S100A3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	S100A3
Entrez Gene ID	6274
Full Name	S100 calcium binding protein A3
Synonyms	S100E
General protein information	Preferred Names S100 calcium binding protein A3 Names protein S100-A3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.3
Summary	The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown. [provided by RefSeq, Jul 2008].
Disorder MIM:	176992

mRNA and Protein(s)

mRNA	Protein	Name
NM_002960.2	NP_002951.1	protein S100-A3
NM_002960.1	NP_002951.1	protein S100-A3

Pathways from BioSystems

Homologies

Homo sapiens (human)	S100A3	NP_002951.1
Mus musculus (house mouse)	S100a3	NP_035440.1
	LOC100426715	XP_002801840.1
Canis lupus familiaris (dog)	S100A3	XP_547582.1
Rattus norvegicus (Norway rat)	S100a3	NP_446133.1
Pan troglodytes (chimpanzee)	S100A3	XP_003339048.1

Gene Ontology
Bibliography

Related articles in PubMed

Human gingiva transcriptome during wound healing.
Wang Y, Tatakis DN
Journal of clinical periodontology44(4)394-402(2017 Apr)

Refined crystal structures of human Ca(2+)/Zn(2+)-binding S100A3 protein characterized by two disulfide bridges.
Unno M, Kawasaki T, Takahara H, Heizmann CW, Kizawa K
Journal of molecular biology408(3)477-90(2011 May)

Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India.
Chattopadhyay I, Singh A, Phukan R, Purkayastha J, Kataki A, Mahanta J, Saxena S, Kapur S
Mutation research696(2)130-8(2010 Feb)

Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.
Stemmler S, Nothnagel M, Parwez Q, Petrasch-Parwez E, Epplen JT, Hoffjan S
International journal of immunogenetics36(4)217-22(2009 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

S100A3 expression is significantly upregulated in human masticatory mucosa during wound healing
Title: Human gingiva transcriptome during wound healing.

One disulfide bridge is between Cys30 in the N-terminal pseudo-EF-hand and Cys68 in the C-terminal EF-hand (SS1), and another disulfide bridge attaches Cys99 in the C-terminal coil structure to Cys81 in helix IV (SS2).
Title: Refined crystal structures of human Ca(2+)/Zn(2+)-binding S100A3 protein characterized by two disulfide bridges.

Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India.

Observational study of gene-disease association. (HuGE Navigator)
Title: Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.

cytoplasmic S100A3 within the cuticular layer is mostly co-localized with the type III isoform of peptidylarginine deiminase (PAD3)
Title: Specific citrullination causes assembly of a globular S100A3 homotetramer: a putative Ca2+ modulator matures human hair cuticle.

The following S100A3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the S100A3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04026	NM_002960.2 Latest version!	Homo sapiens S100 calcium binding protein A3 (S100A3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu04026	NM_002960.1	Homo sapiens S100 calcium binding protein A3 (S100A3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

S100A3 ( NM_002960.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002951.1 Homo sapiens S100 calcium binding protein A3 (S100A3), mRNA.

Price & Availability↑

CloneID	OHu04026
Clone ID Related Accession (Same CDS sequence)	NM_002960.2 , NM_002960.1
Accession Version	NM_002960.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	protein S100-A3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z18948.1 and BX470102.12. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_002960.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Z18948.1, BC012893.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000368713.8/ ENSP00000357702.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCAGGC CTCTGGAGCA GGCGGTAGCT GCCATCGTGT GCACCTTCCA GGAATACGCA 
GGGCGCTGTG GGGACAAATA CAAGCTCTGC CAGGCGGAGC TCAAGGAGCT GCTGCAGAAG 
GAGCTGGCCA CCTGGACCCC GACTGAGTTT CGGGAATGTG ACTACAACAA ATTCATGAGT 
GTTCTGGACA CCAACAAGGA CTGCGAGGTG GACTTTGTGG AGTATGTGCG CTCACTTGCC 
TGCCTCTGTC TCTACTGCCA CGAGTACTTC AAGGACTGCC CCTCAGAGCC CCCCTGCTCC 
CAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002951.1
CDS	84..389
Translation	MARPLEQAVAAIVCTFQEYAGRCGDKYKLCQAELKELLQKELATWTPTEFRECDYNKFMSVLDTNKDCEVDFVEYVRSLACLCLYCHEYFKDCPSEPPCSQ

Target ORF information:

RefSeq Version	NM_002960.2
Organism	Homo sapiens(human)
Definition	Homo sapiens S100 calcium binding protein A3 (S100A3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002960.2

ORF Insert Sequence:

ATGGCCAGGC CTCTGGAGCA GGCGGTAGCT GCCATCGTGT GCACCTTCCA GGAATACGCA 
GGGCGCTGTG GGGACAAATA CAAGCTCTGC CAGGCGGAGC TCAAGGAGCT GCTGCAGAAG 
GAGCTGGCCA CCTGGACCCC GACTGAGTTT CGGGAATGTG ACTACAACAA ATTCATGAGT 
GTTCTGGACA CCAACAAGGA CTGCGAGGTG GACTTTGTGG AGTATGTGCG CTCACTTGCC 
TGCCTCTGTC TCTACTGCCA CGAGTACTTC AAGGACTGCC CCTCAGAGCC CCCCTGCTCC 
CAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

S100A3 ( NM_002960.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_002951.1 Homo sapiens S100 calcium binding protein A3 (S100A3), mRNA.

Price & Availability↑

CloneID	OHu04026
Clone ID Related Accession (Same CDS sequence)	NM_002960.2 , NM_002960.1
Accession Version	NM_002960.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	protein S100-A3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z18948.1. This sequence is a reference standard in the RefSeqGene project. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Z18948.1, BC012893.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCCAGGC CTCTGGAGCA GGCGGTAGCT GCCATCGTGT GCACCTTCCA GGAATACGCA 
GGGCGCTGTG GGGACAAATA CAAGCTCTGC CAGGCGGAGC TCAAGGAGCT GCTGCAGAAG 
GAGCTGGCCA CCTGGACCCC GACTGAGTTT CGGGAATGTG ACTACAACAA ATTCATGAGT 
GTTCTGGACA CCAACAAGGA CTGCGAGGTG GACTTTGTGG AGTATGTGCG CTCACTTGCC 
TGCCTCTGTC TCTACTGCCA CGAGTACTTC AAGGACTGCC CCTCAGAGCC CCCCTGCTCC 
CAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002951.1
CDS	84..389
Translation	MARPLEQAVAAIVCTFQEYAGRCGDKYKLCQAELKELLQKELATWTPTEFRECDYNKFMSVLDTNKDCEVDFVEYVRSLACLCLYCHEYFKDCPSEPPCSQ

Target ORF information:

RefSeq Version	NM_002960.1
Organism	Homo sapiens(human)
Definition	Homo sapiens S100 calcium binding protein A3 (S100A3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002960.1

ORF Insert Sequence:

ATGGCCAGGC CTCTGGAGCA GGCGGTAGCT GCCATCGTGT GCACCTTCCA GGAATACGCA 
GGGCGCTGTG GGGACAAATA CAAGCTCTGC CAGGCGGAGC TCAAGGAGCT GCTGCAGAAG 
GAGCTGGCCA CCTGGACCCC GACTGAGTTT CGGGAATGTG ACTACAACAA ATTCATGAGT 
GTTCTGGACA CCAACAAGGA CTGCGAGGTG GACTTTGTGG AGTATGTGCG CTCACTTGCC 
TGCCTCTGTC TCTACTGCCA CGAGTACTTC AAGGACTGCC CCTCAGAGCC CCCCTGCTCC 
CAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human gingiva transcriptome during wound healing.
Journal of clinical periodontology44(4)394-402(2017 Apr)
Wang Y,Tatakis DN

Refined crystal structures of human Ca(2+)/Zn(2+)-binding S100A3 protein characterized by two disulfide bridges.
Journal of molecular biology408(3)477-90(2011 May)
Unno M,Kawasaki T,Takahara H,Heizmann CW,Kizawa K

Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India.
Mutation research696(2)130-8(2010 Feb)
Chattopadhyay I,Singh A,Phukan R,Purkayastha J,Kataki A,Mahanta J,Saxena S,Kapur S

Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.
International journal of immunogenetics36(4)217-22(2009 Aug)
Stemmler S,Nothnagel M,Parwez Q,Petrasch-Parwez E,Epplen JT,Hoffjan S