KRT76 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KRT76
Entrez Gene ID	51350
Full Name	keratin 76
Synonyms	HUMCYT2A,KRT2B,KRT2P
General protein information	Preferred Names keratin 76 Names keratin, type II cytoskeletal 2 oral CK-2P K2P K76 cytokeratin 2 cytokeratin-2P keratin 2p keratin 76, type II type-II keratin Kb9
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q13.13
Summary	Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq, Jun 2009].
Disorder MIM:	616671

mRNA and Protein(s)

mRNA	Protein	Name
NM_015848.4	NP_056932.2	keratin, type II cytoskeletal 2 oral

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	KRT76	XP_522397.2
Bos taurus (cattle)	LOC100336907	XP_002687307.2
	KRT2B	XP_001097589.1
Homo sapiens (human)	KRT76	NP_056932.2
Canis lupus familiaris (dog)	LOC100683401	XP_003433549.1
Mus musculus (house mouse)	Krt76	NP_001028349.1
Rattus norvegicus (Norway rat)	Krt76	NP_001008805.1

Gene Ontology
Bibliography

Related articles in PubMed

Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballesc? JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)

New consensus nomenclature for mammalian keratins.
Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW
The Journal of cell biology174(2)169-74(2006 Jul)

Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13.
Rogers MA, Edler L, Winter H, Langbein L, Beckmann I, Schweizer J
The Journal of investigative dermatology124(3)536-44(2005 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following KRT76 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KRT76 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu19255	NM_015848.4 Latest version!	Homo sapiens keratin 76 (KRT76), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KRT76 ( NM_015848.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_056932.2 Homo sapiens keratin 76 (KRT76), mRNA.

Price & Availability↑

CloneID	OHu19255
Clone ID Related Accession (Same CDS sequence)	NM_015848.4
Accession Version	NM_015848.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1917bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	keratin, type II cytoskeletal 2 oral
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK299390.1 and M99063.1. This sequence is a reference standard in the RefSeqGene project. On Jul 9, 2009 this sequence version replaced NM_015848.3. ##Evidence-Data-START## Transcript exon combination :: M99063.1, AK299390.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000332411.2/ ENSP00000330101.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAACAGAC AAGTTTGCAA GAAATCCTTC AGTGGCAGGA GCCAGGGTTT CTCTGGCCGC 
TCTGCTGTGG TCTCCGGCAG CAGCAGGATG AGCTGTGTGG CCCGCTCTGG GGGAGCTGGT 
GGAGGGGCCT GTGGCTTCAG GAGCGGAGCA GGCAGCTTTG GCAGTCGCAG CCTCTACAAC 
CTGGGCAGCA ACAAGAGCAT CTCCATCAGC GTGGCAGCTG GCAGCTCCCG GGCTGGAGGC 
TTTGGGGGAG GGCGGAGCAG CTGTGGCTTT GCAGGTGGCT ATGGAGGTGG CTTTGGGGGC 
AGCTATGGTG GTGGCTTTGG TGGTGGCAGA GGAGTAGGTA GTGGTTTTGG AGGGGCTGGT 
GGCTTTGGTG GAGCTGGTGG CTTTGGTGGT CCTGGTGTAT TTGGTGGGCC TGGCAGCTTT 
GGTGGTCCTG GTGGCTTTGG CCCTGGGGGC TTTCCTGGGG GAATTCAGGA AGTGATTGTA 
AACCAGAGTC TCCTGCAGCC CCTCAATGTG GAGATCGACC CCCAGATTGG GCAAGTAAAG 
GCCCAGGAGC GGGAACAGAT CAAGACCCTC AACAACAAGT TTGCCTCCTT CATCGACAAG 
GTGCGGTTCC TGGAACAGCA GAACAAGGTC CTGGAGACCA AGTGGGAACT GCTCCAGCAG 
CAGACCACAG GCTCAGGGCC CAGCAGCCTG GAGCCTTGTT TTGAATCCTA CATCAGCTTC 
CTATGCAAGC AGCTAGATTC ACTTCTAGGG GAGAGGGGGA ACCTGGAGGG AGAGCTGAAA 
AGCATGCAGG ACCTGGTGGA AGACTTCAAA AAGAAGTATG AAGATGAAAT CAACAAACGC 
ACTGCCGCAG AGAATGAGTT TGTGGGGCTC AAGAAGGATG TGGATGCGGC TTTCATGAAC 
AAGGTGGAGC TGCAGGCCAA AGTGGACAGC CTGACAGATG AAGTCAGCTT CCTGAGGACC 
CTCTATGAGA TGGAGCTGTC CCAGATGCAA AGCCATGCCA GTGACACGTC TGTGGTTCTG 
TCCATGGACA ACAACCGCTG CCTGGACCTG GGCAGCATCA TTGCCGAGGT CCGCGCCCAG 
TATGAGGAGA TTGCCCAGAG GAGCAAGTCT GAAGCTGAGG CCCTGTACCA GACCAAGCTT 
GGGGAGCTGC AGACCACAGC TGGCAGGCAT GGGGATGACC TGAGGAACAC CAAGAGTGAG 
ATCATGGAGC TCAACAGGAT GATCCAGAGG CTACGGGCTG AGATTGAAAA TGTCAAGAAG 
CAGAATGCCA ACCTGCAGAC GGCAATTGCA GAGGCTGAGC AGCGTGGAGA GATGGCCCTC 
AAGGACGCCA ATGCCAAGCT CCAAGACTTG CAGACTGCCC TACAGAAGGC TAAGGATGAC 
CTGGCTCGGC TCCTGCGTGA CTACCAGGAG CTGATGAACG TCAAGCTGGC CCTGGATGTG 
GAGATTGCCA CCTACCGCAA GCTGCTGGAG GGAGAGGAGT GCAGGATGTC TGGAGAATGT 
CAGAGTGCCG TGTGCATTTC AGTGGTCAGC AATGTCACCA GCACAAGTGG CAGCTCTGGC 
AGTAGCCGTG GAGTTTTTGG AGGGGTCAGT GGCAGTGGCA GTGGTGGCTA CAAAGGCGGC 
AGCAGCAGCA GCAGCAGCAG TGGCTATGGA GTCAGTGGCG GCAGCGGCAG TGGCTATGGA 
GGGGTCAGCA GTGGCAGCAC TGGGGGCAGG GGTAGCAGCG GGAGCTACCA GAGCAGCAGT 
AGTGGGAGCA GGCTCGGCGG TGCAGGTAGC ATCTCCGTGA GCCACAGTGG AATGGGCTCC 
AGCTCTGGCA GCATCCAGAC TTCTGGAGGA AGTGGCTACA AGTCTGGTGG TGGAGGCAGC 
ACCAGTATCC GCTTCTCCCA GACCACGAGC TCAAGCCAGC ATAGCTCCAC CAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056932.2
CDS	55..1971
Translation	MNRQVCKKSFSGRSQGFSGRSAVVSGSSRMSCVARSGGAGGGACGFRSGAGSFGSRSLYNLGSNKSISISVAAGSSRAGGFGGGRSSCGFAGGYGGGFGGSYGGGFGGGRGVGSGFGGAGGFGGAGGFGGPGVFGGPGSFGGPGGFGPGGFPGGIQEVIVNQSLLQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWELLQQQTTGSGPSSLEPCFESYISFLCKQLDSLLGERGNLEGELKSMQDLVEDFKKKYEDEINKRTAAENEFVGLKKDVDAAFMNKVELQAKVDSLTDEVSFLRTLYEMELSQMQSHASDTSVVLSMDNNRCLDLGSIIAEVRAQYEEIAQRSKSEAEALYQTKLGELQTTAGRHGDDLRNTKSEIMELNRMIQRLRAEIENVKKQNANLQTAIAEAEQRGEMALKDANAKLQDLQTALQKAKDDLARLLRDYQELMNVKLALDVEIATYRKLLEGEECRMSGECQSAVCISVVSNVTSTSGSSGSSRGVFGGVSGSGSGGYKGGSSSSSSSGYGVSGGSGSGYGGVSSGSTGGRGSSGSYQSSSSGSRLGGAGSISVSHSGMGSSSGSIQTSGGSGYKSGGGGSTSIRFSQTTSSSQHSSTK

Target ORF information:

RefSeq Version	NM_015848.4
Organism	Homo sapiens(human)
Definition	Homo sapiens keratin 76 (KRT76), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015848.4

ORF Insert Sequence:

ATGAACAGAC AAGTTTGCAA GAAATCCTTC AGTGGCAGGA GCCAGGGTTT CTCTGGCCGC 
TCTGCTGTGG TCTCCGGCAG CAGCAGGATG AGCTGTGTGG CCCGCTCTGG GGGAGCTGGT 
GGAGGGGCCT GTGGCTTCAG GAGCGGAGCA GGCAGCTTTG GCAGTCGCAG CCTCTACAAC 
CTGGGCAGCA ACAAGAGCAT CTCCATCAGC GTGGCAGCTG GCAGCTCCCG GGCTGGAGGC 
TTTGGGGGAG GGCGGAGCAG CTGTGGCTTT GCAGGTGGCT ATGGAGGTGG CTTTGGGGGC 
AGCTATGGTG GTGGCTTTGG TGGTGGCAGA GGAGTAGGTA GTGGTTTTGG AGGGGCTGGT 
GGCTTTGGTG GAGCTGGTGG CTTTGGTGGT CCTGGTGTAT TTGGTGGGCC TGGCAGCTTT 
GGTGGTCCTG GTGGCTTTGG CCCTGGGGGC TTTCCTGGGG GAATTCAGGA AGTGATTGTA 
AACCAGAGTC TCCTGCAGCC CCTCAATGTG GAGATCGACC CCCAGATTGG GCAAGTAAAG 
GCCCAGGAGC GGGAACAGAT CAAGACCCTC AACAACAAGT TTGCCTCCTT CATCGACAAG 
GTGCGGTTCC TGGAACAGCA GAACAAGGTC CTGGAGACCA AGTGGGAACT GCTCCAGCAG 
CAGACCACAG GCTCAGGGCC CAGCAGCCTG GAGCCTTGTT TTGAATCCTA CATCAGCTTC 
CTATGCAAGC AGCTAGATTC ACTTCTAGGG GAGAGGGGGA ACCTGGAGGG AGAGCTGAAA 
AGCATGCAGG ACCTGGTGGA AGACTTCAAA AAGAAGTATG AAGATGAAAT CAACAAACGC 
ACTGCCGCAG AGAATGAGTT TGTGGGGCTC AAGAAGGATG TGGATGCGGC TTTCATGAAC 
AAGGTGGAGC TGCAGGCCAA AGTGGACAGC CTGACAGATG AAGTCAGCTT CCTGAGGACC 
CTCTATGAGA TGGAGCTGTC CCAGATGCAA AGCCATGCCA GTGACACGTC TGTGGTTCTG 
TCCATGGACA ACAACCGCTG CCTGGACCTG GGCAGCATCA TTGCCGAGGT CCGCGCCCAG 
TATGAGGAGA TTGCCCAGAG GAGCAAGTCT GAAGCTGAGG CCCTGTACCA GACCAAGCTT 
GGGGAGCTGC AGACCACAGC TGGCAGGCAT GGGGATGACC TGAGGAACAC CAAGAGTGAG 
ATCATGGAGC TCAACAGGAT GATCCAGAGG CTACGGGCTG AGATTGAAAA TGTCAAGAAG 
CAGAATGCCA ACCTGCAGAC GGCAATTGCA GAGGCTGAGC AGCGTGGAGA GATGGCCCTC 
AAGGACGCCA ATGCCAAGCT CCAAGACTTG CAGACTGCCC TACAGAAGGC TAAGGATGAC 
CTGGCTCGGC TCCTGCGTGA CTACCAGGAG CTGATGAACG TCAAGCTGGC CCTGGATGTG 
GAGATTGCCA CCTACCGCAA GCTGCTGGAG GGAGAGGAGT GCAGGATGTC TGGAGAATGT 
CAGAGTGCCG TGTGCATTTC AGTGGTCAGC AATGTCACCA GCACAAGTGG CAGCTCTGGC 
AGTAGCCGTG GAGTTTTTGG AGGGGTCAGT GGCAGTGGCA GTGGTGGCTA CAAAGGCGGC 
AGCAGCAGCA GCAGCAGCAG TGGCTATGGA GTCAGTGGCG GCAGCGGCAG TGGCTATGGA 
GGGGTCAGCA GTGGCAGCAC TGGGGGCAGG GGTAGCAGCG GGAGCTACCA GAGCAGCAGT 
AGTGGGAGCA GGCTCGGCGG TGCAGGTAGC ATCTCCGTGA GCCACAGTGG AATGGGCTCC 
AGCTCTGGCA GCATCCAGAC TTCTGGAGGA AGTGGCTACA AGTCTGGTGG TGGAGGCAGC 
ACCAGTATCC GCTTCTCCCA GACCACGAGC TCAAGCCAGC ATAGCTCCAC CAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Proteomic characterization of the human sperm nucleus.
Proteomics11(13)2714-26(2011 Jul)
de Mateo S,Castillo J,Estanyol JM,Ballesc? JL,Oliva R

New consensus nomenclature for mammalian keratins.
The Journal of cell biology174(2)169-74(2006 Jul)
Schweizer J,Bowden PE,Coulombe PA,Langbein L,Lane EB,Magin TM,Maltais L,Omary MB,Parry DA,Rogers MA,Wright MW

Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13.
The Journal of investigative dermatology124(3)536-44(2005 Mar)
Rogers MA,Edler L,Winter H,Langbein L,Beckmann I,Schweizer J