SNRPC cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SNRPC
Entrez Gene ID	6631
Full Name	small nuclear ribonucleoprotein polypeptide C
Synonyms	U1C,Yhc1
General protein information	Preferred Names small nuclear ribonucleoprotein polypeptide C Names U1 small nuclear ribonucleoprotein C U1 small nuclear RNP specific C U1 snRNP C U1 snRNP protein C
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.31
Summary	This gene encodes one of the specific protein components of the U1 small nuclear ribonucleoprotein (snRNP) particle required for the formation of the spliceosome. The encoded protein participates in the processing of nuclear precursor messenger RNA splicing. snRNP particles are attacked by autoantibodies frequently produced by patients with connective tissue diseases. The genome contains several pseudogenes of this functional gene. Alternative splicing results in a non-coding transcript variant.[provided by RefSeq, Oct 2009].
Disorder MIM:	603522

mRNA and Protein(s)

mRNA	Protein	Name
NM_003093.3	NP_003084.1	U1 small nuclear ribonucleoprotein C
NM_003093.2	NP_003084.1	U1 small nuclear ribonucleoprotein C

Pathways from BioSystems

Homologies

Homo sapiens (human)	SNRPC	NP_003084.1
Canis lupus familiaris (dog)	LOC102153257	XP_005618988.1
Pan troglodytes (chimpanzee)	SNRPC	XP_001171894.1
	LOC718654	XP_001111611.2
Rattus norvegicus (Norway rat)	LOC685273	XP_001063116.2

Gene Ontology
Bibliography

Related articles in PubMed

ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP.
Sun S, Ling SC, Qiu J, Albuquerque CP, Zhou Y, Tokunaga S, Li H, Qiu H, Bui A, Yeo GW, Huang EJ, Eggan K, Zhou H, Fu XD, Lagier-Tourenne C, Cleveland DW
Nature communications66171(2015 Jan)

GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
Armstrong DL, Zidovetzki R, Alarc?n-Riquelme ME, Tsao BP, Criswell LA, Kimberly RP, Harley JB, Sivils KL, Vyse TJ, Gaffney PM, Langefeld CD, Jacob CO
Genes and immunity15(6)347-54(2014 Sep)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

Dynamic protein-protein interaction wiring of the human spliceosome.
Hegele A, Kamburov A, Grossmann A, Sourlis C, Wowro S, Weimann M, Will CL, Pena V, L?hrmann R, Stelzl U
Molecular cell45(4)567-80(2012 Feb)

Functional organization of the Sm core in the crystal structure of human U1 snRNP.
Weber G, Trowitzsch S, Kastner B, L?hrmann R, Wahl MC
The EMBO journal29(24)4172-84(2010 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these studies establish potentially converging disease mechanisms in amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy, with ALS-causative mutants acquiring properties representing both gain and loss of function.
Title: ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP.

binding of TIA-1 in the vicinity of a 5' ss helps to stabilize U1 snRNP recruitment, at least in part, via a direct interaction with U1-C
Title: The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5' splice sites.

The following SNRPC gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SNRPC cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu08326	NM_003093.3 Latest version!	Homo sapiens small nuclear ribonucleoprotein polypeptide C (SNRPC), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu08326	NM_003093.2	Homo sapiens small nuclear ribonucleoprotein polypeptide C (SNRPC), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SNRPC ( NM_003093.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003084.1 Homo sapiens small nuclear ribonucleoprotein polypeptide C (SNRPC), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu08326
Clone ID Related Accession (Same CDS sequence)	NM_003093.3 , NM_003093.2
Accession Version	NM_003093.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 480bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Homo sapiens(human)
Product	U1 small nuclear ribonucleoprotein C
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD109745.1, AK311955.1, AI356808.1 and BU153661.1. On Nov 23, 2018 this sequence version replaced NM_003093.2. Transcript Variant: This variant (1) represents the longer transcript. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP338623.1, SRR5189658.56470.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000244520.10/ ENSP00000244520.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCCAAGT TTTATTGTGA CTACTGCGAT ACATACCTCA CCCATGACTC TCCATCTGTG 
AGAAAGACAC ACTGCAGTGG AAGGAAACAC AAAGAGAATG TGAAAGACTA TTATCAGAAA 
TGGATGGAAG AGCAGGCTCA GAGCCTGATT GACAAAACAA CGGCTGCATT TCAACAAGGA 
AAGATACCTC CTACTCCATT CTCTGCTCCT CCTCCTGCAG GGGCGATGAT ACCACCTCCC 
CCCAGCCTTC CGGGTCCTCC TCGCCCTGGT ATGATGCCAG CACCCCATAT GGGGGGCCCT 
CCCATGATGC CAATGATGGG CCCTCCTCCT CCTGGGATGA TGCCAGTGGG ACCTGCTCCT 
GGAATGAGGC CGCCCATGGG AGGCCATATG CCAATGATGC CTGGGCCCCC AATGATGAGA 
CCTCCTGCCC GTCCCATGAT GGTGCCCACT CGGCCCGGAA TGACTCGACC AGACAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003084.1
CDS	40..519
Translation	MPKFYCDYCDTYLTHDSPSVRKTHCSGRKHKENVKDYYQKWMEEQAQSLIDKTTAAFQQGKIPPTPFSAPPPAGAMIPPPPSLPGPPRPGMMPAPHMGGPPMMPMMGPPPPGMMPVGPAPGMRPPMGGHMPMMPGPPMMRPPARPMMVPTRPGMTRPDR

Target ORF information:

RefSeq Version	NM_003093.3
Organism	Homo sapiens(human)
Definition	Homo sapiens small nuclear ribonucleoprotein polypeptide C (SNRPC), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003093.3

ORF Insert Sequence:

ATGCCCAAGT TTTATTGTGA CTACTGCGAT ACATACCTCA CCCATGACTC TCCATCTGTG 
AGAAAGACAC ACTGCAGTGG AAGGAAACAC AAAGAGAATG TGAAAGACTA TTATCAGAAA 
TGGATGGAAG AGCAGGCTCA GAGCCTGATT GACAAAACAA CGGCTGCATT TCAACAAGGA 
AAGATACCTC CTACTCCATT CTCTGCTCCT CCTCCTGCAG GGGCGATGAT ACCACCTCCC 
CCCAGCCTTC CGGGTCCTCC TCGCCCTGGT ATGATGCCAG CACCCCATAT GGGGGGCCCT 
CCCATGATGC CAATGATGGG CCCTCCTCCT CCTGGGATGA TGCCAGTGGG ACCTGCTCCT 
GGAATGAGGC CGCCCATGGG AGGCCATATG CCAATGATGC CTGGGCCCCC AATGATGAGA 
CCTCCTGCCC GTCCCATGAT GGTGCCCACT CGGCCCGGAA TGACTCGACC AGACAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SNRPC ( NM_003093.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003084.1 Homo sapiens small nuclear ribonucleoprotein polypeptide C (SNRPC), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu08326
Clone ID Related Accession (Same CDS sequence)	NM_003093.3 , NM_003093.2
Accession Version	NM_003093.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 480bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	U1 small nuclear ribonucleoprotein C
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL139100.9, CD109745.1, AK311955.1, AI356808.1 and BU153661.1. On Oct 31, 2009 this sequence version replaced NM_003093.1. Transcript Variant: This variant (1) represents the longer transcript. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.584736.1, SRR1163655.214055.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCAAGT TTTATTGTGA CTACTGCGAT ACATACCTCA CCCATGACTC TCCATCTGTG 
AGAAAGACAC ACTGCAGTGG AAGGAAACAC AAAGAGAATG TGAAAGACTA TTATCAGAAA 
TGGATGGAAG AGCAGGCTCA GAGCCTGATT GACAAAACAA CGGCTGCATT TCAACAAGGA 
AAGATACCTC CTACTCCATT CTCTGCTCCT CCTCCTGCAG GGGCGATGAT ACCACCTCCC 
CCCAGCCTTC CGGGTCCTCC TCGCCCTGGT ATGATGCCAG CACCCCATAT GGGGGGCCCT 
CCCATGATGC CAATGATGGG CCCTCCTCCT CCTGGGATGA TGCCAGTGGG ACCTGCTCCT 
GGAATGAGGC CGCCCATGGG AGGCCATATG CCAATGATGC CTGGGCCCCC AATGATGAGA 
CCTCCTGCCC GTCCCATGAT GGTGCCCACT CGGCCCGGAA TGACTCGACC AGACAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003084.1
CDS	451..930
Translation	MPKFYCDYCDTYLTHDSPSVRKTHCSGRKHKENVKDYYQKWMEEQAQSLIDKTTAAFQQGKIPPTPFSAPPPAGAMIPPPPSLPGPPRPGMMPAPHMGGPPMMPMMGPPPPGMMPVGPAPGMRPPMGGHMPMMPGPPMMRPPARPMMVPTRPGMTRPDR

Target ORF information:

RefSeq Version	NM_003093.2
Organism	Homo sapiens(human)
Definition	Homo sapiens small nuclear ribonucleoprotein polypeptide C (SNRPC), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003093.2

ORF Insert Sequence:

ATGCCCAAGT TTTATTGTGA CTACTGCGAT ACATACCTCA CCCATGACTC TCCATCTGTG 
AGAAAGACAC ACTGCAGTGG AAGGAAACAC AAAGAGAATG TGAAAGACTA TTATCAGAAA 
TGGATGGAAG AGCAGGCTCA GAGCCTGATT GACAAAACAA CGGCTGCATT TCAACAAGGA 
AAGATACCTC CTACTCCATT CTCTGCTCCT CCTCCTGCAG GGGCGATGAT ACCACCTCCC 
CCCAGCCTTC CGGGTCCTCC TCGCCCTGGT ATGATGCCAG CACCCCATAT GGGGGGCCCT 
CCCATGATGC CAATGATGGG CCCTCCTCCT CCTGGGATGA TGCCAGTGGG ACCTGCTCCT 
GGAATGAGGC CGCCCATGGG AGGCCATATG CCAATGATGC CTGGGCCCCC AATGATGAGA 
CCTCCTGCCC GTCCCATGAT GGTGCCCACT CGGCCCGGAA TGACTCGACC AGACAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP.
Nature communications66171(2015 Jan)
Sun S,Ling SC,Qiu J,Albuquerque CP,Zhou Y,Tokunaga S,Li H,Qiu H,Bui A,Yeo GW,Huang EJ,Eggan K,Zhou H,Fu XD,Lagier-Tourenne C,Cleveland DW

GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
Genes and immunity15(6)347-54(2014 Sep)
Armstrong DL,Zidovetzki R,Alarc?n-Riquelme ME,Tsao BP,Criswell LA,Kimberly RP,Harley JB,Sivils KL,Vyse TJ,Gaffney PM,Langefeld CD,Jacob CO

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

Dynamic protein-protein interaction wiring of the human spliceosome.
Molecular cell45(4)567-80(2012 Feb)
Hegele A,Kamburov A,Grossmann A,Sourlis C,Wowro S,Weimann M,Will CL,Pena V,L?hrmann R,Stelzl U

Functional organization of the Sm core in the crystal structure of human U1 snRNP.
The EMBO journal29(24)4172-84(2010 Dec)
Weber G,Trowitzsch S,Kastner B,L?hrmann R,Wahl MC

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SNRPC cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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