| Gene Symbol | STAT4 |
| Entrez Gene ID | 6775 |
| Full Name | signal transducer and activator of transcription 4 |
| Synonyms | SLEB11 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]. |
| Disorder MIM: | |
| Disorder Html: | {Systemic lupus erythematosus, susceptibility to, 11}, 612253 (3) |









































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