PRLH cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PRLH
Entrez Gene ID	51052
Full Name	prolactin releasing hormone
Synonyms	PRH,PRRP
General protein information	Preferred Names prolactin releasing hormone Names prolactin-releasing peptide preproprolactin-releasing peptide
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q37.3
Disorder MIM:	602663

mRNA and Protein(s)

mRNA	Protein	Name
NM_015893.1	NP_056977.1	prolactin-releasing peptide precursor

Pathways from BioSystems

Homologies

	PRLH	XP_001084860.1
Homo sapiens (human)	PRLH	NP_056977.1
Mus musculus (house mouse)	Prlh	NP_001095117.1
Rattus norvegicus (Norway rat)	Prlh	NP_071558.1

Gene Ontology
Bibliography

Related articles in PubMed

Prolactin-releasing peptide improved leptin hypothalamic signaling in obese mice.
Holubova M, Hrub? L, Nepra?ov? B, Majercikova Z, Lacinova Z, Kunes J, Maletinska L, Zelezna B
Journal of molecular endocrinology(2017 Dec)

The activity of prolactin releasing peptide correlates with its helicity.
Deluca SH, Rathmann D, Beck-Sickinger AG, Meiler J
Biopolymers99(5)314-25(2013 May)

The ancestry of the prolactin-releasing hormone precursor.
Lagerstr?m MC, Fredriksson R, Bjarnadottir TK, Schi?th HB
Annals of the New York Academy of Sciences1040368-70(2005 Apr)

Expression of prolactin-releasing peptide and its receptor in the human adrenal glands and tumor tissues of adrenocortical tumors, pheochromocytomas and neuroblastomas.
Takahashi K, Totsune K, Murakami O, Sone M, Noshiro T, Hayashi Y, Sasano H, Shibahara S
Peptides23(6)1135-40(2002 Jun)

Expression of prolactin-releasing peptide in human placenta and decidua.
Yasui Y, Yamaguchi M, Jikihara H, Yamamoto T, Kanzaki T, Murata Y
Endocrine journal48(3)397-401(2001 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that formation of a primarily alpha-helical C-terminal region of prolactin releasing peptide (PrRP) is critical for receptor activation.
Title: The activity of prolactin releasing peptide correlates with its helicity.

Review discusses the ancestral relationship between prolactin-releasing hormone and the C-terminal RF-motif amide precursor peptide (C-RF).
Title: The ancestry of the prolactin-releasing hormone precursor.

PrRP has a likely role in pheochromocytomas, based on its high expression in tumor tissue
Title: Expression of prolactin-releasing peptide and its receptor in the human adrenal glands and tumor tissues of adrenocortical tumors, pheochromocytomas and neuroblastomas.

The following PRLH gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PRLH cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu07179	NM_015893.1 Latest version!	Homo sapiens prolactin releasing hormone (PRLH), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PRLH ( NM_015893.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_056977.1 Homo sapiens prolactin releasing hormone (PRLH), mRNA.

Price & Availability↑

CloneID	OHu07179
Clone ID Related Accession (Same CDS sequence)	NM_015893.1
Accession Version	NM_015893.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 264bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Homo sapiens(human)
Product	prolactin-releasing peptide precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AB015419.1. ##Evidence-Data-START## Transcript exon combination :: BC069081.1, AB015419.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148093, SAMEA2153980 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000165524.1/ ENSP00000165524.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAAGGTGC TGAGGGCCTG GCTCCTGTGC CTGCTGATGC TGGGCCTGGC CCTGCGGGGA 
GCTGCAAGTC GTACCCATCG GCACTCCATG GAGATCCGCA CCCCTGACAT CAATCCTGCC 
TGGTACGCCA GTCGCGGGAT CAGGCCTGTG GGCCGCTTCG GTCGGAGGAG GGCAACCCTG 
GGGGACGTCC CCAAGCCTGG CCTGCGACCC CGGCTGACCT GCTTCCCCCT GGAAGGCGGT 
GCTATGTCGT CCCAGGATGG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056977.1
CDS	1..264
Translation	MKVLRAWLLCLLMLGLALRGAASRTHRHSMEIRTPDINPAWYASRGIRPVGRFGRRRATLGDVPKPGLRPRLTCFPLEGGAMSSQDG

Target ORF information:

RefSeq Version	NM_015893.1
Organism	Homo sapiens(human)
Definition	Homo sapiens prolactin releasing hormone (PRLH), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015893.1

ORF Insert Sequence:

ATGAAGGTGC TGAGGGCCTG GCTCCTGTGC CTGCTGATGC TGGGCCTGGC CCTGCGGGGA 
GCTGCAAGTC GTACCCATCG GCACTCCATG GAGATCCGCA CCCCTGACAT CAATCCTGCC 
TGGTACGCCA GTCGCGGGAT CAGGCCTGTG GGCCGCTTCG GTCGGAGGAG GGCAACCCTG 
GGGGACGTCC CCAAGCCTGG CCTGCGACCC CGGCTGACCT GCTTCCCCCT GGAAGGCGGT 
GCTATGTCGT CCCAGGATGG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Prolactin-releasing peptide improved leptin hypothalamic signaling in obese mice.
Journal of molecular endocrinology(2017 Dec)
Holubova M,Hrub? L,Nepra?ov? B,Majercikova Z,Lacinova Z,Kunes J,Maletinska L,Zelezna B

The activity of prolactin releasing peptide correlates with its helicity.
Biopolymers99(5)314-25(2013 May)
Deluca SH,Rathmann D,Beck-Sickinger AG,Meiler J

The ancestry of the prolactin-releasing hormone precursor.
Annals of the New York Academy of Sciences1040368-70(2005 Apr)
Lagerstr?m MC,Fredriksson R,Bjarnadottir TK,Schi?th HB

Expression of prolactin-releasing peptide and its receptor in the human adrenal glands and tumor tissues of adrenocortical tumors, pheochromocytomas and neuroblastomas.
Peptides23(6)1135-40(2002 Jun)
Takahashi K,Totsune K,Murakami O,Sone M,Noshiro T,Hayashi Y,Sasano H,Shibahara S

Expression of prolactin-releasing peptide in human placenta and decidua.
Endocrine journal48(3)397-401(2001 Jun)
Yasui Y,Yamaguchi M,Jikihara H,Yamamoto T,Kanzaki T,Murata Y