IMP3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IMP3
Entrez Gene ID	55272
Full Name	IMP3, U3 small nucleolar ribonucleoprotein
Synonyms	BRMS2,C15orf12,MRPS4
General protein information	Preferred Names IMP3, U3 small nucleolar ribonucleoprotein Names U3 small nucleolar ribonucleoprotein protein IMP3 IMP3, U3 small nucleolar ribonucleoprotein, homolog U3 snoRNP protein 3 homolog U3 snoRNP protein IMP3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q24.2
Summary	This gene encodes the human homolog of the yeast Imp3 protein. The protein localizes to the nucleoli and interacts with the U3 snoRNP complex. The protein contains an S4 domain. [provided by RefSeq, Jul 2008].
Disorder MIM:	612980

mRNA and Protein(s)

mRNA	Protein	Name
NM_018285.3	NP_060755.1	U3 small nucleolar ribonucleoprotein protein IMP3

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Imp3	NP_001101622.1
Saccharomyces cerevisiae (baker's yeast)	IMP3	NP_012018.1
Schizosaccharomyces pombe (fission yeast)	imp3	NP_594903.1
Oryza sativa (rice)	Os04g0662100	NP_001054154.1
Xenopus tropicalis (tropical clawed frog)	imp3	NP_001004848.1
	IMP3	XP_001103881.1
Mus musculus (house mouse)	Imp3	NP_598737.1
Danio rerio (zebrafish)	imp3	NP_956561.1
Drosophila melanogaster (fruit fly)	CG4866	NP_611224.1
Caenorhabditis elegans (roundworm)	C48B6.2	NP_491972.1
Magnaporthe oryzae (rice blast fungus)	MGG_04201	XP_003719621.1
Arabidopsis thaliana (thale cress)	AT5G15750	NP_568321.1
Bos taurus (cattle)	IMP3	NP_001073056.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006372	XP_316402.2
Kluyveromyces lactis	KLLA0E15995g	XP_454669.1
Eremothecium gossypii	AGOS_ADL131C	NP_983965.1
Neurospora crassa	NCU01008	XP_961620.1
Homo sapiens (human)	IMP3	NP_060755.1
Pan troglodytes (chimpanzee)	IMP3	XP_510683.2
Canis lupus familiaris (dog)	IMP3	XP_544781.3

Gene Ontology
Bibliography

Related articles in PubMed

IMP3 expression in NSCLC brain metastases demonstrates its role as a prognostic factor in non-neuroendocrine phenotypes.
Del Gobbo A, Morotti A, Colombo AE, Vaira V, Ercoli G, Pesenti C, Bonaparte E, Guerini-Rocco E, Di Cristofori A, Locatelli M, Palleschi A, Ferrero S
Medical oncology (Northwood, London, England)35(1)2(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

IMP3 is a reliable marker for the diagnosis of colorectal cancer in endoscopic biopsies.
Title: IMP3 expression in biopsy specimens as a diagnostic biomarker for colorectal cancer.

Tissue overexpression of IMP3 might be used as a predictor of advanced disease or lymph node metastasis, and is associated with poorer prognosis in gastric cancers.
Title: Clinicopathological Implication of Insulin-like Growth Factor-II mRNA-Binding Protein 3 (IMP3) Expression in Gastric Cancer.

IMP-3 and its protein partners ILF3/NF90 and PTBP1 bind to the 3'UTRs of the cyclin mRNAs and protect them from the translational repression induced by miRNA-dependent recruitment of AGO2/GW182 complex in human cancer cells.
Title: IMP-3 protects the mRNAs of cyclins D1 and D3 from GW182/AGO2-dependent translational repression.

expression in preoperative biopsy material predictive of perineural invasion in patients with oral squamous cell carcinoma
Title: Laminin-5 and insulin-like growth factor-II mRNA binding protein-3 (IMP3) expression in preoperative biopsy specimens from oral cancer patients: Their role in neural spread risk and survival stratification.

S100P achieved 96.4% sensitivity, 93.3% specificity, 98.2% PPV, 87.5% NPV and 95.8% total accuracy, while IMP3 achieved 91.2% sensitivity, 86.7% specificity, 96.2% PPV, 72.2% NPV and 90.3% total accuracy for pancreatic ductal adenocarcinoma (PDA).Both markers were sensitive and specific for diagnosis of PDA.
Title: The role of S100P and IMP3 in the cytologic diagnosis of pancreatic adenocarcinoma.

The following IMP3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IMP3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu27149	NM_018285.3 Latest version!	Homo sapiens IMP U3 small nucleolar ribonucleoprotein 3 (IMP3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IMP3 ( NM_018285.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_060755.1 Homo sapiens IMP U3 small nucleolar ribonucleoprotein 3 (IMP3), mRNA.

Price & Availability↑

CloneID	OHu27149
Clone ID Related Accession (Same CDS sequence)	NM_018285.3
Accession Version	NM_018285.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 555bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-21
Organism	Homo sapiens(human)
Product	U3 small nucleolar ribonucleoprotein protein IMP3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA375950.1, AY050497.1, AA365493.1 and BM970419.1. On Aug 29, 2009 this sequence version replaced NM_018285.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTGCGGA AGCTTAAGTT CCACGAGCAG AAGCTGCTGA AGCAGGTGGA CTTCCTGAAC 
TGGGAGGTCA CCGACCACAA CCTGCACGAG CTGCGCGTGC TGCGGCGTTA CCGGCTGCAG 
CGGCGGGAGG ACTACACGCG CTACAACCAG CTGAGCCGTG CCGTGCGTGA GCTGGCGCGG 
CGCCTGCGCG ACCTGCCCGA ACGCGACCAG TTCCGCGTGC GCGCTTCGGC CGCGCTGCTG 
GACAAGCTGT ATGCTCTCGG CTTGGTGCCC ACGCGCGGTT CGCTGGAGCT CTGCGACTTC 
GTCACGGCCT CGTCCTTCTG CCGCCGCCGC CTCCCCACCG TGCTCCTCAA GCTGCGCATG 
GCGCAGCACC TTCAGGCTGC CGTGGCCTTT GTGGAGCAAG GGCACGTACG CGTGGGCCCT 
GACGTGGTTA CCGACCCCGC CTTCCTTGTC ACGCGCAGCA TGGAGGACTT TGTCACTTGG 
GTGGACTCGT CCAAGATCAA GCGGCACGTG CTAGAGTACA ATGAGGAGCG CGATGACTTC 
GATCTGGAAG CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060755.1
CDS	156..710
Translation	MVRKLKFHEQKLLKQVDFLNWEVTDHNLHELRVLRRYRLQRREDYTRYNQLSRAVRELARRLRDLPERDQFRVRASAALLDKLYALGLVPTRGSLELCDFVTASSFCRRRLPTVLLKLRMAQHLQAAVAFVEQGHVRVGPDVVTDPAFLVTRSMEDFVTWVDSSKIKRHVLEYNEERDDFDLEA

Target ORF information:

RefSeq Version	NM_018285.3
Organism	Homo sapiens(human)
Definition	Homo sapiens IMP U3 small nucleolar ribonucleoprotein 3 (IMP3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018285.3

ORF Insert Sequence:

ATGGTGCGGA AGCTTAAGTT CCACGAGCAG AAGCTGCTGA AGCAGGTGGA CTTCCTGAAC 
TGGGAGGTCA CCGACCACAA CCTGCACGAG CTGCGCGTGC TGCGGCGTTA CCGGCTGCAG 
CGGCGGGAGG ACTACACGCG CTACAACCAG CTGAGCCGTG CCGTGCGTGA GCTGGCGCGG 
CGCCTGCGCG ACCTGCCCGA ACGCGACCAG TTCCGCGTGC GCGCTTCGGC CGCGCTGCTG 
GACAAGCTGT ATGCTCTCGG CTTGGTGCCC ACGCGCGGTT CGCTGGAGCT CTGCGACTTC 
GTCACGGCCT CGTCCTTCTG CCGCCGCCGC CTCCCCACCG TGCTCCTCAA GCTGCGCATG 
GCGCAGCACC TTCAGGCTGC CGTGGCCTTT GTGGAGCAAG GGCACGTACG CGTGGGCCCT 
GACGTGGTTA CCGACCCCGC CTTCCTTGTC ACGCGCAGCA TGGAGGACTT TGTCACTTGG 
GTGGACTCGT CCAAGATCAA GCGGCACGTG CTAGAGTACA ATGAGGAGCG CGATGACTTC 
GATCTGGAAG CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

IMP3 expression in NSCLC brain metastases demonstrates its role as a prognostic factor in non-neuroendocrine phenotypes.
Medical oncology (Northwood, London, England)35(1)2(2017 Dec)
Del Gobbo A,Morotti A,Colombo AE,Vaira V,Ercoli G,Pesenti C,Bonaparte E,Guerini-Rocco E,Di Cristofori A,Locatelli M,Palleschi A,Ferrero S

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IMP3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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