MCM6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MCM6
Entrez Gene ID	4175
Full Name	minichromosome maintenance complex component 6
Synonyms	MCG40308,Mis5,P105MCM
General protein information	Preferred Names minichromosome maintenance complex component 6 Names DNA replication licensing factor MCM6 MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) minichromosome maintenance deficient (mis5, S. pombe) 6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q21.3
Summary	The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood. [provided by RefSeq, May 2012].
Disorder MIM:	601806
Disorder Html:	Lactase persistence/nonpersistence, 223100 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_005915.5	NP_005906.2	DNA replication licensing factor MCM6
NM_005915.6	NP_005906.2	DNA replication licensing factor MCM6

Pathways from BioSystems

Homologies

Homo sapiens (human)	MCM6	NP_005906.2
Pan troglodytes (chimpanzee)	MCM6	XP_001154732.1
Anopheles gambiae (African malaria mosquito)	MCM6_ANOGA	XP_319406.3
Xenopus tropicalis (tropical clawed frog)	mcm6.2	NP_989393.1
	MCM6	XP_001096068.1
Bos taurus (cattle)	MCM6	NP_001039699.1
Rattus norvegicus (Norway rat)	Mcm6	NP_058983.1
Canis lupus familiaris (dog)	MCM6	XP_533338.3
Mus musculus (house mouse)	Mcm6	NP_032593.1
Gallus gallus (chicken)	MCM6	NP_001006527.1
Danio rerio (zebrafish)	mcm6	NP_001076318.1
Drosophila melanogaster (fruit fly)	Mcm6	NP_511065.1

Gene Ontology
Bibliography

Related articles in PubMed

MCM6 promotes metastasis of hepatocellular carcinoma via MEK/ERK pathway and serves as a novel serum biomarker for early recurrence.
Liu M, Hu Q, Tu M, Wang X, Yang Z, Yang G, Luo R
Journal of experimental & clinical cancer research : CR37(1)10(2018 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This MCM4 mutation affected human MCM4/6/7 complex formation, since the complex containing the mutant MCM4 protein is unstable and the mutant MCM4 protein is tend to be degraded.
Title: An MCM4 mutation detected in cancer cells affects MCM4/6/7 complex formation.

MCM2-MCM6 complex is required for CHK2 chromatin loading and its phosphorylation to DNA damage response in squamous cell carcinoma cells.
Title: Minichromosome Maintenance Complex is Required for Checkpoint Kinase 2 Chromatin Loading and its Phosphorylation to DNA Damage Response in SCC-4 Cells.

knockdown of MCM2 or MCM6 could significantly inhibit foci forming of MDC1 in TE-1 nuclei in response to bleomycin-induced DNA damage (p < 0.001). This study indicates the direct interaction between MDC1 and MCMs in TE-1 nuclei.
Title: Knockdown of Minichromosome Maintenance Proteins Inhibits Foci Forming of Mediator of DNA-Damage Checkpoint 1 in Response to DNA Damage in Human Esophageal Squamous Cell Carcinoma TE-1 Cells.

Methyl(R217)HuR and MCM6 are inversely correlated and are prognostic markers in non small cell lung carcinoma
Title: Methyl(R217)HuR and MCM6 are inversely correlated and are prognostic markers in non small cell lung carcinoma.

Purified MCM4/6/7 complex containing the G364R MCM4 exhibited similar levels of single-stranded DNA binding and ATPase activities to the complex containing wild-type MCM4
Title: G364R mutation of MCM4 detected in human skin cancer cells affects DNA helicase activity of MCM4/6/7 complex.

The following MCM6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MCM6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20108	NM_005915.6 Latest version!	Homo sapiens minichromosome maintenance complex component 6 (MCM6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
View Old Accession Versions >>
OHu20108	NM_005915.5	Homo sapiens minichromosome maintenance complex component 6 (MCM6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MCM6 ( NM_005915.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_005906.2 Homo sapiens minichromosome maintenance complex component 6 (MCM6), mRNA.

Price & Availability↑

CloneID	OHu20108
Clone ID Related Accession (Same CDS sequence)	NM_005915.5 , NM_005915.6
Accession Version	NM_005915.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2466bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	DNA replication licensing factor MCM6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA521248.1, BC020268.1, CN389677.1, BC032374.1 and AA577398.1. This sequence is a reference standard in the RefSeqGene project. On May 10, 2012 this sequence version replaced NM_005915.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.207842.1, SRR1803612.14727.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACCTCG CGGCGGCAGC GGAGCCGGGC GCCGGCAGCC AGCACCTGGA GGTCCGCGAC 
GAGGTGGCCG AGAAGTGCCA GAAACTGTTC CTGGACTTCT TGGAGGAGTT TCAGAGCAGC 
GATGGAGAAA TTAAATACTT GCAATTAGCA GAGGAACTGA TTCGTCCTGA GAGAAACACA 
TTGGTTGTGA GTTTTGTGGA CCTGGAACAA TTTAACCAGC AACTTTCCAC CACCATTCAA 
GAGGAGTTCT ATAGAGTTTA CCCTTACCTG TGTCGGGCCT TGAAAACATT CGTCAAAGAC 
CGTAAAGAGA TCCCTCTTGC CAAGGATTTT TATGTTGCAT TCCAAGACCT GCCTACCAGA 
CACAAGATTC GAGAGCTCAC CTCATCCAGA ATTGGTTTGC TCACTCGCAT CAGTGGGCAG 
GTGGTGCGGA CTCACCCAGT TCACCCAGAG CTTGTGAGCG GAACTTTTCT GTGCTTGGAC 
TGTCAGACAG TGATCAGGGA TGTAGAACAG CAGTTCAAAT ACACACAGCC AAACATCTGC 
CGAAATCCAG TTTGTGCCAA CAGGAGGAGA TTCTTACTGG ATACAAATAA ATCAAGATTT 
GTTGATTTTC AAAAGGTTCG TATTCAAGAG ACCCAAGCTG AGCTTCCTCG AGGGAGTATC 
CCCCGCAGTT TAGAAGTAAT TTTAAGGGCT GAAGCTGTGG AATCAGCTCA AGCTGGTGAC 
AAGTGTGACT TTACAGGGAC ACTGATTGTT GTGCCTGACG TCTCCAAGCT TAGCACACCA 
GGAGCACGTG CAGAAACTAA TTCCCGTGTC AGTGGTGTTG ATGGATATGA GACAGAAGGC 
ATTCGAGGAC TCCGGGCCCT TGGTGTTAGG GACCTTTCTT ATAGGCTGGT CTTTCTTGCC 
TGCTGTGTTG CGCCAACCAA CCCAAGGTTT GGGGGGAAAG AGCTCAGAGA TGAGGAACAG 
ACAGCTGAGA GCATTAAGAA CCAAATGACT GTGAAAGAAT GGGAGAAAGT GTTTGAGATG 
AGTCAAGATA AAAATCTATA CCACAATCTT TGTACCAGCC TGTTCCCTAC TATACATGGC 
AATGATGAAG TAAAACGGGG TGTCCTGCTG ATGCTCTTTG GTGGCGTTCC AAAGACAACA 
GGAGAAGGGA CCTCTCTTCG AGGGGACATA AATGTTTGCA TTGTTGGTGA CCCAAGTACA 
GCTAAGAGCC AATTTCTCAA GCACGTGGAG GAGTTCAGCC CCAGAGCTGT CTACACCAGT 
GGTAAAGCGT CCAGTGCTGC TGGCTTAACA GCAGCTGTTG TGAGAGATGA AGAATCTCAT 
GAGTTTGTCA TTGAGGCTGG AGCTTTGATG TTGGCTGATA ATGGTGTGTG TTGTATTGAT 
GAATTTGATA AGATGGACGT GCGGGATCAA GTTGCTATTC ATGAAGCTAT GGAACAGCAG 
ACCATATCCA TCACTAAAGC AGGAGTGAAG GCTACTCTGA ACGCCCGGAC GTCCATTTTG 
GCAGCAGCAA ACCCAATCAG TGGACACTAT GACAGATCAA AATCATTGAA ACAGAATATA 
AATTTGTCAG CTCCCATCAT GTCCCGATTC GATCTCTTCT TTATCCTTGT GGATGAATGT 
AATGAGGTTA CAGATTATGC CATTGCCAGG CGCATAGTAG ATTTGCATTC AAGAATTGAG 
GAATCAATTG ATCGTGTCTA TTCCCTCGAT GATATCAGAA GATATCTTCT CTTTGCAAGA 
CAGTTTAAAC CCAAGATTTC CAAAGAGTCA GAGGACTTCA TTGTGGAGCA ATATAAACAT 
CTCCGCCAGA GAGATGGTTC TGGAGTGACC AAGTCTTCAT GGAGGATTAC AGTGCGACAG 
CTTGAGAGCA TGATTCGTCT CTCTGAAGCT ATGGCTCGGA TGCACTGCTG TGATGAGGTC 
CAACCTAAAC ATGTGAAGGA AGCTTTCCGG TTACTGAATA AATCAATCAT CCGTGTGGAA 
ACACCTGATG TCAATCTAGA TCAAGAGGAA GAGATCCAGA TGGAGGTAGA TGAGGGTGCT 
GGTGGCATCA ATGGTCATGC TGACAGCCCT GCTCCTGTGA ACGGGATCAA TGGCTACAAT 
GAAGACATAA ATCAAGAGTC TGCTCCCAAA GCCTCCTTAA GGCTGGGCTT CTCTGAGTAC 
TGCCGAATCT CTAACCTTAT TGTGCTTCAC CTCAGAAAGG TGGAAGAAGA AGAGGACGAG 
TCAGCATTAA AGAGGAGCGA GCTTGTTAAC TGGTACTTGA AGGAAATCGA ATCAGAGATA 
GACTCTGAAG AAGAACTTAT AAATAAAAAA AGAATCATAG AGAAAGTTAT TCATCGACTC 
ACACACTATG ATCATGTTCT AATTGAGCTC ACCCAGGCTG GATTGAAAGG CTCCACAGAG 
GGAAGTGAGA GCTATGAAGA AGATCCCTAC TTGGTAGTTA ACCCTAACTA CTTGCTCGAA 
GATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005906.2
CDS	113..2578
Translation	MDLAAAAEPGAGSQHLEVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNTLVVSFVDLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRKEIPLAKDFYVAFQDLPTRHKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQFKYTQPNICRNPVCANRRRFLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDKCDFTGTLIVVPDVSKLSTPGARAETNSRVSGVDGYETEGIRGLRALGVRDLSYRLVFLACCVAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPISGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRIEESIDRVYSLDDIRRYLLFARQFKPKISKESEDFIVEQYKHLRQRDGSGVTKSSWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKSIIRVETPDVNLDQEEEIQMEVDEGAGGINGHADSPAPVNGINGYNEDINQESAPKASLRLGFSEYCRISNLIVLHLRKVEEEEDESALKRSELVNWYLKEIESEIDSEEELINKKRIIEKVIHRLTHYDHVLIELTQAGLKGSTEGSESYEEDPYLVVNPNYLLED

Target ORF information:

RefSeq Version	NM_005915.5
Organism	Homo sapiens(human)
Definition	Homo sapiens minichromosome maintenance complex component 6 (MCM6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005915.5

ORF Insert Sequence:

ATGGACCTCG CGGCGGCAGC GGAGCCGGGC GCCGGCAGCC AGCACCTGGA GGTCCGCGAC 
GAGGTGGCCG AGAAGTGCCA GAAACTGTTC CTGGACTTCT TGGAGGAGTT TCAGAGCAGC 
GATGGAGAAA TTAAATACTT GCAATTAGCA GAGGAACTGA TTCGTCCTGA GAGAAACACA 
TTGGTTGTGA GTTTTGTGGA CCTGGAACAA TTTAACCAGC AACTTTCCAC CACCATTCAA 
GAGGAGTTCT ATAGAGTTTA CCCTTACCTG TGTCGGGCCT TGAAAACATT CGTCAAAGAC 
CGTAAAGAGA TCCCTCTTGC CAAGGATTTT TATGTTGCAT TCCAAGACCT GCCTACCAGA 
CACAAGATTC GAGAGCTCAC CTCATCCAGA ATTGGTTTGC TCACTCGCAT CAGTGGGCAG 
GTGGTGCGGA CTCACCCAGT TCACCCAGAG CTTGTGAGCG GAACTTTTCT GTGCTTGGAC 
TGTCAGACAG TGATCAGGGA TGTAGAACAG CAGTTCAAAT ACACACAGCC AAACATCTGC 
CGAAATCCAG TTTGTGCCAA CAGGAGGAGA TTCTTACTGG ATACAAATAA ATCAAGATTT 
GTTGATTTTC AAAAGGTTCG TATTCAAGAG ACCCAAGCTG AGCTTCCTCG AGGGAGTATC 
CCCCGCAGTT TAGAAGTAAT TTTAAGGGCT GAAGCTGTGG AATCAGCTCA AGCTGGTGAC 
AAGTGTGACT TTACAGGGAC ACTGATTGTT GTGCCTGACG TCTCCAAGCT TAGCACACCA 
GGAGCACGTG CAGAAACTAA TTCCCGTGTC AGTGGTGTTG ATGGATATGA GACAGAAGGC 
ATTCGAGGAC TCCGGGCCCT TGGTGTTAGG GACCTTTCTT ATAGGCTGGT CTTTCTTGCC 
TGCTGTGTTG CGCCAACCAA CCCAAGGTTT GGGGGGAAAG AGCTCAGAGA TGAGGAACAG 
ACAGCTGAGA GCATTAAGAA CCAAATGACT GTGAAAGAAT GGGAGAAAGT GTTTGAGATG 
AGTCAAGATA AAAATCTATA CCACAATCTT TGTACCAGCC TGTTCCCTAC TATACATGGC 
AATGATGAAG TAAAACGGGG TGTCCTGCTG ATGCTCTTTG GTGGCGTTCC AAAGACAACA 
GGAGAAGGGA CCTCTCTTCG AGGGGACATA AATGTTTGCA TTGTTGGTGA CCCAAGTACA 
GCTAAGAGCC AATTTCTCAA GCACGTGGAG GAGTTCAGCC CCAGAGCTGT CTACACCAGT 
GGTAAAGCGT CCAGTGCTGC TGGCTTAACA GCAGCTGTTG TGAGAGATGA AGAATCTCAT 
GAGTTTGTCA TTGAGGCTGG AGCTTTGATG TTGGCTGATA ATGGTGTGTG TTGTATTGAT 
GAATTTGATA AGATGGACGT GCGGGATCAA GTTGCTATTC ATGAAGCTAT GGAACAGCAG 
ACCATATCCA TCACTAAAGC AGGAGTGAAG GCTACTCTGA ACGCCCGGAC GTCCATTTTG 
GCAGCAGCAA ACCCAATCAG TGGACACTAT GACAGATCAA AATCATTGAA ACAGAATATA 
AATTTGTCAG CTCCCATCAT GTCCCGATTC GATCTCTTCT TTATCCTTGT GGATGAATGT 
AATGAGGTTA CAGATTATGC CATTGCCAGG CGCATAGTAG ATTTGCATTC AAGAATTGAG 
GAATCAATTG ATCGTGTCTA TTCCCTCGAT GATATCAGAA GATATCTTCT CTTTGCAAGA 
CAGTTTAAAC CCAAGATTTC CAAAGAGTCA GAGGACTTCA TTGTGGAGCA ATATAAACAT 
CTCCGCCAGA GAGATGGTTC TGGAGTGACC AAGTCTTCAT GGAGGATTAC AGTGCGACAG 
CTTGAGAGCA TGATTCGTCT CTCTGAAGCT ATGGCTCGGA TGCACTGCTG TGATGAGGTC 
CAACCTAAAC ATGTGAAGGA AGCTTTCCGG TTACTGAATA AATCAATCAT CCGTGTGGAA 
ACACCTGATG TCAATCTAGA TCAAGAGGAA GAGATCCAGA TGGAGGTAGA TGAGGGTGCT 
GGTGGCATCA ATGGTCATGC TGACAGCCCT GCTCCTGTGA ACGGGATCAA TGGCTACAAT 
GAAGACATAA ATCAAGAGTC TGCTCCCAAA GCCTCCTTAA GGCTGGGCTT CTCTGAGTAC 
TGCCGAATCT CTAACCTTAT TGTGCTTCAC CTCAGAAAGG TGGAAGAAGA AGAGGACGAG 
TCAGCATTAA AGAGGAGCGA GCTTGTTAAC TGGTACTTGA AGGAAATCGA ATCAGAGATA 
GACTCTGAAG AAGAACTTAT AAATAAAAAA AGAATCATAG AGAAAGTTAT TCATCGACTC 
ACACACTATG ATCATGTTCT AATTGAGCTC ACCCAGGCTG GATTGAAAGG CTCCACAGAG 
GGAAGTGAGA GCTATGAAGA AGATCCCTAC TTGGTAGTTA ACCCTAACTA CTTGCTCGAA 
GATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MCM6 ( NM_005915.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_005906.2 Homo sapiens minichromosome maintenance complex component 6 (MCM6), mRNA.

Price & Availability↑

CloneID	OHu20108
Clone ID Related Accession (Same CDS sequence)	NM_005915.5 , NM_005915.6
Accession Version	NM_005915.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2466bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	DNA replication licensing factor MCM6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA521248.1, BC020268.1, CN389677.1, BC032374.1 and AA577398.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_005915.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.14727.1, SRR1803613.30202.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000264156.3/ ENSP00000264156.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACCTCG CGGCGGCAGC GGAGCCGGGC GCCGGCAGCC AGCACCTGGA GGTCCGCGAC 
GAGGTGGCCG AGAAGTGCCA GAAACTGTTC CTGGACTTCT TGGAGGAGTT TCAGAGCAGC 
GATGGAGAAA TTAAATACTT GCAATTAGCA GAGGAACTGA TTCGTCCTGA GAGAAACACA 
TTGGTTGTGA GTTTTGTGGA CCTGGAACAA TTTAACCAGC AACTTTCCAC CACCATTCAA 
GAGGAGTTCT ATAGAGTTTA CCCTTACCTG TGTCGGGCCT TGAAAACATT CGTCAAAGAC 
CGTAAAGAGA TCCCTCTTGC CAAGGATTTT TATGTTGCAT TCCAAGACCT GCCTACCAGA 
CACAAGATTC GAGAGCTCAC CTCATCCAGA ATTGGTTTGC TCACTCGCAT CAGTGGGCAG 
GTGGTGCGGA CTCACCCAGT TCACCCAGAG CTTGTGAGCG GAACTTTTCT GTGCTTGGAC 
TGTCAGACAG TGATCAGGGA TGTAGAACAG CAGTTCAAAT ACACACAGCC AAACATCTGC 
CGAAATCCAG TTTGTGCCAA CAGGAGGAGA TTCTTACTGG ATACAAATAA ATCAAGATTT 
GTTGATTTTC AAAAGGTTCG TATTCAAGAG ACCCAAGCTG AGCTTCCTCG AGGGAGTATC 
CCCCGCAGTT TAGAAGTAAT TTTAAGGGCT GAAGCTGTGG AATCAGCTCA AGCTGGTGAC 
AAGTGTGACT TTACAGGGAC ACTGATTGTT GTGCCTGACG TCTCCAAGCT TAGCACACCA 
GGAGCACGTG CAGAAACTAA TTCCCGTGTC AGTGGTGTTG ATGGATATGA GACAGAAGGC 
ATTCGAGGAC TCCGGGCCCT TGGTGTTAGG GACCTTTCTT ATAGGCTGGT CTTTCTTGCC 
TGCTGTGTTG CGCCAACCAA CCCAAGGTTT GGGGGGAAAG AGCTCAGAGA TGAGGAACAG 
ACAGCTGAGA GCATTAAGAA CCAAATGACT GTGAAAGAAT GGGAGAAAGT GTTTGAGATG 
AGTCAAGATA AAAATCTATA CCACAATCTT TGTACCAGCC TGTTCCCTAC TATACATGGC 
AATGATGAAG TAAAACGGGG TGTCCTGCTG ATGCTCTTTG GTGGCGTTCC AAAGACAACA 
GGAGAAGGGA CCTCTCTTCG AGGGGACATA AATGTTTGCA TTGTTGGTGA CCCAAGTACA 
GCTAAGAGCC AATTTCTCAA GCACGTGGAG GAGTTCAGCC CCAGAGCTGT CTACACCAGT 
GGTAAAGCGT CCAGTGCTGC TGGCTTAACA GCAGCTGTTG TGAGAGATGA AGAATCTCAT 
GAGTTTGTCA TTGAGGCTGG AGCTTTGATG TTGGCTGATA ATGGTGTGTG TTGTATTGAT 
GAATTTGATA AGATGGACGT GCGGGATCAA GTTGCTATTC ATGAAGCTAT GGAACAGCAG 
ACCATATCCA TCACTAAAGC AGGAGTGAAG GCTACTCTGA ACGCCCGGAC GTCCATTTTG 
GCAGCAGCAA ACCCAATCAG TGGACACTAT GACAGATCAA AATCATTGAA ACAGAATATA 
AATTTGTCAG CTCCCATCAT GTCCCGATTC GATCTCTTCT TTATCCTTGT GGATGAATGT 
AATGAGGTTA CAGATTATGC CATTGCCAGG CGCATAGTAG ATTTGCATTC AAGAATTGAG 
GAATCAATTG ATCGTGTCTA TTCCCTCGAT GATATCAGAA GATATCTTCT CTTTGCAAGA 
CAGTTTAAAC CCAAGATTTC CAAAGAGTCA GAGGACTTCA TTGTGGAGCA ATATAAACAT 
CTCCGCCAGA GAGATGGTTC TGGAGTGACC AAGTCTTCAT GGAGGATTAC AGTGCGACAG 
CTTGAGAGCA TGATTCGTCT CTCTGAAGCT ATGGCTCGGA TGCACTGCTG TGATGAGGTC 
CAACCTAAAC ATGTGAAGGA AGCTTTCCGG TTACTGAATA AATCAATCAT CCGTGTGGAA 
ACACCTGATG TCAATCTAGA TCAAGAGGAA GAGATCCAGA TGGAGGTAGA TGAGGGTGCT 
GGTGGCATCA ATGGTCATGC TGACAGCCCT GCTCCTGTGA ACGGGATCAA TGGCTACAAT 
GAAGACATAA ATCAAGAGTC TGCTCCCAAA GCCTCCTTAA GGCTGGGCTT CTCTGAGTAC 
TGCCGAATCT CTAACCTTAT TGTGCTTCAC CTCAGAAAGG TGGAAGAAGA AGAGGACGAG 
TCAGCATTAA AGAGGAGCGA GCTTGTTAAC TGGTACTTGA AGGAAATCGA ATCAGAGATA 
GACTCTGAAG AAGAACTTAT AAATAAAAAA AGAATCATAG AGAAAGTTAT TCATCGACTC 
ACACACTATG ATCATGTTCT AATTGAGCTC ACCCAGGCTG GATTGAAAGG CTCCACAGAG 
GGAAGTGAGA GCTATGAAGA AGATCCCTAC TTGGTAGTTA ACCCTAACTA CTTGCTCGAA 
GATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005906.2
CDS	79..2544
Translation	MDLAAAAEPGAGSQHLEVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNTLVVSFVDLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRKEIPLAKDFYVAFQDLPTRHKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQFKYTQPNICRNPVCANRRRFLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDKCDFTGTLIVVPDVSKLSTPGARAETNSRVSGVDGYETEGIRGLRALGVRDLSYRLVFLACCVAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPISGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRIEESIDRVYSLDDIRRYLLFARQFKPKISKESEDFIVEQYKHLRQRDGSGVTKSSWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKSIIRVETPDVNLDQEEEIQMEVDEGAGGINGHADSPAPVNGINGYNEDINQESAPKASLRLGFSEYCRISNLIVLHLRKVEEEEDESALKRSELVNWYLKEIESEIDSEEELINKKRIIEKVIHRLTHYDHVLIELTQAGLKGSTEGSESYEEDPYLVVNPNYLLED

Target ORF information:

RefSeq Version	NM_005915.6
Organism	Homo sapiens(human)
Definition	Homo sapiens minichromosome maintenance complex component 6 (MCM6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005915.6

ORF Insert Sequence:

ATGGACCTCG CGGCGGCAGC GGAGCCGGGC GCCGGCAGCC AGCACCTGGA GGTCCGCGAC 
GAGGTGGCCG AGAAGTGCCA GAAACTGTTC CTGGACTTCT TGGAGGAGTT TCAGAGCAGC 
GATGGAGAAA TTAAATACTT GCAATTAGCA GAGGAACTGA TTCGTCCTGA GAGAAACACA 
TTGGTTGTGA GTTTTGTGGA CCTGGAACAA TTTAACCAGC AACTTTCCAC CACCATTCAA 
GAGGAGTTCT ATAGAGTTTA CCCTTACCTG TGTCGGGCCT TGAAAACATT CGTCAAAGAC 
CGTAAAGAGA TCCCTCTTGC CAAGGATTTT TATGTTGCAT TCCAAGACCT GCCTACCAGA 
CACAAGATTC GAGAGCTCAC CTCATCCAGA ATTGGTTTGC TCACTCGCAT CAGTGGGCAG 
GTGGTGCGGA CTCACCCAGT TCACCCAGAG CTTGTGAGCG GAACTTTTCT GTGCTTGGAC 
TGTCAGACAG TGATCAGGGA TGTAGAACAG CAGTTCAAAT ACACACAGCC AAACATCTGC 
CGAAATCCAG TTTGTGCCAA CAGGAGGAGA TTCTTACTGG ATACAAATAA ATCAAGATTT 
GTTGATTTTC AAAAGGTTCG TATTCAAGAG ACCCAAGCTG AGCTTCCTCG AGGGAGTATC 
CCCCGCAGTT TAGAAGTAAT TTTAAGGGCT GAAGCTGTGG AATCAGCTCA AGCTGGTGAC 
AAGTGTGACT TTACAGGGAC ACTGATTGTT GTGCCTGACG TCTCCAAGCT TAGCACACCA 
GGAGCACGTG CAGAAACTAA TTCCCGTGTC AGTGGTGTTG ATGGATATGA GACAGAAGGC 
ATTCGAGGAC TCCGGGCCCT TGGTGTTAGG GACCTTTCTT ATAGGCTGGT CTTTCTTGCC 
TGCTGTGTTG CGCCAACCAA CCCAAGGTTT GGGGGGAAAG AGCTCAGAGA TGAGGAACAG 
ACAGCTGAGA GCATTAAGAA CCAAATGACT GTGAAAGAAT GGGAGAAAGT GTTTGAGATG 
AGTCAAGATA AAAATCTATA CCACAATCTT TGTACCAGCC TGTTCCCTAC TATACATGGC 
AATGATGAAG TAAAACGGGG TGTCCTGCTG ATGCTCTTTG GTGGCGTTCC AAAGACAACA 
GGAGAAGGGA CCTCTCTTCG AGGGGACATA AATGTTTGCA TTGTTGGTGA CCCAAGTACA 
GCTAAGAGCC AATTTCTCAA GCACGTGGAG GAGTTCAGCC CCAGAGCTGT CTACACCAGT 
GGTAAAGCGT CCAGTGCTGC TGGCTTAACA GCAGCTGTTG TGAGAGATGA AGAATCTCAT 
GAGTTTGTCA TTGAGGCTGG AGCTTTGATG TTGGCTGATA ATGGTGTGTG TTGTATTGAT 
GAATTTGATA AGATGGACGT GCGGGATCAA GTTGCTATTC ATGAAGCTAT GGAACAGCAG 
ACCATATCCA TCACTAAAGC AGGAGTGAAG GCTACTCTGA ACGCCCGGAC GTCCATTTTG 
GCAGCAGCAA ACCCAATCAG TGGACACTAT GACAGATCAA AATCATTGAA ACAGAATATA 
AATTTGTCAG CTCCCATCAT GTCCCGATTC GATCTCTTCT TTATCCTTGT GGATGAATGT 
AATGAGGTTA CAGATTATGC CATTGCCAGG CGCATAGTAG ATTTGCATTC AAGAATTGAG 
GAATCAATTG ATCGTGTCTA TTCCCTCGAT GATATCAGAA GATATCTTCT CTTTGCAAGA 
CAGTTTAAAC CCAAGATTTC CAAAGAGTCA GAGGACTTCA TTGTGGAGCA ATATAAACAT 
CTCCGCCAGA GAGATGGTTC TGGAGTGACC AAGTCTTCAT GGAGGATTAC AGTGCGACAG 
CTTGAGAGCA TGATTCGTCT CTCTGAAGCT ATGGCTCGGA TGCACTGCTG TGATGAGGTC 
CAACCTAAAC ATGTGAAGGA AGCTTTCCGG TTACTGAATA AATCAATCAT CCGTGTGGAA 
ACACCTGATG TCAATCTAGA TCAAGAGGAA GAGATCCAGA TGGAGGTAGA TGAGGGTGCT 
GGTGGCATCA ATGGTCATGC TGACAGCCCT GCTCCTGTGA ACGGGATCAA TGGCTACAAT 
GAAGACATAA ATCAAGAGTC TGCTCCCAAA GCCTCCTTAA GGCTGGGCTT CTCTGAGTAC 
TGCCGAATCT CTAACCTTAT TGTGCTTCAC CTCAGAAAGG TGGAAGAAGA AGAGGACGAG 
TCAGCATTAA AGAGGAGCGA GCTTGTTAAC TGGTACTTGA AGGAAATCGA ATCAGAGATA 
GACTCTGAAG AAGAACTTAT AAATAAAAAA AGAATCATAG AGAAAGTTAT TCATCGACTC 
ACACACTATG ATCATGTTCT AATTGAGCTC ACCCAGGCTG GATTGAAAGG CTCCACAGAG 
GGAAGTGAGA GCTATGAAGA AGATCCCTAC TTGGTAGTTA ACCCTAACTA CTTGCTCGAA 
GATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MCM6 promotes metastasis of hepatocellular carcinoma via MEK/ERK pathway and serves as a novel serum biomarker for early recurrence.
Journal of experimental & clinical cancer research : CR37(1)10(2018 Jan)
Liu M,Hu Q,Tu M,Wang X,Yang Z,Yang G,Luo R

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MCM6 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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