SCAND1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SCAND1
Entrez Gene ID	51282
Full Name	SCAN domain containing 1
Synonyms	RAZ1,SDP1
General protein information	Preferred Names SCAN domain containing 1 Names SCAN domain-containing protein 1 SCAN-related protein RAZ1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q11.23
Summary	This gene encodes a SCAN box domain-containing protein. The SCAN domain is a highly conserved, leucine-rich motif of approximately 60 aa originally found within a subfamily of zinc finger proteins. This gene belongs to a family of genes that encode an isolated SCAN domain, but no zinc finger motif. This protein binds to and may regulate the function of the transcription factor myeloid zinc finger 1B. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011].
Disorder MIM:	610416

mRNA and Protein(s)

mRNA	Protein	Name
NM_033630.2	NP_361012.2	SCAN domain-containing protein 1 isoform 2
NM_016558.3	NP_057642.1	SCAN domain-containing protein 1 isoform 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	SCAND1	NP_057642.1
Bos taurus (cattle)	SCAND1	NP_001073059.1
Pan troglodytes (chimpanzee)	SCAND1	NP_001074949.1
Mus musculus (house mouse)	Scand1	NP_064651.2
Rattus norvegicus (Norway rat)	Scand1	NP_001102069.1
Canis lupus familiaris (dog)	SCAND1	XP_852290.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kov?cs IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barab?si AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)

Spectroscopic characterization of the tumor antigen NY-REN-21 and identification of heterodimer formation with SCAND1.
Carneiro FR, Silva TC, Alves AC, Haline-Vaz T, Gozzo FC, Zanchin NI
Biochemical and biophysical research communications343(1)260-8(2006 Apr)

SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain.
Babb R, Bowen BR
The Biochemical journal370(Pt 2)719-27(2003 Mar)

Characterization of the SCAN box encoding RAZ1 gene: analysis of cDNA transcripts, expression, and cellular localization.
Sander TL, Morris JF
Gene296(1-2)53-64(2002 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.

This result indicates that NY-REN-21 can function either as a homodimer or as a heterodimer with SCAND1.
Title: Spectroscopic characterization of the tumor antigen NY-REN-21 and identification of heterodimer formation with SCAND1.

The following SCAND1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SCAND1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu08632	NM_016558.3 Latest version!	Homo sapiens SCAN domain containing 1 (SCAND1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu55788	NM_033630.2 Latest version!	Homo sapiens SCAN domain containing 1 (SCAND1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SCAND1 ( NM_016558.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057642.1 Homo sapiens SCAN domain containing 1 (SCAND1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu08632
Clone ID Related Accession (Same CDS sequence)	NM_016558.3
Accession Version	NM_016558.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 540bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	SCAN domain-containing protein 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU848795.1, AL109965.34, AF207829.1 and BU752664.1. On Jan 15, 2011 this sequence version replaced NM_016558.2. Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## CDS exon combination :: BU848795.1, SRR1163655.697521.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA2145743 [ECO:0000350] ##Evidence-Data-END##

ATGGCGGCTA CGGAGCCGAT CTTGGCGGCC ACTGGGAGTC CCGCGGCGGT GCCACCGGAG 
AAACTGGAAG GAGCCGGTTC GAGCTCAGCC CCTGAGCGTA ACTGTGTGGG CTCCTCGCTG 
CCAGAGGCCT CACCGCCTGC CCCTGAGCCT TCCAGTCCCA ACGCCGCGGT CCCTGAAGCC 
ATCCCTACGC CCCGAGCTGC GGCCTCCGCG GCCCTGGAGC TGCCTCTCGG GCCCGCACCC 
GTGAGCGTAG CGCCTCAGGC CGAAGCTGAA GCGCGCTCCA CACCAGGCCC CGCCGGCTCT 
AGACTCGGTC CCGAGACGTT CCGCCAGCGT TTCCGGCAGT TCCGCTACCA GGATGCGGCG 
GGTCCCCGGG AGGCTTTCCG GCAGCTGCGG GAGCTGTCCC GCCAGTGGCT GCGGCCTGAC 
ATCCGCACCA AGGAGCAGAT CGTGGAGATG CTGGTGCAAG AGCAGCTGCT CGCCATCCTG 
CCCGAGGCGG CTCGGGCCCG GCGGATCCGC CGCCGCACGG ATGTGCGCAT CACTGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057642.1
CDS	704..1243
Translation	MAATEPILAATGSPAAVPPEKLEGAGSSSAPERNCVGSSLPEASPPAPEPSSPNAAVPEAIPTPRAAASAALELPLGPAPVSVAPQAEAEARSTPGPAGSRLGPETFRQRFRQFRYQDAAGPREAFRQLRELSRQWLRPDIRTKEQIVEMLVQEQLLAILPEAARARRIRRRTDVRITG

Target ORF information:

RefSeq Version	NM_016558.3
Organism	Homo sapiens(human)
Definition	Homo sapiens SCAN domain containing 1 (SCAND1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016558.3

ORF Insert Sequence:

ATGGCGGCTA CGGAGCCGAT CTTGGCGGCC ACTGGGAGTC CCGCGGCGGT GCCACCGGAG 
AAACTGGAAG GAGCCGGTTC GAGCTCAGCC CCTGAGCGTA ACTGTGTGGG CTCCTCGCTG 
CCAGAGGCCT CACCGCCTGC CCCTGAGCCT TCCAGTCCCA ACGCCGCGGT CCCTGAAGCC 
ATCCCTACGC CCCGAGCTGC GGCCTCCGCG GCCCTGGAGC TGCCTCTCGG GCCCGCACCC 
GTGAGCGTAG CGCCTCAGGC CGAAGCTGAA GCGCGCTCCA CACCAGGCCC CGCCGGCTCT 
AGACTCGGTC CCGAGACGTT CCGCCAGCGT TTCCGGCAGT TCCGCTACCA GGATGCGGCG 
GGTCCCCGGG AGGCTTTCCG GCAGCTGCGG GAGCTGTCCC GCCAGTGGCT GCGGCCTGAC 
ATCCGCACCA AGGAGCAGAT CGTGGAGATG CTGGTGCAAG AGCAGCTGCT CGCCATCCTG 
CCCGAGGCGG CTCGGGCCCG GCGGATCCGC CGCCGCACGG ATGTGCGCAT CACTGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SCAND1 ( NM_033630.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_361012.2 Homo sapiens SCAN domain containing 1 (SCAND1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu55788
Clone ID Related Accession (Same CDS sequence)	NM_033630.2
Accession Version	NM_033630.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 729bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	SCAN domain-containing protein 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU190039.1, AF207829.1 and BU752664.1. On Jan 19, 2011 this sequence version replaced NM_033630.1. Transcript Variant: This variant (2) differs in the 5' UTR and contains an extra segment in the 5' coding region, compared to variant 1. These differences cause translation initiation at an upstream start codon, compared to variant 1. The encoded protein (isoform 2) has a longer N-terminus, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: BU190039.1, SRR1163655.498510.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGCGACTCG AGAACGCTAG AGGGCGCCGC TTCCGGGAGC CCGCAAGCGG CTTCCGGGTG 
CTCGCGCGCC GACCTGGACG CAGAGAAGCC AGAGACTTTC GCTTCCGGCT GCCGCAGGCG 
CTTCGCTGGT GCAGACGCAG TGCTGAGCAC ACAGCTACCG GACAAAGAGT GACGCCCGGA 
GCTGGAGTTA TGGCGGCTAC GGAGCCGATC TTGGCGGCCA CTGGGAGTCC CGCGGCGGTG 
CCACCGGAGA AACTGGAAGG AGCCGGTTCG AGCTCAGCCC CTGAGCGTAA CTGTGTGGGC 
TCCTCGCTGC CAGAGGCCTC ACCGCCTGCC CCTGAGCCTT CCAGTCCCAA CGCCGCGGTC 
CCTGAAGCCA TCCCTACGCC CCGAGCTGCG GCCTCCGCGG CCCTGGAGCT GCCTCTCGGG 
CCCGCACCCG TGAGCGTAGC GCCTCAGGCC GAAGCTGAAG CGCGCTCCAC ACCAGGCCCC 
GCCGGCTCTA GACTCGGTCC CGAGACGTTC CGCCAGCGTT TCCGGCAGTT CCGCTACCAG 
GATGCGGCGG GTCCCCGGGA GGCTTTCCGG CAGCTGCGGG AGCTGTCCCG CCAGTGGCTG 
CGGCCTGACA TCCGCACCAA GGAGCAGATC GTGGAGATGC TGGTGCAAGA GCAGCTGCTC 
GCCATCCTGC CCGAGGCGGC TCGGGCCCGG CGGATCCGCC GCCGCACGGA TGTGCGCATC 
ACTGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_361012.2
CDS	46..774
Translation	MRLENARGRRFREPASGFRVLARRPGRREARDFRFRLPQALRWCRRSAEHTATGQRVTPGAGVMAATEPILAATGSPAAVPPEKLEGAGSSSAPERNCVGSSLPEASPPAPEPSSPNAAVPEAIPTPRAAASAALELPLGPAPVSVAPQAEAEARSTPGPAGSRLGPETFRQRFRQFRYQDAAGPREAFRQLRELSRQWLRPDIRTKEQIVEMLVQEQLLAILPEAARARRIRRRTDVRITG

Target ORF information:

RefSeq Version	NM_033630.2
Organism	Homo sapiens(human)
Definition	Homo sapiens SCAN domain containing 1 (SCAND1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033630.2

ORF Insert Sequence:

ATGCGACTCG AGAACGCTAG AGGGCGCCGC TTCCGGGAGC CCGCAAGCGG CTTCCGGGTG 
CTCGCGCGCC GACCTGGACG CAGAGAAGCC AGAGACTTTC GCTTCCGGCT GCCGCAGGCG 
CTTCGCTGGT GCAGACGCAG TGCTGAGCAC ACAGCTACCG GACAAAGAGT GACGCCCGGA 
GCTGGAGTTA TGGCGGCTAC GGAGCCGATC TTGGCGGCCA CTGGGAGTCC CGCGGCGGTG 
CCACCGGAGA AACTGGAAGG AGCCGGTTCG AGCTCAGCCC CTGAGCGTAA CTGTGTGGGC 
TCCTCGCTGC CAGAGGCCTC ACCGCCTGCC CCTGAGCCTT CCAGTCCCAA CGCCGCGGTC 
CCTGAAGCCA TCCCTACGCC CCGAGCTGCG GCCTCCGCGG CCCTGGAGCT GCCTCTCGGG 
CCCGCACCCG TGAGCGTAGC GCCTCAGGCC GAAGCTGAAG CGCGCTCCAC ACCAGGCCCC 
GCCGGCTCTA GACTCGGTCC CGAGACGTTC CGCCAGCGTT TCCGGCAGTT CCGCTACCAG 
GATGCGGCGG GTCCCCGGGA GGCTTTCCGG CAGCTGCGGG AGCTGTCCCG CCAGTGGCTG 
CGGCCTGACA TCCGCACCAA GGAGCAGATC GTGGAGATGC TGGTGCAAGA GCAGCTGCTC 
GCCATCCTGC CCGAGGCGGC TCGGGCCCGG CGGATCCGCC GCCGCACGGA TGTGCGCATC 
ACTGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kov?cs IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barab?si AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M

Spectroscopic characterization of the tumor antigen NY-REN-21 and identification of heterodimer formation with SCAND1.
Biochemical and biophysical research communications343(1)260-8(2006 Apr)
Carneiro FR,Silva TC,Alves AC,Haline-Vaz T,Gozzo FC,Zanchin NI

SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain.
The Biochemical journal370(Pt 2)719-27(2003 Mar)
Babb R,Bowen BR

Characterization of the SCAN box encoding RAZ1 gene: analysis of cDNA transcripts, expression, and cellular localization.
Gene296(1-2)53-64(2002 Aug)
Sander TL,Morris JF

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SCAND1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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