UGT1A4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	UGT1A4
Entrez Gene ID	54657
Full Name	UDP glucuronosyltransferase family 1 member A4
Synonyms	HUG-BR2,UDPGT,UDPGT 1-4,UGT-1D,UGT1-04,UGT1.4,UGT1A4S,UGT1D
General protein information	Preferred Names UDP glucuronosyltransferase family 1 member A4 Names UDP-glucuronosyltransferase 1-4 UDP glucuronosyltransferase 1 family, polypeptide A4 UDP glycosyltransferase 1 family, polypeptide A4 UDP-glucuronosyltransferase 1 family polypeptide A4s UDP-glucuronosyltransferase 1-D UDP-glucuronosyltransferase 1A4 bilirubin UDP-glucuronosyltransferase isozyme 2 bilirubin-specific UDPGT isozyme 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q37.1
Summary	This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins. [provided by RefSeq, Jul 2008].
Disorder MIM:	606429

mRNA and Protein(s)

mRNA	Protein	Name
NM_007120.2	NP_009051.1	UDP-glucuronosyltransferase 1-4 precursor
NM_007120.3	NP_009051.1	UDP-glucuronosyltransferase 1-4 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Ugt1a5	NP_001034638.1
Homo sapiens (human)	UGT1A4	NP_009051.1
Mus musculus (house mouse)	Ugt1a5	NP_964005.2

Gene Ontology
Bibliography

Related articles in PubMed

No association between non-bullous skin reactions from lamotrigine and heterozygosity of UGT1A4 genetic variants *2(P24T) or *3(L48V) in Norwegian patients.
Shirzadi M, Reimers A, Helde G, Sjursen W, Brodtkorb E
Seizure45169-171(2017 Feb)

Pharmacogenetics of UGT1A4, UGT2B7 and UGT2B15 and Their Influence on Tamoxifen Disposition in Asian Breast Cancer Patients.
Sutiman N, Lim JSL, Muerdter TE, Singh O, Cheung YB, Ng RCH, Yap YS, Wong NS, Ang PCS, Dent R, Schroth W, Schwab M, Khor CC, Chowbay B
Clinical pharmacokinetics55(10)1239-1250(2016 Oct)

Association of UGT2B7 and UGT1A4 Polymorphisms with Serum Concentration of Antiepileptic Drugs in Children.
Du Z, Jiao Y, Shi L
Medical science monitor : international medical journal of experimental and clinical research224107-4113(2016 Oct)

Drug interaction study of natural steroids from herbs specifically toward human UDP-glucuronosyltransferase (UGT) 1A4 and their quantitative structure activity relationship (QSAR) analysis for prediction.
Xu M, Dong P, Tian X, Wang C, Huo X, Zhang B, Wu L, Deng S, Ma X
Pharmacological research110139-150(2016 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

No association between non-bullous skin reactions from lamotrigine and heterozygosity of UGT1A4 genetic variants *2(P24T) or *3(L48V) in Norwegian patients.
Title: No association between non-bullous skin reactions from lamotrigine and heterozygosity of UGT1A4 genetic variants *2(P24T) or *3(L48V) in Norwegian patients.

Our findings highlight the influence of UGTT1A4 haplotypes on tamoxifen disposition in Asian breast cancer patients, while genetic variants in UGT2B7 and UGT2B15 appear to be of minor importance.
Title: Pharmacogenetics of UGT1A4, UGT2B7 and UGT2B15 and Their Influence on Tamoxifen Disposition in Asian Breast Cancer Patients.

This study aimed to analyze the relationship of UGT2B7 and UGT1A4 polymorphisms with metabolism of valproic acid (VPA) and lamotrigine (LTG) in epileptic children. UGT1A4 L48V polymorphism was not related with the serum concentration of LTG (F=5.328, P=0.006). L48V polymorphism also showed effects on efficacy of LTG (chi2=17.397, P=0.001).
Title: Association of UGT2B7 and UGT1A4 Polymorphisms with Serum Concentration of Antiepileptic Drugs in Children.

Plant steroids competitively inhibited the UGT1A4-catalyzed trifluoperazine glucuronidation reaction suggesting potential for herb-drug interactions to occur.
Title: Drug interaction study of natural steroids from herbs specifically toward human UDP-glucuronosyltransferase (UGT) 1A4 and their quantitative structure activity relationship (QSAR) analysis for prediction.

Influence of valproic acid concentration and polymorphism of UGT1A4*3, UGT2B7 -161C > T and UGT2B7*2 on serum concentration of lamotrigine in Chinese epileptic children
Title: Influence of valproic acid concentration and polymorphism of UGT1A4*3, UGT2B7 -161C?>?T and UGT2B7*2 on serum concentration of lamotrigine in Chinese epileptic children.

The following UGT1A4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UGT1A4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25078	NM_007120.3 Latest version!	Homo sapiens UDP glucuronosyltransferase family 1 member A4 (UGT1A4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
View Old Accession Versions >>
OHu25078	NM_007120.2	Homo sapiens UDP glucuronosyltransferase family 1 member A4 (UGT1A4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

UGT1A4 ( NM_007120.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_009051.1 Homo sapiens UDP glucuronosyltransferase family 1 member A4 (UGT1A4), mRNA.

Price & Availability↑

CloneID	OHu25078
Clone ID Related Accession (Same CDS sequence)	NM_007120.2 , NM_007120.3
Accession Version	NM_007120.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1605bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Homo sapiens(human)
Product	UDP-glucuronosyltransferase 1-4 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M57951.1 and AY435139.1. This sequence is a reference standard in the RefSeqGene project. On Mar 30, 2004 this sequence version replaced NM_007120.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M57951.1, BC131623.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144335, SAMEA2144835 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCAGAG GACTCCAGGT TCCCCTGCCG CGGCTGGCCA CAGGACTGCT GCTCCTCCTC 
AGTGTCCAGC CCTGGGCTGA GAGTGGAAAG GTGTTGGTGG TGCCCACTGA TGGCAGCCCC 
TGGCTCAGCA TGCGGGAGGC CTTGCGGGAG CTCCATGCCA GAGGCCACCA GGCGGTGGTC 
CTCACCCCAG AGGTGAATAT GCACATCAAA GAAGAGAAAT TTTTCACCCT GACAGCCTAT 
GCTGTTCCAT GGACCCAGAA GGAATTTGAT CGCGTTACGC TGGGCTACAC TCAAGGGTTC 
TTTGAAACAG AACATCTTCT GAAGAGATAT TCTAGAAGTA TGGCAATTAT GAACAATGTA 
TCTTTGGCCC TTCATAGGTG TTGTGTGGAG CTACTGCATA ATGAGGCCCT GATCAGGCAC 
CTGAATGCTA CTTCCTTTGA TGTGGTTTTA ACAGACCCCG TTAACCTCTG TGGGGCGGTG 
CTGGCTAAGT ACCTGTCGAT TCCTGCTGTG TTTTTTTGGA GGTACATTCC ATGTGACTTA 
GACTTTAAGG GCACACAGTG TCCAAATCCT TCCTCCTATA TTCCTAAGTT ACTAACGACC 
AATTCAGACC ACATGACATT CCTGCAAAGG GTCAAGAACA TGCTCTACCC TCTGGCCCTG 
TCCTACATTT GCCATACTTT TTCTGCCCCT TATGCAAGTC TTGCCTCTGA GCTTTTTCAG 
AGAGAGGTGT CAGTGGTGGA TCTTGTCAGC TATGCATCCG TGTGGCTGTT CCGAGGGGAC 
TTTGTGATGG ACTACCCCAG GCCGATCATG CCCAACATGG TCTTCATTGG GGGCATCAAC 
TGTGCCAACG GGAAGCCACT ATCTCAGGAA TTTGAAGCCT ACATTAATGC TTCTGGAGAA 
CATGGAATTG TGGTTTTCTC TTTGGGATCA ATGGTCTCAG AAATTCCAGA GAAGAAAGCT 
ATGGCAATTG CTGATGCTTT GGGCAAAATC CCTCAGACAG TCCTGTGGCG GTACACTGGA 
ACCCGACCAT CGAATCTTGC GAACAACACG ATACTTGTTA AGTGGCTACC CCAAAACGAT 
CTGCTTGGTC ACCCGATGAC CCGTGCCTTT ATCACCCATG CTGGTTCCCA TGGTGTTTAT 
GAAAGCATAT GCAATGGCGT TCCCATGGTG ATGATGCCCT TGTTTGGTGA TCAGATGGAC 
AATGCAAAGC GCATGGAGAC TAAGGGAGCT GGAGTGACCC TGAATGTTCT GGAAATGACT 
TCTGAAGATT TAGAAAATGC TCTAAAAGCA GTCATCAATG ACAAAAGTTA CAAGGAGAAC 
ATCATGCGCC TCTCCAGCCT TCACAAGGAC CGCCCGGTGG AGCCGCTGGA CCTGGCCGTG 
TTCTGGGTGG AGTTTGTGAT GAGGCACAAG GGCGCGCCAC ACCTGCGCCC CGCAGCCCAC 
GACCTCACCT GGTACCAGTA CCATTCCTTG GACGTGATTG GTTTCCTCTT GGCCGTCGTG 
CTGACAGTGG CCTTCATCAC CTTTAAATGT TGTGCTTATG GCTACCGGAA ATGCTTGGGG 
AAAAAAGGGC GAGTTAAGAA AGCCCACAAA TCCAAGACCC ATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009051.1
CDS	30..1634
Translation	MARGLQVPLPRLATGLLLLLSVQPWAESGKVLVVPTDGSPWLSMREALRELHARGHQAVVLTPEVNMHIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETEHLLKRYSRSMAIMNNVSLALHRCCVELLHNEALIRHLNATSFDVVLTDPVNLCGAVLAKYLSIPAVFFWRYIPCDLDFKGTQCPNPSSYIPKLLTTNSDHMTFLQRVKNMLYPLALSYICHTFSAPYASLASELFQREVSVVDLVSYASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

Target ORF information:

RefSeq Version	NM_007120.2
Organism	Homo sapiens(human)
Definition	Homo sapiens UDP glucuronosyltransferase family 1 member A4 (UGT1A4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007120.2

ORF Insert Sequence:

ATGGCCAGAG GACTCCAGGT TCCCCTGCCG CGGCTGGCCA CAGGACTGCT GCTCCTCCTC 
AGTGTCCAGC CCTGGGCTGA GAGTGGAAAG GTGTTGGTGG TGCCCACTGA TGGCAGCCCC 
TGGCTCAGCA TGCGGGAGGC CTTGCGGGAG CTCCATGCCA GAGGCCACCA GGCGGTGGTC 
CTCACCCCAG AGGTGAATAT GCACATCAAA GAAGAGAAAT TTTTCACCCT GACAGCCTAT 
GCTGTTCCAT GGACCCAGAA GGAATTTGAT CGCGTTACGC TGGGCTACAC TCAAGGGTTC 
TTTGAAACAG AACATCTTCT GAAGAGATAT TCTAGAAGTA TGGCAATTAT GAACAATGTA 
TCTTTGGCCC TTCATAGGTG TTGTGTGGAG CTACTGCATA ATGAGGCCCT GATCAGGCAC 
CTGAATGCTA CTTCCTTTGA TGTGGTTTTA ACAGACCCCG TTAACCTCTG TGGGGCGGTG 
CTGGCTAAGT ACCTGTCGAT TCCTGCTGTG TTTTTTTGGA GGTACATTCC ATGTGACTTA 
GACTTTAAGG GCACACAGTG TCCAAATCCT TCCTCCTATA TTCCTAAGTT ACTAACGACC 
AATTCAGACC ACATGACATT CCTGCAAAGG GTCAAGAACA TGCTCTACCC TCTGGCCCTG 
TCCTACATTT GCCATACTTT TTCTGCCCCT TATGCAAGTC TTGCCTCTGA GCTTTTTCAG 
AGAGAGGTGT CAGTGGTGGA TCTTGTCAGC TATGCATCCG TGTGGCTGTT CCGAGGGGAC 
TTTGTGATGG ACTACCCCAG GCCGATCATG CCCAACATGG TCTTCATTGG GGGCATCAAC 
TGTGCCAACG GGAAGCCACT ATCTCAGGAA TTTGAAGCCT ACATTAATGC TTCTGGAGAA 
CATGGAATTG TGGTTTTCTC TTTGGGATCA ATGGTCTCAG AAATTCCAGA GAAGAAAGCT 
ATGGCAATTG CTGATGCTTT GGGCAAAATC CCTCAGACAG TCCTGTGGCG GTACACTGGA 
ACCCGACCAT CGAATCTTGC GAACAACACG ATACTTGTTA AGTGGCTACC CCAAAACGAT 
CTGCTTGGTC ACCCGATGAC CCGTGCCTTT ATCACCCATG CTGGTTCCCA TGGTGTTTAT 
GAAAGCATAT GCAATGGCGT TCCCATGGTG ATGATGCCCT TGTTTGGTGA TCAGATGGAC 
AATGCAAAGC GCATGGAGAC TAAGGGAGCT GGAGTGACCC TGAATGTTCT GGAAATGACT 
TCTGAAGATT TAGAAAATGC TCTAAAAGCA GTCATCAATG ACAAAAGTTA CAAGGAGAAC 
ATCATGCGCC TCTCCAGCCT TCACAAGGAC CGCCCGGTGG AGCCGCTGGA CCTGGCCGTG 
TTCTGGGTGG AGTTTGTGAT GAGGCACAAG GGCGCGCCAC ACCTGCGCCC CGCAGCCCAC 
GACCTCACCT GGTACCAGTA CCATTCCTTG GACGTGATTG GTTTCCTCTT GGCCGTCGTG 
CTGACAGTGG CCTTCATCAC CTTTAAATGT TGTGCTTATG GCTACCGGAA ATGCTTGGGG 
AAAAAAGGGC GAGTTAAGAA AGCCCACAAA TCCAAGACCC ATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UGT1A4 ( NM_007120.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_009051.1 Homo sapiens UDP glucuronosyltransferase family 1 member A4 (UGT1A4), mRNA.

Price & Availability↑

CloneID	OHu25078
Clone ID Related Accession (Same CDS sequence)	NM_007120.2 , NM_007120.3
Accession Version	NM_007120.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1605bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	UDP-glucuronosyltransferase 1-4 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC114812.5, M57951.1, AY435139.1 and AC006985.2. This sequence is a reference standard in the RefSeqGene project. On Jun 2, 2019 this sequence version replaced NM_007120.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DRR138515.319683.1, DRR138522.654359.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144335, SAMEA2144835 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCAGAG GACTCCAGGT TCCCCTGCCG CGGCTGGCCA CAGGACTGCT GCTCCTCCTC 
AGTGTCCAGC CCTGGGCTGA GAGTGGAAAG GTGTTGGTGG TGCCCACTGA TGGCAGCCCC 
TGGCTCAGCA TGCGGGAGGC CTTGCGGGAG CTCCATGCCA GAGGCCACCA GGCGGTGGTC 
CTCACCCCAG AGGTGAATAT GCACATCAAA GAAGAGAAAT TTTTCACCCT GACAGCCTAT 
GCTGTTCCAT GGACCCAGAA GGAATTTGAT CGCGTTACGC TGGGCTACAC TCAAGGGTTC 
TTTGAAACAG AACATCTTCT GAAGAGATAT TCTAGAAGTA TGGCAATTAT GAACAATGTA 
TCTTTGGCCC TTCATAGGTG TTGTGTGGAG CTACTGCATA ATGAGGCCCT GATCAGGCAC 
CTGAATGCTA CTTCCTTTGA TGTGGTTTTA ACAGACCCCG TTAACCTCTG TGGGGCGGTG 
CTGGCTAAGT ACCTGTCGAT TCCTGCTGTG TTTTTTTGGA GGTACATTCC ATGTGACTTA 
GACTTTAAGG GCACACAGTG TCCAAATCCT TCCTCCTATA TTCCTAAGTT ACTAACGACC 
AATTCAGACC ACATGACATT CCTGCAAAGG GTCAAGAACA TGCTCTACCC TCTGGCCCTG 
TCCTACATTT GCCATACTTT TTCTGCCCCT TATGCAAGTC TTGCCTCTGA GCTTTTTCAG 
AGAGAGGTGT CAGTGGTGGA TCTTGTCAGC TATGCATCCG TGTGGCTGTT CCGAGGGGAC 
TTTGTGATGG ACTACCCCAG GCCGATCATG CCCAACATGG TCTTCATTGG GGGCATCAAC 
TGTGCCAACG GGAAGCCACT ATCTCAGGAA TTTGAAGCCT ACATTAATGC TTCTGGAGAA 
CATGGAATTG TGGTTTTCTC TTTGGGATCA ATGGTCTCAG AAATTCCAGA GAAGAAAGCT 
ATGGCAATTG CTGATGCTTT GGGCAAAATC CCTCAGACAG TCCTGTGGCG GTACACTGGA 
ACCCGACCAT CGAATCTTGC GAACAACACG ATACTTGTTA AGTGGCTACC CCAAAACGAT 
CTGCTTGGTC ACCCGATGAC CCGTGCCTTT ATCACCCATG CTGGTTCCCA TGGTGTTTAT 
GAAAGCATAT GCAATGGCGT TCCCATGGTG ATGATGCCCT TGTTTGGTGA TCAGATGGAC 
AATGCAAAGC GCATGGAGAC TAAGGGAGCT GGAGTGACCC TGAATGTTCT GGAAATGACT 
TCTGAAGATT TAGAAAATGC TCTAAAAGCA GTCATCAATG ACAAAAGTTA CAAGGAGAAC 
ATCATGCGCC TCTCCAGCCT TCACAAGGAC CGCCCGGTGG AGCCGCTGGA CCTGGCCGTG 
TTCTGGGTGG AGTTTGTGAT GAGGCACAAG GGCGCGCCAC ACCTGCGCCC CGCAGCCCAC 
GACCTCACCT GGTACCAGTA CCATTCCTTG GACGTGATTG GTTTCCTCTT GGCCGTCGTG 
CTGACAGTGG CCTTCATCAC CTTTAAATGT TGTGCTTATG GCTACCGGAA ATGCTTGGGG 
AAAAAAGGGC GAGTTAAGAA AGCCCACAAA TCCAAGACCC ATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009051.1
CDS	86..1690
Translation	MARGLQVPLPRLATGLLLLLSVQPWAESGKVLVVPTDGSPWLSMREALRELHARGHQAVVLTPEVNMHIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETEHLLKRYSRSMAIMNNVSLALHRCCVELLHNEALIRHLNATSFDVVLTDPVNLCGAVLAKYLSIPAVFFWRYIPCDLDFKGTQCPNPSSYIPKLLTTNSDHMTFLQRVKNMLYPLALSYICHTFSAPYASLASELFQREVSVVDLVSYASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

Target ORF information:

RefSeq Version	NM_007120.3
Organism	Homo sapiens(human)
Definition	Homo sapiens UDP glucuronosyltransferase family 1 member A4 (UGT1A4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007120.3

ORF Insert Sequence:

ATGGCCAGAG GACTCCAGGT TCCCCTGCCG CGGCTGGCCA CAGGACTGCT GCTCCTCCTC 
AGTGTCCAGC CCTGGGCTGA GAGTGGAAAG GTGTTGGTGG TGCCCACTGA TGGCAGCCCC 
TGGCTCAGCA TGCGGGAGGC CTTGCGGGAG CTCCATGCCA GAGGCCACCA GGCGGTGGTC 
CTCACCCCAG AGGTGAATAT GCACATCAAA GAAGAGAAAT TTTTCACCCT GACAGCCTAT 
GCTGTTCCAT GGACCCAGAA GGAATTTGAT CGCGTTACGC TGGGCTACAC TCAAGGGTTC 
TTTGAAACAG AACATCTTCT GAAGAGATAT TCTAGAAGTA TGGCAATTAT GAACAATGTA 
TCTTTGGCCC TTCATAGGTG TTGTGTGGAG CTACTGCATA ATGAGGCCCT GATCAGGCAC 
CTGAATGCTA CTTCCTTTGA TGTGGTTTTA ACAGACCCCG TTAACCTCTG TGGGGCGGTG 
CTGGCTAAGT ACCTGTCGAT TCCTGCTGTG TTTTTTTGGA GGTACATTCC ATGTGACTTA 
GACTTTAAGG GCACACAGTG TCCAAATCCT TCCTCCTATA TTCCTAAGTT ACTAACGACC 
AATTCAGACC ACATGACATT CCTGCAAAGG GTCAAGAACA TGCTCTACCC TCTGGCCCTG 
TCCTACATTT GCCATACTTT TTCTGCCCCT TATGCAAGTC TTGCCTCTGA GCTTTTTCAG 
AGAGAGGTGT CAGTGGTGGA TCTTGTCAGC TATGCATCCG TGTGGCTGTT CCGAGGGGAC 
TTTGTGATGG ACTACCCCAG GCCGATCATG CCCAACATGG TCTTCATTGG GGGCATCAAC 
TGTGCCAACG GGAAGCCACT ATCTCAGGAA TTTGAAGCCT ACATTAATGC TTCTGGAGAA 
CATGGAATTG TGGTTTTCTC TTTGGGATCA ATGGTCTCAG AAATTCCAGA GAAGAAAGCT 
ATGGCAATTG CTGATGCTTT GGGCAAAATC CCTCAGACAG TCCTGTGGCG GTACACTGGA 
ACCCGACCAT CGAATCTTGC GAACAACACG ATACTTGTTA AGTGGCTACC CCAAAACGAT 
CTGCTTGGTC ACCCGATGAC CCGTGCCTTT ATCACCCATG CTGGTTCCCA TGGTGTTTAT 
GAAAGCATAT GCAATGGCGT TCCCATGGTG ATGATGCCCT TGTTTGGTGA TCAGATGGAC 
AATGCAAAGC GCATGGAGAC TAAGGGAGCT GGAGTGACCC TGAATGTTCT GGAAATGACT 
TCTGAAGATT TAGAAAATGC TCTAAAAGCA GTCATCAATG ACAAAAGTTA CAAGGAGAAC 
ATCATGCGCC TCTCCAGCCT TCACAAGGAC CGCCCGGTGG AGCCGCTGGA CCTGGCCGTG 
TTCTGGGTGG AGTTTGTGAT GAGGCACAAG GGCGCGCCAC ACCTGCGCCC CGCAGCCCAC 
GACCTCACCT GGTACCAGTA CCATTCCTTG GACGTGATTG GTTTCCTCTT GGCCGTCGTG 
CTGACAGTGG CCTTCATCAC CTTTAAATGT TGTGCTTATG GCTACCGGAA ATGCTTGGGG 
AAAAAAGGGC GAGTTAAGAA AGCCCACAAA TCCAAGACCC ATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

No association between non-bullous skin reactions from lamotrigine and heterozygosity of UGT1A4 genetic variants *2(P24T) or *3(L48V) in Norwegian patients.
Seizure45169-171(2017 Feb)
Shirzadi M,Reimers A,Helde G,Sjursen W,Brodtkorb E

Pharmacogenetics of UGT1A4, UGT2B7 and UGT2B15 and Their Influence on Tamoxifen Disposition in Asian Breast Cancer Patients.
Clinical pharmacokinetics55(10)1239-1250(2016 Oct)
Sutiman N,Lim JSL,Muerdter TE,Singh O,Cheung YB,Ng RCH,Yap YS,Wong NS,Ang PCS,Dent R,Schroth W,Schwab M,Khor CC,Chowbay B

Association of UGT2B7 and UGT1A4 Polymorphisms with Serum Concentration of Antiepileptic Drugs in Children.
Medical science monitor : international medical journal of experimental and clinical research224107-4113(2016 Oct)
Du Z,Jiao Y,Shi L

Drug interaction study of natural steroids from herbs specifically toward human UDP-glucuronosyltransferase (UGT) 1A4 and their quantitative structure activity relationship (QSAR) analysis for prediction.
Pharmacological research110139-150(2016 Aug)
Xu M,Dong P,Tian X,Wang C,Huo X,Zhang B,Wu L,Deng S,Ma X

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UGT1A4 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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