VCX3A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	VCX3A
Entrez Gene ID	51481
Full Name	variable charge, X-linked 3A
Synonyms	VCX-8r,VCX-A,VCX3,VCX8R,VCXA
General protein information	Preferred Names variable charge, X-linked 3A Names variable charge X-linked protein 3 variable charge protein on X with eight repeats variably charged X-A variably charged protein X-A
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp22.31
Summary	This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 8 repeats of the 30-bp unit. [provided by RefSeq, Jul 2008].
Disorder MIM:	300533

mRNA and Protein(s)

mRNA	Protein	Name
NM_016379.3	NP_057463.2	variable charge X-linked protein 3
NM_016379.4	NP_057463.2	variable charge X-linked protein 3
XM_006724494.3	XP_006724557.1	variable charge X-linked protein 3 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	VCX	NP_038480.2
Homo sapiens (human)	VCX3A	NP_057463.2

Gene Ontology
Bibliography

Related articles in PubMed

Modulation of neuritogenesis by a protein implicated in X-linked mental retardation.
Jiao X, Chen H, Chen J, Herrup K, Firestein BL, Kiledjian M
The Journal of neuroscience : the official journal of the Society for Neuroscience29(40)12419-27(2009 Oct)

Analysis of the VCX3A, VCX2 and VCX3B genes shows that VCX3A gene deletion is not sufficient to result in mental retardation in X-linked ichthyosis.
Cuevas-Covarrubias SA, Gonz?lez-Huerta LM
The British journal of dermatology158(3)483-6(2008 Mar)

Identification of an mRNA-decapping regulator implicated in X-linked mental retardation.
Jiao X, Wang Z, Kiledjian M
Molecular cell24(5)713-22(2006 Dec)

A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-linked nonspecific mental retardation.
Fukami M, Kirsch S, Schiller S, Richter A, Benes V, Franco B, Muroya K, Rao E, Merker S, Niesler B, Ballabio A, Ansorge W, Ogata T, Rappold GA
American journal of human genetics67(3)563-73(2000 Sep)

A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins.
Lahn BT, Page DC
Human molecular genetics9(2)311-9(2000 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We demonstrate that VCX-A can specifically bind a subset of mRNAs involved in neuritogenesis and is also capable of promoting translational silencing.
Title: Modulation of neuritogenesis by a protein implicated in X-linked mental retardation.

two different deletion patterns were observed: the first group included 62 patients with deletion of VCX3A & VCX genes. The second group included 18 patients with breakpoints at several regions on either side of the STS gene not including the VCX3A gene.
Title: Analysis of the VCX3A, VCX2 and VCX3B genes shows that VCX3A gene deletion is not sufficient to result in mental retardation in X-linked ichthyosis.

Our data demonstrate that VCX-A can regulate mRNA stability and that it is an example of a tissue-specific decapping regulator.
Title: Identification of an mRNA-decapping regulator implicated in X-linked mental retardation.

The following VCX3A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the VCX3A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22506	NM_016379.4 Latest version!	Homo sapiens variable charge X-linked 3A (VCX3A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu53927	XM_006724494.3 Latest version!	Homo sapiens variable charge, X-linked 3A (VCX3A), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
View Old Accession Versions >>
OHu22506	NM_016379.3	Homo sapiens variable charge X-linked 3A (VCX3A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

VCX3A ( NM_016379.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057463.2 Homo sapiens variable charge X-linked 3A (VCX3A), mRNA.

Price & Availability↑

CloneID	OHu22506
Clone ID Related Accession (Same CDS sequence)	NM_016379.3 , NM_016379.4
Accession Version	NM_016379.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	variable charge X-linked protein 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF167078.1, AC108684.7 and BC039722.1. This sequence is a reference standard in the RefSeqGene project. On Feb 21, 2009 this sequence version replaced NM_016379.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AF167078.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2161674 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTCCAA AGCCGAGAGC CTCGGGACCT CCGGCCAAGG CCACGGAGGC AGGAAAGAGG 
AAGTCCTCCT CTCAGCCGAG CCCCAGTGAC CCGAAGAAGA AGACTACCAA GGTGGCCAAG 
AAGGGAAAAG CAGTTCGTAG AGGGAGACGC GGGAAGAAAG GGGCTGCGAC AAAGATGGCG 
GCCGTGACGG CACCTGAGGC GGAGAGCGGG CCAGCGGCAC CCGGCCCCAG CGACCAGCCC 
AGCCAGGAGC TCCCTCAGCA CGAGCTGCCG CCGGAGGAGC CAGTGAGCGA GGGGACCCAG 
CACGACCCCC TGAGTCAGGA GAGCGAGCTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAGGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGATG 
GAAGAACTAC CGAGTGTGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057463.2
CDS	308..868
Translation	MSPKPRASGPPAKATEAGKRKSSSQPSPSDPKKKTTKVAKKGKAVRRGRRGKKGAATKMAAVTAPEAESGPAAPGPSDQPSQELPQHELPPEEPVSEGTQHDPLSQESELEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEMEELPSV

Target ORF information:

RefSeq Version	NM_016379.3
Organism	Homo sapiens(human)
Definition	Homo sapiens variable charge X-linked 3A (VCX3A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016379.3

ORF Insert Sequence:

ATGAGTCCAA AGCCGAGAGC CTCGGGACCT CCGGCCAAGG CCACGGAGGC AGGAAAGAGG 
AAGTCCTCCT CTCAGCCGAG CCCCAGTGAC CCGAAGAAGA AGACTACCAA GGTGGCCAAG 
AAGGGAAAAG CAGTTCGTAG AGGGAGACGC GGGAAGAAAG GGGCTGCGAC AAAGATGGCG 
GCCGTGACGG CACCTGAGGC GGAGAGCGGG CCAGCGGCAC CCGGCCCCAG CGACCAGCCC 
AGCCAGGAGC TCCCTCAGCA CGAGCTGCCG CCGGAGGAGC CAGTGAGCGA GGGGACCCAG 
CACGACCCCC TGAGTCAGGA GAGCGAGCTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAGGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGATG 
GAAGAACTAC CGAGTGTGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VCX3A ( NM_016379.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057463.2 Homo sapiens variable charge X-linked 3A (VCX3A), mRNA.

Price & Availability↑

CloneID	OHu22506
Clone ID Related Accession (Same CDS sequence)	NM_016379.3 , NM_016379.4
Accession Version	NM_016379.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	variable charge X-linked protein 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF167078.1, AC108684.7 and BC039722.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_016379.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AF167078.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2161674 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000381089.7/ ENSP00000370479.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGTCCAA AGCCGAGAGC CTCGGGACCT CCGGCCAAGG CCACGGAGGC AGGAAAGAGG 
AAGTCCTCCT CTCAGCCGAG CCCCAGTGAC CCGAAGAAGA AGACTACCAA GGTGGCCAAG 
AAGGGAAAAG CAGTTCGTAG AGGGAGACGC GGGAAGAAAG GGGCTGCGAC AAAGATGGCG 
GCCGTGACGG CACCTGAGGC GGAGAGCGGG CCAGCGGCAC CCGGCCCCAG CGACCAGCCC 
AGCCAGGAGC TCCCTCAGCA CGAGCTGCCG CCGGAGGAGC CAGTGAGCGA GGGGACCCAG 
CACGACCCCC TGAGTCAGGA GAGCGAGCTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAGGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGATG 
GAAGAACTAC CGAGTGTGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057463.2
CDS	308..868
Translation	MSPKPRASGPPAKATEAGKRKSSSQPSPSDPKKKTTKVAKKGKAVRRGRRGKKGAATKMAAVTAPEAESGPAAPGPSDQPSQELPQHELPPEEPVSEGTQHDPLSQESELEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEMEELPSV

Target ORF information:

RefSeq Version	NM_016379.4
Organism	Homo sapiens(human)
Definition	Homo sapiens variable charge X-linked 3A (VCX3A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016379.4

ORF Insert Sequence:

ATGAGTCCAA AGCCGAGAGC CTCGGGACCT CCGGCCAAGG CCACGGAGGC AGGAAAGAGG 
AAGTCCTCCT CTCAGCCGAG CCCCAGTGAC CCGAAGAAGA AGACTACCAA GGTGGCCAAG 
AAGGGAAAAG CAGTTCGTAG AGGGAGACGC GGGAAGAAAG GGGCTGCGAC AAAGATGGCG 
GCCGTGACGG CACCTGAGGC GGAGAGCGGG CCAGCGGCAC CCGGCCCCAG CGACCAGCCC 
AGCCAGGAGC TCCCTCAGCA CGAGCTGCCG CCGGAGGAGC CAGTGAGCGA GGGGACCCAG 
CACGACCCCC TGAGTCAGGA GAGCGAGCTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAGGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGATG 
GAAGAACTAC CGAGTGTGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VCX3A ( XM_006724494.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_006724557.1 Homo sapiens variable charge, X-linked 3A (VCX3A), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu53927
Clone ID Related Accession (Same CDS sequence)	XM_006724494.3
Accession Version	XM_006724494.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	variable charge X-linked protein 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006724494.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTCCAA AGCCGAGAGC CTCGGGACCT CCGGCCAAGG CCACGGAGGC AGGAAAGAGG 
AAGTCCTCCT CTCAGCCGAG CCCCAGTGAC CCGAAGAAGA AGACTACCAA GGTGGCCAAG 
AAGGGAAAAG CAGTTCGTAG AGGGAGACGC GGGAAGAAAG GGGCTGCGAC AAAGATGGCG 
GCCGTGACGG CACCTGAGGC GGAGAGCGGG CCAGCGGCAC CCGGCCCCAG CGACCAGCCC 
AGCCAGGAGC TCCCTCAGCA CGAGCTGCCG CCGGAGGAGC CAGTGAGCGA GGGGACCCAG 
CACGACCCCC TGAGTCAGGA GAGCGAGCTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAGGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGATG 
GAAGAACTAC CGAGTGTGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006724557.1
CDS	92..592
Translation	MSPKPRASGPPAKATEAGKRKSSSQPSPSDPKKKTTKVAKKGKAVRRGRRGKKGAATKMAAVTAPEAESGPAAPGPSDQPSQELPQHELPPEEPVSEGTQHDPLSQESELEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEMEELPSV

Target ORF information:

RefSeq Version	XM_006724494.3
Organism	Homo sapiens(human)
Definition	Homo sapiens variable charge, X-linked 3A (VCX3A), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006724494.3

ORF Insert Sequence:

ATGAGTCCAA AGCCGAGAGC CTCGGGACCT CCGGCCAAGG CCACGGAGGC AGGAAAGAGG 
AAGTCCTCCT CTCAGCCGAG CCCCAGTGAC CCGAAGAAGA AGACTACCAA GGTGGCCAAG 
AAGGGAAAAG CAGTTCGTAG AGGGAGACGC GGGAAGAAAG GGGCTGCGAC AAAGATGGCG 
GCCGTGACGG CACCTGAGGC GGAGAGCGGG CCAGCGGCAC CCGGCCCCAG CGACCAGCCC 
AGCCAGGAGC TCCCTCAGCA CGAGCTGCCG CCGGAGGAGC CAGTGAGCGA GGGGACCCAG 
CACGACCCCC TGAGTCAGGA GAGCGAGCTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAGGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGATG 
GAAGAACTAC CGAGTGTGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Modulation of neuritogenesis by a protein implicated in X-linked mental retardation.
The Journal of neuroscience : the official journal of the Society for Neuroscience29(40)12419-27(2009 Oct)
Jiao X,Chen H,Chen J,Herrup K,Firestein BL,Kiledjian M

Analysis of the VCX3A, VCX2 and VCX3B genes shows that VCX3A gene deletion is not sufficient to result in mental retardation in X-linked ichthyosis.
The British journal of dermatology158(3)483-6(2008 Mar)
Cuevas-Covarrubias SA,Gonz?lez-Huerta LM

Identification of an mRNA-decapping regulator implicated in X-linked mental retardation.
Molecular cell24(5)713-22(2006 Dec)
Jiao X,Wang Z,Kiledjian M

A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-linked nonspecific mental retardation.
American journal of human genetics67(3)563-73(2000 Sep)
Fukami M,Kirsch S,Schiller S,Richter A,Benes V,Franco B,Muroya K,Rao E,Merker S,Niesler B,Ballabio A,Ansorge W,Ogata T,Rappold GA

A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins.
Human molecular genetics9(2)311-9(2000 Jan)
Lahn BT,Page DC

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VCX3A cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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