PDE6G cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PDE6G
Entrez Gene ID	5148
Full Name	phosphodiesterase 6G
Synonyms	PDEG,RP57
General protein information	Preferred Names phosphodiesterase 6G Names retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma GMP-PDE gamma phosphodiesterase 6G, cGMP-specific, rod, gamma rod cG-PDE G
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q25.3
Summary	This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009].
Disorder MIM:	180073
Disorder Html:	Retinitis pigmentosa 57, 613582 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_017024735.1	XP_016880224.1	retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma isoform X2
XM_017024734.1	XP_016880223.1	retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma isoform X1
NM_001365724.1	NP_001352653.1	retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
XM_017024736.1	XP_016880225.1	retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma isoform X2
NM_002602.3	NP_002593.1	retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
XM_006721942.3	XP_006722005.1	retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma isoform X3
NM_002602.4	NP_002593.1	retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
NM_001365725.1	NP_001352654.1	retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	pde6g	NP_001165049.1
Homo sapiens (human)	PDE6G	NP_002593.1
Canis lupus familiaris (dog)	PDE6G	NP_001003235.1
Mus musculus (house mouse)	Pde6g	NP_036197.1
Gallus gallus (chicken)	PDE6G	NP_989776.1
Rattus norvegicus (Norway rat)	Pde6g	XP_003751031.1
	LOC719052	XP_001112634.2
Bos taurus (cattle)	PDE6G	NP_776846.1
Danio rerio (zebrafish)	pde6g	NP_997964.1
Xenopus tropicalis (tropical clawed frog)	LOC101732382	XP_004916403.1

Gene Ontology
Bibliography

Related articles in PubMed

Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis.
Nikolova S, Guenther A, Savai R, Weissmann N, Ghofrani HA, Konigshoff M, Eickelberg O, Klepetko W, Voswinckel R, Seeger W, Grimminger F, Schermuly RT, Pullamsetti SS
Respiratory research11146(2010 Oct)

Autosomal-recessive early-onset retinitis pigmentosa caused by a mutation in PDE6G, the gene encoding the gamma subunit of rod cGMP phosphodiesterase.
Dvir L, Srour G, Abu-Ras R, Miller B, Shalev SA, Ben-Yosef T
American journal of human genetics87(2)258-64(2010 Aug)

Determinants for phosphodiesterase 6 inhibition by its gamma-subunit.
Zhang Z, Artemyev NO
Biochemistry49(18)3862-7(2010 May)

Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit.
Barren B, Gakhar L, Muradov H, Boyd KK, Ramaswamy S, Artemyev NO
The EMBO journal28(22)3613-22(2009 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Collectively, we report previously unrecognized PDE6 expression in human lungs, significant alterations of the PDE6D and PDE6G/H subunits in IPF lungs.
Title: Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis.

These findings demonstrate the positive role of the gamma subunit in maintaining phosphodiesterase activity and confirm the contribution of PDE6G to the etiology of retinitis pigmentosa in humans.
Title: Autosomal-recessive early-onset retinitis pigmentosa caused by a mutation in PDE6G, the gene encoding the gamma subunit of rod cGMP phosphodiesterase.

The C-terminus of PED gamma occludes the active site of PDE6, thereby preventing hydrolysis of cGMP.
Title: Determinants for phosphodiesterase 6 inhibition by its gamma-subunit.

Crystal structures of a chimaeric PDE5/PDE6 catalytic domain (PDE5/6cd) complexed with sildenafil or 3-isobutyl-1-methylxanthine and the Pgamma-inhibitory peptide Pgamma(70-87) have been determined at 2.9 and 3.0 A, respectively.
Title: Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit.

PDEG functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor
Title: The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor.

The following PDE6G gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PDE6G cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22361	NM_001365724.1 Latest version!	Homo sapiens phosphodiesterase 6G (PDE6G), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu22361	NM_001365725.1 Latest version!	Homo sapiens phosphodiesterase 6G (PDE6G), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu22361	NM_002602.4 Latest version!	Homo sapiens phosphodiesterase 6G (PDE6G), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu22361	XM_017024736.1 Latest version!	Homo sapiens phosphodiesterase 6G (PDE6G), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu22361	XM_017024735.1 Latest version!	Homo sapiens phosphodiesterase 6G (PDE6G), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu50455	XM_006721942.3 Latest version!	Homo sapiens phosphodiesterase 6G (PDE6G), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu86921	XM_017024734.1 Latest version!	Homo sapiens phosphodiesterase 6G (PDE6G), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu22361	NM_002602.3	Homo sapiens phosphodiesterase 6G (PDE6G), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PDE6G ( NM_001365724.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001352653.1 Homo sapiens phosphodiesterase 6G (PDE6G), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu22361
Clone ID Related Accession (Same CDS sequence)	XM_017024735.1 , NM_001365724.1 , XM_017024736.1 , NM_002602.3 , NM_002602.4 , NM_001365725.1
Accession Version	NM_001365724.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 264bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Homo sapiens(human)
Product	retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from EL945892.1 and AC139530.3. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 3, and 4 all encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EL945892.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACCTGG AACCGCCCAA GGCTGAGTTC CGGTCAGCCA CCAGGGTGGC CGGGGGACCT 
GTCACCCCCA GGAAAGGGCC CCCTAAATTT AAGCAGCGAC AGACCAGGCA GTTCAAGAGC 
AAGCCCCCAA AGAAAGGCGT TCAAGGGTTT GGGGACGACA TCCCTGGAAT GGAAGGCCTG 
GGAACAGACA TCACAGTCAT CTGCCCTTGG GAGGCCTTCA ACCACCTGGA GCTGCACGAG 
CTGGCCCAAT ATGGCATCAT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001352653.1
CDS	129..392
Translation	MNLEPPKAEFRSATRVAGGPVTPRKGPPKFKQRQTRQFKSKPPKKGVQGFGDDIPGMEGLGTDITVICPWEAFNHLELHELAQYGII

Target ORF information:

RefSeq Version	NM_001365724.1
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphodiesterase 6G (PDE6G), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001365724.1

ORF Insert Sequence:

ATGAACCTGG AACCGCCCAA GGCTGAGTTC CGGTCAGCCA CCAGGGTGGC CGGGGGACCT 
GTCACCCCCA GGAAAGGGCC CCCTAAATTT AAGCAGCGAC AGACCAGGCA GTTCAAGAGC 
AAGCCCCCAA AGAAAGGCGT TCAAGGGTTT GGGGACGACA TCCCTGGAAT GGAAGGCCTG 
GGAACAGACA TCACAGTCAT CTGCCCTTGG GAGGCCTTCA ACCACCTGGA GCTGCACGAG 
CTGGCCCAAT ATGGCATCAT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PDE6G ( NM_002602.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002593.1 Homo sapiens phosphodiesterase 6G (PDE6G), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22361
Clone ID Related Accession (Same CDS sequence)	XM_017024735.1 , NM_001365724.1 , XM_017024736.1 , NM_002602.3 , NM_002602.4 , NM_001365725.1
Accession Version	NM_002602.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 264bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ639132.1, BC106884.2, AC139530.3 and BX647779.1. This sequence is a reference standard in the RefSeqGene project. On Feb 18, 2009 this sequence version replaced NM_002602.2. Transcript Variant: This variant (1) represents the longer transcript. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX537414.1, M36476.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149398 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACCTGG AACCGCCCAA GGCTGAGTTC CGGTCAGCCA CCAGGGTGGC CGGGGGACCT 
GTCACCCCCA GGAAAGGGCC CCCTAAATTT AAGCAGCGAC AGACCAGGCA GTTCAAGAGC 
AAGCCCCCAA AGAAAGGCGT TCAAGGGTTT GGGGACGACA TCCCTGGAAT GGAAGGCCTG 
GGAACAGACA TCACAGTCAT CTGCCCTTGG GAGGCCTTCA ACCACCTGGA GCTGCACGAG 
CTGGCCCAAT ATGGCATCAT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002593.1
CDS	145..408
Translation	MNLEPPKAEFRSATRVAGGPVTPRKGPPKFKQRQTRQFKSKPPKKGVQGFGDDIPGMEGLGTDITVICPWEAFNHLELHELAQYGII

Target ORF information:

RefSeq Version	NM_002602.3
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphodiesterase 6G (PDE6G), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002602.3

ORF Insert Sequence:

ATGAACCTGG AACCGCCCAA GGCTGAGTTC CGGTCAGCCA CCAGGGTGGC CGGGGGACCT 
GTCACCCCCA GGAAAGGGCC CCCTAAATTT AAGCAGCGAC AGACCAGGCA GTTCAAGAGC 
AAGCCCCCAA AGAAAGGCGT TCAAGGGTTT GGGGACGACA TCCCTGGAAT GGAAGGCCTG 
GGAACAGACA TCACAGTCAT CTGCCCTTGG GAGGCCTTCA ACCACCTGGA GCTGCACGAG 
CTGGCCCAAT ATGGCATCAT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PDE6G ( NM_002602.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002593.1 Homo sapiens phosphodiesterase 6G (PDE6G), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22361
Clone ID Related Accession (Same CDS sequence)	XM_017024735.1 , NM_001365724.1 , XM_017024736.1 , NM_002602.3 , NM_002602.4 , NM_001365725.1
Accession Version	NM_002602.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 264bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ639132.1, BC106884.2, AC139530.3 and BX647779.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_002602.3. Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 3, and 4 all encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX537414.1, M36476.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149398 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000331056.10/ ENSP00000328412.5 RefSeq Select criteria :: based on conservation ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAACCTGG AACCGCCCAA GGCTGAGTTC CGGTCAGCCA CCAGGGTGGC CGGGGGACCT 
GTCACCCCCA GGAAAGGGCC CCCTAAATTT AAGCAGCGAC AGACCAGGCA GTTCAAGAGC 
AAGCCCCCAA AGAAAGGCGT TCAAGGGTTT GGGGACGACA TCCCTGGAAT GGAAGGCCTG 
GGAACAGACA TCACAGTCAT CTGCCCTTGG GAGGCCTTCA ACCACCTGGA GCTGCACGAG 
CTGGCCCAAT ATGGCATCAT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002593.1
CDS	110..373
Translation	MNLEPPKAEFRSATRVAGGPVTPRKGPPKFKQRQTRQFKSKPPKKGVQGFGDDIPGMEGLGTDITVICPWEAFNHLELHELAQYGII

Target ORF information:

RefSeq Version	NM_002602.4
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphodiesterase 6G (PDE6G), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002602.4

ORF Insert Sequence:

ATGAACCTGG AACCGCCCAA GGCTGAGTTC CGGTCAGCCA CCAGGGTGGC CGGGGGACCT 
GTCACCCCCA GGAAAGGGCC CCCTAAATTT AAGCAGCGAC AGACCAGGCA GTTCAAGAGC 
AAGCCCCCAA AGAAAGGCGT TCAAGGGTTT GGGGACGACA TCCCTGGAAT GGAAGGCCTG 
GGAACAGACA TCACAGTCAT CTGCCCTTGG GAGGCCTTCA ACCACCTGGA GCTGCACGAG 
CTGGCCCAAT ATGGCATCAT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PDE6G ( NM_001365725.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001352654.1 Homo sapiens phosphodiesterase 6G (PDE6G), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu22361
Clone ID Related Accession (Same CDS sequence)	XM_017024735.1 , NM_001365724.1 , XM_017024736.1 , NM_002602.3 , NM_002602.4 , NM_001365725.1
Accession Version	NM_001365725.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 264bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC139530.3. On Sep 13, 2018 this sequence version replaced XM_017024735.1. Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 3, and 4 all encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.125793.1, SRR1163657.429611.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACCTGG AACCGCCCAA GGCTGAGTTC CGGTCAGCCA CCAGGGTGGC CGGGGGACCT 
GTCACCCCCA GGAAAGGGCC CCCTAAATTT AAGCAGCGAC AGACCAGGCA GTTCAAGAGC 
AAGCCCCCAA AGAAAGGCGT TCAAGGGTTT GGGGACGACA TCCCTGGAAT GGAAGGCCTG 
GGAACAGACA TCACAGTCAT CTGCCCTTGG GAGGCCTTCA ACCACCTGGA GCTGCACGAG 
CTGGCCCAAT ATGGCATCAT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001352654.1
CDS	104..367
Translation	MNLEPPKAEFRSATRVAGGPVTPRKGPPKFKQRQTRQFKSKPPKKGVQGFGDDIPGMEGLGTDITVICPWEAFNHLELHELAQYGII

Target ORF information:

RefSeq Version	NM_001365725.1
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphodiesterase 6G (PDE6G), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001365725.1

ORF Insert Sequence:

ATGAACCTGG AACCGCCCAA GGCTGAGTTC CGGTCAGCCA CCAGGGTGGC CGGGGGACCT 
GTCACCCCCA GGAAAGGGCC CCCTAAATTT AAGCAGCGAC AGACCAGGCA GTTCAAGAGC 
AAGCCCCCAA AGAAAGGCGT TCAAGGGTTT GGGGACGACA TCCCTGGAAT GGAAGGCCTG 
GGAACAGACA TCACAGTCAT CTGCCCTTGG GAGGCCTTCA ACCACCTGGA GCTGCACGAG 
CTGGCCCAAT ATGGCATCAT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PDE6G ( XM_017024735.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016880224.1 Homo sapiens phosphodiesterase 6G (PDE6G), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu22361
Clone ID Related Accession (Same CDS sequence)	XM_017024735.1 , NM_001365724.1 , XM_017024736.1 , NM_002602.3 , NM_002602.4 , NM_001365725.1
Accession Version	XM_017024735.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 264bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACCTGG AACCGCCCAA GGCTGAGTTC CGGTCAGCCA CCAGGGTGGC CGGGGGACCT 
GTCACCCCCA GGAAAGGGCC CCCTAAATTT AAGCAGCGAC AGACCAGGCA GTTCAAGAGC 
AAGCCCCCAA AGAAAGGCGT TCAAGGGTTT GGGGACGACA TCCCTGGAAT GGAAGGCCTG 
GGAACAGACA TCACAGTCAT CTGCCCTTGG GAGGCCTTCA ACCACCTGGA GCTGCACGAG 
CTGGCCCAAT ATGGCATCAT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016880224.1
CDS	151..414
Translation	MNLEPPKAEFRSATRVAGGPVTPRKGPPKFKQRQTRQFKSKPPKKGVQGFGDDIPGMEGLGTDITVICPWEAFNHLELHELAQYGII

Target ORF information:

RefSeq Version	XM_017024735.1
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphodiesterase 6G (PDE6G), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017024735.1

ORF Insert Sequence:

ATGAACCTGG AACCGCCCAA GGCTGAGTTC CGGTCAGCCA CCAGGGTGGC CGGGGGACCT 
GTCACCCCCA GGAAAGGGCC CCCTAAATTT AAGCAGCGAC AGACCAGGCA GTTCAAGAGC 
AAGCCCCCAA AGAAAGGCGT TCAAGGGTTT GGGGACGACA TCCCTGGAAT GGAAGGCCTG 
GGAACAGACA TCACAGTCAT CTGCCCTTGG GAGGCCTTCA ACCACCTGGA GCTGCACGAG 
CTGGCCCAAT ATGGCATCAT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PDE6G ( XM_017024736.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016880225.1 Homo sapiens phosphodiesterase 6G (PDE6G), transcript variant X4, mRNA.

Price & Availability↑

CloneID	OHu22361
Clone ID Related Accession (Same CDS sequence)	XM_017024735.1 , NM_001365724.1 , XM_017024736.1 , NM_002602.3 , NM_002602.4 , NM_001365725.1
Accession Version	XM_017024736.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 264bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACCTGG AACCGCCCAA GGCTGAGTTC CGGTCAGCCA CCAGGGTGGC CGGGGGACCT 
GTCACCCCCA GGAAAGGGCC CCCTAAATTT AAGCAGCGAC AGACCAGGCA GTTCAAGAGC 
AAGCCCCCAA AGAAAGGCGT TCAAGGGTTT GGGGACGACA TCCCTGGAAT GGAAGGCCTG 
GGAACAGACA TCACAGTCAT CTGCCCTTGG GAGGCCTTCA ACCACCTGGA GCTGCACGAG 
CTGGCCCAAT ATGGCATCAT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016880225.1
CDS	85..348
Translation	MNLEPPKAEFRSATRVAGGPVTPRKGPPKFKQRQTRQFKSKPPKKGVQGFGDDIPGMEGLGTDITVICPWEAFNHLELHELAQYGII

Target ORF information:

RefSeq Version	XM_017024736.1
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphodiesterase 6G (PDE6G), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017024736.1

ORF Insert Sequence:

ATGAACCTGG AACCGCCCAA GGCTGAGTTC CGGTCAGCCA CCAGGGTGGC CGGGGGACCT 
GTCACCCCCA GGAAAGGGCC CCCTAAATTT AAGCAGCGAC AGACCAGGCA GTTCAAGAGC 
AAGCCCCCAA AGAAAGGCGT TCAAGGGTTT GGGGACGACA TCCCTGGAAT GGAAGGCCTG 
GGAACAGACA TCACAGTCAT CTGCCCTTGG GAGGCCTTCA ACCACCTGGA GCTGCACGAG 
CTGGCCCAAT ATGGCATCAT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PDE6G ( XM_006721942.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_006722005.1 Homo sapiens phosphodiesterase 6G (PDE6G), transcript variant X3, mRNA.

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CloneID	OHu50455
Clone ID Related Accession (Same CDS sequence)	XM_006721942.3
Accession Version	XM_006721942.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 414bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006721942.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGCAGC GAGATAAAGG CCGGGGCTGG CACCCTGCGG AGGGAGGCCC AGCACTCACA 
GCACAGCCCC CTGAGACCCG CCCTGCACTT GACCGCAGCA GGAGGGAGTC CAGGAGCCAA 
GGTTGCCGCG GTGTCTCCGT CAGCCTCACC ATGAACCTGG AACCGCCCAA GGCTGAGTTC 
CGGTCAGCCA CCAGGGTGGC CGGGGGACCT GTCACCCCCA GGAAAGGGCC CCCTAAATTT 
AAGCAGCGAC AGACCAGGCA GTTCAAGAGC AAGCCCCCAA AGAAAGGCGT TCAAGGGTTT 
GGGGACGACA TCCCTGGAAT GGAAGGCCTG GGAACAGACA TCACAGTCAT CTGCCCTTGG 
GAGGCCTTCA ACCACCTGGA GCTGCACGAG CTGGCCCAAT ATGGCATCAT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006722005.1
CDS	968..1381
Translation	MKQRDKGRGWHPAEGGPALTAQPPETRPALDRSRRESRSQGCRGVSVSLTMNLEPPKAEFRSATRVAGGPVTPRKGPPKFKQRQTRQFKSKPPKKGVQGFGDDIPGMEGLGTDITVICPWEAFNHLELHELAQYGII

Target ORF information:

RefSeq Version	XM_006721942.3
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphodiesterase 6G (PDE6G), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006721942.3

ORF Insert Sequence:

ATGAAGCAGC GAGATAAAGG CCGGGGCTGG CACCCTGCGG AGGGAGGCCC AGCACTCACA 
GCACAGCCCC CTGAGACCCG CCCTGCACTT GACCGCAGCA GGAGGGAGTC CAGGAGCCAA 
GGTTGCCGCG GTGTCTCCGT CAGCCTCACC ATGAACCTGG AACCGCCCAA GGCTGAGTTC 
CGGTCAGCCA CCAGGGTGGC CGGGGGACCT GTCACCCCCA GGAAAGGGCC CCCTAAATTT 
AAGCAGCGAC AGACCAGGCA GTTCAAGAGC AAGCCCCCAA AGAAAGGCGT TCAAGGGTTT 
GGGGACGACA TCCCTGGAAT GGAAGGCCTG GGAACAGACA TCACAGTCAT CTGCCCTTGG 
GAGGCCTTCA ACCACCTGGA GCTGCACGAG CTGGCCCAAT ATGGCATCAT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PDE6G ( XM_017024734.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016880223.1 Homo sapiens phosphodiesterase 6G (PDE6G), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu86921
Clone ID Related Accession (Same CDS sequence)	XM_017024734.1
Accession Version	XM_017024734.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 474bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGGATT TGCAACCTTA TGTGGTCCTC CCTGCTCACC TAAGATGTAA TCTACAGCTA 
CCCTATTATC TAAGACAACC TGAGCCGGTG AATGAATTCC TCTCTGCTGG GCGGCCTTGC 
CGACGCACTT TTCTCAGCAA GAATTCCCGA AACCGCAGCA GGAGGGAGTC CAGGAGCCAA 
GGTTGCCGCG GTGTCTCCGT CAGCCTCACC ATGAACCTGG AACCGCCCAA GGCTGAGTTC 
CGGTCAGCCA CCAGGGTGGC CGGGGGACCT GTCACCCCCA GGAAAGGGCC CCCTAAATTT 
AAGCAGCGAC AGACCAGGCA GTTCAAGAGC AAGCCCCCAA AGAAAGGCGT TCAAGGGTTT 
GGGGACGACA TCCCTGGAAT GGAAGGCCTG GGAACAGACA TCACAGTCAT CTGCCCTTGG 
GAGGCCTTCA ACCACCTGGA GCTGCACGAG CTGGCCCAAT ATGGCATCAT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016880223.1
CDS	210..683
Translation	MWDLQPYVVLPAHLRCNLQLPYYLRQPEPVNEFLSAGRPCRRTFLSKNSRNRSRRESRSQGCRGVSVSLTMNLEPPKAEFRSATRVAGGPVTPRKGPPKFKQRQTRQFKSKPPKKGVQGFGDDIPGMEGLGTDITVICPWEAFNHLELHELAQYGII

Target ORF information:

RefSeq Version	XM_017024734.1
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphodiesterase 6G (PDE6G), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017024734.1

ORF Insert Sequence:

ATGTGGGATT TGCAACCTTA TGTGGTCCTC CCTGCTCACC TAAGATGTAA TCTACAGCTA 
CCCTATTATC TAAGACAACC TGAGCCGGTG AATGAATTCC TCTCTGCTGG GCGGCCTTGC 
CGACGCACTT TTCTCAGCAA GAATTCCCGA AACCGCAGCA GGAGGGAGTC CAGGAGCCAA 
GGTTGCCGCG GTGTCTCCGT CAGCCTCACC ATGAACCTGG AACCGCCCAA GGCTGAGTTC 
CGGTCAGCCA CCAGGGTGGC CGGGGGACCT GTCACCCCCA GGAAAGGGCC CCCTAAATTT 
AAGCAGCGAC AGACCAGGCA GTTCAAGAGC AAGCCCCCAA AGAAAGGCGT TCAAGGGTTT 
GGGGACGACA TCCCTGGAAT GGAAGGCCTG GGAACAGACA TCACAGTCAT CTGCCCTTGG 
GAGGCCTTCA ACCACCTGGA GCTGCACGAG CTGGCCCAAT ATGGCATCAT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis.
Respiratory research11146(2010 Oct)
Nikolova S,Guenther A,Savai R,Weissmann N,Ghofrani HA,Konigshoff M,Eickelberg O,Klepetko W,Voswinckel R,Seeger W,Grimminger F,Schermuly RT,Pullamsetti SS

Autosomal-recessive early-onset retinitis pigmentosa caused by a mutation in PDE6G, the gene encoding the gamma subunit of rod cGMP phosphodiesterase.
American journal of human genetics87(2)258-64(2010 Aug)
Dvir L,Srour G,Abu-Ras R,Miller B,Shalev SA,Ben-Yosef T

Determinants for phosphodiesterase 6 inhibition by its gamma-subunit.
Biochemistry49(18)3862-7(2010 May)
Zhang Z,Artemyev NO

Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit.
The EMBO journal28(22)3613-22(2009 Nov)
Barren B,Gakhar L,Muradov H,Boyd KK,Ramaswamy S,Artemyev NO

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PDE6G cDNA ORF clone, Homo sapiens(human)

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gRNAs

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Target ORF information:

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ORF Insert Sequence:

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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FAX

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