TMED7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TMED7
Entrez Gene ID	51014
Full Name	transmembrane p24 trafficking protein 7
Synonyms	CGI-109,p24g3,p24gamma3,p27
General protein information	Preferred Names transmembrane p24 trafficking protein 7 Names transmembrane emp24 domain-containing protein 7 p24 family protein gamma-3 transmembrane emp24 protein transport domain containing 7
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q22.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_181836.6	NP_861974.1	transmembrane emp24 domain-containing protein 7 precursor
NM_181836.5	NP_861974.1	transmembrane emp24 domain-containing protein 7 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	TMED7	NP_861974.1
Mus musculus (house mouse)	Tmed7	NP_079974.1
Saccharomyces cerevisiae (baker's yeast)	ERP2	NP_009395.1
Pan troglodytes (chimpanzee)	TMED7	NP_001191238.1
Drosophila melanogaster (fruit fly)	p24-1	NP_001259465.1
Kluyveromyces lactis	KLLA0D14641g	XP_453709.1
Eremothecium gossypii	AGOS_ADR026W	NP_984122.1
Neurospora crassa	NCU03800	XP_961189.2
Canis lupus familiaris (dog)	TMED7	NP_001191267.1
Bos taurus (cattle)	TMED7	NP_001098966.1
Gallus gallus (chicken)	TMED7	XP_003643122.2
Caenorhabditis elegans (roundworm)	F57B10.5	NP_491892.1
Saccharomyces cerevisiae (baker's yeast)	ERP4	NP_014659.1
Schizosaccharomyces pombe (fission yeast)	SPAC17A5.08	NP_593476.1
Magnaporthe oryzae (rice blast fungus)	MGG_07471	XP_003711375.1
Xenopus tropicalis (tropical clawed frog)	tmed7	NP_989261.1
Rattus norvegicus (Norway rat)	Tmed7	NP_001099228.1
Danio rerio (zebrafish)	tmed7	NP_998077.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000949	XP_309138.3

Gene Ontology
Bibliography

Related articles in PubMed

The COP II adaptor protein TMED7 is required to initiate and mediate the delivery of TLR4 to the plasma membrane.
Liaunardy-Jopeace A, Bryant CE, Gay NJ
Science signaling7(336)ra70(2014 Jul)

The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation.
Doyle SL, Husebye H, Connolly DJ, Espevik T, O'Neill LA, McGettrick AF
Nature communications3707(2012 Feb)

Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Casabonne D, Reina O, Benavente Y, Becker N, Maynadi? M, Foretov? L, Cocco P, Gonz?lez-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S
Haematologica96(2)323-7(2011 Feb)

Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway.
Jenne N, Frey K, Brugger B, Wieland FT
The Journal of biological chemistry277(48)46504-11(2002 Nov)

Localization and recycling of gp27 (hp24gamma3): complex formation with other p24 family members.
F?llekrug J, Suganuma T, Tang BL, Hong W, Storrie B, Nilsson T
Molecular biology of the cell10(6)1939-55(1999 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TMED7 is required to initiate and mediate the delivery of TLR4 to the plasma membrane
Title: The COP II adaptor protein TMED7 is required to initiate and mediate the delivery of TLR4 to the plasma membrane.

TMED7 is essential for TAG-mediated disruption of the TRAM/TRIF complex and the degradation of toll-like receptor 4
Title: The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation.

Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.

The following TMED7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TMED7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09257	NM_181836.6 Latest version!	Homo sapiens transmembrane p24 trafficking protein 7 (TMED7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu09257	NM_181836.5	Homo sapiens transmembrane p24 trafficking protein 7 (TMED7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TMED7 ( NM_181836.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_861974.1 Homo sapiens transmembrane p24 trafficking protein 7 (TMED7), mRNA.

Price & Availability↑

CloneID	OHu09257
Clone ID Related Accession (Same CDS sequence)	NM_181836.6 , NM_181836.5
Accession Version	NM_181836.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 675bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	transmembrane emp24 domain-containing protein 7 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC321837.1, BC019349.2 and AC010226.5. On Nov 23, 2018 this sequence version replaced NM_181836.5. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.475859.1, SRR1660805.201572.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2145313 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000456936.4/ ENSP00000405926.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCGCGGC CGGGGTCCGC GCAGCGCTGG GCGGCCGTCG CGGGCCGTTG GGGGTGCAGG 
CTGCTCGCAC TGCTGCTACT GGTGCCTGGA CCCGGCGGCG CCTCTGAGAT CACCTTCGAG 
CTTCCTGACA ACGCCAAGCA GTGCTTCTAC GAGGACATCG CTCAGGGCAC CAAGTGCACC 
CTGGAGTTCC AGGTGATTAC TGGTGGTCAC TATGATGTAG ATTGTCGATT AGAAGATCCT 
GATGGTAAAG TGTTATACAA AGAGATGAAG AAACAGTATG ATAGTTTTAC CTTCACAGCC 
TCCAAAAATG GGACATACAA ATTTTGCTTC AGCAATGAAT TTTCTACTTT CACACATAAA 
ACTGTATATT TTGATTTTCA AGTTGGAGAA GACCCACCTT TGTTTCCTAG TGAGAACCGA 
GTCAGTGCTC TTACCCAGAT GGAATCTGCC TGTGTTTCAA TTCACGAAGC TCTGAAGTCT 
GTCATCGATT ATCAGACTCA TTTCCGTTTA AGAGAAGCTC AAGGCCGAAG CCGAGCAGAG 
GATCTAAATA CAAGAGTGGC CTATTGGTCA GTAGGAGAAG CCCTCATTCT TCTGGTGGTT 
AGCATAGGGC AGGTATTTCT TTTGAAAAGC TTTTTCTCAG ATAAAAGAAC CACCACAACT 
CGTGTTGGAT CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_861974.1
CDS	245..919
Translation	MPRPGSAQRWAAVAGRWGCRLLALLLLVPGPGGASEITFELPDNAKQCFYEDIAQGTKCTLEFQVITGGHYDVDCRLEDPDGKVLYKEMKKQYDSFTFTASKNGTYKFCFSNEFSTFTHKTVYFDFQVGEDPPLFPSENRVSALTQMESACVSIHEALKSVIDYQTHFRLREAQGRSRAEDLNTRVAYWSVGEALILLVVSIGQVFLLKSFFSDKRTTTTRVGS

Target ORF information:

RefSeq Version	NM_181836.6
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane p24 trafficking protein 7 (TMED7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181836.6

ORF Insert Sequence:

ATGCCGCGGC CGGGGTCCGC GCAGCGCTGG GCGGCCGTCG CGGGCCGTTG GGGGTGCAGG 
CTGCTCGCAC TGCTGCTACT GGTGCCTGGA CCCGGCGGCG CCTCTGAGAT CACCTTCGAG 
CTTCCTGACA ACGCCAAGCA GTGCTTCTAC GAGGACATCG CTCAGGGCAC CAAGTGCACC 
CTGGAGTTCC AGGTGATTAC TGGTGGTCAC TATGATGTAG ATTGTCGATT AGAAGATCCT 
GATGGTAAAG TGTTATACAA AGAGATGAAG AAACAGTATG ATAGTTTTAC CTTCACAGCC 
TCCAAAAATG GGACATACAA ATTTTGCTTC AGCAATGAAT TTTCTACTTT CACACATAAA 
ACTGTATATT TTGATTTTCA AGTTGGAGAA GACCCACCTT TGTTTCCTAG TGAGAACCGA 
GTCAGTGCTC TTACCCAGAT GGAATCTGCC TGTGTTTCAA TTCACGAAGC TCTGAAGTCT 
GTCATCGATT ATCAGACTCA TTTCCGTTTA AGAGAAGCTC AAGGCCGAAG CCGAGCAGAG 
GATCTAAATA CAAGAGTGGC CTATTGGTCA GTAGGAGAAG CCCTCATTCT TCTGGTGGTT 
AGCATAGGGC AGGTATTTCT TTTGAAAAGC TTTTTCTCAG ATAAAAGAAC CACCACAACT 
CGTGTTGGAT CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMED7 ( NM_181836.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_861974.1 Homo sapiens transmembrane p24 trafficking protein 7 (TMED7), mRNA.

Price & Availability↑

CloneID	OHu09257
Clone ID Related Accession (Same CDS sequence)	NM_181836.6 , NM_181836.5
Accession Version	NM_181836.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 675bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	transmembrane emp24 domain-containing protein 7 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC321837.1, BC019349.2 and AC010226.5. On Sep 1, 2009 this sequence version replaced NM_181836.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.201572.1, SRR1660803.8256.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2145313 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGCGGC CGGGGTCCGC GCAGCGCTGG GCGGCCGTCG CGGGCCGTTG GGGGTGCAGG 
CTGCTCGCAC TGCTGCTACT GGTGCCTGGA CCCGGCGGCG CCTCTGAGAT CACCTTCGAG 
CTTCCTGACA ACGCCAAGCA GTGCTTCTAC GAGGACATCG CTCAGGGCAC CAAGTGCACC 
CTGGAGTTCC AGGTGATTAC TGGTGGTCAC TATGATGTAG ATTGTCGATT AGAAGATCCT 
GATGGTAAAG TGTTATACAA AGAGATGAAG AAACAGTATG ATAGTTTTAC CTTCACAGCC 
TCCAAAAATG GGACATACAA ATTTTGCTTC AGCAATGAAT TTTCTACTTT CACACATAAA 
ACTGTATATT TTGATTTTCA AGTTGGAGAA GACCCACCTT TGTTTCCTAG TGAGAACCGA 
GTCAGTGCTC TTACCCAGAT GGAATCTGCC TGTGTTTCAA TTCACGAAGC TCTGAAGTCT 
GTCATCGATT ATCAGACTCA TTTCCGTTTA AGAGAAGCTC AAGGCCGAAG CCGAGCAGAG 
GATCTAAATA CAAGAGTGGC CTATTGGTCA GTAGGAGAAG CCCTCATTCT TCTGGTGGTT 
AGCATAGGGC AGGTATTTCT TTTGAAAAGC TTTTTCTCAG ATAAAAGAAC CACCACAACT 
CGTGTTGGAT CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_861974.1
CDS	388..1062
Translation	MPRPGSAQRWAAVAGRWGCRLLALLLLVPGPGGASEITFELPDNAKQCFYEDIAQGTKCTLEFQVITGGHYDVDCRLEDPDGKVLYKEMKKQYDSFTFTASKNGTYKFCFSNEFSTFTHKTVYFDFQVGEDPPLFPSENRVSALTQMESACVSIHEALKSVIDYQTHFRLREAQGRSRAEDLNTRVAYWSVGEALILLVVSIGQVFLLKSFFSDKRTTTTRVGS

Target ORF information:

RefSeq Version	NM_181836.5
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane p24 trafficking protein 7 (TMED7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181836.5

ORF Insert Sequence:

ATGCCGCGGC CGGGGTCCGC GCAGCGCTGG GCGGCCGTCG CGGGCCGTTG GGGGTGCAGG 
CTGCTCGCAC TGCTGCTACT GGTGCCTGGA CCCGGCGGCG CCTCTGAGAT CACCTTCGAG 
CTTCCTGACA ACGCCAAGCA GTGCTTCTAC GAGGACATCG CTCAGGGCAC CAAGTGCACC 
CTGGAGTTCC AGGTGATTAC TGGTGGTCAC TATGATGTAG ATTGTCGATT AGAAGATCCT 
GATGGTAAAG TGTTATACAA AGAGATGAAG AAACAGTATG ATAGTTTTAC CTTCACAGCC 
TCCAAAAATG GGACATACAA ATTTTGCTTC AGCAATGAAT TTTCTACTTT CACACATAAA 
ACTGTATATT TTGATTTTCA AGTTGGAGAA GACCCACCTT TGTTTCCTAG TGAGAACCGA 
GTCAGTGCTC TTACCCAGAT GGAATCTGCC TGTGTTTCAA TTCACGAAGC TCTGAAGTCT 
GTCATCGATT ATCAGACTCA TTTCCGTTTA AGAGAAGCTC AAGGCCGAAG CCGAGCAGAG 
GATCTAAATA CAAGAGTGGC CTATTGGTCA GTAGGAGAAG CCCTCATTCT TCTGGTGGTT 
AGCATAGGGC AGGTATTTCT TTTGAAAAGC TTTTTCTCAG ATAAAAGAAC CACCACAACT 
CGTGTTGGAT CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The COP II adaptor protein TMED7 is required to initiate and mediate the delivery of TLR4 to the plasma membrane.
Science signaling7(336)ra70(2014 Jul)
Liaunardy-Jopeace A,Bryant CE,Gay NJ

The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation.
Nature communications3707(2012 Feb)
Doyle SL,Husebye H,Connolly DJ,Espevik T,O'Neill LA,McGettrick AF

Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Haematologica96(2)323-7(2011 Feb)
Casabonne D,Reina O,Benavente Y,Becker N,Maynadi? M,Foretov? L,Cocco P,Gonz?lez-Neira A,Nieters A,Boffetta P,Middeldorp JM,de Sanjose S

Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway.
The Journal of biological chemistry277(48)46504-11(2002 Nov)
Jenne N,Frey K,Brugger B,Wieland FT

Localization and recycling of gp27 (hp24gamma3): complex formation with other p24 family members.
Molecular biology of the cell10(6)1939-55(1999 Jun)
F?llekrug J,Suganuma T,Tang BL,Hong W,Storrie B,Nilsson T