MICOS10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MICOS10
Entrez Gene ID	440574
Full Name	mitochondrial inner membrane organizing system 1
Synonyms	C1orf151,MIO10,Mic10
General protein information	Preferred Names mitochondrial inner membrane organizing system 1 Names MICOS complex subunit MIC10 RP5-1056L3.2 UPF0327 protein C1orf151 mitochondrial inner membrane organizing system protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p36.13
Disorder MIM:	616574

mRNA and Protein(s)

mRNA	Protein	Name
NM_001032363.4	NP_001027535.1	MICOS complex subunit MIC10 isoform a
NM_001204082.1	NP_001191011.1	MICOS complex subunit MIC10 isoform b
NM_001032363.3	NP_001027535.1	MICOS complex subunit MIC10 isoform a
NM_001204083.2	NP_001191012.1	MICOS complex subunit MIC10 isoform c
NM_001204083.1	NP_001191012.1	MICOS complex subunit MIC10 isoform c

Pathways from BioSystems

Homologies

Homo sapiens (human)	MINOS1	NP_001191012.1
Canis lupus familiaris (dog)	MINOS1	XP_853078.1
Bos taurus (cattle)	MINOS1	XP_003585848.1
Mus musculus (house mouse)	Minos1	NP_001156478.1
Rattus norvegicus (Norway rat)	Minos1	NP_001167027.1
Gallus gallus (chicken)	MINOS1	NP_001264834.1
	LOC100429218	XP_002800617.1
Xenopus tropicalis (tropical clawed frog)	LOC100135143	NP_001165140.1
Pan troglodytes (chimpanzee)	MINOS1	XP_001159311.1
Rattus norvegicus (Norway rat)	LOC100361944	XP_006240278.1
Danio rerio (zebrafish)	minos1	NP_001136427.1

Gene Ontology
Bibliography

Related articles in PubMed

The non-glycosylated isoform of MIC26 is a constituent of the mammalian MICOS complex and promotes formation of crista junctions.
Koob S, Barrera M, Anand R, Reichert AS
Biochimica et biophysica acta1853(7)1551-63(2015 Jul)

Genome-wide association study identifies a novel susceptibility gene for serum TSH levels in Chinese populations.
Zhan M, Chen G, Pan CM, Gu ZH, Zhao SX, Liu W, Wang HN, Ye XP, Xie HJ, Yu SS, Liang J, Gao GQ, Yuan GY, Zhang XM, Zuo CL, Su B, Huang W, Ning G, Chen SJ, Chen JL, Song HD,
Human molecular genetics23(20)5505-17(2014 Oct)

Uniform nomenclature for the mitochondrial contact site and cristae organizing system.
Pfanner N, van der Laan M, Amati P, Capaldi RA, Caudy AA, Chacinska A, Darshi M, Deckers M, Hoppins S, Icho T, Jakobs S, Ji J, Kozjak-Pavlovic V, Meisinger C, Odgren PR, Park SK, Rehling P, Reichert AS, Sheikh MS, Taylor SS, Tsuchida N, van der Bliek AM, van der Klei IJ, Weissman JS, Westermann B, Zha J, Neupert W, Nunnari J
The Journal of cell biology204(7)1083-6(2014 Mar)

APOOL is a cardiolipin-binding constituent of the Mitofilin/MINOS protein complex determining cristae morphology in mammalian mitochondria.
Weber TA, Koob S, Heide H, Wittig I, Head B, van der Bliek A, Brandt U, Mittelbronn M, Reichert AS
PloS one8(5)e63683(2013)

MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization.
Alkhaja AK, Jans DC, Nikolov M, Vukotic M, Lytovchenko O, Ludewig F, Schliebs W, Riedel D, Urlaub H, Jakobs S, Deckers M
Molecular biology of the cell23(2)247-57(2012 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

APOOL is a cardiolipin-binding component of the Mitofilin/MINOS protein complex.
Title: APOOL is a cardiolipin-binding constituent of the Mitofilin/MINOS protein complex determining cristae morphology in mammalian mitochondria.

Proteomic analyses reveal MINOS1/Mio10 as a novel constituent of Mitofilin/Fcj1 complexes in human and yeast mitochondria
Title: MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following MICOS10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MICOS10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15514	NM_001032363.4 Latest version!	Homo sapiens mitochondrial contact site and cristae organizing system subunit 10 (MICOS10), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu15404	NM_001204082.1 Latest version!	Homo sapiens mitochondrial contact site and cristae organizing system subunit 10 (MICOS10), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu15464	NM_001204083.2 Latest version!	Homo sapiens mitochondrial contact site and cristae organizing system subunit 10 (MICOS10), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu15514	NM_001032363.3	Homo sapiens mitochondrial inner membrane organizing system 1 (MINOS1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu15464	NM_001204083.1	Homo sapiens mitochondrial contact site and cristae organizing system subunit 10 (MICOS10), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MICOS10 ( NM_001032363.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001027535.1 Homo sapiens mitochondrial contact site and cristae organizing system subunit 10 (MICOS10), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu15514
Clone ID Related Accession (Same CDS sequence)	NM_001032363.4 , NM_001032363.3
Accession Version	NM_001032363.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 237bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	MICOS complex subunit MIC10 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA523181.1, BC070388.1, AL031727.43 and DB323148.1. On Nov 23, 2018 this sequence version replaced NM_001032363.3. Transcript Variant: This variant (1) encodes isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: DA245944.1, SRR1803617.6377.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000322753.7/ ENSP00000325562.6 RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCTGAGT CGGAGCTCGG CAGGAAGTGG GACCGGTGTC TGGCGGATGC GGTCGTGAAG 
ATAGGTACTG GTTTTGGATT AGGAATTGTT TTCTCACTTA CCTTCTTTAA AAGAAGAATG 
TGGCCATTAG CCTTCGGTTC TGGCATGGGA TTAGGAATGG CTTATTCCAA CTGTCAGCAT 
GATTTCCAGG CTCCATATCT TCTACATGGA AAATATGTCA AAGAGCAGGA GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001027535.1
CDS	68..304
Translation	MSESELGRKWDRCLADAVVKIGTGFGLGIVFSLTFFKRRMWPLAFGSGMGLGMAYSNCQHDFQAPYLLHGKYVKEQEQ

Target ORF information:

RefSeq Version	NM_001032363.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial contact site and cristae organizing system subunit 10 (MICOS10), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001032363.4

ORF Insert Sequence:

ATGTCTGAGT CGGAGCTCGG CAGGAAGTGG GACCGGTGTC TGGCGGATGC GGTCGTGAAG 
ATAGGTACTG GTTTTGGATT AGGAATTGTT TTCTCACTTA CCTTCTTTAA AAGAAGAATG 
TGGCCATTAG CCTTCGGTTC TGGCATGGGA TTAGGAATGG CTTATTCCAA CTGTCAGCAT 
GATTTCCAGG CTCCATATCT TCTACATGGA AAATATGTCA AAGAGCAGGA GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MICOS10 ( NM_001032363.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001027535.1 Homo sapiens mitochondrial inner membrane organizing system 1 (MINOS1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu15514
Clone ID Related Accession (Same CDS sequence)	NM_001032363.4 , NM_001032363.3
Accession Version	NM_001032363.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 237bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	MICOS complex subunit MIC10 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA523181.1, BC070388.1, AL031727.43 and DB323148.1. On Feb 11, 2011 this sequence version replaced NM_001032363.2. Transcript Variant: This variant (1) encodes isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: DA523181.1, SRR1803617.6377.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCTGAGT CGGAGCTCGG CAGGAAGTGG GACCGGTGTC TGGCGGATGC GGTCGTGAAG 
ATAGGTACTG GTTTTGGATT AGGAATTGTT TTCTCACTTA CCTTCTTTAA AAGAAGAATG 
TGGCCATTAG CCTTCGGTTC TGGCATGGGA TTAGGAATGG CTTATTCCAA CTGTCAGCAT 
GATTTCCAGG CTCCATATCT TCTACATGGA AAATATGTCA AAGAGCAGGA GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001027535.1
CDS	70..306
Translation	MSESELGRKWDRCLADAVVKIGTGFGLGIVFSLTFFKRRMWPLAFGSGMGLGMAYSNCQHDFQAPYLLHGKYVKEQEQ

Target ORF information:

RefSeq Version	NM_001032363.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial inner membrane organizing system 1 (MINOS1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001032363.3

ORF Insert Sequence:

ATGTCTGAGT CGGAGCTCGG CAGGAAGTGG GACCGGTGTC TGGCGGATGC GGTCGTGAAG 
ATAGGTACTG GTTTTGGATT AGGAATTGTT TTCTCACTTA CCTTCTTTAA AAGAAGAATG 
TGGCCATTAG CCTTCGGTTC TGGCATGGGA TTAGGAATGG CTTATTCCAA CTGTCAGCAT 
GATTTCCAGG CTCCATATCT TCTACATGGA AAATATGTCA AAGAGCAGGA GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MICOS10 ( NM_001204082.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001191011.1 Homo sapiens mitochondrial contact site and cristae organizing system subunit 10 (MICOS10), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu15404
Clone ID Related Accession (Same CDS sequence)	NM_001204082.1
Accession Version	NM_001204082.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 189bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-21
Organism	Homo sapiens(human)
Product	MICOS complex subunit MIC10 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA523181.1, BM784596.1, AL031727.43 and DB323148.1. Transcript Variant: This variant (4) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BM784596.1, BE620270.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCTGAGT CGGAGCTCGG CAGGAAGTGG GACCGGTGTC TGGCGGATGC GGTCGTGAAG 
ATAGGAAGAA TGTGGCCATT AGCCTTCGGT TCTGGCATGG GATTAGGAAT GGCTTATTCC 
AACTGTCAGC ATGATTTCCA GGCTCCATAT CTTCTACATG GAAAATATGT CAAAGAGCAG 
GAGCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001191011.1
CDS	70..258
Translation	MSESELGRKWDRCLADAVVKIGRMWPLAFGSGMGLGMAYSNCQHDFQAPYLLHGKYVKEQEQ

Target ORF information:

RefSeq Version	NM_001204082.1
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial contact site and cristae organizing system subunit 10 (MICOS10), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001204082.1

ORF Insert Sequence:

ATGTCTGAGT CGGAGCTCGG CAGGAAGTGG GACCGGTGTC TGGCGGATGC GGTCGTGAAG 
ATAGGAAGAA TGTGGCCATT AGCCTTCGGT TCTGGCATGG GATTAGGAAT GGCTTATTCC 
AACTGTCAGC ATGATTTCCA GGCTCCATAT CTTCTACATG GAAAATATGT CAAAGAGCAG 
GAGCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MICOS10 ( NM_001204083.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001191012.1 Homo sapiens mitochondrial contact site and cristae organizing system subunit 10 (MICOS10), transcript variant 5, mRNA.

Price & Availability↑

CloneID	OHu15464
Clone ID Related Accession (Same CDS sequence)	NM_001204083.2 , NM_001204083.1
Accession Version	NM_001204083.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 423bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-30
Organism	Homo sapiens(human)
Product	MICOS complex subunit MIC10 isoform c
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA523181.1, CB157536.1, AL031727.43 and DB323148.1. On May 31, 2019 this sequence version replaced NM_001204083.1. Transcript Variant: This variant (5) contains an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform c, which is longer and has a distinct C-terminus, compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: ERR279831.10625.1, SRR1163657.568101.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCTGAGT CGGAGCTCGG CAGGAAGTGG GACCGGTGTC TGGCGGATGC GGTCGTGAAG 
ATAGGTACTG GTTTTGGATT AGGAATTGTT TTCTCACTTA CCTTCTTTAA AAGAAGAATG 
TGGCCATTAG CCTTCGGTTC TGGCATGGGA TTAGGAATGG CTTATTCCAA CTGTCAGCAT 
GATTTCCAGG CTCCATATCT TCTACATGGA AAATATGTCA AAAACCTGCT GAAACCGTCA 
GCTGCCTGCA GCCAGCCCAT GTCTGCTGGA GAGATGGGAG TAGGGGAGCC ATCTCTGCAC 
CAAAGCAAGA GTGAGGTCAT CACAGGGACC ATGCAAGAAG AGGCGCAGCT GTGTGGCACT 
GAAGCCGGCA GCCGGCCTTT TCCACCACTC CCTGGCTCCT CGCTTTCCTG GCATCAGAGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001191012.1
CDS	68..490
Translation	MSESELGRKWDRCLADAVVKIGTGFGLGIVFSLTFFKRRMWPLAFGSGMGLGMAYSNCQHDFQAPYLLHGKYVKNLLKPSAACSQPMSAGEMGVGEPSLHQSKSEVITGTMQEEAQLCGTEAGSRPFPPLPGSSLSWHQS

Target ORF information:

RefSeq Version	NM_001204083.2
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial contact site and cristae organizing system subunit 10 (MICOS10), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001204083.2

ORF Insert Sequence:

ATGTCTGAGT CGGAGCTCGG CAGGAAGTGG GACCGGTGTC TGGCGGATGC GGTCGTGAAG 
ATAGGTACTG GTTTTGGATT AGGAATTGTT TTCTCACTTA CCTTCTTTAA AAGAAGAATG 
TGGCCATTAG CCTTCGGTTC TGGCATGGGA TTAGGAATGG CTTATTCCAA CTGTCAGCAT 
GATTTCCAGG CTCCATATCT TCTACATGGA AAATATGTCA AAAACCTGCT GAAACCGTCA 
GCTGCCTGCA GCCAGCCCAT GTCTGCTGGA GAGATGGGAG TAGGGGAGCC ATCTCTGCAC 
CAAAGCAAGA GTGAGGTCAT CACAGGGACC ATGCAAGAAG AGGCGCAGCT GTGTGGCACT 
GAAGCCGGCA GCCGGCCTTT TCCACCACTC CCTGGCTCCT CGCTTTCCTG GCATCAGAGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MICOS10 ( NM_001204083.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001191012.1 Homo sapiens mitochondrial contact site and cristae organizing system subunit 10 (MICOS10), transcript variant 5, mRNA.

Price & Availability↑

CloneID	OHu15464
Clone ID Related Accession (Same CDS sequence)	NM_001204083.2 , NM_001204083.1
Accession Version	NM_001204083.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 423bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	MICOS complex subunit MIC10 isoform c
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA523181.1, CB157536.1, AL031727.43 and DB323148.1. Transcript Variant: This variant (5) contains an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform c, which is longer and has a distinct C-terminus, compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: ERR279831.10625.1, SRR1163657.568101.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCTGAGT CGGAGCTCGG CAGGAAGTGG GACCGGTGTC TGGCGGATGC GGTCGTGAAG 
ATAGGTACTG GTTTTGGATT AGGAATTGTT TTCTCACTTA CCTTCTTTAA AAGAAGAATG 
TGGCCATTAG CCTTCGGTTC TGGCATGGGA TTAGGAATGG CTTATTCCAA CTGTCAGCAT 
GATTTCCAGG CTCCATATCT TCTACATGGA AAATATGTCA AAAACCTGCT GAAACCGTCA 
GCTGCCTGCA GCCAGCCCAT GTCTGCTGGA GAGATGGGAG TAGGGGAGCC ATCTCTGCAC 
CAAAGCAAGA GTGAGGTCAT CACAGGGACC ATGCAAGAAG AGGCGCAGCT GTGTGGCACT 
GAAGCCGGCA GCCGGCCTTT TCCACCACTC CCTGGCTCCT CGCTTTCCTG GCATCAGAGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001191012.1
CDS	70..492
Translation	MSESELGRKWDRCLADAVVKIGTGFGLGIVFSLTFFKRRMWPLAFGSGMGLGMAYSNCQHDFQAPYLLHGKYVKNLLKPSAACSQPMSAGEMGVGEPSLHQSKSEVITGTMQEEAQLCGTEAGSRPFPPLPGSSLSWHQS

Target ORF information:

RefSeq Version	NM_001204083.1
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial contact site and cristae organizing system subunit 10 (MICOS10), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001204083.1

ORF Insert Sequence:

ATGTCTGAGT CGGAGCTCGG CAGGAAGTGG GACCGGTGTC TGGCGGATGC GGTCGTGAAG 
ATAGGTACTG GTTTTGGATT AGGAATTGTT TTCTCACTTA CCTTCTTTAA AAGAAGAATG 
TGGCCATTAG CCTTCGGTTC TGGCATGGGA TTAGGAATGG CTTATTCCAA CTGTCAGCAT 
GATTTCCAGG CTCCATATCT TCTACATGGA AAATATGTCA AAAACCTGCT GAAACCGTCA 
GCTGCCTGCA GCCAGCCCAT GTCTGCTGGA GAGATGGGAG TAGGGGAGCC ATCTCTGCAC 
CAAAGCAAGA GTGAGGTCAT CACAGGGACC ATGCAAGAAG AGGCGCAGCT GTGTGGCACT 
GAAGCCGGCA GCCGGCCTTT TCCACCACTC CCTGGCTCCT CGCTTTCCTG GCATCAGAGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The non-glycosylated isoform of MIC26 is a constituent of the mammalian MICOS complex and promotes formation of crista junctions.
Biochimica et biophysica acta1853(7)1551-63(2015 Jul)
Koob S,Barrera M,Anand R,Reichert AS

Genome-wide association study identifies a novel susceptibility gene for serum TSH levels in Chinese populations.
Human molecular genetics23(20)5505-17(2014 Oct)
Zhan M,Chen G,Pan CM,Gu ZH,Zhao SX,Liu W,Wang HN,Ye XP,Xie HJ,Yu SS,Liang J,Gao GQ,Yuan GY,Zhang XM,Zuo CL,Su B,Huang W,Ning G,Chen SJ,Chen JL,Song HD,

Uniform nomenclature for the mitochondrial contact site and cristae organizing system.
The Journal of cell biology204(7)1083-6(2014 Mar)
Pfanner N,van der Laan M,Amati P,Capaldi RA,Caudy AA,Chacinska A,Darshi M,Deckers M,Hoppins S,Icho T,Jakobs S,Ji J,Kozjak-Pavlovic V,Meisinger C,Odgren PR,Park SK,Rehling P,Reichert AS,Sheikh MS,Taylor SS,Tsuchida N,van der Bliek AM,van der Klei IJ,Weissman JS,Westermann B,Zha J,Neupert W,Nunnari J

APOOL is a cardiolipin-binding constituent of the Mitofilin/MINOS protein complex determining cristae morphology in mammalian mitochondria.
PloS one8(5)e63683(2013)
Weber TA,Koob S,Heide H,Wittig I,Head B,van der Bliek A,Brandt U,Mittelbronn M,Reichert AS

MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization.
Molecular biology of the cell23(2)247-57(2012 Jan)
Alkhaja AK,Jans DC,Nikolov M,Vukotic M,Lytovchenko O,Ludewig F,Schliebs W,Riedel D,Urlaub H,Jakobs S,Deckers M

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MICOS10 cDNA ORF clone, Homo sapiens(human)

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ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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