BMP3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BMP3
Entrez Gene ID	651
Full Name	bone morphogenetic protein 3
Synonyms	BMP-3A
General protein information	Preferred Names bone morphogenetic protein 3 Names bone morphogenetic protein 3 bone morphogenetic protein 3 (osteogenic) bone morphogenetic protein 3A osteogenin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q21.21
Summary	This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands. [provided by RefSeq, Jul 2016].
Disorder MIM:	112263

mRNA and Protein(s)

mRNA	Protein	Name
XM_006714291.3	XP_006714354.1	bone morphogenetic protein 3 isoform X1
NM_001201.3	NP_001192.3	bone morphogenetic protein 3 preproprotein
NM_001201.4	NP_001192.3	bone morphogenetic protein 3 preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	BMP3	NP_001192.2
Pan troglodytes (chimpanzee)	BMP3	XP_001144027.1
	BMP3	XP_001089525.1
Bos taurus (cattle)	BMP3	NP_001179197.1
Mus musculus (house mouse)	Bmp3	NP_775580.1
Gallus gallus (chicken)	BMP3	NP_001029991.1
Danio rerio (zebrafish)	bmp3	NP_001071233.1
Canis lupus familiaris (dog)	BMP3	XP_005639168.1
Rattus norvegicus (Norway rat)	Bmp3	NP_058801.1
Xenopus tropicalis (tropical clawed frog)	bmp3	XP_002934044.1

Gene Ontology
Bibliography

Related articles in PubMed

Genetic Biomarker Prevalence Is Similar in Fecal Immunochemical Test Positive and Negative Colorectal Cancer Tissue.
Levin TR, Corley DA, Jensen CD, Marks AR, Zhao WK, Zebrowski AM, Quinn VP, Browne LW, Taylor WR, Ahlquist DA, Lidgard GP, Berger BM
Digestive diseases and sciences62(3)678-688(2017 03)

Stool methylated DNA markers decrease following colorectal cancer resection--implications for surveillance.
Kisiel JB, Yab TC, Taylor WR, Mahoney DW, Ahlquist DA
Digestive diseases and sciences59(8)1764-7(2014 Aug)

Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
Cousminer DL, Berry DJ, Timpson NJ, Ang W, Thiering E, Byrne EM, Taal HR, Huikari V, Bradfield JP, Kerkhof M, Groen-Blokhuis MM, Kreiner-M?ller E, Marinelli M, Holst C, Leinonen JT, Perry JR, Surakka I, Pietil?inen O, Kettunen J, Anttila V, Kaakinen M, Sovio U, Pouta A, Das S, Lagou V, Power C, Prokopenko I, Evans DM, Kemp JP, St Pourcain B, Ring S, Palotie A, Kajantie E, Osmond C, Lehtim?ki T, Viikari JS, K?h?nen M, Warrington NM, Lye SJ, Palmer LJ, Tiesler CM, Flexeder C, Montgomery GW, Medland SE, Hofman A, Hakonarson H, Guxens M, Bartels M, Salomaa V, , Murabito JM, Kaprio J, S?rensen TI, Ballester F, Bisgaard H, Boomsma DI, Koppelman GH, Grant SF, Jaddoe VW, Martin NG, Heinrich J, Pennell CE, Raitakari OT, Eriksson JG, Smith GD, Hypp?nen E, J?rvelin MR, McCarthy MI, Ripatti S, Wid?n E,
Human molecular genetics22(13)2735-47(2013 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

BMP3 - the biomarker of a currently in-use multi-target stool DNA test was commonly expressed in tumor tissue specimens, independent of Fecal Immunochemical Test result.
Title: Genetic Biomarker Prevalence Is Similar in Fecal Immunochemical Test Positive and Negative Colorectal Cancer Tissue.

Methylation level in stool decreases dramatically following colorectal cancer resection
Title: Stool methylated DNA markers decrease following colorectal cancer resection--implications for surveillance.

Bone morphogenic protein 3 signaling in the regulation of osteogenesis.
Title: Bone morphogenic protein 3 signaling in the regulation of osteogenesis.

a critical link between HNF1A-MODY-induced alterations in Bmp-3 expression and insulin gene levels
Title: Bone morphogenetic protein 3 controls insulin gene expression and is down-regulated in INS-1 cells inducibly expressing a hepatocyte nuclear factor 1A-maturity-onset diabetes of the young mutation.

As an addition to PRKG2 and RASGEFIB genes, we propose to include BMP3 gene as the principal determinant of the observed common phenotype.
Title: 8.6Mb interstitial deletion of chromosome 4q13.3q21.23 in a boy with cognitive impairment, short stature, hearing loss, skeletal abnormalities and facial dysmorphism.

The following BMP3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BMP3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu100682	NM_001201.4 Latest version!	Homo sapiens bone morphogenetic protein 3 (BMP3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu39055	XM_006714291.3 Latest version!	Homo sapiens bone morphogenetic protein 3 (BMP3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu100682	NM_001201.3	Homo sapiens bone morphogenetic protein 3 (BMP3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BMP3 ( NM_001201.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001192.3 Homo sapiens bone morphogenetic protein 3 (BMP3), mRNA.

Price & Availability↑

CloneID	OHu100682
Clone ID Related Accession (Same CDS sequence)	NM_001201.3 , NM_001201.4
Accession Version	NM_001201.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1419bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-03
Organism	Homo sapiens(human)
Product	bone morphogenetic protein 3 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M22491.1 and AC093883.2. On Jul 27, 2016 this sequence version replaced NM_001201.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M22491.1, SRR1803611.225165.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGGGG CGAGCAGGCT GCTCTTTCTG TGGCTGGGCT GCTTCTGCGT GAGCCTGGCG 
CAGGGAGAGA GACCGAAGCC ACCTTTCCCG GAGCTCCGCA AAGCTGTGCC AGGTGACCGC 
ACGGCAGGTG GTGGCCCGGA CTCCGAGCTG CAGCCGCAAG ACAAGGTCTC TGAACACATG 
CTGCGGCTCT ATGACAGGTA CAGCACGGTC CAGGCGGCCC GGACACCGGG CTCCCTGGAG 
GGAGGCTCGC AGCCCTGGCG CCCTCGGCTC CTGCGCGAAG GCAACACGGT TCGCAGCTTT 
CGGGCGGCAG CAGCAGAAAC TCTTGAAAGA AAAGGACTGT ATATCTTCAA TCTGACATCG 
CTAACCAAGT CTGAAAACAT TTTGTCTGCC ACACTGTATT TCTGTATTGG AGAGCTAGGA 
AACATCAGCC TGAGTTGTCC AGTGTCTGGA GGATGCTCCC ATCATGCTCA GAGGAAACAC 
ATTCAGATTG ATCTTTCTGC ATGGACCCTC AAATTCAGCA GAAACCAAAG TCAACTCCTT 
GGCCATCTGT CAGTGGATAT GGCCAAATCT CATCGAGATA TTATGTCCTG GCTGTCTAAA 
GATATCACTC AATTCTTGAG GAAGGCCAAA GAAAATGAAG AGTTCCTCAT AGGATTTAAC 
ATTACGTCCA AGGGACGCCA GCTGCCAAAG AGGAGGTTAC CTTTTCCAGA GCCTTATATC 
TTGGTATATG CCAATGATGC CGCCATTTCT GAGCCAGAAA GTGTGGTATC AAGCTTACAG 
GGACACCGGA ATTTTCCCAC TGGAACTGTT CCCAAATGGG ATAGCCACAT CAGAGCTGCC 
CTTTCCATTG AGCGGAGGAA GAAGCGCTCT ACTGGGGTCT TGCTGCCTCT GCAGAACAAC 
GAGCTTCCTG GGGCAGAATA CCAGTATAAA AAGGATGAGG TGTGGGAGGA GAGAAAGCCT 
TACAAGACCC TTCAGGCTCA GGCCCCTGAA AAGAGTAAGA ATAAAAAGAA ACAGAGAAAG 
GGGCCTCATC GGAAGAGCCA GACGCTCCAA TTTGATGAGC AGACCCTGAA AAAGGCAAGG 
AGAAAGCAGT GGATTGAACC TCGGAATTGC GCCAGGAGAT ACCTCAAGGT AGACTTTGCA 
GATATTGGCT GGAGTGAATG GATTATCTCC CCCAAGTCCT TTGATGCCTA TTATTGCTCT 
GGAGCATGCC AGTTCCCCAT GCCAAAGTCT TTGAAGCCAT CAAATCATGC TACCATCCAG 
AGTATAGTGA GAGCTGTGGG GGTCGTTCCT GGGATTCCTG AGCCTTGCTG TGTACCAGAA 
AAGATGTCCT CACTCAGTAT TTTATTCTTT GATGAAAATA AGAATGTAGT GCTTAAAGTA 
TACCCTAACA TGACAGTAGA GTCTTGCGCT TGCAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001192.3
CDS	321..1739
Translation	MAGASRLLFLWLGCFCVSLAQGERPKPPFPELRKAVPGDRTAGGGPDSELQPQDKVSEHMLRLYDRYSTVQAARTPGSLEGGSQPWRPRLLREGNTVRSFRAAAAETLERKGLYIFNLTSLTKSENILSATLYFCIGELGNISLSCPVSGGCSHHAQRKHIQIDLSAWTLKFSRNQSQLLGHLSVDMAKSHRDIMSWLSKDITQFLRKAKENEEFLIGFNITSKGRQLPKRRLPFPEPYILVYANDAAISEPESVVSSLQGHRNFPTGTVPKWDSHIRAALSIERRKKRSTGVLLPLQNNELPGAEYQYKKDEVWEERKPYKTLQAQAPEKSKNKKKQRKGPHRKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR

Target ORF information:

RefSeq Version	NM_001201.3
Organism	Homo sapiens(human)
Definition	Homo sapiens bone morphogenetic protein 3 (BMP3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001201.3

ORF Insert Sequence:

ATGGCTGGGG CGAGCAGGCT GCTCTTTCTG TGGCTGGGCT GCTTCTGCGT GAGCCTGGCG 
CAGGGAGAGA GACCGAAGCC ACCTTTCCCG GAGCTCCGCA AAGCTGTGCC AGGTGACCGC 
ACGGCAGGTG GTGGCCCGGA CTCCGAGCTG CAGCCGCAAG ACAAGGTCTC TGAACACATG 
CTGCGGCTCT ATGACAGGTA CAGCACGGTC CAGGCGGCCC GGACACCGGG CTCCCTGGAG 
GGAGGCTCGC AGCCCTGGCG CCCTCGGCTC CTGCGCGAAG GCAACACGGT TCGCAGCTTT 
CGGGCGGCAG CAGCAGAAAC TCTTGAAAGA AAAGGACTGT ATATCTTCAA TCTGACATCG 
CTAACCAAGT CTGAAAACAT TTTGTCTGCC ACACTGTATT TCTGTATTGG AGAGCTAGGA 
AACATCAGCC TGAGTTGTCC AGTGTCTGGA GGATGCTCCC ATCATGCTCA GAGGAAACAC 
ATTCAGATTG ATCTTTCTGC ATGGACCCTC AAATTCAGCA GAAACCAAAG TCAACTCCTT 
GGCCATCTGT CAGTGGATAT GGCCAAATCT CATCGAGATA TTATGTCCTG GCTGTCTAAA 
GATATCACTC AATTCTTGAG GAAGGCCAAA GAAAATGAAG AGTTCCTCAT AGGATTTAAC 
ATTACGTCCA AGGGACGCCA GCTGCCAAAG AGGAGGTTAC CTTTTCCAGA GCCTTATATC 
TTGGTATATG CCAATGATGC CGCCATTTCT GAGCCAGAAA GTGTGGTATC AAGCTTACAG 
GGACACCGGA ATTTTCCCAC TGGAACTGTT CCCAAATGGG ATAGCCACAT CAGAGCTGCC 
CTTTCCATTG AGCGGAGGAA GAAGCGCTCT ACTGGGGTCT TGCTGCCTCT GCAGAACAAC 
GAGCTTCCTG GGGCAGAATA CCAGTATAAA AAGGATGAGG TGTGGGAGGA GAGAAAGCCT 
TACAAGACCC TTCAGGCTCA GGCCCCTGAA AAGAGTAAGA ATAAAAAGAA ACAGAGAAAG 
GGGCCTCATC GGAAGAGCCA GACGCTCCAA TTTGATGAGC AGACCCTGAA AAAGGCAAGG 
AGAAAGCAGT GGATTGAACC TCGGAATTGC GCCAGGAGAT ACCTCAAGGT AGACTTTGCA 
GATATTGGCT GGAGTGAATG GATTATCTCC CCCAAGTCCT TTGATGCCTA TTATTGCTCT 
GGAGCATGCC AGTTCCCCAT GCCAAAGTCT TTGAAGCCAT CAAATCATGC TACCATCCAG 
AGTATAGTGA GAGCTGTGGG GGTCGTTCCT GGGATTCCTG AGCCTTGCTG TGTACCAGAA 
AAGATGTCCT CACTCAGTAT TTTATTCTTT GATGAAAATA AGAATGTAGT GCTTAAAGTA 
TACCCTAACA TGACAGTAGA GTCTTGCGCT TGCAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BMP3 ( NM_001201.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001192.3 Homo sapiens bone morphogenetic protein 3 (BMP3), mRNA.

Price & Availability↑

CloneID	OHu100682
Clone ID Related Accession (Same CDS sequence)	NM_001201.3 , NM_001201.4
Accession Version	NM_001201.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1419bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Homo sapiens(human)
Product	bone morphogenetic protein 3 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC093883.2 and M22491.1. On Nov 22, 2018 this sequence version replaced NM_001201.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.225165.1, M22491.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTGGGG CGAGCAGGCT GCTCTTTCTG TGGCTGGGCT GCTTCTGCGT GAGCCTGGCG 
CAGGGAGAGA GACCGAAGCC ACCTTTCCCG GAGCTCCGCA AAGCTGTGCC AGGTGACCGC 
ACGGCAGGTG GTGGCCCGGA CTCCGAGCTG CAGCCGCAAG ACAAGGTCTC TGAACACATG 
CTGCGGCTCT ATGACAGGTA CAGCACGGTC CAGGCGGCCC GGACACCGGG CTCCCTGGAG 
GGAGGCTCGC AGCCCTGGCG CCCTCGGCTC CTGCGCGAAG GCAACACGGT TCGCAGCTTT 
CGGGCGGCAG CAGCAGAAAC TCTTGAAAGA AAAGGACTGT ATATCTTCAA TCTGACATCG 
CTAACCAAGT CTGAAAACAT TTTGTCTGCC ACACTGTATT TCTGTATTGG AGAGCTAGGA 
AACATCAGCC TGAGTTGTCC AGTGTCTGGA GGATGCTCCC ATCATGCTCA GAGGAAACAC 
ATTCAGATTG ATCTTTCTGC ATGGACCCTC AAATTCAGCA GAAACCAAAG TCAACTCCTT 
GGCCATCTGT CAGTGGATAT GGCCAAATCT CATCGAGATA TTATGTCCTG GCTGTCTAAA 
GATATCACTC AATTCTTGAG GAAGGCCAAA GAAAATGAAG AGTTCCTCAT AGGATTTAAC 
ATTACGTCCA AGGGACGCCA GCTGCCAAAG AGGAGGTTAC CTTTTCCAGA GCCTTATATC 
TTGGTATATG CCAATGATGC CGCCATTTCT GAGCCAGAAA GTGTGGTATC AAGCTTACAG 
GGACACCGGA ATTTTCCCAC TGGAACTGTT CCCAAATGGG ATAGCCACAT CAGAGCTGCC 
CTTTCCATTG AGCGGAGGAA GAAGCGCTCT ACTGGGGTCT TGCTGCCTCT GCAGAACAAC 
GAGCTTCCTG GGGCAGAATA CCAGTATAAA AAGGATGAGG TGTGGGAGGA GAGAAAGCCT 
TACAAGACCC TTCAGGCTCA GGCCCCTGAA AAGAGTAAGA ATAAAAAGAA ACAGAGAAAG 
GGGCCTCATC GGAAGAGCCA GACGCTCCAA TTTGATGAGC AGACCCTGAA AAAGGCAAGG 
AGAAAGCAGT GGATTGAACC TCGGAATTGC GCCAGGAGAT ACCTCAAGGT AGACTTTGCA 
GATATTGGCT GGAGTGAATG GATTATCTCC CCCAAGTCCT TTGATGCCTA TTATTGCTCT 
GGAGCATGCC AGTTCCCCAT GCCAAAGTCT TTGAAGCCAT CAAATCATGC TACCATCCAG 
AGTATAGTGA GAGCTGTGGG GGTCGTTCCT GGGATTCCTG AGCCTTGCTG TGTACCAGAA 
AAGATGTCCT CACTCAGTAT TTTATTCTTT GATGAAAATA AGAATGTAGT GCTTAAAGTA 
TACCCTAACA TGACAGTAGA GTCTTGCGCT TGCAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001192.3
CDS	578..1996
Translation	MAGASRLLFLWLGCFCVSLAQGERPKPPFPELRKAVPGDRTAGGGPDSELQPQDKVSEHMLRLYDRYSTVQAARTPGSLEGGSQPWRPRLLREGNTVRSFRAAAAETLERKGLYIFNLTSLTKSENILSATLYFCIGELGNISLSCPVSGGCSHHAQRKHIQIDLSAWTLKFSRNQSQLLGHLSVDMAKSHRDIMSWLSKDITQFLRKAKENEEFLIGFNITSKGRQLPKRRLPFPEPYILVYANDAAISEPESVVSSLQGHRNFPTGTVPKWDSHIRAALSIERRKKRSTGVLLPLQNNELPGAEYQYKKDEVWEERKPYKTLQAQAPEKSKNKKKQRKGPHRKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR

Target ORF information:

RefSeq Version	NM_001201.4
Organism	Homo sapiens(human)
Definition	Homo sapiens bone morphogenetic protein 3 (BMP3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001201.4

ORF Insert Sequence:

ATGGCTGGGG CGAGCAGGCT GCTCTTTCTG TGGCTGGGCT GCTTCTGCGT GAGCCTGGCG 
CAGGGAGAGA GACCGAAGCC ACCTTTCCCG GAGCTCCGCA AAGCTGTGCC AGGTGACCGC 
ACGGCAGGTG GTGGCCCGGA CTCCGAGCTG CAGCCGCAAG ACAAGGTCTC TGAACACATG 
CTGCGGCTCT ATGACAGGTA CAGCACGGTC CAGGCGGCCC GGACACCGGG CTCCCTGGAG 
GGAGGCTCGC AGCCCTGGCG CCCTCGGCTC CTGCGCGAAG GCAACACGGT TCGCAGCTTT 
CGGGCGGCAG CAGCAGAAAC TCTTGAAAGA AAAGGACTGT ATATCTTCAA TCTGACATCG 
CTAACCAAGT CTGAAAACAT TTTGTCTGCC ACACTGTATT TCTGTATTGG AGAGCTAGGA 
AACATCAGCC TGAGTTGTCC AGTGTCTGGA GGATGCTCCC ATCATGCTCA GAGGAAACAC 
ATTCAGATTG ATCTTTCTGC ATGGACCCTC AAATTCAGCA GAAACCAAAG TCAACTCCTT 
GGCCATCTGT CAGTGGATAT GGCCAAATCT CATCGAGATA TTATGTCCTG GCTGTCTAAA 
GATATCACTC AATTCTTGAG GAAGGCCAAA GAAAATGAAG AGTTCCTCAT AGGATTTAAC 
ATTACGTCCA AGGGACGCCA GCTGCCAAAG AGGAGGTTAC CTTTTCCAGA GCCTTATATC 
TTGGTATATG CCAATGATGC CGCCATTTCT GAGCCAGAAA GTGTGGTATC AAGCTTACAG 
GGACACCGGA ATTTTCCCAC TGGAACTGTT CCCAAATGGG ATAGCCACAT CAGAGCTGCC 
CTTTCCATTG AGCGGAGGAA GAAGCGCTCT ACTGGGGTCT TGCTGCCTCT GCAGAACAAC 
GAGCTTCCTG GGGCAGAATA CCAGTATAAA AAGGATGAGG TGTGGGAGGA GAGAAAGCCT 
TACAAGACCC TTCAGGCTCA GGCCCCTGAA AAGAGTAAGA ATAAAAAGAA ACAGAGAAAG 
GGGCCTCATC GGAAGAGCCA GACGCTCCAA TTTGATGAGC AGACCCTGAA AAAGGCAAGG 
AGAAAGCAGT GGATTGAACC TCGGAATTGC GCCAGGAGAT ACCTCAAGGT AGACTTTGCA 
GATATTGGCT GGAGTGAATG GATTATCTCC CCCAAGTCCT TTGATGCCTA TTATTGCTCT 
GGAGCATGCC AGTTCCCCAT GCCAAAGTCT TTGAAGCCAT CAAATCATGC TACCATCCAG 
AGTATAGTGA GAGCTGTGGG GGTCGTTCCT GGGATTCCTG AGCCTTGCTG TGTACCAGAA 
AAGATGTCCT CACTCAGTAT TTTATTCTTT GATGAAAATA AGAATGTAGT GCTTAAAGTA 
TACCCTAACA TGACAGTAGA GTCTTGCGCT TGCAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BMP3 ( XM_006714291.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_006714354.1 Homo sapiens bone morphogenetic protein 3 (BMP3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu39055
Clone ID Related Accession (Same CDS sequence)	XM_006714291.3
Accession Version	XM_006714291.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1320bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	bone morphogenetic protein 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006714291.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTGGGG CGAGCAGGCT GCTCTTTCTG TGGCTGGGCT GCTTCTGCGT GAGCCTGGCG 
CAGGGAGAGA GACCGAAGCC ACCTTTCCCG GAGCTCCGCA AAGCTGTGCC AGGTGACCGC 
ACGGCAGGTG GTGGCCCGGA CTCCGAGCTG CAGCCGCAAG ACAAGGTCTC TGAACACATG 
CTGCGGCTCT ATGACAGGTA CAGCACGGTC CAGGCGGCCC GGACACCGGG CTCCCTGGAG 
GGAGGCTCGC AGCCCTGGCG CCCTCGGCTC CTGCGCGAAG GCAACACGGT TCGCAGCTTT 
CGGGCGGCAG CAGCAGAAAC TCTTGAAAGA AAAGGACTGT ATATCTTCAA TCTGACATCG 
CTAACCAAGT CTGAAAACAT TTTGTCTGCC ACACTGTATT TCTGTATTGG AGAGCTAGGA 
AACATCAGCC TGAGTTGTCC AGTGTCTGGA GGATGCTCCC ATCATGCTCA GAGGAAACAC 
ATTCAGATTG ATCTTTCTGC ATGGACCCTC AAATTCAGCA GAAACCAAAG TCAACTCCTT 
GGCCATCTGT CAGTGGATAT GGCCAAATCT CATCGAGATA TTATGTCCTG GCTGTCTAAA 
GATATCACTC AACTCTTGAG GAAGGCCAAA GAAAATGAAG AGTTCCTCAT AGGATTTAAC 
ATTACGTCCA AGGGACGCCA GCTGCCAAAG AGGAGGTTAC CTTTTCCAGA GCCTTATATC 
TTGGTATATG CCAATGATGC CGCCATTTCT GAGCCAGAAA GTGTGGTATC AAGCTTACAG 
GGACACCGGA ATTTTCCCAC TGGAACTGTT CCCAAATGGG ATAGCCACAT CAGAGCTGCC 
CTTTCCATTG AGCGGAGGAA GAAGCGCTCT ACTGGGGTCT TGCTGCCTCT GCAGAACAAC 
GAGCTTCCTG GGGCAGAATA CCAGTATAAA AAGGATGAGG TGTGGGAGGA GAGAAAGCCT 
TACAAGACCC TTCAGGCTCA GGCCCCTGAA AAGAGTAAGA ATAAAAAGAA ACAGAGAAAG 
GGGCCTCATC GGAAGAGCCA GACGCTCCAA TTTGATGAGC AGACCCTGAA AAAGGCAAGG 
AGAAAGCAGT GGATTGAACC TCGGAATTGC GCCAGGAGAT ACCTCAAGTC TTTGAAGCCA 
TCAAATCATG CTACCATCCA GAGTATAGTG AGAGCTGTGG GGGTCGTTCC TGGGATTCCT 
GAGCCTTGCT GTGTACCAGA AAAGATGTCC TCACTCAGTA TTTTATTCTT TGATGAAAAT 
AAGAATGTAG TGCTTAAAGT ATACCCTAAC ATGACAGTAG AGTCTTGCGC TTGCAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006714354.1
CDS	508..1827
Translation	MAGASRLLFLWLGCFCVSLAQGERPKPPFPELRKAVPGDRTAGGGPDSELQPQDKVSEHMLRLYDRYSTVQAARTPGSLEGGSQPWRPRLLREGNTVRSFRAAAAETLERKGLYIFNLTSLTKSENILSATLYFCIGELGNISLSCPVSGGCSHHAQRKHIQIDLSAWTLKFSRNQSQLLGHLSVDMAKSHRDIMSWLSKDITQLLRKAKENEEFLIGFNITSKGRQLPKRRLPFPEPYILVYANDAAISEPESVVSSLQGHRNFPTGTVPKWDSHIRAALSIERRKKRSTGVLLPLQNNELPGAEYQYKKDEVWEERKPYKTLQAQAPEKSKNKKKQRKGPHRKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR

Target ORF information:

RefSeq Version	XM_006714291.3
Organism	Homo sapiens(human)
Definition	Homo sapiens bone morphogenetic protein 3 (BMP3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006714291.3

ORF Insert Sequence:

ATGGCTGGGG CGAGCAGGCT GCTCTTTCTG TGGCTGGGCT GCTTCTGCGT GAGCCTGGCG 
CAGGGAGAGA GACCGAAGCC ACCTTTCCCG GAGCTCCGCA AAGCTGTGCC AGGTGACCGC 
ACGGCAGGTG GTGGCCCGGA CTCCGAGCTG CAGCCGCAAG ACAAGGTCTC TGAACACATG 
CTGCGGCTCT ATGACAGGTA CAGCACGGTC CAGGCGGCCC GGACACCGGG CTCCCTGGAG 
GGAGGCTCGC AGCCCTGGCG CCCTCGGCTC CTGCGCGAAG GCAACACGGT TCGCAGCTTT 
CGGGCGGCAG CAGCAGAAAC TCTTGAAAGA AAAGGACTGT ATATCTTCAA TCTGACATCG 
CTAACCAAGT CTGAAAACAT TTTGTCTGCC ACACTGTATT TCTGTATTGG AGAGCTAGGA 
AACATCAGCC TGAGTTGTCC AGTGTCTGGA GGATGCTCCC ATCATGCTCA GAGGAAACAC 
ATTCAGATTG ATCTTTCTGC ATGGACCCTC AAATTCAGCA GAAACCAAAG TCAACTCCTT 
GGCCATCTGT CAGTGGATAT GGCCAAATCT CATCGAGATA TTATGTCCTG GCTGTCTAAA 
GATATCACTC AACTCTTGAG GAAGGCCAAA GAAAATGAAG AGTTCCTCAT AGGATTTAAC 
ATTACGTCCA AGGGACGCCA GCTGCCAAAG AGGAGGTTAC CTTTTCCAGA GCCTTATATC 
TTGGTATATG CCAATGATGC CGCCATTTCT GAGCCAGAAA GTGTGGTATC AAGCTTACAG 
GGACACCGGA ATTTTCCCAC TGGAACTGTT CCCAAATGGG ATAGCCACAT CAGAGCTGCC 
CTTTCCATTG AGCGGAGGAA GAAGCGCTCT ACTGGGGTCT TGCTGCCTCT GCAGAACAAC 
GAGCTTCCTG GGGCAGAATA CCAGTATAAA AAGGATGAGG TGTGGGAGGA GAGAAAGCCT 
TACAAGACCC TTCAGGCTCA GGCCCCTGAA AAGAGTAAGA ATAAAAAGAA ACAGAGAAAG 
GGGCCTCATC GGAAGAGCCA GACGCTCCAA TTTGATGAGC AGACCCTGAA AAAGGCAAGG 
AGAAAGCAGT GGATTGAACC TCGGAATTGC GCCAGGAGAT ACCTCAAGTC TTTGAAGCCA 
TCAAATCATG CTACCATCCA GAGTATAGTG AGAGCTGTGG GGGTCGTTCC TGGGATTCCT 
GAGCCTTGCT GTGTACCAGA AAAGATGTCC TCACTCAGTA TTTTATTCTT TGATGAAAAT 
AAGAATGTAG TGCTTAAAGT ATACCCTAAC ATGACAGTAG AGTCTTGCGC TTGCAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic Biomarker Prevalence Is Similar in Fecal Immunochemical Test Positive and Negative Colorectal Cancer Tissue.
Digestive diseases and sciences62(3)678-688(2017 03)
Levin TR,Corley DA,Jensen CD,Marks AR,Zhao WK,Zebrowski AM,Quinn VP,Browne LW,Taylor WR,Ahlquist DA,Lidgard GP,Berger BM

Stool methylated DNA markers decrease following colorectal cancer resection--implications for surveillance.
Digestive diseases and sciences59(8)1764-7(2014 Aug)
Kisiel JB,Yab TC,Taylor WR,Mahoney DW,Ahlquist DA

Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
Human molecular genetics22(13)2735-47(2013 Jul)
Cousminer DL,Berry DJ,Timpson NJ,Ang W,Thiering E,Byrne EM,Taal HR,Huikari V,Bradfield JP,Kerkhof M,Groen-Blokhuis MM,Kreiner-M?ller E,Marinelli M,Holst C,Leinonen JT,Perry JR,Surakka I,Pietil?inen O,Kettunen J,Anttila V,Kaakinen M,Sovio U,Pouta A,Das S,Lagou V,Power C,Prokopenko I,Evans DM,Kemp JP,St Pourcain B,Ring S,Palotie A,Kajantie E,Osmond C,Lehtim?ki T,Viikari JS,K?h?nen M,Warrington NM,Lye SJ,Palmer LJ,Tiesler CM,Flexeder C,Montgomery GW,Medland SE,Hofman A,Hakonarson H,Guxens M,Bartels M,Salomaa V,,Murabito JM,Kaprio J,S?rensen TI,Ballester F,Bisgaard H,Boomsma DI,Koppelman GH,Grant SF,Jaddoe VW,Martin NG,Heinrich J,Pennell CE,Raitakari OT,Eriksson JG,Smith GD,Hypp?nen E,J?rvelin MR,McCarthy MI,Ripatti S,Wid?n E,

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BMP3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

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