GLRX5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GLRX5
Entrez Gene ID	51218
Full Name	glutaredoxin 5
Synonyms	C14orf87,FLB4739,GRX5,PR01238,PRO1238,PRSA,SIDBA3,SPAHGC
General protein information	Preferred Names glutaredoxin 5 Names glutaredoxin-related protein 5, mitochondrial glutaredoxin 5 homolog monothiol glutaredoxin-5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q32.13
Summary	This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, May 2010].
Disorder MIM:	609588
Disorder Html:	Anemia, sideroblastic, 3, pyridoxine-refractory, 616860 (3); Spasticity, childhood-onset, with hyperglycinemia, 616859 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_016417.3	NP_057501.2	glutaredoxin-related protein 5, mitochondrial precursor
NM_016417.2	NP_057501.2	glutaredoxin-related protein 5, mitochondrial precursor

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	GLRX5	NP_001008472.1
Danio rerio (zebrafish)	glrx5	NP_998186.1
Kluyveromyces lactis	KLLA0B09636g	XP_451957.1
Rattus norvegicus (Norway rat)	Glrx5	NP_001102192.1
Drosophila melanogaster (fruit fly)	CG14407	NP_572974.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002500	XP_312440.3
	GLRX5	XP_001101070.1
Bos taurus (cattle)	GLRX5	NP_001093773.1
Caenorhabditis elegans (roundworm)	glrx-5	NP_499610.1
Saccharomyces cerevisiae (baker's yeast)	GRX5	NP_015266.1
Schizosaccharomyces pombe (fission yeast)	grx5	NP_593888.1
Homo sapiens (human)	GLRX5	NP_057501.2
Pan troglodytes (chimpanzee)	GLRX5	XP_001154482.1
Mus musculus (house mouse)	Glrx5	NP_082695.1
Eremothecium gossypii	AGOS_ADR053W	NP_984149.1
Magnaporthe oryzae (rice blast fungus)	MGG_09542	XP_003712199.1
Neurospora crassa	NCU04098	XP_960860.1
Xenopus tropicalis (tropical clawed frog)	glrx5	NP_001004919.1

Gene Ontology
Bibliography

Related articles in PubMed

A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.
Maio N, Kim KS, Singh A, Rouault TA
Cell metabolism25(4)945-953.e6(2017 Apr)

Association study of the GLRX5 rs1007814 polymorphism with schizophrenia in the Han Chinese population.
Yang B, Niu W, Chen S, Xu F, Li X, Wu X, Cao Y, Zhang R, Yang F, Wang L, Li W, Xu Y, He L, He G
Psychiatric genetics27(2)76-77(2017 04)

Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
Xie T, Deng L, Mei P, Zhou Y, Wang B, Zhang J, Lin J, Wei Y, Zhang X, Xu R
Neurobiology of aging35(7)1778.e9-1778.e23(2014 Jul)

Cochaperone binding to LYR motifs confers specificity of iron sulfur cluster delivery.
Maio N, Singh A, Uhrigshardt H, Saxena N, Tong WH, Rouault TA
Cell metabolism19(3)445-57(2014 Mar)

Variant non ketotic hyperglycinemia is caused by mutations in LIAS, BOLA3 and the novel gene GLRX5.
Baker PR 2nd, Friederich MW, Swanson MA, Shaikh T, Bhattacharya K, Scharer GH, Aicher J, Creadon-Swindell G, Geiger E, MacLean KN, Lee WT, Deshpande C, Freckmann ML, Shih LY, Wasserstein M, Rasmussen MB, Lund AM, Procopis P, Cameron JM, Robinson BH, Brown GK, Brown RM, Compton AG, Dieckmann CL, Collard R, Coughlin CR 2nd, Spector E, Wempe MF, Van Hove JL
Brain : a journal of neurology137(Pt 2)366-79(2014 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Patients with GLRX5-associated variant nonketotic hyperglycemia had normal development with childhood-onset spastic paraplegia, spinal lesion, and optic atrophy.
Title: Variant non ketotic hyperglycinemia is caused by mutations in LIAS, BOLA3 and the novel gene GLRX5.

crystal structure of GLRX5 revealed a tetrameric organization with the [2Fe-2S] clusters buried in the interior and shielded from the solvent by the conserved beta1-alpha2 loop
Title: The crystal structure of human GLRX5: iron-sulfur cluster co-ordination, tetrameric assembly and monomer activity.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts
Title: Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts.

The following GLRX5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GLRX5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18481	NM_016417.3 Latest version!	Homo sapiens glutaredoxin 5 (GLRX5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu18481	NM_016417.2	Homo sapiens glutaredoxin 5 (GLRX5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GLRX5 ( NM_016417.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057501.2 Homo sapiens glutaredoxin 5 (GLRX5), mRNA.

Price & Availability↑

CloneID	OHu18481
Clone ID Related Accession (Same CDS sequence)	NM_016417.3 , NM_016417.2
Accession Version	NM_016417.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 474bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	glutaredoxin-related protein 5, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX248075.1, BC047680.1, BI834047.1 and AI089763.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_016417.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.220860.1, SRR1163655.305522.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000331334.5/ ENSP00000328570.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCGGGT CCCTCGGCCG AGCTGCGGCG GCTCTGCTCC GCTGGGGGCG CGGCGCGGGC 
GGCGGTGGCC TTTGGGGTCC GGGCGTGCGG GCGGCGGGCT CGGGCGCGGG CGGCGGCGGC 
TCGGCGGAGC AGTTGGACGC GCTGGTGAAG AAGGACAAGG TGGTGGTCTT CCTCAAGGGG 
ACGCCGGAGC AGCCCCAGTG CGGCTTCAGC AACGCCGTGG TGCAGATCCT GCGGCTGCAC 
GGCGTCCGCG ATTACGCGGC CTACAACGTG CTGGACGACC CGGAGCTCCG ACAAGGCATT 
AAAGACTATT CCAACTGGCC CACCATCCCG CAAGTGTACC TCAATGGCGA GTTTGTAGGG 
GGCTGTGACA TTCTTCTGCA GATGCACCAG AATGGGGACT TGGTGGAAGA ACTGAAAAAG 
CTGGGGATCC ACTCCGCCCT TTTAGATGAA AAGAAAGACC AAGACTCCAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057501.2
CDS	41..514
Translation	MSGSLGRAAAALLRWGRGAGGGGLWGPGVRAAGSGAGGGGSAEQLDALVKKDKVVVFLKGTPEQPQCGFSNAVVQILRLHGVRDYAAYNVLDDPELRQGIKDYSNWPTIPQVYLNGEFVGGCDILLQMHQNGDLVEELKKLGIHSALLDEKKDQDSK

Target ORF information:

RefSeq Version	NM_016417.3
Organism	Homo sapiens(human)
Definition	Homo sapiens glutaredoxin 5 (GLRX5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016417.3

ORF Insert Sequence:

ATGAGCGGGT CCCTCGGCCG AGCTGCGGCG GCTCTGCTCC GCTGGGGGCG CGGCGCGGGC 
GGCGGTGGCC TTTGGGGTCC GGGCGTGCGG GCGGCGGGCT CGGGCGCGGG CGGCGGCGGC 
TCGGCGGAGC AGTTGGACGC GCTGGTGAAG AAGGACAAGG TGGTGGTCTT CCTCAAGGGG 
ACGCCGGAGC AGCCCCAGTG CGGCTTCAGC AACGCCGTGG TGCAGATCCT GCGGCTGCAC 
GGCGTCCGCG ATTACGCGGC CTACAACGTG CTGGACGACC CGGAGCTCCG ACAAGGCATT 
AAAGACTATT CCAACTGGCC CACCATCCCG CAAGTGTACC TCAATGGCGA GTTTGTAGGG 
GGCTGTGACA TTCTTCTGCA GATGCACCAG AATGGGGACT TGGTGGAAGA ACTGAAAAAG 
CTGGGGATCC ACTCCGCCCT TTTAGATGAA AAGAAAGACC AAGACTCCAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GLRX5 ( NM_016417.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_057501.2 Homo sapiens glutaredoxin 5 (GLRX5), mRNA.

Price & Availability↑

CloneID	OHu18481
Clone ID Related Accession (Same CDS sequence)	NM_016417.3 , NM_016417.2
Accession Version	NM_016417.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 474bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	glutaredoxin-related protein 5, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI259789.1, BX248075.1, BC047680.1, BI834047.1 and AI089763.1. This sequence is a reference standard in the RefSeqGene project. On Feb 10, 2004 this sequence version replaced NM_016417.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.2408.1, ERR279834.923.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGCGGGT CCCTCGGCCG AGCTGCGGCG GCTCTGCTCC GCTGGGGGCG CGGCGCGGGC 
GGCGGTGGCC TTTGGGGTCC GGGCGTGCGG GCGGCGGGCT CGGGCGCGGG CGGCGGCGGC 
TCGGCGGAGC AGTTGGACGC GCTGGTGAAG AAGGACAAGG TGGTGGTCTT CCTCAAGGGG 
ACGCCGGAGC AGCCCCAGTG CGGCTTCAGC AACGCCGTGG TGCAGATCCT GCGGCTGCAC 
GGCGTCCGCG ATTACGCGGC CTACAACGTG CTGGACGACC CGGAGCTCCG ACAAGGCATT 
AAAGACTATT CCAACTGGCC CACCATCCCG CAAGTGTACC TCAATGGCGA GTTTGTAGGG 
GGCTGTGACA TTCTTCTGCA GATGCACCAG AATGGGGACT TGGTGGAAGA ACTGAAAAAG 
CTGGGGATCC ACTCCGCCCT TTTAGATGAA AAGAAAGACC AAGACTCCAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057501.2
CDS	105..578
Translation	MSGSLGRAAAALLRWGRGAGGGGLWGPGVRAAGSGAGGGGSAEQLDALVKKDKVVVFLKGTPEQPQCGFSNAVVQILRLHGVRDYAAYNVLDDPELRQGIKDYSNWPTIPQVYLNGEFVGGCDILLQMHQNGDLVEELKKLGIHSALLDEKKDQDSK

Target ORF information:

RefSeq Version	NM_016417.2
Organism	Homo sapiens(human)
Definition	Homo sapiens glutaredoxin 5 (GLRX5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016417.2

ORF Insert Sequence:

ATGAGCGGGT CCCTCGGCCG AGCTGCGGCG GCTCTGCTCC GCTGGGGGCG CGGCGCGGGC 
GGCGGTGGCC TTTGGGGTCC GGGCGTGCGG GCGGCGGGCT CGGGCGCGGG CGGCGGCGGC 
TCGGCGGAGC AGTTGGACGC GCTGGTGAAG AAGGACAAGG TGGTGGTCTT CCTCAAGGGG 
ACGCCGGAGC AGCCCCAGTG CGGCTTCAGC AACGCCGTGG TGCAGATCCT GCGGCTGCAC 
GGCGTCCGCG ATTACGCGGC CTACAACGTG CTGGACGACC CGGAGCTCCG ACAAGGCATT 
AAAGACTATT CCAACTGGCC CACCATCCCG CAAGTGTACC TCAATGGCGA GTTTGTAGGG 
GGCTGTGACA TTCTTCTGCA GATGCACCAG AATGGGGACT TGGTGGAAGA ACTGAAAAAG 
CTGGGGATCC ACTCCGCCCT TTTAGATGAA AAGAAAGACC AAGACTCCAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.
Cell metabolism25(4)945-953.e6(2017 Apr)
Maio N,Kim KS,Singh A,Rouault TA

Association study of the GLRX5 rs1007814 polymorphism with schizophrenia in the Han Chinese population.
Psychiatric genetics27(2)76-77(2017 04)
Yang B,Niu W,Chen S,Xu F,Li X,Wu X,Cao Y,Zhang R,Yang F,Wang L,Li W,Xu Y,He L,He G

Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
Neurobiology of aging35(7)1778.e9-1778.e23(2014 Jul)
Xie T,Deng L,Mei P,Zhou Y,Wang B,Zhang J,Lin J,Wei Y,Zhang X,Xu R

Cochaperone binding to LYR motifs confers specificity of iron sulfur cluster delivery.
Cell metabolism19(3)445-57(2014 Mar)
Maio N,Singh A,Uhrigshardt H,Saxena N,Tong WH,Rouault TA

Variant non ketotic hyperglycinemia is caused by mutations in LIAS, BOLA3 and the novel gene GLRX5.
Brain : a journal of neurology137(Pt 2)366-79(2014 Feb)
Baker PR 2nd,Friederich MW,Swanson MA,Shaikh T,Bhattacharya K,Scharer GH,Aicher J,Creadon-Swindell G,Geiger E,MacLean KN,Lee WT,Deshpande C,Freckmann ML,Shih LY,Wasserstein M,Rasmussen MB,Lund AM,Procopis P,Cameron JM,Robinson BH,Brown GK,Brown RM,Compton AG,Dieckmann CL,Collard R,Coughlin CR 2nd,Spector E,Wempe MF,Van Hove JL

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GLRX5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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