CHRNA10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CHRNA10
Entrez Gene ID	57053
Full Name	cholinergic receptor nicotinic alpha 10 subunit
General protein information	Preferred Names cholinergic receptor nicotinic alpha 10 subunit Names neuronal acetylcholine receptor subunit alpha-10 NACHR alpha-10 acetylcholine receptor, nicotinic, alpha 10 (neuronal) cholinergic receptor, nicotinic alpha 10 cholinergic receptor, nicotinic, alpha 10 (neuronal) cholinergic receptor, nicotinic, alpha polypeptide 10 nicotinic acetylcholine receptor subunit alpha-10
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p15.4
Disorder MIM:	606372

mRNA and Protein(s)

mRNA	Protein	Name
XM_011520234.2	XP_011518536.1	neuronal acetylcholine receptor subunit alpha-10 isoform X1
XM_011520234.1	XP_011518536.1	neuronal acetylcholine receptor subunit alpha-10 isoform X1
NM_020402.3	NP_065135.2	neuronal acetylcholine receptor subunit alpha-10 isoform a precursor
NM_001303034.1	NP_001289963.1	neuronal acetylcholine receptor subunit alpha-10 isoform b
NM_020402.4	NP_065135.2	neuronal acetylcholine receptor subunit alpha-10 isoform a precursor
NM_001303035.1	NP_001289964.1	neuronal acetylcholine receptor subunit alpha-10 isoform b

Pathways from BioSystems

Homologies

	CHRNA10	XP_001113644.1
Gallus gallus (chicken)	CHRNA10	NP_001094506.1
Danio rerio (zebrafish)	chrna10a	NP_001038269.1
Xenopus tropicalis (tropical clawed frog)	chrna10	XP_002942918.2
Bos taurus (cattle)	CHRNA10	XP_005216267.1
Mus musculus (house mouse)	Chrna10	NP_001074893.1
Homo sapiens (human)	CHRNA10	NP_065135.2
Rattus norvegicus (Norway rat)	Chrna10	NP_072161.1
Caenorhabditis elegans (roundworm)	acr-21	NP_498452.3
Pan troglodytes (chimpanzee)	CHRNA10	XP_001158734.1

Gene Ontology
Bibliography

Related articles in PubMed

Molecular basis for the differential sensitivity of rat and human ?9?10 nAChRs to ?-conotoxin RgIA.
Azam L, McIntosh JM
Journal of neurochemistry122(6)1137-44(2012 Sep)

Why do young women smoke? VI. A controlled study of nicotine effects on attention: pharmacogenetic interactions.
Rigbi A, Yakir A, Sarner-Kanyas K, Pollak Y, Lerer B
The pharmacogenomics journal11(1)45-52(2011 Feb)

Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.
Saccone NL, Schwantes-An TH, Wang JC, Grucza RA, Breslau N, Hatsukami D, Johnson EO, Rice JP, Goate AM, Bierut LJ
Genes, brain, and behavior9(7)741-50(2010 Oct)

Association of CHRN genes with "dizziness" to tobacco.
Ehringer MA, McQueen MB, Hoft NR, Saccone NL, Stitzel JA, Wang JC, Bierut LJ
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics153B(2)600-609(2010 Mar)

Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.
Saccone NL, Saccone SF, Hinrichs AL, Stitzel JA, Duan W, Pergadia ML, Agrawal A, Breslau N, Grucza RA, Hatsukami D, Johnson EO, Madden PA, Swan GE, Wang JC, Goate AM, Rice JP, Bierut LJ
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics150B(4)453-66(2009 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A two order of magnitude species difference is reported in potency of alpha-conotoxin RgIA for rat versus human alpha9alpha10 nAChR.
Title: Molecular basis for the differential sensitivity of rat and human ?9?10 nAChRs to ?-conotoxin RgIA.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Why do young women smoke? VI. A controlled study of nicotine effects on attention: pharmacogenetic interactions.

Observational study of gene-disease association. (HuGE Navigator)
Title: A large-scale candidate gene association study of age at menarche and age at natural menopause.

Observational study of gene-disease association. (HuGE Navigator)
Title: Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

The following CHRNA10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CHRNA10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu70258	NM_020402.4 Latest version!	Homo sapiens cholinergic receptor nicotinic alpha 10 subunit (CHRNA10), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu70257	NM_001303035.1 Latest version!	Homo sapiens cholinergic receptor nicotinic alpha 10 subunit (CHRNA10), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu70257	NM_001303034.1 Latest version!	Homo sapiens cholinergic receptor nicotinic alpha 10 subunit (CHRNA10), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu70257	XM_011520234.2 Latest version!	Homo sapiens cholinergic receptor nicotinic alpha 10 subunit (CHRNA10), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu70257	XM_011520234.1	Homo sapiens cholinergic receptor nicotinic alpha 10 subunit (CHRNA10), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu70258	NM_020402.3	Homo sapiens cholinergic receptor nicotinic alpha 10 subunit (CHRNA10), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CHRNA10 ( NM_020402.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_065135.2 Homo sapiens cholinergic receptor nicotinic alpha 10 subunit (CHRNA10), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu70258
Clone ID Related Accession (Same CDS sequence)	NM_020402.3 , NM_020402.4
Accession Version	NM_020402.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1353bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	neuronal acetylcholine receptor subunit alpha-10 isoform a precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF199235.2 and AC060812.15. On May 17, 2019 this sequence version replaced NM_020402.3. Transcript Variant: This variant (1) encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF199235.2, AJ278118.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01820697, SAMN04284274 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000250699.2/ ENSP00000250699.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGGCTCC GGAGCCACCA CCTCAGCCTG GGCCTTCTGC TTCTGTTTCT ACTCCCTGCA 
GAGTGCCTGG GAGCTGAGGG CCGGCTGGCT CTCAAGCTGT TCCGTGACCT CTTTGCCAAC 
TACACAAGTG CCCTGAGACC TGTGGCAGAC ACAGACCAGA CTCTGAATGT GACCCTGGAG 
GTGACACTGT CCCAGATCAT CGACATGGAT GAACGGAACC AGGTGCTGAC CCTGTATCTG 
TGGATACGGC AGGAGTGGAC AGATGCCTAC CTACGATGGG ACCCCAATGC CTATGGTGGC 
CTGGATGCCA TCCGCATCCC CAGCAGTCTT GTGTGGCGGC CAGACATCGT ACTCTATAAC 
AAAGCCGACG CGCAGCCTCC AGGTTCCGCC AGCACCAACG TGGTCCTGCG CCACGATGGC 
GCCGTGCGCT GGGACGCGCC GGCCATCACG CGCAGCTCGT GCCGCGTGGA TGTAGCAGCC 
TTCCCGTTCG ACGCCCAGCA CTGCGGCCTG ACGTTCGGCT CCTGGACTCA CGGCGGGCAC 
CAACTGGATG TGCGGCCGCG CGGCGCTGCA GCCAGCCTGG CGGACTTCGT GGAGAACGTG 
GAGTGGCGCG TGCTGGGCAT GCCGGCGCGG CGGCGCGTGC TCACCTACGG CTGCTGCTCC 
GAGCCCTACC CCGACGTCAC CTTCACGCTG CTGCTGCGCC GCCGCGCCGC CGCCTACGTG 
TGCAACCTGC TGCTGCCCTG CGTGCTCATC TCGCTGCTTG CGCCGCTCGC CTTCCACCTG 
CCTGCCGACT CAGGCGAGAA GGTGTCGCTG GGCGTCACCG TGCTGCTGGC GCTCACCGTC 
TTCCAGTTGC TGCTGGCCGA GAGCATGCCA CCGGCCGAGA GCGTGCCGCT CATCGGGAAG 
TACTACATGG CCACTATGAC CATGGTCACA TTCTCAACAG CACTCACCAT CCTTATCATG 
AACCTGCATT ACTGTGGTCC CAGTGTCCGC CCAGTGCCAG CCTGGGCTAG GGCCCTCCTG 
CTGGGACACC TGGCACGGGG CCTGTGCGTG CGGGAAAGAG GGGAGCCCTG TGGGCAGTCC 
AGGCCACCTG AGTTATCTCC TAGCCCCCAG TCGCCTGAAG GAGGGGCTGG CCCCCCAGCG 
GGCCCTTGCC ACGAGCCACG ATGTCTGTGC CGCCAGGAAG CCCTACTGCA CCACGTAGCC 
ACCATTGCCA ATACCTTCCG CAGCCACCGA GCTGCCCAGC GCTGCCATGA GGACTGGAAG 
CGCCTGGCCC GTGTGATGGA CCGCTTCTTC CTGGCCATCT TCTTCTCCAT GGCCCTGGTC 
ATGAGCCTCC TGGTGCTGGT GCAGGCCCTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065135.2
CDS	73..1425
Translation	MGLRSHHLSLGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL

Target ORF information:

RefSeq Version	NM_020402.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cholinergic receptor nicotinic alpha 10 subunit (CHRNA10), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020402.4

ORF Insert Sequence:

ATGGGGCTCC GGAGCCACCA CCTCAGCCTG GGCCTTCTGC TTCTGTTTCT ACTCCCTGCA 
GAGTGCCTGG GAGCTGAGGG CCGGCTGGCT CTCAAGCTGT TCCGTGACCT CTTTGCCAAC 
TACACAAGTG CCCTGAGACC TGTGGCAGAC ACAGACCAGA CTCTGAATGT GACCCTGGAG 
GTGACACTGT CCCAGATCAT CGACATGGAT GAACGGAACC AGGTGCTGAC CCTGTATCTG 
TGGATACGGC AGGAGTGGAC AGATGCCTAC CTACGATGGG ACCCCAATGC CTATGGTGGC 
CTGGATGCCA TCCGCATCCC CAGCAGTCTT GTGTGGCGGC CAGACATCGT ACTCTATAAC 
AAAGCCGACG CGCAGCCTCC AGGTTCCGCC AGCACCAACG TGGTCCTGCG CCACGATGGC 
GCCGTGCGCT GGGACGCGCC GGCCATCACG CGCAGCTCGT GCCGCGTGGA TGTAGCAGCC 
TTCCCGTTCG ACGCCCAGCA CTGCGGCCTG ACGTTCGGCT CCTGGACTCA CGGCGGGCAC 
CAACTGGATG TGCGGCCGCG CGGCGCTGCA GCCAGCCTGG CGGACTTCGT GGAGAACGTG 
GAGTGGCGCG TGCTGGGCAT GCCGGCGCGG CGGCGCGTGC TCACCTACGG CTGCTGCTCC 
GAGCCCTACC CCGACGTCAC CTTCACGCTG CTGCTGCGCC GCCGCGCCGC CGCCTACGTG 
TGCAACCTGC TGCTGCCCTG CGTGCTCATC TCGCTGCTTG CGCCGCTCGC CTTCCACCTG 
CCTGCCGACT CAGGCGAGAA GGTGTCGCTG GGCGTCACCG TGCTGCTGGC GCTCACCGTC 
TTCCAGTTGC TGCTGGCCGA GAGCATGCCA CCGGCCGAGA GCGTGCCGCT CATCGGGAAG 
TACTACATGG CCACTATGAC CATGGTCACA TTCTCAACAG CACTCACCAT CCTTATCATG 
AACCTGCATT ACTGTGGTCC CAGTGTCCGC CCAGTGCCAG CCTGGGCTAG GGCCCTCCTG 
CTGGGACACC TGGCACGGGG CCTGTGCGTG CGGGAAAGAG GGGAGCCCTG TGGGCAGTCC 
AGGCCACCTG AGTTATCTCC TAGCCCCCAG TCGCCTGAAG GAGGGGCTGG CCCCCCAGCG 
GGCCCTTGCC ACGAGCCACG ATGTCTGTGC CGCCAGGAAG CCCTACTGCA CCACGTAGCC 
ACCATTGCCA ATACCTTCCG CAGCCACCGA GCTGCCCAGC GCTGCCATGA GGACTGGAAG 
CGCCTGGCCC GTGTGATGGA CCGCTTCTTC CTGGCCATCT TCTTCTCCAT GGCCCTGGTC 
ATGAGCCTCC TGGTGCTGGT GCAGGCCCTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CHRNA10 ( NM_001303034.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001289963.1 Homo sapiens cholinergic receptor nicotinic alpha 10 subunit (CHRNA10), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu70257
Clone ID Related Accession (Same CDS sequence)	XM_011520234.2 , XM_011520234.1 , NM_001303034.1 , NM_001303035.1
Accession Version	NM_001303034.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 735bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	neuronal acetylcholine receptor subunit alpha-10 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF199235.2, BC143303.1 and AC060812.15. Transcript Variant: This variant (2) uses an alternate splice site at an internal exon compared to variant 1. This difference results in translation initiation at a downstream in-frame start site through ribosomal re-initiation or leaky scanning. The encoded isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC143303.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2158188, SAMN01820697 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGGCGC GGCGGCGCGT GCTCACCTAC GGCTGCTGCT CCGAGCCCTA CCCCGACGTC 
ACCTTCACGC TGCTGCTGCG CCGCCGCGCC GCCGCCTACG TGTGCAACCT GCTGCTGCCC 
TGCGTGCTCA TCTCGCTGCT TGCGCCGCTC GCCTTCCACC TGCCTGCCGA CTCAGGCGAG 
AAGGTGTCGC TGGGCGTCAC CGTGCTGCTG GCGCTCACCG TCTTCCAGTT GCTGCTGGCC 
GAGAGCATGC CACCGGCCGA GAGCGTGCCG CTCATCGGGA AGTACTACAT GGCCACTATG 
ACCATGGTCA CATTCTCAAC AGCACTCACC ATCCTTATCA TGAACCTGCA TTACTGTGGT 
CCCAGTGTCC GCCCAGTGCC AGCCTGGGCT AGGGCCCTCC TGCTGGGACA CCTGGCACGG 
GGCCTGTGCG TGCGGGAAAG AGGGGAGCCC TGTGGGCAGT CCAGGCCACC TGAGTTATCT 
CCTAGCCCCC AGTCGCCTGA AGGAGGGGCT GGCCCCCCAG CGGGCCCTTG CCACGAGCCA 
CGATGTCTGT GCCGCCAGGA AGCCCTACTG CACCACGTAG CCACCATTGC CAATACCTTC 
CGCAGCCACC GAGCTGCCCA GCGCTGCCAT GAGGACTGGA AGCGCCTGGC CCGTGTGATG 
GACCGCTTCT TCCTGGCCAT CTTCTTCTCC ATGGCCCTGG TCATGAGCCT CCTGGTGCTG 
GTGCAGGCCC TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001289963.1
CDS	753..1487
Translation	MPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL

Target ORF information:

RefSeq Version	NM_001303034.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cholinergic receptor nicotinic alpha 10 subunit (CHRNA10), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001303034.1

ORF Insert Sequence:

ATGCCGGCGC GGCGGCGCGT GCTCACCTAC GGCTGCTGCT CCGAGCCCTA CCCCGACGTC 
ACCTTCACGC TGCTGCTGCG CCGCCGCGCC GCCGCCTACG TGTGCAACCT GCTGCTGCCC 
TGCGTGCTCA TCTCGCTGCT TGCGCCGCTC GCCTTCCACC TGCCTGCCGA CTCAGGCGAG 
AAGGTGTCGC TGGGCGTCAC CGTGCTGCTG GCGCTCACCG TCTTCCAGTT GCTGCTGGCC 
GAGAGCATGC CACCGGCCGA GAGCGTGCCG CTCATCGGGA AGTACTACAT GGCCACTATG 
ACCATGGTCA CATTCTCAAC AGCACTCACC ATCCTTATCA TGAACCTGCA TTACTGTGGT 
CCCAGTGTCC GCCCAGTGCC AGCCTGGGCT AGGGCCCTCC TGCTGGGACA CCTGGCACGG 
GGCCTGTGCG TGCGGGAAAG AGGGGAGCCC TGTGGGCAGT CCAGGCCACC TGAGTTATCT 
CCTAGCCCCC AGTCGCCTGA AGGAGGGGCT GGCCCCCCAG CGGGCCCTTG CCACGAGCCA 
CGATGTCTGT GCCGCCAGGA AGCCCTACTG CACCACGTAG CCACCATTGC CAATACCTTC 
CGCAGCCACC GAGCTGCCCA GCGCTGCCAT GAGGACTGGA AGCGCCTGGC CCGTGTGATG 
GACCGCTTCT TCCTGGCCAT CTTCTTCTCC ATGGCCCTGG TCATGAGCCT CCTGGTGCTG 
GTGCAGGCCC TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CHRNA10 ( NM_001303035.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001289964.1 Homo sapiens cholinergic receptor nicotinic alpha 10 subunit (CHRNA10), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu70257
Clone ID Related Accession (Same CDS sequence)	XM_011520234.2 , XM_011520234.1 , NM_001303034.1 , NM_001303035.1
Accession Version	NM_001303035.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 735bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	neuronal acetylcholine receptor subunit alpha-10 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF199235.2, BC136250.1 and AC060812.15. Transcript Variant: This variant (3) uses two alternate splice sites at an internal exon compared to variant 1. These differences result in translation initiation at a downstream in-frame start site through ribosomal re-initiation or leaky scanning. The encoded isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC136250.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1968832 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGGCGC GGCGGCGCGT GCTCACCTAC GGCTGCTGCT CCGAGCCCTA CCCCGACGTC 
ACCTTCACGC TGCTGCTGCG CCGCCGCGCC GCCGCCTACG TGTGCAACCT GCTGCTGCCC 
TGCGTGCTCA TCTCGCTGCT TGCGCCGCTC GCCTTCCACC TGCCTGCCGA CTCAGGCGAG 
AAGGTGTCGC TGGGCGTCAC CGTGCTGCTG GCGCTCACCG TCTTCCAGTT GCTGCTGGCC 
GAGAGCATGC CACCGGCCGA GAGCGTGCCG CTCATCGGGA AGTACTACAT GGCCACTATG 
ACCATGGTCA CATTCTCAAC AGCACTCACC ATCCTTATCA TGAACCTGCA TTACTGTGGT 
CCCAGTGTCC GCCCAGTGCC AGCCTGGGCT AGGGCCCTCC TGCTGGGACA CCTGGCACGG 
GGCCTGTGCG TGCGGGAAAG AGGGGAGCCC TGTGGGCAGT CCAGGCCACC TGAGTTATCT 
CCTAGCCCCC AGTCGCCTGA AGGAGGGGCT GGCCCCCCAG CGGGCCCTTG CCACGAGCCA 
CGATGTCTGT GCCGCCAGGA AGCCCTACTG CACCACGTAG CCACCATTGC CAATACCTTC 
CGCAGCCACC GAGCTGCCCA GCGCTGCCAT GAGGACTGGA AGCGCCTGGC CCGTGTGATG 
GACCGCTTCT TCCTGGCCAT CTTCTTCTCC ATGGCCCTGG TCATGAGCCT CCTGGTGCTG 
GTGCAGGCCC TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001289964.1
CDS	686..1420
Translation	MPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL

Target ORF information:

RefSeq Version	NM_001303035.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cholinergic receptor nicotinic alpha 10 subunit (CHRNA10), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001303035.1

ORF Insert Sequence:

ATGCCGGCGC GGCGGCGCGT GCTCACCTAC GGCTGCTGCT CCGAGCCCTA CCCCGACGTC 
ACCTTCACGC TGCTGCTGCG CCGCCGCGCC GCCGCCTACG TGTGCAACCT GCTGCTGCCC 
TGCGTGCTCA TCTCGCTGCT TGCGCCGCTC GCCTTCCACC TGCCTGCCGA CTCAGGCGAG 
AAGGTGTCGC TGGGCGTCAC CGTGCTGCTG GCGCTCACCG TCTTCCAGTT GCTGCTGGCC 
GAGAGCATGC CACCGGCCGA GAGCGTGCCG CTCATCGGGA AGTACTACAT GGCCACTATG 
ACCATGGTCA CATTCTCAAC AGCACTCACC ATCCTTATCA TGAACCTGCA TTACTGTGGT 
CCCAGTGTCC GCCCAGTGCC AGCCTGGGCT AGGGCCCTCC TGCTGGGACA CCTGGCACGG 
GGCCTGTGCG TGCGGGAAAG AGGGGAGCCC TGTGGGCAGT CCAGGCCACC TGAGTTATCT 
CCTAGCCCCC AGTCGCCTGA AGGAGGGGCT GGCCCCCCAG CGGGCCCTTG CCACGAGCCA 
CGATGTCTGT GCCGCCAGGA AGCCCTACTG CACCACGTAG CCACCATTGC CAATACCTTC 
CGCAGCCACC GAGCTGCCCA GCGCTGCCAT GAGGACTGGA AGCGCCTGGC CCGTGTGATG 
GACCGCTTCT TCCTGGCCAT CTTCTTCTCC ATGGCCCTGG TCATGAGCCT CCTGGTGCTG 
GTGCAGGCCC TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CHRNA10 ( NM_020402.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_065135.2 Homo sapiens cholinergic receptor nicotinic alpha 10 subunit (CHRNA10), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu70258
Clone ID Related Accession (Same CDS sequence)	NM_020402.3 , NM_020402.4
Accession Version	NM_020402.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1353bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	neuronal acetylcholine receptor subunit alpha-10 isoform a precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF199235.2 and AC060812.15. On Dec 14, 2014 this sequence version replaced NM_020402.2. Transcript Variant: This variant (1) encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF199235.2, AJ295237.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01820697, SAMN04284274 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGCTCC GGAGCCACCA CCTCAGCCTG GGCCTTCTGC TTCTGTTTCT ACTCCCTGCA 
GAGTGCCTGG GAGCTGAGGG CCGGCTGGCT CTCAAGCTGT TCCGTGACCT CTTTGCCAAC 
TACACAAGTG CCCTGAGACC TGTGGCAGAC ACAGACCAGA CTCTGAATGT GACCCTGGAG 
GTGACACTGT CCCAGATCAT CGACATGGAT GAACGGAACC AGGTGCTGAC CCTGTATCTG 
TGGATACGGC AGGAGTGGAC AGATGCCTAC CTACGATGGG ACCCCAATGC CTATGGTGGC 
CTGGATGCCA TCCGCATCCC CAGCAGTCTT GTGTGGCGGC CAGACATCGT ACTCTATAAC 
AAAGCCGACG CGCAGCCTCC AGGTTCCGCC AGCACCAACG TGGTCCTGCG CCACGATGGC 
GCCGTGCGCT GGGACGCGCC GGCCATCACG CGCAGCTCGT GCCGCGTGGA TGTAGCAGCC 
TTCCCGTTCG ACGCCCAGCA CTGCGGCCTG ACGTTCGGCT CCTGGACTCA CGGCGGGCAC 
CAACTGGATG TGCGGCCGCG CGGCGCTGCA GCCAGCCTGG CGGACTTCGT GGAGAACGTG 
GAGTGGCGCG TGCTGGGCAT GCCGGCGCGG CGGCGCGTGC TCACCTACGG CTGCTGCTCC 
GAGCCCTACC CCGACGTCAC CTTCACGCTG CTGCTGCGCC GCCGCGCCGC CGCCTACGTG 
TGCAACCTGC TGCTGCCCTG CGTGCTCATC TCGCTGCTTG CGCCGCTCGC CTTCCACCTG 
CCTGCCGACT CAGGCGAGAA GGTGTCGCTG GGCGTCACCG TGCTGCTGGC GCTCACCGTC 
TTCCAGTTGC TGCTGGCCGA GAGCATGCCA CCGGCCGAGA GCGTGCCGCT CATCGGGAAG 
TACTACATGG CCACTATGAC CATGGTCACA TTCTCAACAG CACTCACCAT CCTTATCATG 
AACCTGCATT ACTGTGGTCC CAGTGTCCGC CCAGTGCCAG CCTGGGCTAG GGCCCTCCTG 
CTGGGACACC TGGCACGGGG CCTGTGCGTG CGGGAAAGAG GGGAGCCCTG TGGGCAGTCC 
AGGCCACCTG AGTTATCTCC TAGCCCCCAG TCGCCTGAAG GAGGGGCTGG CCCCCCAGCG 
GGCCCTTGCC ACGAGCCACG ATGTCTGTGC CGCCAGGAAG CCCTACTGCA CCACGTAGCC 
ACCATTGCCA ATACCTTCCG CAGCCACCGA GCTGCCCAGC GCTGCCATGA GGACTGGAAG 
CGCCTGGCCC GTGTGATGGA CCGCTTCTTC CTGGCCATCT TCTTCTCCAT GGCCCTGGTC 
ATGAGCCTCC TGGTGCTGGT GCAGGCCCTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065135.2
CDS	73..1425
Translation	MGLRSHHLSLGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL

Target ORF information:

RefSeq Version	NM_020402.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cholinergic receptor nicotinic alpha 10 subunit (CHRNA10), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020402.3

ORF Insert Sequence:

ATGGGGCTCC GGAGCCACCA CCTCAGCCTG GGCCTTCTGC TTCTGTTTCT ACTCCCTGCA 
GAGTGCCTGG GAGCTGAGGG CCGGCTGGCT CTCAAGCTGT TCCGTGACCT CTTTGCCAAC 
TACACAAGTG CCCTGAGACC TGTGGCAGAC ACAGACCAGA CTCTGAATGT GACCCTGGAG 
GTGACACTGT CCCAGATCAT CGACATGGAT GAACGGAACC AGGTGCTGAC CCTGTATCTG 
TGGATACGGC AGGAGTGGAC AGATGCCTAC CTACGATGGG ACCCCAATGC CTATGGTGGC 
CTGGATGCCA TCCGCATCCC CAGCAGTCTT GTGTGGCGGC CAGACATCGT ACTCTATAAC 
AAAGCCGACG CGCAGCCTCC AGGTTCCGCC AGCACCAACG TGGTCCTGCG CCACGATGGC 
GCCGTGCGCT GGGACGCGCC GGCCATCACG CGCAGCTCGT GCCGCGTGGA TGTAGCAGCC 
TTCCCGTTCG ACGCCCAGCA CTGCGGCCTG ACGTTCGGCT CCTGGACTCA CGGCGGGCAC 
CAACTGGATG TGCGGCCGCG CGGCGCTGCA GCCAGCCTGG CGGACTTCGT GGAGAACGTG 
GAGTGGCGCG TGCTGGGCAT GCCGGCGCGG CGGCGCGTGC TCACCTACGG CTGCTGCTCC 
GAGCCCTACC CCGACGTCAC CTTCACGCTG CTGCTGCGCC GCCGCGCCGC CGCCTACGTG 
TGCAACCTGC TGCTGCCCTG CGTGCTCATC TCGCTGCTTG CGCCGCTCGC CTTCCACCTG 
CCTGCCGACT CAGGCGAGAA GGTGTCGCTG GGCGTCACCG TGCTGCTGGC GCTCACCGTC 
TTCCAGTTGC TGCTGGCCGA GAGCATGCCA CCGGCCGAGA GCGTGCCGCT CATCGGGAAG 
TACTACATGG CCACTATGAC CATGGTCACA TTCTCAACAG CACTCACCAT CCTTATCATG 
AACCTGCATT ACTGTGGTCC CAGTGTCCGC CCAGTGCCAG CCTGGGCTAG GGCCCTCCTG 
CTGGGACACC TGGCACGGGG CCTGTGCGTG CGGGAAAGAG GGGAGCCCTG TGGGCAGTCC 
AGGCCACCTG AGTTATCTCC TAGCCCCCAG TCGCCTGAAG GAGGGGCTGG CCCCCCAGCG 
GGCCCTTGCC ACGAGCCACG ATGTCTGTGC CGCCAGGAAG CCCTACTGCA CCACGTAGCC 
ACCATTGCCA ATACCTTCCG CAGCCACCGA GCTGCCCAGC GCTGCCATGA GGACTGGAAG 
CGCCTGGCCC GTGTGATGGA CCGCTTCTTC CTGGCCATCT TCTTCTCCAT GGCCCTGGTC 
ATGAGCCTCC TGGTGCTGGT GCAGGCCCTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CHRNA10 ( XM_011520234.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011518536.1 Homo sapiens cholinergic receptor nicotinic alpha 10 subunit (CHRNA10), transcript variant X1, mRNA.

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CloneID	OHu70257
Clone ID Related Accession (Same CDS sequence)	XM_011520234.2 , XM_011520234.1 , NM_001303034.1 , NM_001303035.1
Accession Version	XM_011520234.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 735bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	neuronal acetylcholine receptor subunit alpha-10 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011520234.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCGGCGC GGCGGCGCGT GCTCACCTAC GGCTGCTGCT CCGAGCCCTA CCCCGACGTC 
ACCTTCACGC TGCTGCTGCG CCGCCGCGCC GCCGCCTACG TGTGCAACCT GCTGCTGCCC 
TGCGTGCTCA TCTCGCTGCT TGCGCCGCTC GCCTTCCACC TGCCTGCCGA CTCAGGCGAG 
AAGGTGTCGC TGGGCGTCAC CGTGCTGCTG GCGCTCACCG TCTTCCAGTT GCTGCTGGCC 
GAGAGCATGC CACCGGCCGA GAGCGTGCCG CTCATCGGGA AGTACTACAT GGCCACTATG 
ACCATGGTCA CATTCTCAAC AGCACTCACC ATCCTTATCA TGAACCTGCA TTACTGTGGT 
CCCAGTGTCC GCCCAGTGCC AGCCTGGGCT AGGGCCCTCC TGCTGGGACA CCTGGCACGG 
GGCCTGTGCG TGCGGGAAAG AGGGGAGCCC TGTGGGCAGT CCAGGCCACC TGAGTTATCT 
CCTAGCCCCC AGTCGCCTGA AGGAGGGGCT GGCCCCCCAG CGGGCCCTTG CCACGAGCCA 
CGATGTCTGT GCCGCCAGGA AGCCCTACTG CACCACGTAG CCACCATTGC CAATACCTTC 
CGCAGCCACC GAGCTGCCCA GCGCTGCCAT GAGGACTGGA AGCGCCTGGC CCGTGTGATG 
GACCGCTTCT TCCTGGCCAT CTTCTTCTCC ATGGCCCTGG TCATGAGCCT CCTGGTGCTG 
GTGCAGGCCC TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011518536.1
CDS	4308..5042
Translation	MPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL

Target ORF information:

RefSeq Version	XM_011520234.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cholinergic receptor nicotinic alpha 10 subunit (CHRNA10), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011520234.2

ORF Insert Sequence:

ATGCCGGCGC GGCGGCGCGT GCTCACCTAC GGCTGCTGCT CCGAGCCCTA CCCCGACGTC 
ACCTTCACGC TGCTGCTGCG CCGCCGCGCC GCCGCCTACG TGTGCAACCT GCTGCTGCCC 
TGCGTGCTCA TCTCGCTGCT TGCGCCGCTC GCCTTCCACC TGCCTGCCGA CTCAGGCGAG 
AAGGTGTCGC TGGGCGTCAC CGTGCTGCTG GCGCTCACCG TCTTCCAGTT GCTGCTGGCC 
GAGAGCATGC CACCGGCCGA GAGCGTGCCG CTCATCGGGA AGTACTACAT GGCCACTATG 
ACCATGGTCA CATTCTCAAC AGCACTCACC ATCCTTATCA TGAACCTGCA TTACTGTGGT 
CCCAGTGTCC GCCCAGTGCC AGCCTGGGCT AGGGCCCTCC TGCTGGGACA CCTGGCACGG 
GGCCTGTGCG TGCGGGAAAG AGGGGAGCCC TGTGGGCAGT CCAGGCCACC TGAGTTATCT 
CCTAGCCCCC AGTCGCCTGA AGGAGGGGCT GGCCCCCCAG CGGGCCCTTG CCACGAGCCA 
CGATGTCTGT GCCGCCAGGA AGCCCTACTG CACCACGTAG CCACCATTGC CAATACCTTC 
CGCAGCCACC GAGCTGCCCA GCGCTGCCAT GAGGACTGGA AGCGCCTGGC CCGTGTGATG 
GACCGCTTCT TCCTGGCCAT CTTCTTCTCC ATGGCCCTGG TCATGAGCCT CCTGGTGCTG 
GTGCAGGCCC TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CHRNA10 ( XM_011520234.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011518536.1 Homo sapiens cholinergic receptor nicotinic alpha 10 subunit (CHRNA10), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu70257
Clone ID Related Accession (Same CDS sequence)	XM_011520234.2 , XM_011520234.1 , NM_001303034.1 , NM_001303035.1
Accession Version	XM_011520234.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 735bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	neuronal acetylcholine receptor subunit alpha-10 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCGGCGC GGCGGCGCGT GCTCACCTAC GGCTGCTGCT CCGAGCCCTA CCCCGACGTC 
ACCTTCACGC TGCTGCTGCG CCGCCGCGCC GCCGCCTACG TGTGCAACCT GCTGCTGCCC 
TGCGTGCTCA TCTCGCTGCT TGCGCCGCTC GCCTTCCACC TGCCTGCCGA CTCAGGCGAG 
AAGGTGTCGC TGGGCGTCAC CGTGCTGCTG GCGCTCACCG TCTTCCAGTT GCTGCTGGCC 
GAGAGCATGC CACCGGCCGA GAGCGTGCCG CTCATCGGGA AGTACTACAT GGCCACTATG 
ACCATGGTCA CATTCTCAAC AGCACTCACC ATCCTTATCA TGAACCTGCA TTACTGTGGT 
CCCAGTGTCC GCCCAGTGCC AGCCTGGGCT AGGGCCCTCC TGCTGGGACA CCTGGCACGG 
GGCCTGTGCG TGCGGGAAAG AGGGGAGCCC TGTGGGCAGT CCAGGCCACC TGAGTTATCT 
CCTAGCCCCC AGTCGCCTGA AGGAGGGGCT GGCCCCCCAG CGGGCCCTTG CCACGAGCCA 
CGATGTCTGT GCCGCCAGGA AGCCCTACTG CACCACGTAG CCACCATTGC CAATACCTTC 
CGCAGCCACC GAGCTGCCCA GCGCTGCCAT GAGGACTGGA AGCGCCTGGC CCGTGTGATG 
GACCGCTTCT TCCTGGCCAT CTTCTTCTCC ATGGCCCTGG TCATGAGCCT CCTGGTGCTG 
GTGCAGGCCC TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011518536.1
CDS	3887..4621
Translation	MPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL

Target ORF information:

RefSeq Version	XM_011520234.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cholinergic receptor nicotinic alpha 10 subunit (CHRNA10), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011520234.1

ORF Insert Sequence:

ATGCCGGCGC GGCGGCGCGT GCTCACCTAC GGCTGCTGCT CCGAGCCCTA CCCCGACGTC 
ACCTTCACGC TGCTGCTGCG CCGCCGCGCC GCCGCCTACG TGTGCAACCT GCTGCTGCCC 
TGCGTGCTCA TCTCGCTGCT TGCGCCGCTC GCCTTCCACC TGCCTGCCGA CTCAGGCGAG 
AAGGTGTCGC TGGGCGTCAC CGTGCTGCTG GCGCTCACCG TCTTCCAGTT GCTGCTGGCC 
GAGAGCATGC CACCGGCCGA GAGCGTGCCG CTCATCGGGA AGTACTACAT GGCCACTATG 
ACCATGGTCA CATTCTCAAC AGCACTCACC ATCCTTATCA TGAACCTGCA TTACTGTGGT 
CCCAGTGTCC GCCCAGTGCC AGCCTGGGCT AGGGCCCTCC TGCTGGGACA CCTGGCACGG 
GGCCTGTGCG TGCGGGAAAG AGGGGAGCCC TGTGGGCAGT CCAGGCCACC TGAGTTATCT 
CCTAGCCCCC AGTCGCCTGA AGGAGGGGCT GGCCCCCCAG CGGGCCCTTG CCACGAGCCA 
CGATGTCTGT GCCGCCAGGA AGCCCTACTG CACCACGTAG CCACCATTGC CAATACCTTC 
CGCAGCCACC GAGCTGCCCA GCGCTGCCAT GAGGACTGGA AGCGCCTGGC CCGTGTGATG 
GACCGCTTCT TCCTGGCCAT CTTCTTCTCC ATGGCCCTGG TCATGAGCCT CCTGGTGCTG 
GTGCAGGCCC TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Molecular basis for the differential sensitivity of rat and human ?9?10 nAChRs to ?-conotoxin RgIA.
Journal of neurochemistry122(6)1137-44(2012 Sep)
Azam L,McIntosh JM

Why do young women smoke? VI. A controlled study of nicotine effects on attention: pharmacogenetic interactions.
The pharmacogenomics journal11(1)45-52(2011 Feb)
Rigbi A,Yakir A,Sarner-Kanyas K,Pollak Y,Lerer B

Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.
Genes, brain, and behavior9(7)741-50(2010 Oct)
Saccone NL,Schwantes-An TH,Wang JC,Grucza RA,Breslau N,Hatsukami D,Johnson EO,Rice JP,Goate AM,Bierut LJ

Association of CHRN genes with "dizziness" to tobacco.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics153B(2)600-609(2010 Mar)
Ehringer MA,McQueen MB,Hoft NR,Saccone NL,Stitzel JA,Wang JC,Bierut LJ

Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics150B(4)453-66(2009 Jun)
Saccone NL,Saccone SF,Hinrichs AL,Stitzel JA,Duan W,Pergadia ML,Agrawal A,Breslau N,Grucza RA,Hatsukami D,Johnson EO,Madden PA,Swan GE,Wang JC,Goate AM,Rice JP,Bierut LJ

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CHRNA10 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム