NOP58 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NOP58
Entrez Gene ID	51602
Full Name	NOP58 ribonucleoprotein
Synonyms	HSPC120,NOP5,NOP5/NOP58
General protein information	Preferred Names NOP58 ribonucleoprotein Names nucleolar protein 58 NOP58 ribonucleoprotein homolog nucleolar protein 5 nucleolar protein NOP5/NOP58
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q33.1
Summary	The protein encoded by this gene is a core component of box C/D small nucleolar ribonucleoproteins. Some box C/D small nucleolar RNAs (snoRNAs), such as U3, U8, and U14, are dependent upon the encoded protein for their synthesis. This protein is SUMOylated, which is necessary for high affinity binding to snoRNAs. [provided by RefSeq, Nov 2015].
Disorder MIM:	616742

mRNA and Protein(s)

mRNA	Protein	Name
NM_015934.5	NP_057018.1	nucleolar protein 58
NM_015934.3	NP_057018.1	nucleolar protein 58
NM_015934.4	NP_057018.1	nucleolar protein 58

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	NOP58	XP_005640604.1
Kluyveromyces lactis	KLLA0F08613g	XP_455471.1
Magnaporthe oryzae (rice blast fungus)	MGG_07008	XP_003709766.1
Arabidopsis thaliana (thale cress)	AT5G27120	NP_198064.1
Homo sapiens (human)	NOP58	NP_057018.1
Arabidopsis thaliana (thale cress)	AT3G05060	NP_187157.1
Pan troglodytes (chimpanzee)	NOP58	XP_516036.2
	NOP58	XP_001101291.1
Bos taurus (cattle)	NOP58	NP_001179886.1
Rattus norvegicus (Norway rat)	Nop58	NP_068522.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002171	XP_308017.5
Eremothecium gossypii	AGOS_AFR328C	NP_985875.2
Oryza sativa (rice)	Os03g0350300	NP_001050113.1
Mus musculus (house mouse)	Nop58	NP_061356.2
Caenorhabditis elegans (roundworm)	nol-5	NP_491134.1
Schizosaccharomyces pombe (fission yeast)	SPAC23G3.06	NP_593106.1
Gallus gallus (chicken)	NOP58	XP_421942.1
Danio rerio (zebrafish)	nop58	NP_001009889.1
Drosophila melanogaster (fruit fly)	nop5	NP_477412.1
Saccharomyces cerevisiae (baker's yeast)	NOP58	NP_014955.1
Neurospora crassa	NCU03396	XP_956843.1
Oryza sativa (rice)	Os03g0350100	NP_001050112.1
Xenopus tropicalis (tropical clawed frog)	nop58	NP_989298.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification of discrete classes of small nucleolar RNA featuring different ends and RNA binding protein dependency.
Deschamps-Francoeur G, Garneau D, Dupuis-Sandoval F, Roy A, Frappier M, Catala M, Couture S, Barbe-Marcoux M, Abou-Elela S, Scott MS
Nucleic acids research42(15)10073-85(2014 Sep)

CRM1 controls the composition of nucleoplasmic pre-snoRNA complexes to licence them for nucleolar transport.
Pradet-Balade B, Girard C, Boulon S, Paul C, Azzag K, Bordonn? R, Bertrand E, Verheggen C
The EMBO journal30(11)2205-18(2011 Jun)

A proteomic screen for nucleolar SUMO targets shows SUMOylation modulates the function of Nop5/Nop58.
Westman BJ, Verheggen C, Hutten S, Lam YW, Bertrand E, Lamond AI
Molecular cell39(4)618-31(2010 Aug)

Evidence that the AAA+ proteins TIP48 and TIP49 bridge interactions between 15.5K and the related NOP56 and NOP58 proteins during box C/D snoRNP biogenesis.
McKeegan KS, Debieux CM, Watkins NJ
Molecular and cellular biology29(18)4971-81(2009 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SUMOylation is essential for high-affinity Nop58 binding to small nucleolar riboproteins.
Title: A proteomic screen for nucleolar SUMO targets shows SUMOylation modulates the function of Nop5/Nop58.

snoRNP assembly factor NUFIP can regulate the interactions between TIP48 and TIP49 and the core box C/D proteins.
Title: Evidence that the AAA+ proteins TIP48 and TIP49 bridge interactions between 15.5K and the related NOP56 and NOP58 proteins during box C/D snoRNP biogenesis.

Mammalian and yeast U3 snoRNPs are matured in specific and related nuclear compartments.
Title: Mammalian and yeast U3 snoRNPs are matured in specific and related nuclear compartments.

The following NOP58 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NOP58 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29366	NM_015934.5 Latest version!	Homo sapiens NOP58 ribonucleoprotein (NOP58), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu29366	NM_015934.3	Homo sapiens NOP58 ribonucleoprotein (NOP58), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu29366	NM_015934.4	Homo sapiens NOP58 ribonucleoprotein (NOP58), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NOP58 ( NM_015934.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_057018.1 Homo sapiens NOP58 ribonucleoprotein (NOP58), mRNA.

Price & Availability↑

CloneID	OHu29366
Clone ID Related Accession (Same CDS sequence)	NM_015934.5 , NM_015934.3 , NM_015934.4
Accession Version	NM_015934.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1590bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	nucleolar protein 58
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP245255.1 and BC032592.2. On Nov 22, 2018 this sequence version replaced NM_015934.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.86755.1, SRR1660807.223343.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000264279.10/ ENSP00000264279.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTTGGTGC TGTTTGAAAC GTCTGTGGGT TACGCCATCT TTAAGGTTCT AAATGAGAAG 
AAACTTCAAG AGGTTGATAG TTTATGGAAA GAATTTGAAA CTCCAGAGAA AGCAAACAAA 
ATAGTAAAGC TAAAACATTT TGAGAAATTT CAGGATACAG CAGAAGCATT AGCAGCATTC 
ACAGCTCTGA TGGAGGGCAA AATCAATAAG CAGCTGAAAA AAGTTCTGAA GAAAATAGTA 
AAAGAAGCCC ATGAACCGCT GGCAGTAGCT GATGCTAAAC TAGGAGGGGT CATAAAGGAA 
AAGCTGAATC TCAGTTGTAT CCATAGTCCT GTTGTTAATG AACTTATGAG AGGAATTCGT 
TCACAAATGG ATGGATTAAT CCCTGGGGTA GAACCACGTG AAATGGCAGC TATGTGTCTT 
GGATTGGCTC ACAGCCTGTC TCGATATAGA TTGAAGTTTA GCGCTGATAA AGTAGACACA 
ATGATTGTTC AGGCAATTTC CTTGTTAGAT GACTTGGATA AAGAACTAAA CAACTACATT 
ATGCGATGTA GAGAATGGTA TGGCTGGCAT TTCCCTGAAT TAGGAAAAAT TATTTCAGAT 
AATTTAACAT ACTGCAAGTG TTTACAGAAA GTTGGCGATA GGAAGAACTA TGCCTCTGCC 
AAGCTTTCTG AGTTGCTGCC AGAAGAAGTT GAAGCAGAAG TGAAAGCAGC TGCAGAGATA 
TCAATGGGAA CAGAGGTTTC AGAAGAAGAT ATTTGCAATA TTCTGCATCT TTGCACCCAG 
GTGATTGAAA TCTCTGAATA TCGAACCCAG CTCTATGAAT ATCTACAAAA TCGAATGATG 
GCCATTGCAC CCAATGTTAC AGTCATGGTT GGGGAATTAG TTGGAGCACG GCTTATTGCT 
CATGCAGGTT CTCTTTTAAA TTTGGCCAAG CATGCAGCTT CTACCGTTCA GATTCTTGGA 
GCTGAAAAGG CACTTTTCAG AGCCCTCAAA TCTAGACGGG ATACCCCTAA GTATGGTCTC 
ATTTATCATG CTTCACTCGT GGGCCAGACA AGTCCCAAAC ACAAAGGAAA GATTTCTCGA 
ATGCTGGCAG CCAAAACCGT TTTGGCTATC CGTTATGATG CTTTTGGTGA GGATTCAAGT 
TCTGCAATGG GAGTTGAGAA CAGAGCCAAA TTAGAGGCCA GGTTGAGAAC TTTGGAAGAC 
AGAGGGATAA GAAAAATAAG TGGAACAGGA AAAGCATTAG CAAAAACAGA AAAATATGAA 
CACAAAAGTG AAGTGAAGAC TTACGATCCT TCTGGTGACT CCACACTTCC AACCTGTTCT 
AAAAAACGCA AAATAGAACA GGTAGATAAA GAGGATGAAA TTACTGAAAA GAAAGCCAAA 
AAAGCCAAGA TTAAAGTTAA AGTTGAAGAA GAGGAAGAAG AAAAAGTGGC AGAAGAAGAA 
GAAACATCTG TGAAGAAGAA GAAGAAAAGG GGTAAAAAGA AACACATTAA GGAAGAACCA 
CTTTCTGAGG AAGAACCATG TACCAGCACA GCAATTGCTA GTCCAGAGAA AAAGAAGAAA 
AAGAAAAAAA AGAGAGAGAA CGAGGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057018.1
CDS	180..1769
Translation	MLVLFETSVGYAIFKVLNEKKLQEVDSLWKEFETPEKANKIVKLKHFEKFQDTAEALAAFTALMEGKINKQLKKVLKKIVKEAHEPLAVADAKLGGVIKEKLNLSCIHSPVVNELMRGIRSQMDGLIPGVEPREMAAMCLGLAHSLSRYRLKFSADKVDTMIVQAISLLDDLDKELNNYIMRCREWYGWHFPELGKIISDNLTYCKCLQKVGDRKNYASAKLSELLPEEVEAEVKAAAEISMGTEVSEEDICNILHLCTQVIEISEYRTQLYEYLQNRMMAIAPNVTVMVGELVGARLIAHAGSLLNLAKHAASTVQILGAEKALFRALKSRRDTPKYGLIYHASLVGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED

Target ORF information:

RefSeq Version	NM_015934.5
Organism	Homo sapiens(human)
Definition	Homo sapiens NOP58 ribonucleoprotein (NOP58), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015934.5

ORF Insert Sequence:

ATGTTGGTGC TGTTTGAAAC GTCTGTGGGT TACGCCATCT TTAAGGTTCT AAATGAGAAG 
AAACTTCAAG AGGTTGATAG TTTATGGAAA GAATTTGAAA CTCCAGAGAA AGCAAACAAA 
ATAGTAAAGC TAAAACATTT TGAGAAATTT CAGGATACAG CAGAAGCATT AGCAGCATTC 
ACAGCTCTGA TGGAGGGCAA AATCAATAAG CAGCTGAAAA AAGTTCTGAA GAAAATAGTA 
AAAGAAGCCC ATGAACCGCT GGCAGTAGCT GATGCTAAAC TAGGAGGGGT CATAAAGGAA 
AAGCTGAATC TCAGTTGTAT CCATAGTCCT GTTGTTAATG AACTTATGAG AGGAATTCGT 
TCACAAATGG ATGGATTAAT CCCTGGGGTA GAACCACGTG AAATGGCAGC TATGTGTCTT 
GGATTGGCTC ACAGCCTGTC TCGATATAGA TTGAAGTTTA GCGCTGATAA AGTAGACACA 
ATGATTGTTC AGGCAATTTC CTTGTTAGAT GACTTGGATA AAGAACTAAA CAACTACATT 
ATGCGATGTA GAGAATGGTA TGGCTGGCAT TTCCCTGAAT TAGGAAAAAT TATTTCAGAT 
AATTTAACAT ACTGCAAGTG TTTACAGAAA GTTGGCGATA GGAAGAACTA TGCCTCTGCC 
AAGCTTTCTG AGTTGCTGCC AGAAGAAGTT GAAGCAGAAG TGAAAGCAGC TGCAGAGATA 
TCAATGGGAA CAGAGGTTTC AGAAGAAGAT ATTTGCAATA TTCTGCATCT TTGCACCCAG 
GTGATTGAAA TCTCTGAATA TCGAACCCAG CTCTATGAAT ATCTACAAAA TCGAATGATG 
GCCATTGCAC CCAATGTTAC AGTCATGGTT GGGGAATTAG TTGGAGCACG GCTTATTGCT 
CATGCAGGTT CTCTTTTAAA TTTGGCCAAG CATGCAGCTT CTACCGTTCA GATTCTTGGA 
GCTGAAAAGG CACTTTTCAG AGCCCTCAAA TCTAGACGGG ATACCCCTAA GTATGGTCTC 
ATTTATCATG CTTCACTCGT GGGCCAGACA AGTCCCAAAC ACAAAGGAAA GATTTCTCGA 
ATGCTGGCAG CCAAAACCGT TTTGGCTATC CGTTATGATG CTTTTGGTGA GGATTCAAGT 
TCTGCAATGG GAGTTGAGAA CAGAGCCAAA TTAGAGGCCA GGTTGAGAAC TTTGGAAGAC 
AGAGGGATAA GAAAAATAAG TGGAACAGGA AAAGCATTAG CAAAAACAGA AAAATATGAA 
CACAAAAGTG AAGTGAAGAC TTACGATCCT TCTGGTGACT CCACACTTCC AACCTGTTCT 
AAAAAACGCA AAATAGAACA GGTAGATAAA GAGGATGAAA TTACTGAAAA GAAAGCCAAA 
AAAGCCAAGA TTAAAGTTAA AGTTGAAGAA GAGGAAGAAG AAAAAGTGGC AGAAGAAGAA 
GAAACATCTG TGAAGAAGAA GAAGAAAAGG GGTAAAAAGA AACACATTAA GGAAGAACCA 
CTTTCTGAGG AAGAACCATG TACCAGCACA GCAATTGCTA GTCCAGAGAA AAAGAAGAAA 
AAGAAAAAAA AGAGAGAGAA CGAGGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NOP58 ( NM_015934.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057018.1 Homo sapiens NOP58 ribonucleoprotein (NOP58), mRNA.

Price & Availability↑

CloneID	OHu29366
Clone ID Related Accession (Same CDS sequence)	NM_015934.5 , NM_015934.3 , NM_015934.4
Accession Version	NM_015934.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1590bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	nucleolar protein 58
Comment

ATGTTGGTGC TGTTTGAAAC GTCTGTGGGT TACGCCATCT TTAAGGTTCT AAATGAGAAG 
AAACTTCAAG AGGTTGATAG TTTATGGAAA GAATTTGAAA CTCCAGAGAA AGCAAACAAA 
ATAGTAAAGC TAAAACATTT TGAGAAATTT CAGGATACAG CAGAAGCATT AGCAGCATTC 
ACAGCTCTGA TGGAGGGCAA AATCAATAAG CAGCTGAAAA AAGTTCTGAA GAAAATAGTA 
AAAGAAGCCC ATGAACCGCT GGCAGTAGCT GATGCTAAAC TAGGAGGGGT CATAAAGGAA 
AAGCTGAATC TCAGTTGTAT CCATAGTCCT GTTGTTAATG AACTTATGAG AGGAATTCGT 
TCACAAATGG ATGGATTAAT CCCTGGGGTA GAACCACGTG AAATGGCAGC TATGTGTCTT 
GGATTGGCTC ACAGCCTGTC TCGATATAGA TTGAAGTTTA GCGCTGATAA AGTAGACACA 
ATGATTGTTC AGGCAATTTC CTTGTTAGAT GACTTGGATA AAGAACTAAA CAACTACATT 
ATGCGATGTA GAGAATGGTA TGGCTGGCAT TTCCCTGAAT TAGGAAAAAT TATTTCAGAT 
AATTTAACAT ACTGCAAGTG TTTACAGAAA GTTGGCGATA GGAAGAACTA TGCCTCTGCC 
AAGCTTTCTG AGTTGCTGCC AGAAGAAGTT GAAGCAGAAG TGAAAGCAGC TGCAGAGATA 
TCAATGGGAA CAGAGGTTTC AGAAGAAGAT ATTTGCAATA TTCTGCATCT TTGCACCCAG 
GTGATTGAAA TCTCTGAATA TCGAACCCAG CTCTATGAAT ATCTACAAAA TCGAATGATG 
GCCATTGCAC CCAATGTTAC AGTCATGGTT GGGGAATTAG TTGGAGCACG GCTTATTGCT 
CATGCAGGTT CTCTTTTAAA TTTGGCCAAG CATGCAGCTT CTACCGTTCA GATTCTTGGA 
GCTGAAAAGG CACTTTTCAG AGCCCTCAAA TCTAGACGGG ATACCCCTAA GTATGGTCTC 
ATTTATCATG CTTCACTCGT GGGCCAGACA AGTCCCAAAC ACAAAGGAAA GATTTCTCGA 
ATGCTGGCAG CCAAAACCGT TTTGGCTATC CGTTATGATG CTTTTGGTGA GGATTCAAGT 
TCTGCAATGG GAGTTGAGAA CAGAGCCAAA TTAGAGGCCA GGTTGAGAAC TTTGGAAGAC 
AGAGGGATAA GAAAAATAAG TGGAACAGGA AAAGCATTAG CAAAAACAGA AAAATATGAA 
CACAAAAGTG AAGTGAAGAC TTACGATCCT TCTGGTGACT CCACACTTCC AACCTGTTCT 
AAAAAACGCA AAATAGAACA GGTAGATAAA GAGGATGAAA TTACTGAAAA GAAAGCCAAA 
AAAGCCAAGA TTAAAGTTAA AGTTGAAGAA GAGGAAGAAG AAAAAGTGGC AGAAGAAGAA 
GAAACATCTG TGAAGAAGAA GAAGAAAAGG GGTAAAAAGA AACACATTAA GGAAGAACCA 
CTTTCTGAGG AAGAACCATG TACCAGCACA GCAATTGCTA GTCCAGAGAA AAAGAAGAAA 
AAGAAAAAAA AGAGAGAGAA CGAGGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_057018.1

Translation

MLVLFETSVGYAIFKVLNEKKLQEVDSLWKEFETPEKANKIVKLKHFEKFQDTAEALAAFTALMEGKINKQLKKVLKKIVKEAHEPLAVADAKLGGVIKEKLNLSCIHSPVVNELMRGIRSQMDGLIPGVEPREMAAMCLGLAHSLSRYRLKFSADKVDTMIVQAISLLDDLDKELNNYIMRCREWYGWHFPELGKIISDNLTYCKCLQKVGDRKNYASAKLSELLPEEVEAEVKAAAEISMGTEVSEEDICNILHLCTQVIEISEYRTQLYEYLQNRMMAIAPNVTVMVGELVGARLIAHAGSLLNLAKHAASTVQILGAEKALFRALKSRRDTPKYGLIYHASLVGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED

Target ORF information:

RefSeq Version	NM_015934.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens NOP58 ribonucleoprotein (NOP58), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015934.3

ORF Insert Sequence:

ATGTTGGTGC TGTTTGAAAC GTCTGTGGGT TACGCCATCT TTAAGGTTCT AAATGAGAAG 
AAACTTCAAG AGGTTGATAG TTTATGGAAA GAATTTGAAA CTCCAGAGAA AGCAAACAAA 
ATAGTAAAGC TAAAACATTT TGAGAAATTT CAGGATACAG CAGAAGCATT AGCAGCATTC 
ACAGCTCTGA TGGAGGGCAA AATCAATAAG CAGCTGAAAA AAGTTCTGAA GAAAATAGTA 
AAAGAAGCCC ATGAACCGCT GGCAGTAGCT GATGCTAAAC TAGGAGGGGT CATAAAGGAA 
AAGCTGAATC TCAGTTGTAT CCATAGTCCT GTTGTTAATG AACTTATGAG AGGAATTCGT 
TCACAAATGG ATGGATTAAT CCCTGGGGTA GAACCACGTG AAATGGCAGC TATGTGTCTT 
GGATTGGCTC ACAGCCTGTC TCGATATAGA TTGAAGTTTA GCGCTGATAA AGTAGACACA 
ATGATTGTTC AGGCAATTTC CTTGTTAGAT GACTTGGATA AAGAACTAAA CAACTACATT 
ATGCGATGTA GAGAATGGTA TGGCTGGCAT TTCCCTGAAT TAGGAAAAAT TATTTCAGAT 
AATTTAACAT ACTGCAAGTG TTTACAGAAA GTTGGCGATA GGAAGAACTA TGCCTCTGCC 
AAGCTTTCTG AGTTGCTGCC AGAAGAAGTT GAAGCAGAAG TGAAAGCAGC TGCAGAGATA 
TCAATGGGAA CAGAGGTTTC AGAAGAAGAT ATTTGCAATA TTCTGCATCT TTGCACCCAG 
GTGATTGAAA TCTCTGAATA TCGAACCCAG CTCTATGAAT ATCTACAAAA TCGAATGATG 
GCCATTGCAC CCAATGTTAC AGTCATGGTT GGGGAATTAG TTGGAGCACG GCTTATTGCT 
CATGCAGGTT CTCTTTTAAA TTTGGCCAAG CATGCAGCTT CTACCGTTCA GATTCTTGGA 
GCTGAAAAGG CACTTTTCAG AGCCCTCAAA TCTAGACGGG ATACCCCTAA GTATGGTCTC 
ATTTATCATG CTTCACTCGT GGGCCAGACA AGTCCCAAAC ACAAAGGAAA GATTTCTCGA 
ATGCTGGCAG CCAAAACCGT TTTGGCTATC CGTTATGATG CTTTTGGTGA GGATTCAAGT 
TCTGCAATGG GAGTTGAGAA CAGAGCCAAA TTAGAGGCCA GGTTGAGAAC TTTGGAAGAC 
AGAGGGATAA GAAAAATAAG TGGAACAGGA AAAGCATTAG CAAAAACAGA AAAATATGAA 
CACAAAAGTG AAGTGAAGAC TTACGATCCT TCTGGTGACT CCACACTTCC AACCTGTTCT 
AAAAAACGCA AAATAGAACA GGTAGATAAA GAGGATGAAA TTACTGAAAA GAAAGCCAAA 
AAAGCCAAGA TTAAAGTTAA AGTTGAAGAA GAGGAAGAAG AAAAAGTGGC AGAAGAAGAA 
GAAACATCTG TGAAGAAGAA GAAGAAAAGG GGTAAAAAGA AACACATTAA GGAAGAACCA 
CTTTCTGAGG AAGAACCATG TACCAGCACA GCAATTGCTA GTCCAGAGAA AAAGAAGAAA 
AAGAAAAAAA AGAGAGAGAA CGAGGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NOP58 ( NM_015934.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057018.1 Homo sapiens NOP58 ribonucleoprotein (NOP58), mRNA.

Price & Availability↑

CloneID	OHu29366
Clone ID Related Accession (Same CDS sequence)	NM_015934.5 , NM_015934.3 , NM_015934.4
Accession Version	NM_015934.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1590bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	nucleolar protein 58
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP245255.1 and BC032592.2. On Nov 19, 2015 this sequence version replaced NM_015934.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC032592.2, SRR1660807.223343.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTGGTGC TGTTTGAAAC GTCTGTGGGT TACGCCATCT TTAAGGTTCT AAATGAGAAG 
AAACTTCAAG AGGTTGATAG TTTATGGAAA GAATTTGAAA CTCCAGAGAA AGCAAACAAA 
ATAGTAAAGC TAAAACATTT TGAGAAATTT CAGGATACAG CAGAAGCATT AGCAGCATTC 
ACAGCTCTGA TGGAGGGCAA AATCAATAAG CAGCTGAAAA AAGTTCTGAA GAAAATAGTA 
AAAGAAGCCC ATGAACCGCT GGCAGTAGCT GATGCTAAAC TAGGAGGGGT CATAAAGGAA 
AAGCTGAATC TCAGTTGTAT CCATAGTCCT GTTGTTAATG AACTTATGAG AGGAATTCGT 
TCACAAATGG ATGGATTAAT CCCTGGGGTA GAACCACGTG AAATGGCAGC TATGTGTCTT 
GGATTGGCTC ACAGCCTGTC TCGATATAGA TTGAAGTTTA GCGCTGATAA AGTAGACACA 
ATGATTGTTC AGGCAATTTC CTTGTTAGAT GACTTGGATA AAGAACTAAA CAACTACATT 
ATGCGATGTA GAGAATGGTA TGGCTGGCAT TTCCCTGAAT TAGGAAAAAT TATTTCAGAT 
AATTTAACAT ACTGCAAGTG TTTACAGAAA GTTGGCGATA GGAAGAACTA TGCCTCTGCC 
AAGCTTTCTG AGTTGCTGCC AGAAGAAGTT GAAGCAGAAG TGAAAGCAGC TGCAGAGATA 
TCAATGGGAA CAGAGGTTTC AGAAGAAGAT ATTTGCAATA TTCTGCATCT TTGCACCCAG 
GTGATTGAAA TCTCTGAATA TCGAACCCAG CTCTATGAAT ATCTACAAAA TCGAATGATG 
GCCATTGCAC CCAATGTTAC AGTCATGGTT GGGGAATTAG TTGGAGCACG GCTTATTGCT 
CATGCAGGTT CTCTTTTAAA TTTGGCCAAG CATGCAGCTT CTACCGTTCA GATTCTTGGA 
GCTGAAAAGG CACTTTTCAG AGCCCTCAAA TCTAGACGGG ATACCCCTAA GTATGGTCTC 
ATTTATCATG CTTCACTCGT GGGCCAGACA AGTCCCAAAC ACAAAGGAAA GATTTCTCGA 
ATGCTGGCAG CCAAAACCGT TTTGGCTATC CGTTATGATG CTTTTGGTGA GGATTCAAGT 
TCTGCAATGG GAGTTGAGAA CAGAGCCAAA TTAGAGGCCA GGTTGAGAAC TTTGGAAGAC 
AGAGGGATAA GAAAAATAAG TGGAACAGGA AAAGCATTAG CAAAAACAGA AAAATATGAA 
CACAAAAGTG AAGTGAAGAC TTACGATCCT TCTGGTGACT CCACACTTCC AACCTGTTCT 
AAAAAACGCA AAATAGAACA GGTAGATAAA GAGGATGAAA TTACTGAAAA GAAAGCCAAA 
AAAGCCAAGA TTAAAGTTAA AGTTGAAGAA GAGGAAGAAG AAAAAGTGGC AGAAGAAGAA 
GAAACATCTG TGAAGAAGAA GAAGAAAAGG GGTAAAAAGA AACACATTAA GGAAGAACCA 
CTTTCTGAGG AAGAACCATG TACCAGCACA GCAATTGCTA GTCCAGAGAA AAAGAAGAAA 
AAGAAAAAAA AGAGAGAGAA CGAGGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057018.1
CDS	227..1816
Translation	MLVLFETSVGYAIFKVLNEKKLQEVDSLWKEFETPEKANKIVKLKHFEKFQDTAEALAAFTALMEGKINKQLKKVLKKIVKEAHEPLAVADAKLGGVIKEKLNLSCIHSPVVNELMRGIRSQMDGLIPGVEPREMAAMCLGLAHSLSRYRLKFSADKVDTMIVQAISLLDDLDKELNNYIMRCREWYGWHFPELGKIISDNLTYCKCLQKVGDRKNYASAKLSELLPEEVEAEVKAAAEISMGTEVSEEDICNILHLCTQVIEISEYRTQLYEYLQNRMMAIAPNVTVMVGELVGARLIAHAGSLLNLAKHAASTVQILGAEKALFRALKSRRDTPKYGLIYHASLVGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED

Target ORF information:

RefSeq Version	NM_015934.4
Organism	Homo sapiens(human)
Definition	Homo sapiens NOP58 ribonucleoprotein (NOP58), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015934.4

ORF Insert Sequence:

ATGTTGGTGC TGTTTGAAAC GTCTGTGGGT TACGCCATCT TTAAGGTTCT AAATGAGAAG 
AAACTTCAAG AGGTTGATAG TTTATGGAAA GAATTTGAAA CTCCAGAGAA AGCAAACAAA 
ATAGTAAAGC TAAAACATTT TGAGAAATTT CAGGATACAG CAGAAGCATT AGCAGCATTC 
ACAGCTCTGA TGGAGGGCAA AATCAATAAG CAGCTGAAAA AAGTTCTGAA GAAAATAGTA 
AAAGAAGCCC ATGAACCGCT GGCAGTAGCT GATGCTAAAC TAGGAGGGGT CATAAAGGAA 
AAGCTGAATC TCAGTTGTAT CCATAGTCCT GTTGTTAATG AACTTATGAG AGGAATTCGT 
TCACAAATGG ATGGATTAAT CCCTGGGGTA GAACCACGTG AAATGGCAGC TATGTGTCTT 
GGATTGGCTC ACAGCCTGTC TCGATATAGA TTGAAGTTTA GCGCTGATAA AGTAGACACA 
ATGATTGTTC AGGCAATTTC CTTGTTAGAT GACTTGGATA AAGAACTAAA CAACTACATT 
ATGCGATGTA GAGAATGGTA TGGCTGGCAT TTCCCTGAAT TAGGAAAAAT TATTTCAGAT 
AATTTAACAT ACTGCAAGTG TTTACAGAAA GTTGGCGATA GGAAGAACTA TGCCTCTGCC 
AAGCTTTCTG AGTTGCTGCC AGAAGAAGTT GAAGCAGAAG TGAAAGCAGC TGCAGAGATA 
TCAATGGGAA CAGAGGTTTC AGAAGAAGAT ATTTGCAATA TTCTGCATCT TTGCACCCAG 
GTGATTGAAA TCTCTGAATA TCGAACCCAG CTCTATGAAT ATCTACAAAA TCGAATGATG 
GCCATTGCAC CCAATGTTAC AGTCATGGTT GGGGAATTAG TTGGAGCACG GCTTATTGCT 
CATGCAGGTT CTCTTTTAAA TTTGGCCAAG CATGCAGCTT CTACCGTTCA GATTCTTGGA 
GCTGAAAAGG CACTTTTCAG AGCCCTCAAA TCTAGACGGG ATACCCCTAA GTATGGTCTC 
ATTTATCATG CTTCACTCGT GGGCCAGACA AGTCCCAAAC ACAAAGGAAA GATTTCTCGA 
ATGCTGGCAG CCAAAACCGT TTTGGCTATC CGTTATGATG CTTTTGGTGA GGATTCAAGT 
TCTGCAATGG GAGTTGAGAA CAGAGCCAAA TTAGAGGCCA GGTTGAGAAC TTTGGAAGAC 
AGAGGGATAA GAAAAATAAG TGGAACAGGA AAAGCATTAG CAAAAACAGA AAAATATGAA 
CACAAAAGTG AAGTGAAGAC TTACGATCCT TCTGGTGACT CCACACTTCC AACCTGTTCT 
AAAAAACGCA AAATAGAACA GGTAGATAAA GAGGATGAAA TTACTGAAAA GAAAGCCAAA 
AAAGCCAAGA TTAAAGTTAA AGTTGAAGAA GAGGAAGAAG AAAAAGTGGC AGAAGAAGAA 
GAAACATCTG TGAAGAAGAA GAAGAAAAGG GGTAAAAAGA AACACATTAA GGAAGAACCA 
CTTTCTGAGG AAGAACCATG TACCAGCACA GCAATTGCTA GTCCAGAGAA AAAGAAGAAA 
AAGAAAAAAA AGAGAGAGAA CGAGGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of discrete classes of small nucleolar RNA featuring different ends and RNA binding protein dependency.
Nucleic acids research42(15)10073-85(2014 Sep)
Deschamps-Francoeur G,Garneau D,Dupuis-Sandoval F,Roy A,Frappier M,Catala M,Couture S,Barbe-Marcoux M,Abou-Elela S,Scott MS

CRM1 controls the composition of nucleoplasmic pre-snoRNA complexes to licence them for nucleolar transport.
The EMBO journal30(11)2205-18(2011 Jun)
Pradet-Balade B,Girard C,Boulon S,Paul C,Azzag K,Bordonn? R,Bertrand E,Verheggen C

A proteomic screen for nucleolar SUMO targets shows SUMOylation modulates the function of Nop5/Nop58.
Molecular cell39(4)618-31(2010 Aug)
Westman BJ,Verheggen C,Hutten S,Lam YW,Bertrand E,Lamond AI

Evidence that the AAA+ proteins TIP48 and TIP49 bridge interactions between 15.5K and the related NOP56 and NOP58 proteins during box C/D snoRNP biogenesis.
Molecular and cellular biology29(18)4971-81(2009 Sep)
McKeegan KS,Debieux CM,Watkins NJ

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NOP58 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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