JPH3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	JPH3
Entrez Gene ID	57338
Full Name	junctophilin 3
Synonyms	CAGL237,HDL2,JP-3,JP3,TNRC22
General protein information	Preferred Names junctophilin 3 Names junctophilin-3 junctophilin type 3 trinucleotide repeat containing 22
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16q24.2
Summary	Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. CAG/CTG repeat expansion from normally 6-28 repeats to 40-59 repeats in the 3' UTR of this gene have been associated with Huntington disease-like 2 (HDL2). This gene is a member of the junctophilin gene family. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2016].
Disorder MIM:	605268
Disorder Html:	?Huntington disease-like 2, 606438 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001271605.2	NP_001258534.1	junctophilin-3 isoform 3
XM_017023484.1	XP_016878973.1	junctophilin-3 isoform X2
NM_001271604.2	NP_001258533.1	junctophilin-3 isoform 2
NM_020655.3	NP_065706.2	junctophilin-3 isoform 1
XM_017023483.1	XP_016878972.1	junctophilin-3 isoform X1
NM_001271604.3	NP_001258533.1	junctophilin-3 isoform 2
NM_001271605.1	NP_001258534.1	junctophilin-3 isoform 3
NM_020655.4	NP_065706.2	junctophilin-3 isoform 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	JPH3	NP_065706.2
Pan troglodytes (chimpanzee)	JPH3	XP_001153256.2
Canis lupus familiaris (dog)	JPH3	XP_546789.2
Mus musculus (house mouse)	Jph3	NP_065630.1
Rattus norvegicus (Norway rat)	Jph3	NP_001100907.1
Gallus gallus (chicken)	JPH3	XP_414192.1
Danio rerio (zebrafish)	LOC569861	NP_001116174.1
	LOC704611	XP_001092976.2
Bos taurus (cattle)	JPH3	NP_001192548.1
Xenopus tropicalis (tropical clawed frog)	jph3	XP_002936140.2

Gene Ontology
Bibliography

Related articles in PubMed

Epigenomic and Functional Characterization of Junctophilin 3 (JPH3) as a Novel Tumor Suppressor Being Frequently Inactivated by Promoter CpG Methylation in Digestive Cancers.
Hu X, Kuang Y, Li L, Tang H, Shi Q, Shu X, Zhang Y, Chan FK, Tao Q, He C
Theranostics7(7)2150-2163(2017)

Expanding the Spectrum of Genes Involved in Huntington Disease Using a Combined Clinical and Genetic Approach.
Mariani LL, Tesson C, Charles P, Cazeneuve C, Hahn V, Youssov K, Freeman L, Grabli D, Roze E, No?l S, Peuvion JN, Bachoud-Levi AC, Brice A, Stevanin G, Durr A
JAMA neurology73(9)1105-14(2016 Sep)

Junctophilin 3 expresses in pancreatic beta cells and is required for glucose-stimulated insulin secretion.
Li L, Pan ZF, Huang X, Wu BW, Li T, Kang MX, Ge RS, Hu XY, Zhang YH, Ge LJ, Zhu DY, Wu YL, Lou YJ
Cell death & disease7(6)e2275(2016 Jun)

Junctophilin 3 (JPH3) expansion mutations causing Huntington disease like 2 (HDL2) are common in South African patients with African ancestry and a Huntington disease phenotype.
Krause A, Mitchell C, Essop F, Tager S, Temlett J, Stevanin G, Ross C, Rudnicki D, Margolis R
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics168(7)573-85(2015 Oct)

The Repeat Expansion Diseases: The dark side of DNA repair.
Zhao XN, Usdin K
DNA repair3296-105(2015 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study identified that abnormal CTG expansions in JPH3 in patient with Huntington Disease.
Title: Expanding the Spectrum of Genes Involved in Huntington Disease Using a Combined Clinical and Genetic Approach.

The expression of JPH isoforms was examined in human and mouse pancreatic tissues, and JPH3 expression was found in both the beta cells.
Title: Junctophilin 3 expresses in pancreatic beta cells and is required for glucose-stimulated insulin secretion.

The present study aimed to characterize the genetic basis of the Huntington disease phenotype in South Africans and to investigate the possible origin of the JPH3 mutation.
Title: Junctophilin 3 (JPH3) expansion mutations causing Huntington disease like 2 (HDL2) are common in South African patients with African ancestry and a Huntington disease phenotype.

JPH3 mutations should be considered in the differential diagnosis of early-onset dementia and hypokinetic-rigid syndromes in individuals of African descent.
Title: JPH3 repeat expansions cause a progressive akinetic-rigid syndrome with severe dementia and putaminal rim in a five-generation African-American family.

The pathogenic mechanism of Huntington disease-like 2 is multifactorial, involving both a toxic gain of function of JPH3 RNA transcripts and a toxic loss of JPH3 expression in an experimental Huntington disease-like 2 mouse model.
Title: Loss of junctophilin-3 contributes to Huntington disease-like 2 pathogenesis.

The following JPH3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the JPH3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27485	NM_020655.4 Latest version!	Homo sapiens junctophilin 3 (JPH3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu16801	NM_001271605.2 Latest version!	Homo sapiens junctophilin 3 (JPH3), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu86169	XM_017023484.1 Latest version!	Homo sapiens junctophilin 3 (JPH3), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu27611	NM_001271604.3 Latest version!	Homo sapiens junctophilin 3 (JPH3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
OHu86168	XM_017023483.1 Latest version!	Homo sapiens junctophilin 3 (JPH3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
View Old Accession Versions >>
OHu27611	NM_001271604.2	Homo sapiens junctophilin 3 (JPH3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
OHu16801	NM_001271605.1	Homo sapiens junctophilin 3 (JPH3), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu27485	NM_020655.3	Homo sapiens junctophilin 3 (JPH3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

JPH3 ( NM_020655.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_065706.2 Homo sapiens junctophilin 3 (JPH3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu27485
Clone ID Related Accession (Same CDS sequence)	NM_020655.3 , NM_020655.4
Accession Version	NM_020655.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2247bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	junctophilin-3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB593088.1, BC036533.2, AK295518.1, AW954561.1 and BQ014355.1. This sequence is a reference standard in the RefSeqGene project. On Oct 24, 2012 this sequence version replaced NM_020655.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC036533.2, AB042636.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCAGTG GGGGCAGGTT TAATTTTGAC GACGGAGGGT CCTACTGTGG AGGCTGGGAG 
GACGGCAAGG CGCACGGCCA TGGCGTCTGC ACCGGCCCCA AGGGCCAAGG CGAATACACC 
GGCTCGTGGA GCCACGGCTT CGAGGTGCTG GGCGTCTACA CCTGGCCCAG CGGCAACACG 
TACCAGGGCA CCTGGGCGCA GGGCAAGCGC CACGGCATCG GCCTGGAGAG CAAGGGGAAG 
TGGGTGTACA AGGGCGAGTG GACGCACGGA TTCAAGGGGC GCTACGGGGT GCGGGAGTGC 
GCGGGCAACG GGGCCAAATA CGAAGGGACC TGGAGCAACG GGCTGCAGGA CGGCTACGGG 
ACCGAGACCT ACTCGGACGG AGGGACCTAC CAGGGCCAGT GGGTCGGTGG CATGCGCCAG 
GGCTACGGCG TCCGGCAGAG CGTCCCGTAT GGCATGGCCG CGGTCATCCG CTCACCCCTG 
AGGACGTCCA TCAACTCCCT GCGCAGCGAG CACACCAACG GCACGGCGCT GCATCCCGAC 
GCCTCTCCGG CGGTGGCCGG CAGCCCGGCC GTGTCCCGCG GGGGCTTCGT GCTCGTGGCC 
CACAGTGACT CCGAGATCCT CAAGAGCAAG AAGAAGGGGC TGTTTCGGCG CTCGCTGCTG 
AGTGGGCTGA AGCTGCGCAA GTCGGAGTCC AAGAGCAGCC TGGCCAGCCA ACGCAGCAAG 
CAGAGCTCCT TTCGCAGCGA GGCGGGCATG AGCACCGTCA GCTCCACGGC CAGCGACATC 
CACTCCACCA TCAGCCTGGG CGAGGCTGAG GCCGAGCTGG CGGTCATCGA GGACGACATC 
GACGCCACCA CCACCGAGAC CTACGTGGGC GAGTGGAAGA ACGACAAACG CTCCGGCTTC 
GGCGTGAGCC AGCGCTCGGA CGGGCTCAAG TACGAGGGCG AGTGGGCCAG CAACCGGCGC 
CATGGCTACG GCTGCATGAC CTTCCCGGAC GGCACCAAGG AGGAGGGCAA GTACAAGCAG 
AACATCCTCG TCGGCGGCAA GCGCAAGAAC CTCATCCCCC TGCGGGCCAG CAAGATCCGC 
GAGAAGGTGG ACCGCGCCGT TGAGGCCGCT GAGCGGGCCG CCACCATCGC CAAGCAGAAG 
GCTGAGATCG CGGCTTCCAG GACCTCCCAC TCTCGGGCAA AGGCCGAGGC AGCCCTCACA 
GCAGCTCAGA AAGCCCAGGA GGAGGCGCGG ATCGCCAGGA TCACTGCCAA AGAGTTCTCC 
CCTTCCTTCC AGCACCGGGA AAACGGGCTG GAGTACCAGA GGCCGAAGCG TCAGACCTCC 
TGTGACGACA TCGAGGTGCT GTCCACCGGG ACACCCCTGC AGCAGGAGAG CCCCGAGCTG 
TACCGCAAGG GCACCACTCC CTCCGACCTG ACCCCCGACG ACAGCCCCCT GCAGAGCTTC 
CCCACCAGCC CCGCGGCCAC CCCGCCGCCC GCGCCCGCCG CCAGGAACAA GGTCGCCCAC 
TTCTCGAGGC AGGTGTCGGT GGACGAGGAG CGGGGCGGGG ACATCCAGAT GCTCCTGGAG 
GGCCGGGCCG GGGACTGCGC CCGCAGCAGC TGGGGCGAGG AGCAGGCCGG GGGCTCCAGG 
GGTGTCCGCA GCGGTGCCCT GCGCGGCGGC CTGCTCGTGG ATGACTTCCG CACCCGAGGT 
TCGGGCCGCA AGCAGCCCGG GAACCCCAAG CCGCGGGAGC GGCGGACGGA GTCACCCCCC 
GTGTTCACGT GGACTTCCCA CCACCGGGCC AGCAACCACA GCCCCGGAGG CTCCAGGCTG 
CTGGAGCTGC AGGAGGAGAA GCTGAGCAAC TACCGGATGG AGATGAAACC CTTGCTGAGG 
ATGGAGACGC ATCCCCAGAA AAGACGCTAC AGCAAGGGCG GCGCCTGCCG GGGCTTGGGG 
GACGACCACC GCCCCGAGGA CCGGGGCTTC GGGGTGCAGA GACTGCGGTC CAAGGCCCAG 
AACAAGGAGA ACTTCAGGCC GGCCTCCTCC GCGGAGCCCG CCGTGCAGAA ACTGGCGAGC 
CTGCGGCTGG GCGGGGCCGA GCCCCGGTTG CTGCGTTGGG ACTTGACCTT CTCCCCGCCC 
CAGAAATCCT TGCCTGTCGC TCTAGAGTCC GACGAGGAGA ATGGGGATGA GCTCAAGTCC 
AGTACGGGCT CAGCGCCTAT CCTGGTGGTC ATGGTGATCT TGCTCAACAT CGGAGTCGCC 
ATTCTGTTTA TTAACTTTTT CATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065706.2
CDS	261..2507
Translation	MSSGGRFNFDDGGSYCGGWEDGKAHGHGVCTGPKGQGEYTGSWSHGFEVLGVYTWPSGNTYQGTWAQGKRHGIGLESKGKWVYKGEWTHGFKGRYGVRECAGNGAKYEGTWSNGLQDGYGTETYSDGGTYQGQWVGGMRQGYGVRQSVPYGMAAVIRSPLRTSINSLRSEHTNGTALHPDASPAVAGSPAVSRGGFVLVAHSDSEILKSKKKGLFRRSLLSGLKLRKSESKSSLASQRSKQSSFRSEAGMSTVSSTASDIHSTISLGEAEAELAVIEDDIDATTTETYVGEWKNDKRSGFGVSQRSDGLKYEGEWASNRRHGYGCMTFPDGTKEEGKYKQNILVGGKRKNLIPLRASKIREKVDRAVEAAERAATIAKQKAEIAASRTSHSRAKAEAALTAAQKAQEEARIARITAKEFSPSFQHRENGLEYQRPKRQTSCDDIEVLSTGTPLQQESPELYRKGTTPSDLTPDDSPLQSFPTSPAATPPPAPAARNKVAHFSRQVSVDEERGGDIQMLLEGRAGDCARSSWGEEQAGGSRGVRSGALRGGLLVDDFRTRGSGRKQPGNPKPRERRTESPPVFTWTSHHRASNHSPGGSRLLELQEEKLSNYRMEMKPLLRMETHPQKRRYSKGGACRGLGDDHRPEDRGFGVQRLRSKAQNKENFRPASSAEPAVQKLASLRLGGAEPRLLRWDLTFSPPQKSLPVALESDEENGDELKSSTGSAPILVVMVILLNIGVAILFINFFI

Target ORF information:

RefSeq Version	NM_020655.3
Organism	Homo sapiens(human)
Definition	Homo sapiens junctophilin 3 (JPH3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020655.3

ORF Insert Sequence:

ATGTCCAGTG GGGGCAGGTT TAATTTTGAC GACGGAGGGT CCTACTGTGG AGGCTGGGAG 
GACGGCAAGG CGCACGGCCA TGGCGTCTGC ACCGGCCCCA AGGGCCAAGG CGAATACACC 
GGCTCGTGGA GCCACGGCTT CGAGGTGCTG GGCGTCTACA CCTGGCCCAG CGGCAACACG 
TACCAGGGCA CCTGGGCGCA GGGCAAGCGC CACGGCATCG GCCTGGAGAG CAAGGGGAAG 
TGGGTGTACA AGGGCGAGTG GACGCACGGA TTCAAGGGGC GCTACGGGGT GCGGGAGTGC 
GCGGGCAACG GGGCCAAATA CGAAGGGACC TGGAGCAACG GGCTGCAGGA CGGCTACGGG 
ACCGAGACCT ACTCGGACGG AGGGACCTAC CAGGGCCAGT GGGTCGGTGG CATGCGCCAG 
GGCTACGGCG TCCGGCAGAG CGTCCCGTAT GGCATGGCCG CGGTCATCCG CTCACCCCTG 
AGGACGTCCA TCAACTCCCT GCGCAGCGAG CACACCAACG GCACGGCGCT GCATCCCGAC 
GCCTCTCCGG CGGTGGCCGG CAGCCCGGCC GTGTCCCGCG GGGGCTTCGT GCTCGTGGCC 
CACAGTGACT CCGAGATCCT CAAGAGCAAG AAGAAGGGGC TGTTTCGGCG CTCGCTGCTG 
AGTGGGCTGA AGCTGCGCAA GTCGGAGTCC AAGAGCAGCC TGGCCAGCCA ACGCAGCAAG 
CAGAGCTCCT TTCGCAGCGA GGCGGGCATG AGCACCGTCA GCTCCACGGC CAGCGACATC 
CACTCCACCA TCAGCCTGGG CGAGGCTGAG GCCGAGCTGG CGGTCATCGA GGACGACATC 
GACGCCACCA CCACCGAGAC CTACGTGGGC GAGTGGAAGA ACGACAAACG CTCCGGCTTC 
GGCGTGAGCC AGCGCTCGGA CGGGCTCAAG TACGAGGGCG AGTGGGCCAG CAACCGGCGC 
CATGGCTACG GCTGCATGAC CTTCCCGGAC GGCACCAAGG AGGAGGGCAA GTACAAGCAG 
AACATCCTCG TCGGCGGCAA GCGCAAGAAC CTCATCCCCC TGCGGGCCAG CAAGATCCGC 
GAGAAGGTGG ACCGCGCCGT TGAGGCCGCT GAGCGGGCCG CCACCATCGC CAAGCAGAAG 
GCTGAGATCG CGGCTTCCAG GACCTCCCAC TCTCGGGCAA AGGCCGAGGC AGCCCTCACA 
GCAGCTCAGA AAGCCCAGGA GGAGGCGCGG ATCGCCAGGA TCACTGCCAA AGAGTTCTCC 
CCTTCCTTCC AGCACCGGGA AAACGGGCTG GAGTACCAGA GGCCGAAGCG TCAGACCTCC 
TGTGACGACA TCGAGGTGCT GTCCACCGGG ACACCCCTGC AGCAGGAGAG CCCCGAGCTG 
TACCGCAAGG GCACCACTCC CTCCGACCTG ACCCCCGACG ACAGCCCCCT GCAGAGCTTC 
CCCACCAGCC CCGCGGCCAC CCCGCCGCCC GCGCCCGCCG CCAGGAACAA GGTCGCCCAC 
TTCTCGAGGC AGGTGTCGGT GGACGAGGAG CGGGGCGGGG ACATCCAGAT GCTCCTGGAG 
GGCCGGGCCG GGGACTGCGC CCGCAGCAGC TGGGGCGAGG AGCAGGCCGG GGGCTCCAGG 
GGTGTCCGCA GCGGTGCCCT GCGCGGCGGC CTGCTCGTGG ATGACTTCCG CACCCGAGGT 
TCGGGCCGCA AGCAGCCCGG GAACCCCAAG CCGCGGGAGC GGCGGACGGA GTCACCCCCC 
GTGTTCACGT GGACTTCCCA CCACCGGGCC AGCAACCACA GCCCCGGAGG CTCCAGGCTG 
CTGGAGCTGC AGGAGGAGAA GCTGAGCAAC TACCGGATGG AGATGAAACC CTTGCTGAGG 
ATGGAGACGC ATCCCCAGAA AAGACGCTAC AGCAAGGGCG GCGCCTGCCG GGGCTTGGGG 
GACGACCACC GCCCCGAGGA CCGGGGCTTC GGGGTGCAGA GACTGCGGTC CAAGGCCCAG 
AACAAGGAGA ACTTCAGGCC GGCCTCCTCC GCGGAGCCCG CCGTGCAGAA ACTGGCGAGC 
CTGCGGCTGG GCGGGGCCGA GCCCCGGTTG CTGCGTTGGG ACTTGACCTT CTCCCCGCCC 
CAGAAATCCT TGCCTGTCGC TCTAGAGTCC GACGAGGAGA ATGGGGATGA GCTCAAGTCC 
AGTACGGGCT CAGCGCCTAT CCTGGTGGTC ATGGTGATCT TGCTCAACAT CGGAGTCGCC 
ATTCTGTTTA TTAACTTTTT CATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

JPH3 ( NM_020655.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_065706.2 Homo sapiens junctophilin 3 (JPH3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu27485
Clone ID Related Accession (Same CDS sequence)	NM_020655.3 , NM_020655.4
Accession Version	NM_020655.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2247bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	junctophilin-3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC092720.4, AB593088.1, BC036533.2, AK295518.1, AW954561.1 and BQ014355.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_020655.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC036533.2, AB042636.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000284262.3/ ENSP00000284262.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCCAGTG GGGGCAGGTT TAATTTTGAC GACGGAGGGT CCTACTGTGG AGGCTGGGAG 
GACGGCAAGG CGCACGGCCA TGGCGTCTGC ACCGGCCCCA AGGGCCAAGG CGAATACACC 
GGCTCGTGGA GCCACGGCTT CGAGGTGCTG GGCGTCTACA CCTGGCCCAG CGGCAACACG 
TACCAGGGCA CCTGGGCGCA GGGCAAGCGC CACGGCATCG GCCTGGAGAG CAAGGGGAAG 
TGGGTGTACA AGGGCGAGTG GACGCACGGA TTCAAGGGGC GCTACGGGGT GCGGGAGTGC 
GCGGGCAACG GGGCCAAATA CGAAGGGACC TGGAGCAACG GGCTGCAGGA CGGCTACGGG 
ACCGAGACCT ACTCGGACGG AGGGACCTAC CAGGGCCAGT GGGTCGGTGG CATGCGCCAG 
GGCTACGGCG TCCGGCAGAG CGTCCCGTAT GGCATGGCCG CGGTCATCCG CTCACCCCTG 
AGGACGTCCA TCAACTCCCT GCGCAGCGAG CACACCAACG GCACGGCGCT GCATCCCGAC 
GCCTCTCCGG CGGTGGCCGG CAGCCCGGCC GTGTCCCGCG GGGGCTTCGT GCTCGTGGCC 
CACAGTGACT CCGAGATCCT CAAGAGCAAG AAGAAGGGGC TGTTTCGGCG CTCGCTGCTG 
AGTGGGCTGA AGCTGCGCAA GTCGGAGTCC AAGAGCAGCC TGGCCAGCCA ACGCAGCAAG 
CAGAGCTCCT TTCGCAGCGA GGCGGGCATG AGCACCGTCA GCTCCACGGC CAGCGACATC 
CACTCCACCA TCAGCCTGGG CGAGGCTGAG GCCGAGCTGG CGGTCATCGA GGACGACATC 
GACGCCACCA CCACCGAGAC CTACGTGGGC GAGTGGAAGA ACGACAAACG CTCCGGCTTC 
GGCGTGAGCC AGCGCTCGGA CGGGCTCAAG TACGAGGGCG AGTGGGCCAG CAACCGGCGC 
CATGGCTACG GCTGCATGAC CTTCCCGGAC GGCACCAAGG AGGAGGGCAA GTACAAGCAG 
AACATCCTCG TCGGCGGCAA GCGCAAGAAC CTCATCCCCC TGCGGGCCAG CAAGATCCGC 
GAGAAGGTGG ACCGCGCCGT TGAGGCCGCT GAGCGGGCCG CCACCATCGC CAAGCAGAAG 
GCTGAGATCG CGGCTTCCAG GACCTCCCAC TCTCGGGCAA AGGCCGAGGC AGCCCTCACA 
GCAGCTCAGA AAGCCCAGGA GGAGGCGCGG ATCGCCAGGA TCACTGCCAA AGAGTTCTCC 
CCTTCCTTCC AGCACCGGGA AAACGGGCTG GAGTACCAGA GGCCGAAGCG TCAGACCTCC 
TGTGACGACA TCGAGGTGCT GTCCACCGGG ACACCCCTGC AGCAGGAGAG CCCCGAGCTG 
TACCGCAAGG GCACCACTCC CTCCGACCTG ACCCCCGACG ACAGCCCCCT GCAGAGCTTC 
CCCACCAGCC CCGCGGCCAC CCCGCCGCCC GCGCCCGCCG CCAGGAACAA GGTCGCCCAC 
TTCTCGAGGC AGGTGTCGGT GGACGAGGAG CGGGGCGGGG ACATCCAGAT GCTCCTGGAG 
GGCCGGGCCG GGGACTGCGC CCGCAGCAGC TGGGGCGAGG AGCAGGCCGG GGGCTCCAGG 
GGTGTCCGCA GCGGTGCCCT GCGCGGCGGC CTGCTCGTGG ATGACTTCCG CACCCGAGGT 
TCGGGCCGCA AGCAGCCCGG GAACCCCAAG CCGCGGGAGC GGCGGACGGA GTCACCCCCC 
GTGTTCACGT GGACTTCCCA CCACCGGGCC AGCAACCACA GCCCCGGAGG CTCCAGGCTG 
CTGGAGCTGC AGGAGGAGAA GCTGAGCAAC TACCGGATGG AGATGAAACC CTTGCTGAGG 
ATGGAGACGC ATCCCCAGAA AAGACGCTAC AGCAAGGGCG GCGCCTGCCG GGGCTTGGGG 
GACGACCACC GCCCCGAGGA CCGGGGCTTC GGGGTGCAGA GACTGCGGTC CAAGGCCCAG 
AACAAGGAGA ACTTCAGGCC GGCCTCCTCC GCGGAGCCCG CCGTGCAGAA ACTGGCGAGC 
CTGCGGCTGG GCGGGGCCGA GCCCCGGTTG CTGCGTTGGG ACTTGACCTT CTCCCCGCCC 
CAGAAATCCT TGCCTGTCGC TCTAGAGTCC GACGAGGAGA ATGGGGATGA GCTCAAGTCC 
AGTACGGGCT CAGCGCCTAT CCTGGTGGTC ATGGTGATCT TGCTCAACAT CGGAGTCGCC 
ATTCTGTTTA TTAACTTTTT CATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065706.2
CDS	640..2886
Translation	MSSGGRFNFDDGGSYCGGWEDGKAHGHGVCTGPKGQGEYTGSWSHGFEVLGVYTWPSGNTYQGTWAQGKRHGIGLESKGKWVYKGEWTHGFKGRYGVRECAGNGAKYEGTWSNGLQDGYGTETYSDGGTYQGQWVGGMRQGYGVRQSVPYGMAAVIRSPLRTSINSLRSEHTNGTALHPDASPAVAGSPAVSRGGFVLVAHSDSEILKSKKKGLFRRSLLSGLKLRKSESKSSLASQRSKQSSFRSEAGMSTVSSTASDIHSTISLGEAEAELAVIEDDIDATTTETYVGEWKNDKRSGFGVSQRSDGLKYEGEWASNRRHGYGCMTFPDGTKEEGKYKQNILVGGKRKNLIPLRASKIREKVDRAVEAAERAATIAKQKAEIAASRTSHSRAKAEAALTAAQKAQEEARIARITAKEFSPSFQHRENGLEYQRPKRQTSCDDIEVLSTGTPLQQESPELYRKGTTPSDLTPDDSPLQSFPTSPAATPPPAPAARNKVAHFSRQVSVDEERGGDIQMLLEGRAGDCARSSWGEEQAGGSRGVRSGALRGGLLVDDFRTRGSGRKQPGNPKPRERRTESPPVFTWTSHHRASNHSPGGSRLLELQEEKLSNYRMEMKPLLRMETHPQKRRYSKGGACRGLGDDHRPEDRGFGVQRLRSKAQNKENFRPASSAEPAVQKLASLRLGGAEPRLLRWDLTFSPPQKSLPVALESDEENGDELKSSTGSAPILVVMVILLNIGVAILFINFFI

Target ORF information:

RefSeq Version	NM_020655.4
Organism	Homo sapiens(human)
Definition	Homo sapiens junctophilin 3 (JPH3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020655.4

ORF Insert Sequence:

ATGTCCAGTG GGGGCAGGTT TAATTTTGAC GACGGAGGGT CCTACTGTGG AGGCTGGGAG 
GACGGCAAGG CGCACGGCCA TGGCGTCTGC ACCGGCCCCA AGGGCCAAGG CGAATACACC 
GGCTCGTGGA GCCACGGCTT CGAGGTGCTG GGCGTCTACA CCTGGCCCAG CGGCAACACG 
TACCAGGGCA CCTGGGCGCA GGGCAAGCGC CACGGCATCG GCCTGGAGAG CAAGGGGAAG 
TGGGTGTACA AGGGCGAGTG GACGCACGGA TTCAAGGGGC GCTACGGGGT GCGGGAGTGC 
GCGGGCAACG GGGCCAAATA CGAAGGGACC TGGAGCAACG GGCTGCAGGA CGGCTACGGG 
ACCGAGACCT ACTCGGACGG AGGGACCTAC CAGGGCCAGT GGGTCGGTGG CATGCGCCAG 
GGCTACGGCG TCCGGCAGAG CGTCCCGTAT GGCATGGCCG CGGTCATCCG CTCACCCCTG 
AGGACGTCCA TCAACTCCCT GCGCAGCGAG CACACCAACG GCACGGCGCT GCATCCCGAC 
GCCTCTCCGG CGGTGGCCGG CAGCCCGGCC GTGTCCCGCG GGGGCTTCGT GCTCGTGGCC 
CACAGTGACT CCGAGATCCT CAAGAGCAAG AAGAAGGGGC TGTTTCGGCG CTCGCTGCTG 
AGTGGGCTGA AGCTGCGCAA GTCGGAGTCC AAGAGCAGCC TGGCCAGCCA ACGCAGCAAG 
CAGAGCTCCT TTCGCAGCGA GGCGGGCATG AGCACCGTCA GCTCCACGGC CAGCGACATC 
CACTCCACCA TCAGCCTGGG CGAGGCTGAG GCCGAGCTGG CGGTCATCGA GGACGACATC 
GACGCCACCA CCACCGAGAC CTACGTGGGC GAGTGGAAGA ACGACAAACG CTCCGGCTTC 
GGCGTGAGCC AGCGCTCGGA CGGGCTCAAG TACGAGGGCG AGTGGGCCAG CAACCGGCGC 
CATGGCTACG GCTGCATGAC CTTCCCGGAC GGCACCAAGG AGGAGGGCAA GTACAAGCAG 
AACATCCTCG TCGGCGGCAA GCGCAAGAAC CTCATCCCCC TGCGGGCCAG CAAGATCCGC 
GAGAAGGTGG ACCGCGCCGT TGAGGCCGCT GAGCGGGCCG CCACCATCGC CAAGCAGAAG 
GCTGAGATCG CGGCTTCCAG GACCTCCCAC TCTCGGGCAA AGGCCGAGGC AGCCCTCACA 
GCAGCTCAGA AAGCCCAGGA GGAGGCGCGG ATCGCCAGGA TCACTGCCAA AGAGTTCTCC 
CCTTCCTTCC AGCACCGGGA AAACGGGCTG GAGTACCAGA GGCCGAAGCG TCAGACCTCC 
TGTGACGACA TCGAGGTGCT GTCCACCGGG ACACCCCTGC AGCAGGAGAG CCCCGAGCTG 
TACCGCAAGG GCACCACTCC CTCCGACCTG ACCCCCGACG ACAGCCCCCT GCAGAGCTTC 
CCCACCAGCC CCGCGGCCAC CCCGCCGCCC GCGCCCGCCG CCAGGAACAA GGTCGCCCAC 
TTCTCGAGGC AGGTGTCGGT GGACGAGGAG CGGGGCGGGG ACATCCAGAT GCTCCTGGAG 
GGCCGGGCCG GGGACTGCGC CCGCAGCAGC TGGGGCGAGG AGCAGGCCGG GGGCTCCAGG 
GGTGTCCGCA GCGGTGCCCT GCGCGGCGGC CTGCTCGTGG ATGACTTCCG CACCCGAGGT 
TCGGGCCGCA AGCAGCCCGG GAACCCCAAG CCGCGGGAGC GGCGGACGGA GTCACCCCCC 
GTGTTCACGT GGACTTCCCA CCACCGGGCC AGCAACCACA GCCCCGGAGG CTCCAGGCTG 
CTGGAGCTGC AGGAGGAGAA GCTGAGCAAC TACCGGATGG AGATGAAACC CTTGCTGAGG 
ATGGAGACGC ATCCCCAGAA AAGACGCTAC AGCAAGGGCG GCGCCTGCCG GGGCTTGGGG 
GACGACCACC GCCCCGAGGA CCGGGGCTTC GGGGTGCAGA GACTGCGGTC CAAGGCCCAG 
AACAAGGAGA ACTTCAGGCC GGCCTCCTCC GCGGAGCCCG CCGTGCAGAA ACTGGCGAGC 
CTGCGGCTGG GCGGGGCCGA GCCCCGGTTG CTGCGTTGGG ACTTGACCTT CTCCCCGCCC 
CAGAAATCCT TGCCTGTCGC TCTAGAGTCC GACGAGGAGA ATGGGGATGA GCTCAAGTCC 
AGTACGGGCT CAGCGCCTAT CCTGGTGGTC ATGGTGATCT TGCTCAACAT CGGAGTCGCC 
ATTCTGTTTA TTAACTTTTT CATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

JPH3 ( NM_001271605.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001258534.1 Homo sapiens junctophilin 3 (JPH3), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu16801
Clone ID Related Accession (Same CDS sequence)	NM_001271605.2 , NM_001271605.1
Accession Version	NM_001271605.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 453bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	junctophilin-3 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC092720.4, AB593088.1 and BC008690.1. On May 31, 2019 this sequence version replaced NM_001271605.1. Transcript Variant: This variant (3) lacks several exons and includes an alternate 3' terminal exon compared to variant 1. The latter results in a frame-shift and a much shorter isoform (3) with a distinct C-terminus compared to isoform 1. This variant is described in PMID:11694876. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC008690.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCAGTG GGGGCAGGTT TAATTTTGAC GACGGAGGGT CCTACTGTGG AGGCTGGGAG 
GACGGCAAGG CGCACGGCCA TGGCGTCTGC ACCGGCCCCA AGGGCCAAGG CGAATACACC 
GGCTCGTGGA GCCACGGCTT CGAGGTGCTG GGCGTCTACA CCTGGCCCAG CGGCAACACG 
TACCAGGGCA CCTGGGCGCA GGGCAAGCGC CACGGCATCG GCCTGGAGAG CAAGGGGAAG 
TGGGTGTACA AGGGCGAGTG GACGCACGGA TTCAAGGGGC GCTACGGGGT GCGGGAGTGC 
GCGGGCAACG GGGCCAAATA CGAAGGGACC TGGAGCAACG GGCTGCAGGA CGGCTACGGG 
ACCGAGACCT ACTCGGACGG AGGTGGTTGG ACGCGGACTA GCGCTGTCGA AGCAGGCTGC 
TGGAGGGAGG AGGGAGGCCC ATCTGCTCAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258534.1
CDS	640..1092
Translation	MSSGGRFNFDDGGSYCGGWEDGKAHGHGVCTGPKGQGEYTGSWSHGFEVLGVYTWPSGNTYQGTWAQGKRHGIGLESKGKWVYKGEWTHGFKGRYGVRECAGNGAKYEGTWSNGLQDGYGTETYSDGGGWTRTSAVEAGCWREEGGPSAQ

Target ORF information:

RefSeq Version	NM_001271605.2
Organism	Homo sapiens(human)
Definition	Homo sapiens junctophilin 3 (JPH3), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271605.2

ORF Insert Sequence:

ATGTCCAGTG GGGGCAGGTT TAATTTTGAC GACGGAGGGT CCTACTGTGG AGGCTGGGAG 
GACGGCAAGG CGCACGGCCA TGGCGTCTGC ACCGGCCCCA AGGGCCAAGG CGAATACACC 
GGCTCGTGGA GCCACGGCTT CGAGGTGCTG GGCGTCTACA CCTGGCCCAG CGGCAACACG 
TACCAGGGCA CCTGGGCGCA GGGCAAGCGC CACGGCATCG GCCTGGAGAG CAAGGGGAAG 
TGGGTGTACA AGGGCGAGTG GACGCACGGA TTCAAGGGGC GCTACGGGGT GCGGGAGTGC 
GCGGGCAACG GGGCCAAATA CGAAGGGACC TGGAGCAACG GGCTGCAGGA CGGCTACGGG 
ACCGAGACCT ACTCGGACGG AGGTGGTTGG ACGCGGACTA GCGCTGTCGA AGCAGGCTGC 
TGGAGGGAGG AGGGAGGCCC ATCTGCTCAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

JPH3 ( NM_001271605.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001258534.1 Homo sapiens junctophilin 3 (JPH3), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu16801
Clone ID Related Accession (Same CDS sequence)	NM_001271605.2 , NM_001271605.1
Accession Version	NM_001271605.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 453bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	junctophilin-3 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB593088.1 and BC008690.1. Transcript Variant: This variant (3) lacks several exons and includes an alternate 3' terminal exon compared to variant 1. The latter results in a frame-shift and a much shorter isoform (3) with a distinct C-terminus compared to isoform 1. This variant is described in PMID:11694876. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC008690.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCAGTG GGGGCAGGTT TAATTTTGAC GACGGAGGGT CCTACTGTGG AGGCTGGGAG 
GACGGCAAGG CGCACGGCCA TGGCGTCTGC ACCGGCCCCA AGGGCCAAGG CGAATACACC 
GGCTCGTGGA GCCACGGCTT CGAGGTGCTG GGCGTCTACA CCTGGCCCAG CGGCAACACG 
TACCAGGGCA CCTGGGCGCA GGGCAAGCGC CACGGCATCG GCCTGGAGAG CAAGGGGAAG 
TGGGTGTACA AGGGCGAGTG GACGCACGGA TTCAAGGGGC GCTACGGGGT GCGGGAGTGC 
GCGGGCAACG GGGCCAAATA CGAAGGGACC TGGAGCAACG GGCTGCAGGA CGGCTACGGG 
ACCGAGACCT ACTCGGACGG AGGTGGTTGG ACGCGGACTA GCGCTGTCGA AGCAGGCTGC 
TGGAGGGAGG AGGGAGGCCC ATCTGCTCAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258534.1
CDS	261..713
Translation	MSSGGRFNFDDGGSYCGGWEDGKAHGHGVCTGPKGQGEYTGSWSHGFEVLGVYTWPSGNTYQGTWAQGKRHGIGLESKGKWVYKGEWTHGFKGRYGVRECAGNGAKYEGTWSNGLQDGYGTETYSDGGGWTRTSAVEAGCWREEGGPSAQ

Target ORF information:

RefSeq Version	NM_001271605.1
Organism	Homo sapiens(human)
Definition	Homo sapiens junctophilin 3 (JPH3), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271605.1

ORF Insert Sequence:

ATGTCCAGTG GGGGCAGGTT TAATTTTGAC GACGGAGGGT CCTACTGTGG AGGCTGGGAG 
GACGGCAAGG CGCACGGCCA TGGCGTCTGC ACCGGCCCCA AGGGCCAAGG CGAATACACC 
GGCTCGTGGA GCCACGGCTT CGAGGTGCTG GGCGTCTACA CCTGGCCCAG CGGCAACACG 
TACCAGGGCA CCTGGGCGCA GGGCAAGCGC CACGGCATCG GCCTGGAGAG CAAGGGGAAG 
TGGGTGTACA AGGGCGAGTG GACGCACGGA TTCAAGGGGC GCTACGGGGT GCGGGAGTGC 
GCGGGCAACG GGGCCAAATA CGAAGGGACC TGGAGCAACG GGCTGCAGGA CGGCTACGGG 
ACCGAGACCT ACTCGGACGG AGGTGGTTGG ACGCGGACTA GCGCTGTCGA AGCAGGCTGC 
TGGAGGGAGG AGGGAGGCCC ATCTGCTCAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

JPH3 ( XM_017023484.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016878973.1 Homo sapiens junctophilin 3 (JPH3), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu86169
Clone ID Related Accession (Same CDS sequence)	XM_017023484.1
Accession Version	XM_017023484.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 447bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	junctophilin-3 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCAGTG GGGGCAGGTT TAATTTTGAC GACGGAGGGT CCTACTGTGG AGGCTGGGAG 
GACGGCAAGG CGCACGGCCA TGGCGTCTGC ACCGGCCCCA AGGGCCAAGG CGAATACACC 
GGCTCGTGGA GCCACGGCTT CGAGGTGCTG GGCGTCTACA CCTGGCCCAG CGGCAACACG 
TACCAGGGCA CCTGGGCGCA GGGCAAGCGC CACGGCATCG GCCTGGAGAG CAAGGGGAAG 
TGGGTGTACA AGGGCGAGTG GACGCACGGA TTCAAGGGGC GCTACGGGGT GCGGGAGTGC 
GCGGGCAACG GGGCCAAATA CGAAGGGACC TGGAGCAACG GGCTGCAGGA CGGCTACGGG 
ACCGAGACCT ACTCGGACGG AGTTATAGCT GAGAAACAAA TGTGGCTGAA GGGCACCCCT 
ACCCACGTTG GCCGTGAGGC CGTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016878973.1
CDS	287..733
Translation	MSSGGRFNFDDGGSYCGGWEDGKAHGHGVCTGPKGQGEYTGSWSHGFEVLGVYTWPSGNTYQGTWAQGKRHGIGLESKGKWVYKGEWTHGFKGRYGVRECAGNGAKYEGTWSNGLQDGYGTETYSDGVIAEKQMWLKGTPTHVGREAV

Target ORF information:

RefSeq Version	XM_017023484.1
Organism	Homo sapiens(human)
Definition	Homo sapiens junctophilin 3 (JPH3), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017023484.1

ORF Insert Sequence:

ATGTCCAGTG GGGGCAGGTT TAATTTTGAC GACGGAGGGT CCTACTGTGG AGGCTGGGAG 
GACGGCAAGG CGCACGGCCA TGGCGTCTGC ACCGGCCCCA AGGGCCAAGG CGAATACACC 
GGCTCGTGGA GCCACGGCTT CGAGGTGCTG GGCGTCTACA CCTGGCCCAG CGGCAACACG 
TACCAGGGCA CCTGGGCGCA GGGCAAGCGC CACGGCATCG GCCTGGAGAG CAAGGGGAAG 
TGGGTGTACA AGGGCGAGTG GACGCACGGA TTCAAGGGGC GCTACGGGGT GCGGGAGTGC 
GCGGGCAACG GGGCCAAATA CGAAGGGACC TGGAGCAACG GGCTGCAGGA CGGCTACGGG 
ACCGAGACCT ACTCGGACGG AGTTATAGCT GAGAAACAAA TGTGGCTGAA GGGCACCCCT 
ACCCACGTTG GCCGTGAGGC CGTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

JPH3 ( NM_001271604.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001258533.1 Homo sapiens junctophilin 3 (JPH3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu27611
Clone ID Related Accession (Same CDS sequence)	NM_001271604.2 , NM_001271604.3
Accession Version	NM_001271604.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	junctophilin-3 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB593088.1 and BC008690.1. On Nov 10, 2012 this sequence version replaced NM_001271604.1. Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon compared to variant 1. The latter results in a frame-shift and a much shorter isoform (2) with a distinct C-terminus containing a 13 aa polyalanine stretch compared to isoform 1. This variant is described in PMID:11694876. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB593088.1, BE042890.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148093, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCAGTG GGGGCAGGTT TAATTTTGAC GACGGAGGGT CCTACTGTGG AGGCTGGGAG 
GACGGCAAGG CGCACGGCCA TGGCGTCTGC ACCGGCCCCA AGGGCCAAGG CGAATACACC 
GGCTCGTGGA GCCACGGCTT CGAGGTGCTG GGCGTCTACA CCTGGCCCAG CGGCAACACG 
TACCAGGGCA CCTGGGCGCA GGGCAAGCGC CACGGCATCG GCCTGGAGAG CAAGGGGAAG 
TGGGTGTACA AGGGCGAGTG GACGCACGGA TTCAAGGGGC GCTACGGGGT GCGGGAGTGC 
GCGGGCAACG GGGCCAAATA CGAAGGGACC TGGAGCAACG GGCTGCAGGA CGGCTACGGG 
ACCGAGACCT ACTCGGACGG AGATGCCACC GCATTCGGGG CAGAGCCGGG GCCGGAAGCC 
AGGGAGCTGC CTGCTGCTGC TGCTGCTGCT GCTGCTGCTG CTGCTGCTGC TGTAAGATGG 
TTTCTGTGCA GGGAACCTTG GCCGGCTCTG CAGCTGCCCG CCTGCCTGGA CTCTCCGATA 
TCCACTCCTC AGTGCACCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258533.1
CDS	261..821
Translation	MSSGGRFNFDDGGSYCGGWEDGKAHGHGVCTGPKGQGEYTGSWSHGFEVLGVYTWPSGNTYQGTWAQGKRHGIGLESKGKWVYKGEWTHGFKGRYGVRECAGNGAKYEGTWSNGLQDGYGTETYSDGDATAFGAEPGPEARELPAAAAAAAAAAAAAVRWFLCREPWPALQLPACLDSPISTPQCT

Target ORF information:

RefSeq Version	NM_001271604.2
Organism	Homo sapiens(human)
Definition	Homo sapiens junctophilin 3 (JPH3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271604.2

ORF Insert Sequence:

ATGTCCAGTG GGGGCAGGTT TAATTTTGAC GACGGAGGGT CCTACTGTGG AGGCTGGGAG 
GACGGCAAGG CGCACGGCCA TGGCGTCTGC ACCGGCCCCA AGGGCCAAGG CGAATACACC 
GGCTCGTGGA GCCACGGCTT CGAGGTGCTG GGCGTCTACA CCTGGCCCAG CGGCAACACG 
TACCAGGGCA CCTGGGCGCA GGGCAAGCGC CACGGCATCG GCCTGGAGAG CAAGGGGAAG 
TGGGTGTACA AGGGCGAGTG GACGCACGGA TTCAAGGGGC GCTACGGGGT GCGGGAGTGC 
GCGGGCAACG GGGCCAAATA CGAAGGGACC TGGAGCAACG GGCTGCAGGA CGGCTACGGG 
ACCGAGACCT ACTCGGACGG AGATGCCACC GCATTCGGGG CAGAGCCGGG GCCGGAAGCC 
AGGGAGCTGC CTGCTGCTGC TGCTGCTGCT GCTGCTGCTG CTGCTGCTGC TGTAAGATGG 
TTTCTGTGCA GGGAACCTTG GCCGGCTCTG CAGCTGCCCG CCTGCCTGGA CTCTCCGATA 
TCCACTCCTC AGTGCACCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

JPH3 ( NM_001271604.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001258533.1 Homo sapiens junctophilin 3 (JPH3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu27611
Clone ID Related Accession (Same CDS sequence)	NM_001271604.2 , NM_001271604.3
Accession Version	NM_001271604.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	junctophilin-3 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC092720.4, AB593088.1 and BC008690.1. On May 31, 2019 this sequence version replaced NM_001271604.2. Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon compared to variant 1. The latter results in a frame-shift and a much shorter isoform (2) with a distinct C-terminus containing a 13 aa polyalanine stretch compared to isoform 1. This variant is described in PMID:11694876. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB593088.1, SRR7410570.627337.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148093, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCAGTG GGGGCAGGTT TAATTTTGAC GACGGAGGGT CCTACTGTGG AGGCTGGGAG 
GACGGCAAGG CGCACGGCCA TGGCGTCTGC ACCGGCCCCA AGGGCCAAGG CGAATACACC 
GGCTCGTGGA GCCACGGCTT CGAGGTGCTG GGCGTCTACA CCTGGCCCAG CGGCAACACG 
TACCAGGGCA CCTGGGCGCA GGGCAAGCGC CACGGCATCG GCCTGGAGAG CAAGGGGAAG 
TGGGTGTACA AGGGCGAGTG GACGCACGGA TTCAAGGGGC GCTACGGGGT GCGGGAGTGC 
GCGGGCAACG GGGCCAAATA CGAAGGGACC TGGAGCAACG GGCTGCAGGA CGGCTACGGG 
ACCGAGACCT ACTCGGACGG AGATGCCACC GCATTCGGGG CAGAGCCGGG GCCGGAAGCC 
AGGGAGCTGC CTGCTGCTGC TGCTGCTGCT GCTGCTGCTG CTGCTGCTGC TGTAAGATGG 
TTTCTGTGCA GGGAACCTTG GCCGGCTCTG CAGCTGCCCG CCTGCCTGGA CTCTCCGATA 
TCCACTCCTC AGTGCACCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258533.1
CDS	640..1200
Translation	MSSGGRFNFDDGGSYCGGWEDGKAHGHGVCTGPKGQGEYTGSWSHGFEVLGVYTWPSGNTYQGTWAQGKRHGIGLESKGKWVYKGEWTHGFKGRYGVRECAGNGAKYEGTWSNGLQDGYGTETYSDGDATAFGAEPGPEARELPAAAAAAAAAAAAAVRWFLCREPWPALQLPACLDSPISTPQCT

Target ORF information:

RefSeq Version	NM_001271604.3
Organism	Homo sapiens(human)
Definition	Homo sapiens junctophilin 3 (JPH3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271604.3

ORF Insert Sequence:

ATGTCCAGTG GGGGCAGGTT TAATTTTGAC GACGGAGGGT CCTACTGTGG AGGCTGGGAG 
GACGGCAAGG CGCACGGCCA TGGCGTCTGC ACCGGCCCCA AGGGCCAAGG CGAATACACC 
GGCTCGTGGA GCCACGGCTT CGAGGTGCTG GGCGTCTACA CCTGGCCCAG CGGCAACACG 
TACCAGGGCA CCTGGGCGCA GGGCAAGCGC CACGGCATCG GCCTGGAGAG CAAGGGGAAG 
TGGGTGTACA AGGGCGAGTG GACGCACGGA TTCAAGGGGC GCTACGGGGT GCGGGAGTGC 
GCGGGCAACG GGGCCAAATA CGAAGGGACC TGGAGCAACG GGCTGCAGGA CGGCTACGGG 
ACCGAGACCT ACTCGGACGG AGATGCCACC GCATTCGGGG CAGAGCCGGG GCCGGAAGCC 
AGGGAGCTGC CTGCTGCTGC TGCTGCTGCT GCTGCTGCTG CTGCTGCTGC TGTAAGATGG 
TTTCTGTGCA GGGAACCTTG GCCGGCTCTG CAGCTGCCCG CCTGCCTGGA CTCTCCGATA 
TCCACTCCTC AGTGCACCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

JPH3 ( XM_017023483.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016878972.1 Homo sapiens junctophilin 3 (JPH3), transcript variant X1, mRNA.

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CloneID	OHu86168
Clone ID Related Accession (Same CDS sequence)	XM_017023483.1
Accession Version	XM_017023483.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 531bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	junctophilin-3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCAGTG GGGGCAGGTT TAATTTTGAC GACGGAGGGT CCTACTGTGG AGGCTGGGAG 
GACGGCAAGG CGCACGGCCA TGGCGTCTGC ACCGGCCCCA AGGGCCAAGG CGAATACACC 
GGCTCGTGGA GCCACGGCTT CGAGGTGCTG GGCGTCTACA CCTGGCCCAG CGGCAACACG 
TACCAGGGCA CCTGGGCGCA GGGCAAGCGC CACGGCATCG GCCTGGAGAG CAAGGGGAAG 
TGGGTGTACA AGGGCGAGTG GACGCACGGA TTCAAGGGGC GCTACGGGGT GCGGGAGTGC 
GCGGGCAACG GGGCCAAATA CGAAGGGACC TGGAGCAACG GGCTGCAGGA CGGCTACGGG 
ACCGAGACCT ACTCGGACGG AGTGGCTGCA TCGTTTTCAC CATTAGTTGA GGGAATCGAT 
CTGTGCCTTC ATTCTAAGAT GCCACCGCAT TCGGGGCAGA GCCGGGGCCG GAAGCCAGGG 
AGCTGCCTGC TGCTGCTGCT GCTGCTGCTG CTGCTGCTGC TGCTGCTGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016878972.1
CDS	287..817
Translation	MSSGGRFNFDDGGSYCGGWEDGKAHGHGVCTGPKGQGEYTGSWSHGFEVLGVYTWPSGNTYQGTWAQGKRHGIGLESKGKWVYKGEWTHGFKGRYGVRECAGNGAKYEGTWSNGLQDGYGTETYSDGVAASFSPLVEGIDLCLHSKMPPHSGQSRGRKPGSCLLLLLLLLLLLLLL

Target ORF information:

RefSeq Version	XM_017023483.1
Organism	Homo sapiens(human)
Definition	Homo sapiens junctophilin 3 (JPH3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017023483.1

ORF Insert Sequence:

ATGTCCAGTG GGGGCAGGTT TAATTTTGAC GACGGAGGGT CCTACTGTGG AGGCTGGGAG 
GACGGCAAGG CGCACGGCCA TGGCGTCTGC ACCGGCCCCA AGGGCCAAGG CGAATACACC 
GGCTCGTGGA GCCACGGCTT CGAGGTGCTG GGCGTCTACA CCTGGCCCAG CGGCAACACG 
TACCAGGGCA CCTGGGCGCA GGGCAAGCGC CACGGCATCG GCCTGGAGAG CAAGGGGAAG 
TGGGTGTACA AGGGCGAGTG GACGCACGGA TTCAAGGGGC GCTACGGGGT GCGGGAGTGC 
GCGGGCAACG GGGCCAAATA CGAAGGGACC TGGAGCAACG GGCTGCAGGA CGGCTACGGG 
ACCGAGACCT ACTCGGACGG AGTGGCTGCA TCGTTTTCAC CATTAGTTGA GGGAATCGAT 
CTGTGCCTTC ATTCTAAGAT GCCACCGCAT TCGGGGCAGA GCCGGGGCCG GAAGCCAGGG 
AGCTGCCTGC TGCTGCTGCT GCTGCTGCTG CTGCTGCTGC TGCTGCTGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Epigenomic and Functional Characterization of Junctophilin 3 (JPH3) as a Novel Tumor Suppressor Being Frequently Inactivated by Promoter CpG Methylation in Digestive Cancers.
Theranostics7(7)2150-2163(2017)
Hu X,Kuang Y,Li L,Tang H,Shi Q,Shu X,Zhang Y,Chan FK,Tao Q,He C

Expanding the Spectrum of Genes Involved in Huntington Disease Using a Combined Clinical and Genetic Approach.
JAMA neurology73(9)1105-14(2016 Sep)
Mariani LL,Tesson C,Charles P,Cazeneuve C,Hahn V,Youssov K,Freeman L,Grabli D,Roze E,No?l S,Peuvion JN,Bachoud-Levi AC,Brice A,Stevanin G,Durr A

Junctophilin 3 expresses in pancreatic beta cells and is required for glucose-stimulated insulin secretion.
Cell death & disease7(6)e2275(2016 Jun)
Li L,Pan ZF,Huang X,Wu BW,Li T,Kang MX,Ge RS,Hu XY,Zhang YH,Ge LJ,Zhu DY,Wu YL,Lou YJ

Junctophilin 3 (JPH3) expansion mutations causing Huntington disease like 2 (HDL2) are common in South African patients with African ancestry and a Huntington disease phenotype.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics168(7)573-85(2015 Oct)
Krause A,Mitchell C,Essop F,Tager S,Temlett J,Stevanin G,Ross C,Rudnicki D,Margolis R

The Repeat Expansion Diseases: The dark side of DNA repair.
DNA repair3296-105(2015 Aug)
Zhao XN,Usdin K

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JPH3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

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ORF Insert Sequence:

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

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ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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