BBS1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BBS1
Entrez Gene ID	582
Full Name	Bardet-Biedl syndrome 1
Synonyms	BBS2L2
General protein information	Preferred Names Bardet-Biedl syndrome 1 Names Bardet-Biedl syndrome 1 protein BBS2-like protein 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q13.2
Summary	Mutations in this gene have been observed in patients with the major form (type 1) of Bardet-Biedl syndrome. The encoded protein may play a role in eye, limb, cardiac and reproductive system development. [provided by RefSeq, Jul 2008].
Disorder MIM:	209901
Disorder Html:	Bardet-Biedl syndrome 1, 209900 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_024649.4	NP_078925.3	Bardet-Biedl syndrome 1 protein
NM_024649.5	NP_078925.3	Bardet-Biedl syndrome 1 protein

Pathways from BioSystems

Homologies

Homo sapiens (human)	BBS1	NP_078925.3
Canis lupus familiaris (dog)	BBS1	XP_540830.2
Bos taurus (cattle)	BBS1	XP_003588094.2
Mus musculus (house mouse)	Bbs1	NP_001028300.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007459	XP_308406.4
Pan troglodytes (chimpanzee)	BBS1	XP_001171950.1
Rattus norvegicus (Norway rat)	Bbs1	NP_001101039.1
Danio rerio (zebrafish)	bbs1	NP_001091721.1
Drosophila melanogaster (fruit fly)	BBS1	NP_648080.1
Caenorhabditis elegans (roundworm)	bbs-1	NP_740933.1
Xenopus tropicalis (tropical clawed frog)	bbs1	NP_001116276.1

Gene Ontology
Bibliography

Related articles in PubMed

Protein interaction perturbation profiling at amino-acid resolution.
Woodsmith J, Apelt L, Casado-Medrano V, ?zkan Z, Timmermann B, Stelzl U
Nature methods14(12)1213-1221(2017 Dec)

Molecular genetic analysis of 30 families with Joubert syndrome.
Suzuki T, Miyake N, Tsurusaki Y, Okamoto N, Alkindy A, Inaba A, Sato M, Ito S, Muramatsu K, Kimura S, Ieda D, Saitoh S, Hiyane M, Suzumura H, Yagyu K, Shiraishi H, Nakajima M, Fueki N, Habata Y, Ueda Y, Komatsu Y, Yan K, Shimoda K, Shitara Y, Mizuno S, Ichinomiya K, Sameshima K, Tsuyusaki Y, Kurosawa K, Sakai Y, Haginoya K, Kobayashi Y, Yoshizawa C, Hisano M, Nakashima M, Saitsu H, Takeda S, Matsumoto N
Clinical genetics90(6)526-535(2016 Dec)

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y, van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ, Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B, Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM, Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E, Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ, Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U, Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB, Roepman R,
Nature communications711491(2016 May)

Computational genomic analysis of PARK7 interactome reveals high BBS1 gene expression as a prognostic factor favoring survival in malignant pleural mesothelioma.
Vavougios GD, Solenov EI, Hatzoglou C, Baturina GS, Katkova LE, Molyvdas PA, Gourgoulianis KI, Zarogiannis SG
American journal of physiology. Lung cellular and molecular physiology309(7)L677-86(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Importantly, one Japanese and one Omani families carried compound biallelic mutations in two distinct genes (TMEM67/RPGRIP1L and TMEM138/BBS1, respectively).
Title: Molecular genetic analysis of 30 families with Joubert syndrome.

BBS1 emerged as a novel predictor of overall survival in MPM.
Title: Computational genomic analysis of PARK7 interactome reveals high BBS1 gene expression as a prognostic factor favoring survival in malignant pleural mesothelioma.

We report a case in which whole-exome sequencing in a patient previously suspected to have Usher syndrome revealed disease-causing mutations in BBS1 and SLC26A4.
Title: Apparent Usher Syndrome Caused by the Combination of BBS1-Associated Retinitis Pigmentosa and SLC26A4-Associated Deafness.

M390R mutation in BBS1 reduces surface expression of insulin receptor in fibroblasts derived from BBS patients.
Title: Regulation of Insulin Receptor Trafficking by Bardet Biedl Syndrome Proteins.

A homozygous BBS1 p.M390R mutation is associated with Bardet-Biedl syndrome.
Title: Novel RP1 mutations and a recurrent BBS1 variant explain the co-existence of two distinct retinal phenotypes in the same pedigree.

The following BBS1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BBS1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25726	NM_024649.5 Latest version!	Homo sapiens Bardet-Biedl syndrome 1 (BBS1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$249.50-$349.30 $499.00
View Old Accession Versions >>
OHu25726	NM_024649.4	Homo sapiens Bardet-Biedl syndrome 1 (BBS1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$249.50-$349.30 $499.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BBS1 ( NM_024649.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_078925.3 Homo sapiens Bardet-Biedl syndrome 1 (BBS1), mRNA.

Price & Availability↑

CloneID	OHu25726
Clone ID Related Accession (Same CDS sequence)	NM_024649.4 , NM_024649.5
Accession Version	NM_024649.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1782bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	Bardet-Biedl syndrome 1 protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF503941.1. This sequence is a reference standard in the RefSeqGene project. On Mar 18, 2003 this sequence version replaced NM_024649.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF503941.1, BX647612.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGCTG CGTCCTCATC GGATTCCGAC GCCTGCGGAG CTGAGAGCAA TGAGGCCAAT 
TCGAAGTGGT TGGATGCGCA CTACGACCCA ATGGCCAATA TCCACACCTT TTCTGCCTGC 
CTAGCGCTGG CAGATTTACA TGGGGATGGG GAATACAAGC TGGTGGTAGG GGACCTTGGC 
CCTGGTGGGC AGCAGCCCCG CCTGAAGGTG CTCAAAGGAC CACTGGTGAT GACCGAAAGC 
CCGCTACCTG CTCTGCCAGC TGCTGCTGCC ACCTTCCTCA TGGAGCAACA TGAGCCCCGG 
ACCCCAGCTC TGGCACTTGC TTCAGGCCCT TGTGTCTATG TGTATAAGAA TCTCAGACCC 
TACTTCAAGT TCAGCCTGCC CCAATTGCCT CCAAATCCTC TGGAACAAGA CCTTTGGAAC 
CAGGCCAAAG AGGACCGAAT CGACCCCTTA ACCCTGAAGG AGATGCTGGA GAGCATCCGG 
GAGACGGCAG AGGAGCCTTT GTCCATCCAG TCACTCAGGT TTCTGCAGCT GGAGCTAAGT 
GAAATGGAGG CATTTGTAAA CCAACACAAG TCCAACTCCA TCAAGCGGCA GACAGTCATC 
ACCACCATGA CCACCTTGAA GAAGAACCTG GCTGACGAGG ATGCTGTGTC TTGCCTGGTG 
CTGGGCACCG AGAACAAGGA GCTCCTGGTG CTTGACCCCG AGGCCTTCAC CATTTTAGCC 
AAGATGAGCC TTCCCAGCGT CCCCGTCTTC CTAGAGGTTT CTGGCCAGTT TGATGTTGAG 
TTCCGGCTTG CCGCGGCCTG CCGCAATGGA AACATCTATA TTCTGAGAAG AGACTCCAAG 
CACCCCAAGT ACTGCATCGA GCTGAGCGCC CAGCCTGTGG GACTTATCCG GGTACACAAG 
GTCCTAGTGG TGGGCAGCAC CCAAGACAGC CTGCATGGCT TCACCCACAA GGGGAAGAAG 
CTGTGGACAG TGCAGATGCC CGCAGCCATC CTGACCATGA ACCTCCTGGA GCAGCATTCC 
CGGGGCCTGC AGGCCGTCAT GGCTGGGCTG GCCAATGGAG AGGTCCGCAT TTATCGTGAC 
AAGGCCCTGC TCAATGTCAT CCACACCCCG GATGCAGTGA CCAGCCTTTG CTTTGGCCGG 
TACGGGCGGG AGGACAACAC CCTCATCATG ACCACTCGAG GTGGTGGCCT GATCATCAAG 
ATCCTGAAGC GTACAGCAGT GTTTGTAGAG GGAGGAAGTG AGGTGGGTCC CCCACCAGCC 
CAGGCCATGA AACTCAATGT GCCCCGAAAG ACCCGGCTTT ACGTGGATCA GACACTGCGA 
GAGCGGGAGG CTGGCACCGC CATGCACCGG GCCTTCCAGA CAGACCTATA CCTGCTGCGC 
CTACGTGCTG CCCGCGCCTA CCTGCAGGCC CTCGAGTCCA GCCTGAGCCC CCTGTCCACG 
ACAGCCCGAG AGCCACTCAA GCTGCACGCC GTGGTTCAGG GCCTTGGCCC CACCTTTAAG 
CTCACACTTC ACCTGCAGAA CACCTCAACA ACCCGTCCTG TCCTGGGGCT GCTGGTCTGC 
TTCCTGTACA ACGAGGCGCT CTATTCCCTG CCCCGGGCCT TCTTCAAGGT ACCCTTGCTG 
GTGCCAGGGC TCAACTACCC CCTGGAGACC TTTGTGGAGA GTCTCAGTAA CAAGGGCATC 
TCAGACATCA TCAAGGTGCT GGTGCTTCGA GAAGGCCAAA GTGCACCCCT GCTGAGTGCC 
CACGTCAACA TGCCTGGGAG CGAGGGGCTG GCGGCCGCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_078925.3
CDS	13..1794
Translation	MAAASSSDSDACGAESNEANSKWLDAHYDPMANIHTFSACLALADLHGDGEYKLVVGDLGPGGQQPRLKVLKGPLVMTESPLPALPAAAATFLMEQHEPRTPALALASGPCVYVYKNLRPYFKFSLPQLPPNPLEQDLWNQAKEDRIDPLTLKEMLESIRETAEEPLSIQSLRFLQLELSEMEAFVNQHKSNSIKRQTVITTMTTLKKNLADEDAVSCLVLGTENKELLVLDPEAFTILAKMSLPSVPVFLEVSGQFDVEFRLAAACRNGNIYILRRDSKHPKYCIELSAQPVGLIRVHKVLVVGSTQDSLHGFTHKGKKLWTVQMPAAILTMNLLEQHSRGLQAVMAGLANGEVRIYRDKALLNVIHTPDAVTSLCFGRYGREDNTLIMTTRGGGLIIKILKRTAVFVEGGSEVGPPPAQAMKLNVPRKTRLYVDQTLREREAGTAMHRAFQTDLYLLRLRAARAYLQALESSLSPLSTTAREPLKLHAVVQGLGPTFKLTLHLQNTSTTRPVLGLLVCFLYNEALYSLPRAFFKVPLLVPGLNYPLETFVESLSNKGISDIIKVLVLREGQSAPLLSAHVNMPGSEGLAAA

Target ORF information:

RefSeq Version	NM_024649.4
Organism	Homo sapiens(human)
Definition	Homo sapiens Bardet-Biedl syndrome 1 (BBS1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024649.4

ORF Insert Sequence:

ATGGCCGCTG CGTCCTCATC GGATTCCGAC GCCTGCGGAG CTGAGAGCAA TGAGGCCAAT 
TCGAAGTGGT TGGATGCGCA CTACGACCCA ATGGCCAATA TCCACACCTT TTCTGCCTGC 
CTAGCGCTGG CAGATTTACA TGGGGATGGG GAATACAAGC TGGTGGTAGG GGACCTTGGC 
CCTGGTGGGC AGCAGCCCCG CCTGAAGGTG CTCAAAGGAC CACTGGTGAT GACCGAAAGC 
CCGCTACCTG CTCTGCCAGC TGCTGCTGCC ACCTTCCTCA TGGAGCAACA TGAGCCCCGG 
ACCCCAGCTC TGGCACTTGC TTCAGGCCCT TGTGTCTATG TGTATAAGAA TCTCAGACCC 
TACTTCAAGT TCAGCCTGCC CCAATTGCCT CCAAATCCTC TGGAACAAGA CCTTTGGAAC 
CAGGCCAAAG AGGACCGAAT CGACCCCTTA ACCCTGAAGG AGATGCTGGA GAGCATCCGG 
GAGACGGCAG AGGAGCCTTT GTCCATCCAG TCACTCAGGT TTCTGCAGCT GGAGCTAAGT 
GAAATGGAGG CATTTGTAAA CCAACACAAG TCCAACTCCA TCAAGCGGCA GACAGTCATC 
ACCACCATGA CCACCTTGAA GAAGAACCTG GCTGACGAGG ATGCTGTGTC TTGCCTGGTG 
CTGGGCACCG AGAACAAGGA GCTCCTGGTG CTTGACCCCG AGGCCTTCAC CATTTTAGCC 
AAGATGAGCC TTCCCAGCGT CCCCGTCTTC CTAGAGGTTT CTGGCCAGTT TGATGTTGAG 
TTCCGGCTTG CCGCGGCCTG CCGCAATGGA AACATCTATA TTCTGAGAAG AGACTCCAAG 
CACCCCAAGT ACTGCATCGA GCTGAGCGCC CAGCCTGTGG GACTTATCCG GGTACACAAG 
GTCCTAGTGG TGGGCAGCAC CCAAGACAGC CTGCATGGCT TCACCCACAA GGGGAAGAAG 
CTGTGGACAG TGCAGATGCC CGCAGCCATC CTGACCATGA ACCTCCTGGA GCAGCATTCC 
CGGGGCCTGC AGGCCGTCAT GGCTGGGCTG GCCAATGGAG AGGTCCGCAT TTATCGTGAC 
AAGGCCCTGC TCAATGTCAT CCACACCCCG GATGCAGTGA CCAGCCTTTG CTTTGGCCGG 
TACGGGCGGG AGGACAACAC CCTCATCATG ACCACTCGAG GTGGTGGCCT GATCATCAAG 
ATCCTGAAGC GTACAGCAGT GTTTGTAGAG GGAGGAAGTG AGGTGGGTCC CCCACCAGCC 
CAGGCCATGA AACTCAATGT GCCCCGAAAG ACCCGGCTTT ACGTGGATCA GACACTGCGA 
GAGCGGGAGG CTGGCACCGC CATGCACCGG GCCTTCCAGA CAGACCTATA CCTGCTGCGC 
CTACGTGCTG CCCGCGCCTA CCTGCAGGCC CTCGAGTCCA GCCTGAGCCC CCTGTCCACG 
ACAGCCCGAG AGCCACTCAA GCTGCACGCC GTGGTTCAGG GCCTTGGCCC CACCTTTAAG 
CTCACACTTC ACCTGCAGAA CACCTCAACA ACCCGTCCTG TCCTGGGGCT GCTGGTCTGC 
TTCCTGTACA ACGAGGCGCT CTATTCCCTG CCCCGGGCCT TCTTCAAGGT ACCCTTGCTG 
GTGCCAGGGC TCAACTACCC CCTGGAGACC TTTGTGGAGA GTCTCAGTAA CAAGGGCATC 
TCAGACATCA TCAAGGTGCT GGTGCTTCGA GAAGGCCAAA GTGCACCCCT GCTGAGTGCC 
CACGTCAACA TGCCTGGGAG CGAGGGGCTG GCGGCCGCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BBS1 ( NM_024649.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_078925.3 Homo sapiens Bardet-Biedl syndrome 1 (BBS1), mRNA.

Price & Availability↑

CloneID	OHu25726
Clone ID Related Accession (Same CDS sequence)	NM_024649.4 , NM_024649.5
Accession Version	NM_024649.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1782bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	Bardet-Biedl syndrome 1 protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP002748.4. This sequence is a reference standard in the RefSeqGene project. On Nov 25, 2018 this sequence version replaced NM_024649.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.173357.1, BX647612.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000318312.12/ ENSP00000317469.7 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCGCTG CGTCCTCATC GGATTCCGAC GCCTGCGGAG CTGAGAGCAA TGAGGCCAAT 
TCGAAGTGGT TGGATGCGCA CTACGACCCA ATGGCCAATA TCCACACCTT TTCTGCCTGC 
CTAGCGCTGG CAGATTTACA TGGGGATGGG GAATACAAGC TGGTGGTAGG GGACCTTGGC 
CCTGGTGGGC AGCAGCCCCG CCTGAAGGTG CTCAAAGGAC CACTGGTGAT GACCGAAAGC 
CCGCTACCTG CTCTGCCAGC TGCTGCTGCC ACCTTCCTCA TGGAGCAACA TGAGCCCCGG 
ACCCCAGCTC TGGCACTTGC TTCAGGCCCT TGTGTCTATG TGTATAAGAA TCTCAGACCC 
TACTTCAAGT TCAGCCTGCC CCAATTGCCT CCAAATCCTC TGGAACAAGA CCTTTGGAAC 
CAGGCCAAAG AGGACCGAAT CGACCCCTTA ACCCTGAAGG AGATGCTGGA GAGCATCCGG 
GAGACGGCAG AGGAGCCTTT GTCCATCCAG TCACTCAGGT TTCTGCAGCT GGAGCTAAGT 
GAAATGGAGG CATTTGTAAA CCAACACAAG TCCAACTCCA TCAAGCGGCA GACAGTCATC 
ACCACCATGA CCACCTTGAA GAAGAACCTG GCTGACGAGG ATGCTGTGTC TTGCCTGGTG 
CTGGGCACCG AGAACAAGGA GCTCCTGGTG CTTGACCCCG AGGCCTTCAC CATTTTAGCC 
AAGATGAGCC TTCCCAGCGT CCCCGTCTTC CTAGAGGTTT CTGGCCAGTT TGATGTTGAG 
TTCCGGCTTG CCGCGGCCTG CCGCAATGGA AACATCTATA TTCTGAGAAG AGACTCCAAG 
CACCCCAAGT ACTGCATCGA GCTGAGCGCC CAGCCTGTGG GACTTATCCG GGTACACAAG 
GTCCTAGTGG TGGGCAGCAC CCAAGACAGC CTGCATGGCT TCACCCACAA GGGGAAGAAG 
CTGTGGACAG TGCAGATGCC CGCAGCCATC CTGACCATGA ACCTCCTGGA GCAGCATTCC 
CGGGGCCTGC AGGCCGTCAT GGCTGGGCTG GCCAATGGAG AGGTCCGCAT TTATCGTGAC 
AAGGCCCTGC TCAATGTCAT CCACACCCCG GATGCAGTGA CCAGCCTTTG CTTTGGCCGG 
TACGGGCGGG AGGACAACAC CCTCATCATG ACCACTCGAG GTGGTGGCCT GATCATCAAG 
ATCCTGAAGC GTACAGCAGT GTTTGTAGAG GGAGGAAGTG AGGTGGGTCC CCCACCAGCC 
CAGGCCATGA AACTCAATGT GCCCCGAAAG ACCCGGCTTT ACGTGGATCA GACACTGCGA 
GAGCGGGAGG CTGGCACCGC CATGCACCGG GCCTTCCAGA CAGACCTATA CCTGCTGCGC 
CTACGTGCTG CCCGCGCCTA CCTGCAGGCC CTCGAGTCCA GCCTGAGCCC CCTGTCCACG 
ACAGCCCGAG AGCCACTCAA GCTGCACGCC GTGGTTCAGG GCCTTGGCCC CACCTTTAAG 
CTCACACTTC ACCTGCAGAA CACCTCAACA ACCCGTCCTG TCCTGGGGCT GCTGGTCTGC 
TTCCTGTACA ACGAGGCGCT CTATTCCCTG CCCCGGGCCT TCTTCAAGGT ACCCTTGCTG 
GTGCCAGGGC TCAACTACCC CCTGGAGACC TTTGTGGAGA GTCTCAGTAA CAAGGGCATC 
TCAGACATCA TCAAGGTGCT GGTGCTTCGA GAAGGCCAAA GTGCACCCCT GCTGAGTGCC 
CACGTCAACA TGCCTGGGAG CGAGGGGCTG GCGGCCGCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_078925.3
CDS	26..1807
Translation	MAAASSSDSDACGAESNEANSKWLDAHYDPMANIHTFSACLALADLHGDGEYKLVVGDLGPGGQQPRLKVLKGPLVMTESPLPALPAAAATFLMEQHEPRTPALALASGPCVYVYKNLRPYFKFSLPQLPPNPLEQDLWNQAKEDRIDPLTLKEMLESIRETAEEPLSIQSLRFLQLELSEMEAFVNQHKSNSIKRQTVITTMTTLKKNLADEDAVSCLVLGTENKELLVLDPEAFTILAKMSLPSVPVFLEVSGQFDVEFRLAAACRNGNIYILRRDSKHPKYCIELSAQPVGLIRVHKVLVVGSTQDSLHGFTHKGKKLWTVQMPAAILTMNLLEQHSRGLQAVMAGLANGEVRIYRDKALLNVIHTPDAVTSLCFGRYGREDNTLIMTTRGGGLIIKILKRTAVFVEGGSEVGPPPAQAMKLNVPRKTRLYVDQTLREREAGTAMHRAFQTDLYLLRLRAARAYLQALESSLSPLSTTAREPLKLHAVVQGLGPTFKLTLHLQNTSTTRPVLGLLVCFLYNEALYSLPRAFFKVPLLVPGLNYPLETFVESLSNKGISDIIKVLVLREGQSAPLLSAHVNMPGSEGLAAA

Target ORF information:

RefSeq Version	NM_024649.5
Organism	Homo sapiens(human)
Definition	Homo sapiens Bardet-Biedl syndrome 1 (BBS1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024649.5

ORF Insert Sequence:

ATGGCCGCTG CGTCCTCATC GGATTCCGAC GCCTGCGGAG CTGAGAGCAA TGAGGCCAAT 
TCGAAGTGGT TGGATGCGCA CTACGACCCA ATGGCCAATA TCCACACCTT TTCTGCCTGC 
CTAGCGCTGG CAGATTTACA TGGGGATGGG GAATACAAGC TGGTGGTAGG GGACCTTGGC 
CCTGGTGGGC AGCAGCCCCG CCTGAAGGTG CTCAAAGGAC CACTGGTGAT GACCGAAAGC 
CCGCTACCTG CTCTGCCAGC TGCTGCTGCC ACCTTCCTCA TGGAGCAACA TGAGCCCCGG 
ACCCCAGCTC TGGCACTTGC TTCAGGCCCT TGTGTCTATG TGTATAAGAA TCTCAGACCC 
TACTTCAAGT TCAGCCTGCC CCAATTGCCT CCAAATCCTC TGGAACAAGA CCTTTGGAAC 
CAGGCCAAAG AGGACCGAAT CGACCCCTTA ACCCTGAAGG AGATGCTGGA GAGCATCCGG 
GAGACGGCAG AGGAGCCTTT GTCCATCCAG TCACTCAGGT TTCTGCAGCT GGAGCTAAGT 
GAAATGGAGG CATTTGTAAA CCAACACAAG TCCAACTCCA TCAAGCGGCA GACAGTCATC 
ACCACCATGA CCACCTTGAA GAAGAACCTG GCTGACGAGG ATGCTGTGTC TTGCCTGGTG 
CTGGGCACCG AGAACAAGGA GCTCCTGGTG CTTGACCCCG AGGCCTTCAC CATTTTAGCC 
AAGATGAGCC TTCCCAGCGT CCCCGTCTTC CTAGAGGTTT CTGGCCAGTT TGATGTTGAG 
TTCCGGCTTG CCGCGGCCTG CCGCAATGGA AACATCTATA TTCTGAGAAG AGACTCCAAG 
CACCCCAAGT ACTGCATCGA GCTGAGCGCC CAGCCTGTGG GACTTATCCG GGTACACAAG 
GTCCTAGTGG TGGGCAGCAC CCAAGACAGC CTGCATGGCT TCACCCACAA GGGGAAGAAG 
CTGTGGACAG TGCAGATGCC CGCAGCCATC CTGACCATGA ACCTCCTGGA GCAGCATTCC 
CGGGGCCTGC AGGCCGTCAT GGCTGGGCTG GCCAATGGAG AGGTCCGCAT TTATCGTGAC 
AAGGCCCTGC TCAATGTCAT CCACACCCCG GATGCAGTGA CCAGCCTTTG CTTTGGCCGG 
TACGGGCGGG AGGACAACAC CCTCATCATG ACCACTCGAG GTGGTGGCCT GATCATCAAG 
ATCCTGAAGC GTACAGCAGT GTTTGTAGAG GGAGGAAGTG AGGTGGGTCC CCCACCAGCC 
CAGGCCATGA AACTCAATGT GCCCCGAAAG ACCCGGCTTT ACGTGGATCA GACACTGCGA 
GAGCGGGAGG CTGGCACCGC CATGCACCGG GCCTTCCAGA CAGACCTATA CCTGCTGCGC 
CTACGTGCTG CCCGCGCCTA CCTGCAGGCC CTCGAGTCCA GCCTGAGCCC CCTGTCCACG 
ACAGCCCGAG AGCCACTCAA GCTGCACGCC GTGGTTCAGG GCCTTGGCCC CACCTTTAAG 
CTCACACTTC ACCTGCAGAA CACCTCAACA ACCCGTCCTG TCCTGGGGCT GCTGGTCTGC 
TTCCTGTACA ACGAGGCGCT CTATTCCCTG CCCCGGGCCT TCTTCAAGGT ACCCTTGCTG 
GTGCCAGGGC TCAACTACCC CCTGGAGACC TTTGTGGAGA GTCTCAGTAA CAAGGGCATC 
TCAGACATCA TCAAGGTGCT GGTGCTTCGA GAAGGCCAAA GTGCACCCCT GCTGAGTGCC 
CACGTCAACA TGCCTGGGAG CGAGGGGCTG GCGGCCGCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Protein interaction perturbation profiling at amino-acid resolution.
Nature methods14(12)1213-1221(2017 Dec)
Woodsmith J,Apelt L,Casado-Medrano V,?zkan Z,Timmermann B,Stelzl U

Molecular genetic analysis of 30 families with Joubert syndrome.
Clinical genetics90(6)526-535(2016 Dec)
Suzuki T,Miyake N,Tsurusaki Y,Okamoto N,Alkindy A,Inaba A,Sato M,Ito S,Muramatsu K,Kimura S,Ieda D,Saitoh S,Hiyane M,Suzumura H,Yagyu K,Shiraishi H,Nakajima M,Fueki N,Habata Y,Ueda Y,Komatsu Y,Yan K,Shimoda K,Shitara Y,Mizuno S,Ichinomiya K,Sameshima K,Tsuyusaki Y,Kurosawa K,Sakai Y,Haginoya K,Kobayashi Y,Yoshizawa C,Hisano M,Nakashima M,Saitsu H,Takeda S,Matsumoto N

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Nature communications711491(2016 May)
Boldt K,van Reeuwijk J,Lu Q,Koutroumpas K,Nguyen TM,Texier Y,van Beersum SE,Horn N,Willer JR,Mans DA,Dougherty G,Lamers IJ,Coene KL,Arts HH,Betts MJ,Beyer T,Bolat E,Gloeckner CJ,Haidari K,Hetterschijt L,Iaconis D,Jenkins D,Klose F,Knapp B,Latour B,Letteboer SJ,Marcelis CL,Mitic D,Morleo M,Oud MM,Riemersma M,Rix S,Terhal PA,Toedt G,van Dam TJ,de Vrieze E,Wissinger Y,Wu KM,Apic G,Beales PL,Blacque OE,Gibson TJ,Huynen MA,Katsanis N,Kremer H,Omran H,van Wijk E,Wolfrum U,Kepes F,Davis EE,Franco B,Giles RH,Ueffing M,Russell RB,Roepman R,

Computational genomic analysis of PARK7 interactome reveals high BBS1 gene expression as a prognostic factor favoring survival in malignant pleural mesothelioma.
American journal of physiology. Lung cellular and molecular physiology309(7)L677-86(2015 Oct)
Vavougios GD,Solenov EI,Hatzoglou C,Baturina GS,Katkova LE,Molyvdas PA,Gourgoulianis KI,Zarogiannis SG

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BBS1 cDNA ORF clone, Homo sapiens(human)

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