTGCGGG GACAAGTCGA GCGGCAAGCA CTACGGCCAA 
TTCACCTGCG AGGGCTGCAA AAGTTTCTTC AAGAGGAGCG TCCGCAGGAA CTTAACTTAC 
ACATGCCGTG CCAACAGGAA CTGTCCCATC GACCAGCACC ACCGCAACCA GTGCCAATAC 
TGCCGCCTCA AGAAGTGCCT CAAAGTGGGC ATGAGGCGGG AAGCGGTTCA GCGAGGAAGA 
ATGCCTCCAA CCCAGCCCAA TCCAGGCCAG TACGCACTCA CCAACGGGGA CCCCCTCAAC 
GGCCACTGCT ACCTGTCCGG CTACATCTCG CTGCTGCTGC GCGCCGAGCC CTACCCCACG 
TCGCGCTACG GCAGCCAGTG CATGCAGCCC AACAACATTA TGGGCATCGA GAACATCTGC 
GAGCTGGCCG CGCGCCTGCT CTTCAGCGCC GTCGAGTGGG CCCGCAACAT CCCCTTCTTC 
CCGGATCTGC AGATCACCGA CCAGGTGTCC CTGCTACGCC TCACCTGGAG CGAGCTGTTC 
GTGCTCAACG CGGCCCAGTG CTCTATGCCG CTGCACGTGG CGCCGTTGCT GGCCGCCGCC 
GGCCTGCATG CCTCGCCCAT GTCTGCCGAC CGCGTCGTGG CCTTCATGGA CCACATCCGC 
ATCTTCCAGG AGCAGGTGGA GAAGCTCAAG GCGCTACACG TCGACTCAGC CGAGTACAGC 
TGCCTCAAAG CCATCGTGCT GTTCACGTCA GACGCCTGTG GCCTGTCGGA TGCGGCCCAC 
ATCGAGAGCC TGCAGGAGAA GTCGCAGTGC GCACTGGAGG AGTACGTGAG GAGCCAGTAC 
CCCAACCAGC CCAGCCGTTT TGGCAAACTG CTGCTGCGAC TGCCCTCGCT GCGCACCGTG 
TCCTCCTCCG TCATCGAGCA GCTCTTCTTC GTCCGTTTGG TAGGTAAAAC CCCCATCGAA 
ACTCTCATCC GCGATATGTT ACTGTCTGGG AGCAGCTTCA ACTGGCCTTA CATGTCCATC 
CAGTGCTCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NR2F1 ( XM_017009797.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016865286.1 Homo sapiens nuclear receptor subfamily 2 group F member 1 (NR2F1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu96037
Clone ID Related Accession (Same CDS sequence)	XM_017009797.1
Accession Version	XM_017009797.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	COUP transcription factor 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTTGGCT ACTCGGTTCA GCGAGGAAGA ATGCCTCCAA CCCAGCCCAA TCCAGGCCAG 
TACGCACTCA CCAACGGGGA CCCCCTCAAC GGCCACTGCT ACCTGTCCGG CTACATCTCG 
CTGCTGCTGC GCGCCGAGCC CTACCCCACG TCGCGCTACG GCAGCCAGTG CATGCAGCCC 
AACAACATTA TGGGCATCGA GAACATCTGC GAGCTGGCCG CGCGCCTGCT CTTCAGCGCC 
GTCGAGTGGG CCCGCAACAT CCCCTTCTTC CCGGATCTGC AGATCACCGA CCAGGTGTCC 
CTGCTACGCC TCACCTGGAG CGAGCTGTTC GTGCTCAACG CGGCCCAGTG CTCTATGCCG 
CTGCACGTGG CGCCGTTGCT GGCCGCCGCC GGCCTGCATG CCTCGCCCAT GTCTGCCGAC 
CGCGTCGTGG CCTTCATGGA CCACATCCGC ATCTTCCAGG AGCAGGTGGA GAAGCTCAAG 
GCGCTACACG TCGACTCAGC CGAGTACAGC TGCCTCAAAG CCATCGTGCT GTTCACGTCA 
GACGCCTGTG GCCTGTCGGA TGCGGCCCAC ATCGAGAGCC TGCAGGAGAA GTCGCAGTGC 
GCACTGGAGG AGTACGTGAG GAGCCAGTAC CCCAACCAGC CCAGCCGTTT TGGCAAACTG 
CTGCTGCGAC TGCCCTCGCT GCGCACCGTG TCCTCCTCCG TCATCGAGCA GCTCTTCTTC 
GTCCGTTTGG TAGGTAAAAC CCCCATCGAA ACTCTCATCC GCGATATGTT ACTGTCTGGG 
AGCAGCTTCA ACTGGCCTTA CATGTCCATC CAGTGCTCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016865286.1
CDS	131..952
Translation	MFGYSVQRGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSIQCS

Target ORF information:

RefSeq Version	XM_017009797.1
Organism	Homo sapiens(human)
Definition	Homo sapiens nuclear receptor subfamily 2 group F member 1 (NR2F1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017009797.1

ORF Insert Sequence:

ATGTTTGGCT ACTCGGTTCA GCGAGGAAGA ATGCCTCCAA CCCAGCCCAA TCCAGGCCAG 
TACGCACTCA CCAACGGGGA CCCCCTCAAC GGCCACTGCT ACCTGTCCGG CTACATCTCG 
CTGCTGCTGC GCGCCGAGCC CTACCCCACG TCGCGCTACG GCAGCCAGTG CATGCAGCCC 
AACAACATTA TGGGCATCGA GAACATCTGC GAGCTGGCCG CGCGCCTGCT CTTCAGCGCC 
GTCGAGTGGG CCCGCAACAT CCCCTTCTTC CCGGATCTGC AGATCACCGA CCAGGTGTCC 
CTGCTACGCC TCACCTGGAG CGAGCTGTTC GTGCTCAACG CGGCCCAGTG CTCTATGCCG 
CTGCACGTGG CGCCGTTGCT GGCCGCCGCC GGCCTGCATG CCTCGCCCAT GTCTGCCGAC 
CGCGTCGTGG CCTTCATGGA CCACATCCGC ATCTTCCAGG AGCAGGTGGA GAAGCTCAAG 
GCGCTACACG TCGACTCAGC CGAGTACAGC TGCCTCAAAG CCATCGTGCT GTTCACGTCA 
GACGCCTGTG GCCTGTCGGA TGCGGCCCAC ATCGAGAGCC TGCAGGAGAA GTCGCAGTGC 
GCACTGGAGG AGTACGTGAG GAGCCAGTAC CCCAACCAGC CCAGCCGTTT TGGCAAACTG 
CTGCTGCGAC TGCCCTCGCT GCGCACCGTG TCCTCCTCCG TCATCGAGCA GCTCTTCTTC 
GTCCGTTTGG TAGGTAAAAC CCCCATCGAA ACTCTCATCC GCGATATGTT ACTGTCTGGG 
AGCAGCTTCA ACTGGCCTTA CATGTCCATC CAGTGCTCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Novel
Cold Spring Harbor molecular case studies3(6)(2017 Nov)
Kaiwar C,Zimmermann MT,Ferber MJ,Niu Z,Urrutia RA,Klee EW,Babovic-Vuksanovic D

The Transcription Factors COUP-TFI and COUP-TFII have Distinct Roles in Arealisation and GABAergic Interneuron Specification in the Early Human Fetal Telencephalon.
Cerebral cortex (New York, N.Y. : 1991)27(10)4971-4987(2017 Oct)
Alzu'bi A,Lindsay SJ,Harkin LF,McIntyre J,Lisgo SN,Clowry GJ

The expanding clinical phenotype of Bosch-Boonstra-Schaaf optic atrophy syndrome: 20 new cases and possible genotype-phenotype correlations.
Genetics in medicine : official journal of the American College of Medical Genetics18(11)1143-1150(2016 Nov)
Chen CA,Bosch DG,Cho MT,Rosenfeld JA,Shinawi M,Lewis RA,Mann J,Jayakar P,Payne K,Walsh L,Moss T,Schreiber A,Schoonveld C,Monaghan KG,Elmslie F,Douglas G,Boonstra FN,Millan F,Cremers FP,McKnight D,Richard G,Juusola J,Kendall F,Ramsey K,Anyane-Yeboa K,Malkin E,Chung WK,Niyazov D,Pascual JM,Walkiewicz M,Veluchamy V,Li C,Hisama FM,de Vries BB,Schaaf C

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NR2F1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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